Light-Induced Resetting of a Mammalian Circadian Clock Is Associated with Rapid Induction of the Transcript
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To understand how light might entrain a mammalian circadian clock, we examined the effects of light on mPer1, a sequence homolog of Drosophila per, that exhibits robust rhythmic expression in the SCN. mPer1 is rapidly induced by short duration exposure to light at levels sufficient to reset the clock, and dose-response curves reveal that mPer1 induction shows both reciprocity and a strong correlation with phase shifting of the overt rhythm. Thus, in both the phasing of dark expression and the response to light mPer1 is most similar to the Neurospora clock gene frq. Within the SCN there appears to be localization of the induction phenomenon, consistent with the localization of both light-sensitive and light-insensitive oscillators in this circadian center.
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Light exposure during the night phase shifts the clock transcription-translation cycle by rapidly inducing expression of Per1 or Per2, depending on whether the light occurs during the early or late night.
“Light exposure during the night phase shifts the clock transcription-translations cycle by rapidly inducing expression of Per1 or Per2, depending on whether the light occurs during the early or late night42–44.”
From Circadian rhythm disruption and mental health (2020) · cites this paper as [44]
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- Authors
- Shigeyoshi, Y., Taguchi, K., Yamamoto, S., Takekida, S., Yan, L., Tei, H., Moriya, T., Shibata, S., Loros, J. J., Dunlap, J. C., & Okamura, H.
- Affiliations
- Kobe University (JP)
- Institute of Medical Science, The University of Tokyo (JP)
- Waseda University (JP)
- Dartmouth College (US)
- Corresponding author
- Okamura, Hitoshi
- ORCID
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 1997-12
- Volume
- 91
- Issue
- 7
- Pages
- 1043-1053
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2057522076
- Cited by
- 891
- References
- 49
- Citations by year
- 2026: 14 · 2025: 22 · 2024: 22 · 2023: 21 · 2022: 25 · 2021: 24 · 2020: 18 · 2019: 29 · 2018: 21 · 2017: 26 · 2016: 28 · 2015: 21 · 2014: 17 · 2013: 22 · 2012: 19
- FWCI
- 14.88
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Cell (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (1k05mh001186-01)
- National Institute of Mental Health (MH01186, MH 44651, R01MH044651)
- National Institute of General Medical Sciences (GM34985)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Light effects on plants
- Keywords
- circadian clock, light entrainment, mPer1, suprachiasmatic nucleus, phase shifting, FRQ, clock gene expression
- MeSH terms
- Animals, Circadian Rhythm, Dose-Response Relationship, Radiation, Light, Male, Mice, Inbred BALB C, Molecular Sequence Data, Motor Activity, Nuclear Proteins, RNA, Messenger, Transcription, Genetic, Cell Cycle Proteins, Mice, Period Circadian Proteins
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