The DOI matches its Crossref record; 45 of the 45 references it cites were found in a registry or an index.
Acute Induction of Eya3 by Late-Night Light Stimulation Triggers TSHβ Expression in Photoperiodism
Open accessAbstract
Living organisms detect seasonal changes in day length (photoperiod) [1-3] and alter their physiological functions accordingly to fit seasonal environmental changes. TSHβ, induced in the pars tuberalis (PT), plays a key role in the pathway that regulates vertebrate photoperiodism [4, 5]. However, the upstream inducers of TSHβ expression remain unknown. Here we performed genome-wide expression analysis of the PT under chronic short-day and long-day conditions in melatonin-proficient CBA/N mice, in which the photoperiodic TSHβ expression response is preserved [6]. This analysis identified "short-day" and "long-day" genes, including TSHβ, and further predicted the acute induction of long-day genes by late-night light stimulation. We verified this by advancing and extending the light period by 8 hr, which induced TSHβ expression within one day. In the following genome-wide expression analysis under this acute long-day condition, we searched for candidate upstream genes by looking for expression that preceded TSHβ's, and we identified the Eya3 gene. We demonstrated that Eya3 and its partner Six1 synergistically activate TSHβ expression and that this activation is further enhanced by Tef and Hlf. These results elucidate the comprehensive transcriptional photoperiodic response in the PT, revealing the complex regulation of TSHβ expression and unexpectedly rapid response to light changes in the mammalian photoperiodic system.
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“Melatonin-proficient mice appear to possess a similar ability to induce eya3, suggesting that this mechanism could be evolutionarily conserved (57).”
From An Overview of Monthly Rhythms and Clocks (2017) · cites this paper as [57]
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Cites
Statistical significance for genomewide studies
Storey, J. D., & Tibshirani, R. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1530509100 · Cited by 9,692
Summaries of Affymetrix GeneChip probe level data
Irizarry, R. A. (2003) · Nucleic Acids Research · doi:10.1093/nar/gng015 · Cited by 4,837
An Introduction to Systems Biology: Design Principles of Biological Circuits
Alon, U. (2006) · doi:10.1201/9781420011432 · Cited by 2,825
Yoo, S.-H., Yamazaki, S., Lowrey, P. L., Shimomura, K., Ko, C. H., Buhr, E. D., Siepka, S. M., Hong, H.-K., Oh, W. J., Yoo, O. J., et al. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0308709101 · Cited by 2,329
Photoperiodic Control of Seasonality in Birds
Dawson, A., King, V. M., Bentley, G. E., & Ball, G. F. (2001) · Journal of Biological Rhythms · doi:10.1177/074873001129002079 · Cited by 1,023
The melatonin rhythm: both a clock and a calendar
Reiter, R. J. (1993) · Cellular and Molecular Life Sciences · doi:10.1007/bf01923947 · Cited by 997
Shigeyoshi, Y., Taguchi, K., Yamamoto, S., Takekida, S., Yan, L., Tei, H., Moriya, T., Shibata, S., Loros, J. J., Dunlap, J. C., et al. (1997) · Cell · doi:10.1016/s0092-8674(00)80494-8 · Cited by 891
Goldman, B. D. (2001) · Journal of Biological Rhythms · doi:10.1177/074873001129001980 · Cited by 771
Li, X., Ohgi, K. A., Zhang, J., Krones, A., Bush, K. T., Glass, C. K., Nigám, S. K., Aggarwal, A. K., Maas, R. L., Rose, D. W., et al. (2003) · Nature · doi:10.1038/nature02083 · Cited by 636
Bonini, N. M., Leiserson, W. M., & Benzer, S. (1993) · Cell · doi:10.1016/0092-8674(93)90115-7 · Cited by 559
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Xia, Q., Di, R., He, X., Wei, C., & Chu, M. (2020) · Archives animal breeding/Archiv für Tierzucht · doi:10.5194/aab-63-451-2020 · Cited by 2
Long Noncoding RNAs Expressed in Mouse Pituitary Development and Mature Hormone-Producing Cells
Brinkmeier, M. L., George, A. S., Cheung, L., Mills, R. E., Melamed, P., & Camper, S. A. (2024) · Endocrinology · doi:10.1210/endocr/bqae147 · Cited by 2
Photoperiodism and Circannual Timing: Introduction and Historical Perspective
Lincoln, G. A., & Ebling, F. J. P. (2020) · Masterclass in neuroendocrinology · doi:10.1007/978-3-030-55643-3_1 · Cited by 2
Wang, L., Ying, Y., Li, N., Song, Y., Zhao, L., Sun, H. Q., Wang, Z., Liu, X., & Wang, D. (2025) · Functional & Integrative Genomics · doi:10.1007/s10142-025-01562-9 · Cited by 1
West, A. C., Wood, S. H., Iversen, M., van Dalum, M. J., Jørgensen, E. H., Sandve, S. R., & Hazlerigg, D. G. (2025) · Journal of Comparative Physiology A · doi:10.1007/s00359-025-01779-w · Cited by 1
Adenosine stimulates neuromedin U mRNA expression in the rat pars tuberalis
Aizawa, S., Gu, T., Kaminoda, A., Fujioka, R., Ojima, F., Sakata, I., Sakai, T., Ogoshi, M., Takahashi, S., & Takeuchi, S. (2019) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2019.110518 · Cited by 3
Transcripts from the Circadian Clock: Telling Time and Season
Brand, K. (2011) · EUR Research Repository (Erasmus University Rotterdam)
Evolution of Photoperiodism in the Threespine Stickleback Gasterosteus aculeatus
O’Brien, C. S. (2011) · Scholars' Bank (University of Oregon)
Adaptive value of circadian rhythms in High Arctic Svalbard ptarmiganPreprint
Appenroth, D., Wagner, G., Hazlerigg, D. G., & West, A. C. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.08.17.254011
Kawabe, J., Kawakami, N., Hirose, M., Kitamura, Y., Nagano, M., Maruyama, Y., Matsuyama, Y., Hamano, T., Koinuma, S., Shiina, T., et al. (2025) · PNAS Nexus · doi:10.1093/pnasnexus/pgaf159
The role of photoperiodic history and internal long‐term timing in seasonal neuroendocrinology
de Miera, C. S. (2014) · theses.fr (ABES) · doi:10.70675/47096af2zc13ez4ec6zb129z7459026d6fe7
Photoperiodic regulation of reproductive behaviour in female white-rumped munia ( Lonchura striata )
Lalpekhlui, R., Hnamler, L., & Trivedi, A. K. (2026) · Chronobiology International · doi:10.1080/07420528.2026.2658024
A missense mutation in FBXL3 links circadian regulation to out-of-season estrus in sheepPreprint
Yang, Y., Zhang, N., Li, T., Wang, H., Huang, X., Ma, R., Zhang, H., Jing, X., Di, R., Xia, Q., et al. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.06.18.733072
Hnamler, L., Lalpekhlui, R., Lalrinawma, T. S. K., Lalhmingmawii, R. C., Renthlei, Z., & Trivedi, A. K. (2026) · Journal of Experimental Zoology Part A Ecological and Integrative Physiology · doi:10.1002/jez.70113
Vivarelli, S., Falzone, L., Fiorino, F. S., Giambò, F., Libra, M., & Fenga, C. (2026) · Frontiers in Endocrinology · doi:10.3389/fendo.2026.1934310
The seasonal regulation of prolactin in the pituitary gland
Sarri, S. (2013) · Research Explorer (The University of Manchester)
Metadata
- Authors
- Masumoto, K.-H., Ukai-Tadenuma, M., Kasukawa, T., Nagano, M., Uno, K. D., Tsujino, K., Horikawa, K., Shigeyoshi, Y., & Ueda, H. R.
- Affiliations
- RIKEN (JP)
- Kindai University (JP)
- Kyoto University (JP)
- Corresponding author
- Shigeyoshi, Yasufumi
- Ueda, Hiroki R.
- Venue
- Current Biology
- Publisher
- Elsevier BV
- Published
- 2010-12
- Volume
- 20
- Issue
- 24
- Pages
- 2199-2206
- ISSN
- 0960-9822 (ISSN-L)
- OpenAlex
- W2079304693
- Cited by
- 118
- References
- 45
- Citations by year
- 2026: 4 · 2025: 7 · 2024: 4 · 2023: 10 · 2022: 5 · 2021: 9 · 2020: 11 · 2019: 4 · 2018: 5 · 2017: 7 · 2016: 4 · 2015: 4 · 2014: 8 · 2013: 11 · 2012: 12
- FWCI
- 5.20
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Current Biology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Keywords
- photoperiodism, EYA3, Six1, pars tuberalis, transcriptional regulation, Eragrostis tef, HLF, melatonin, circadian rhythm
- MeSH terms
- Animals, Circadian Rhythm, DNA-Binding Proteins, Molecular Sequence Data, Photic Stimulation, Promoter Regions, Genetic, Photoperiod, Homeodomain Proteins, Oligonucleotide Array Sequence Analysis, Gene Expression Profiling, Thyrotropin, beta Subunit, Mice
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