The DOI matches its Crossref record; 45 of the 45 references it cites were found in a registry or an index.
Acute Induction of Eya3 by Late-Night Light Stimulation Triggers TSHβ Expression in Photoperiodism
Open accessAbstract
Living organisms detect seasonal changes in day length (photoperiod) [1-3] and alter their physiological functions accordingly to fit seasonal environmental changes. TSHβ, induced in the pars tuberalis (PT), plays a key role in the pathway that regulates vertebrate photoperiodism [4, 5]. However, the upstream inducers of TSHβ expression remain unknown. Here we performed genome-wide expression analysis of the PT under chronic short-day and long-day conditions in melatonin-proficient CBA/N mice, in which the photoperiodic TSHβ expression response is preserved [6]. This analysis identified "short-day" and "long-day" genes, including TSHβ, and further predicted the acute induction of long-day genes by late-night light stimulation. We verified this by advancing and extending the light period by 8 hr, which induced TSHβ expression within one day. In the following genome-wide expression analysis under this acute long-day condition, we searched for candidate upstream genes by looking for expression that preceded TSHβ's, and we identified the Eya3 gene. We demonstrated that Eya3 and its partner Six1 synergistically activate TSHβ expression and that this activation is further enhanced by Tef and Hlf. These results elucidate the comprehensive transcriptional photoperiodic response in the PT, revealing the complex regulation of TSHβ expression and unexpectedly rapid response to light changes in the mammalian photoperiodic system.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Melatonin-proficient mice appear to possess a similar ability to induce eya3, suggesting that this mechanism could be evolutionarily conserved (57).”
From An Overview of Monthly Rhythms and Clocks (2017) · cites this paper as [57]
Citations
Cites
Statistical significance for genomewide studies
Storey, J. D., & Tibshirani, R. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1530509100 · Cited by 9,692
Summaries of Affymetrix GeneChip probe level data
Irizarry, R. A. (2003) · Nucleic Acids Research · doi:10.1093/nar/gng015 · Cited by 4,837
An Introduction to Systems Biology: Design Principles of Biological Circuits
Alon, U. (2006) · doi:10.1201/9781420011432 · Cited by 2,825
Yoo, S.-H., Yamazaki, S., Lowrey, P. L., Shimomura, K., Ko, C. H., Buhr, E. D., Siepka, S. M., Hong, H.-K., Oh, W. J., Yoo, O. J., et al. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0308709101 · Cited by 2,329
Photoperiodic Control of Seasonality in Birds
Dawson, A., King, V. M., Bentley, G. E., & Ball, G. F. (2001) · Journal of Biological Rhythms · doi:10.1177/074873001129002079 · Cited by 1,023
The melatonin rhythm: both a clock and a calendar
Reiter, R. J. (1993) · Cellular and Molecular Life Sciences · doi:10.1007/bf01923947 · Cited by 997
Shigeyoshi, Y., Taguchi, K., Yamamoto, S., Takekida, S., Yan, L., Tei, H., Moriya, T., Shibata, S., Loros, J. J., Dunlap, J. C., et al. (1997) · Cell · doi:10.1016/s0092-8674(00)80494-8 · Cited by 891
Goldman, B. D. (2001) · Journal of Biological Rhythms · doi:10.1177/074873001129001980 · Cited by 771
Li, X., Ohgi, K. A., Zhang, J., Krones, A., Bush, K. T., Glass, C. K., Nigám, S. K., Aggarwal, A. K., Maas, R. L., Rose, D. W., et al. (2003) · Nature · doi:10.1038/nature02083 · Cited by 636
Bonini, N. M., Leiserson, W. M., & Benzer, S. (1993) · Cell · doi:10.1016/0092-8674(93)90115-7 · Cited by 559
Cited by
Sorted by citations
Seasonal Regulation of Reproduction in Mammals
Hazlerigg, D. G., & Simonneaux, V. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-397175-3.00034-x · Cited by 288
Latitudinal clines: an evolutionary view on biological rhythms,
Hut, R. A., Paolucci, S., Dor, R., Kyriacou, C. P., & Daan, S. (2013) · Proceedings of the Royal Society B Biological Sciences · doi:10.1098/rspb.2013.0433 · Cited by 241
Thyroid Hormone and Seasonal Rhythmicity
Dardente, H., Hazlerigg, D. G., & Ebling, F. J. P. (2014) · Frontiers in Endocrinology · doi:10.3389/fendo.2014.00019 · Cited by 226
Human blood metabolite timetable indicates internal body time
Kasukawa, T., Sugimoto, M., Hida, A., Minami, Y., Mori, M., Honma, S., Honma, K.-I., Mishima, K., Soga, T., & Ueda, H. R. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1207768109 · Cited by 211
Wood, S. H., & Loudon, A. S. I. (2014) · Journal of Endocrinology · doi:10.1530/joe-14-0141 · Cited by 197
Metadata
- Authors
- Masumoto, K.-H., Ukai-Tadenuma, M., Kasukawa, T., Nagano, M., Uno, K. D., Tsujino, K., Horikawa, K., Shigeyoshi, Y., & Ueda, H. R.
- Affiliations
- RIKEN (JP)
- Kindai University (JP)
- Kyoto University (JP)
- Corresponding author
- Shigeyoshi, Yasufumi
- Ueda, Hiroki R.
- Venue
- Current Biology
- Publisher
- Elsevier BV
- Published
- 2010-12
- Volume
- 20
- Issue
- 24
- Pages
- 2199-2206
- ISSN
- 0960-9822 (ISSN-L)
- OpenAlex
- W2079304693
- Cited by
- 118
- References
- 45
- Citations by year
- 2026: 4 · 2025: 7 · 2024: 4 · 2023: 10 · 2022: 5 · 2021: 9 · 2020: 11 · 2019: 4 · 2018: 5 · 2017: 7 · 2016: 4 · 2015: 4 · 2014: 8 · 2013: 11 · 2012: 12
- FWCI
- 5.20
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Current Biology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Keywords
- photoperiodism, EYA3, Six1, pars tuberalis, transcriptional regulation, Eragrostis tef, HLF, melatonin, circadian rhythm
- MeSH terms
- Animals, Circadian Rhythm, DNA-Binding Proteins, Molecular Sequence Data, Photic Stimulation, Promoter Regions, Genetic, Photoperiod, Homeodomain Proteins, Oligonucleotide Array Sequence Analysis, Gene Expression Profiling, Thyrotropin, beta Subunit, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
