Cited by 118Circadian rhythm and melatoninHypothalamic control of reproductive hormonesDevelopmental Biology and Gene Regulation

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Acute Induction of Eya3 by Late-Night Light Stimulation Triggers TSHβ Expression in Photoperiodism

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Masumoto, Koh-hei, Ukai-Tadenuma, Maki, Kasukawa, Takeya, Nagano, Mamoru, Uno, Kenichiro D., Tsujino, Kaori, Horikawa, Kazumasa, Shigeyoshi, Yasufumi, Ueda, Hiroki R.·2010·Current Biology

DOI 10.1016/j.cub.2010.11.038

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Abstract

Living organisms detect seasonal changes in day length (photoperiod) [1-3] and alter their physiological functions accordingly to fit seasonal environmental changes. TSHβ, induced in the pars tuberalis (PT), plays a key role in the pathway that regulates vertebrate photoperiodism [4, 5]. However, the upstream inducers of TSHβ expression remain unknown. Here we performed genome-wide expression analysis of the PT under chronic short-day and long-day conditions in melatonin-proficient CBA/N mice, in which the photoperiodic TSHβ expression response is preserved [6]. This analysis identified "short-day" and "long-day" genes, including TSHβ, and further predicted the acute induction of long-day genes by late-night light stimulation. We verified this by advancing and extending the light period by 8 hr, which induced TSHβ expression within one day. In the following genome-wide expression analysis under this acute long-day condition, we searched for candidate upstream genes by looking for expression that preceded TSHβ's, and we identified the Eya3 gene. We demonstrated that Eya3 and its partner Six1 synergistically activate TSHβ expression and that this activation is further enhanced by Tef and Hlf. These results elucidate the comprehensive transcriptional photoperiodic response in the PT, revealing the complex regulation of TSHβ expression and unexpectedly rapid response to light changes in the mammalian photoperiodic system.

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Authors: Masumoto, K.-H., Ukai-Tadenuma, M., Kasukawa, T., Nagano, M., Uno, K. D., Tsujino, K., Horikawa, K., Shigeyoshi, Y., & Ueda, H. R.
Affiliations: RIKEN (JP)
Kindai University (JP)
Kyoto University (JP)
Corresponding author: Shigeyoshi, Yasufumi
Ueda, Hiroki R.
ORCID: Masumoto, Koh-hei
Kasukawa, Takeya
Nagano, Mamoru
Shigeyoshi, Yasufumi
Ueda, Hiroki R.
Venue: Current Biology
Publisher: Elsevier BV
Published: 2010-12
Volume: 20
Issue: 24
Pages: 2199-2206
ISSN: 0960-9822 (ISSN-L)
DOI: 10.1016/j.cub.2010.11.038
OpenAlex: W2079304693
Cited by: 118
References: 45
Citations by year: 2026: 4 · 2025: 7 · 2024: 4 · 2023: 10 · 2022: 5 · 2021: 9 · 2020: 11 · 2019: 4 · 2018: 5 · 2017: 7 · 2016: 4 · 2015: 4 · 2014: 8 · 2013: 11 · 2012: 12
FWCI: 5.20
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 995 d)
Locations: Current Biology (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
Keywords: photoperiodism, EYA3, Six1, pars tuberalis, transcriptional regulation, Eragrostis tef, HLF, melatonin, circadian rhythm
MeSH terms: Animals, Circadian Rhythm, DNA-Binding Proteins, Molecular Sequence Data, Photic Stimulation, Promoter Regions, Genetic, Photoperiod, Homeodomain Proteins, Oligonucleotide Array Sequence Analysis, Gene Expression Profiling, Thyrotropin, beta Subunit, Mice

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Acute Induction of Eya3 by Late-Night Light Stimulation Triggers TSHβ Expression in Photoperiodism

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