Human blood metabolite timetable indicates internal body time
Open accessAbstract
A convenient way to estimate internal body time (BT) is essential for chronotherapy and time-restricted feeding, both of which use body-time information to maximize potency and minimize toxicity during drug administration and feeding, respectively. Previously, we proposed a molecular timetable based on circadian-oscillating substances in multiple mouse organs or blood to estimate internal body time from samples taken at only a few time points. Here we applied this molecular-timetable concept to estimate and evaluate internal body time in humans. We constructed a 1.5-d reference timetable of oscillating metabolites in human blood samples with 2-h sampling frequency while simultaneously controlling for the confounding effects of activity level, light, temperature, sleep, and food intake. By using this metabolite timetable as a reference, we accurately determined internal body time within 3 h from just two anti-phase blood samples. Our minimally invasive, molecular-timetable method with human blood enables highly optimized and personalized medicine.
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Under constant routine conditions in which exogenous factors are removed or fixed, only 10-20% of metabolites appear rhythmic.
“However, under constant routine conditions in which exogenous factors are removed or fixed, only 10–20% of metabolites appear rhythmic (5–7).”
From Separation of circadian- and behavior-driven metabolite rhythms in humans provides a window on peripheral oscillators and metabolism (2018) · cites this paper as [6]
Cites
Coordination of circadian timing in mammals
Reppert, S. M., & Weaver, D. R. (2002) · Nature · doi:10.1038/nature00965 · Cited by 4,379 · see citing works
Coordinated Transcription of Key Pathways in the Mouse by the Circadian Clock
Panda, S., Antoch, M. P., Miller, B. H., Su, A. I., Schook, A. C., Straume, M., Schultz, P. G., Kay, S. A., Takahashi, J. S., & Hogenesch, J. B. (2002) · Cell · doi:10.1016/s0092-8674(02)00722-5 · Cited by 2,272 · see citing works
Hatori, M., Vollmers, C., Zarrinpar, A., DiTacchio, L., Bushong, E. A., Gill, S., Leblanc, M., Chaix, A., Joens, M., Fitzpatrick, J. A. J., et al. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.04.019 · Cited by 1,986 · see citing works
Circadian integration of metabolism and energetics
Bass, J., & Takahashi, J. S. (2010) · Science · doi:10.1126/science.1195027 · Cited by 1,910 · see citing works
Stability, precision, and near-24-hour period of the human circadian pacemaker
Czeisler, C. A., Duffy, J. F., Shanahan, T. L., Brown, E. N., Mitchell, J. F., Rimmer, D. W., Ronda, J. M., Silva, E. J., Allan, J. S., Emens, J. S., et al. (1999) · Science · doi:10.1126/science.284.5423.2177 · Cited by 1,705 · see citing works
The genetics of mammalian circadian order and disorder: implications for physiology and disease
Takahashi, J. S., Hong, H.-K., Ko, C. H., & McDearmon, E. L. (2008) · Nature Reviews Genetics · doi:10.1038/nrg2430 · Cited by 1,611 · see citing works
Extensive and divergent circadian gene expression in liver and heart
Storch, K.-F., Lipan, O., Leykin, I., Viswanathan, N., Davis, F. C., Wong, W. H., & Weitz, C. J. (2002) · Nature · doi:10.1038/nature744 · Cited by 1,509 · see citing works
An h <i>Per2</i> Phosphorylation Site Mutation in Familial Advanced Sleep Phase Syndrome
Toh, K. L., Jones, C. R., He, Y., Eide, E. J., Hinz, W. A., Virshup, D. M., Ptáček, L. J., & Fu, Y.-H. (2001) · Science · doi:10.1126/science.1057499 · Cited by 1,460 · see citing works
Nakahata, Y., Kaluzova, M., Grimaldi, B., Sahar, S., Hirayama, J., Chen, D., Guarente, L. P., & Sassone-Corsi, P. (2008) · Cell · doi:10.1016/j.cell.2008.07.002 · Cited by 1,427 · see citing works
Twenty-four hour pattern of the episodic secretion of cortisol in normal subjects
WEITZMAN, E. D., FUKUSHIMA, D., NOGEIRE, C., ROFFWARG, H., GALLAGHER, T. F., & HELLMAN, L. (1971) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-33-1-14 · Cited by 1,258 · see citing works
Sugimoto, M., Wong, D. T., Hirayama, A., Soga, T., & Tomita, M. (2009) · Metabolomics · doi:10.1007/s11306-009-0178-y · Cited by 999 · see citing works
Self-citationInouye, S. T., & Kawamura, H. (1979) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.76.11.5962 · Cited by 985 · see citing works
Circadian timing of food intake contributes to weight gain
Arble, D. M., Bass, J., Laposky, A. D., Vitaterna, M. H., & Turek, F. W. (2009) · Obesity · doi:10.1038/oby.2009.264 · Cited by 953 · see citing works
Nuclear Receptor Expression Links the Circadian Clock to Metabolism
Yang, X., Downes, M., Yu, R. T., Bookout, A. L., He, W., Straume, M., Mangelsdorf, D. J., & Evans, R. M. (2006) · Cell · doi:10.1016/j.cell.2006.06.050 · Cited by 934 · see citing works
Green, C. B., Takahashi, J. S., & Bass, J. (2008) · Cell · doi:10.1016/j.cell.2008.08.022 · Cited by 902 · see citing works
Functional consequences of a CKIδ mutation causing familial advanced sleep phase syndrome
Xu, Y., Padiath, Q. S., Shapiro, R. E., Jones, C. R., Wu, S. C., Saigoh, N., Saigoh, K., Ptáček, L. J., & Fu, Y.-H. (2005) · Nature · doi:10.1038/nature03453 · Cited by 861 · see citing works
A transcription factor response element for gene expression during circadian night
Ueda, H. R., Chen, W., Adachi, A. A., Wakamatsu, H., Hayashi, S., Takasugi, T., Nagano, M., Nakahama, K., Suzuki, Y., Sugano, S., et al. (2002) · Nature · doi:10.1038/nature00906 · Cited by 850 · see citing works
Self-citationAkhtar, R. A., Reddy, A. B., Maywood, E. S., Clayton, J. D., King, V. M., Smith, A. G., Gant, T. W., Hastings, M. H., & Kyriacou, C. P. (2002) · Current Biology · doi:10.1016/s0960-9822(02)00759-5 · Cited by 777 · see citing works
Time of feeding and the intrinsic circadian clock drive rhythms in hepatic gene expression.
Vollmers, C., Gill, S., DiTacchio, L., Pulivarthy, S. R., Le, H. D., & Panda, S. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0909591106 · Cited by 765 · see citing works
Lévi, F. A., Zidani, R., & Misset, J. L. (1997) · The Lancet · doi:10.1016/s0140-6736(97)03358-8 · Cited by 702 · see citing works
Halberg, F. E. (1969) · Annual Review of Physiology · doi:10.1146/annurev.ph.31.030169.003331 · Cited by 700 · see citing works
Familial advanced sleep-phase syndrome: a short-period circadian rhythm variant in humans
Jones, C. R., Campbell, S. S., Zone, S. E., Cooper, F., DeSano, A., Murphy, P. J., Jones, B., Czajkowski, L., & Ptček, L. J. (1999) · Nature Medicine · doi:10.1038/12502 · Cited by 567 · see citing works
Cryptochrome mediates circadian regulation of cAMP signaling and hepatic gluconeogenesis
Zhang, E. E., Liu, Y., Dentin, R., Pongsawakul, P. Y., Liu, A. C., Hirota, T., Nusinow, D. A., Sun, X., Landais, S., Kodama, Y., et al. (2010) · Nature Medicine · doi:10.1038/nm.2214 · Cited by 567 · see citing works
The human circadian metabolome
Dallmann, R., Viola, A. U., Tarokh, L., Cajochen, C., & Brown, S. A. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1114410109 · Cited by 566 · see citing works
Metabolism and Circadian Rhythms—Implications for Obesity
Froy, O. (2010) · Endocrine Reviews · doi:10.1210/er.2009-0014 · Cited by 505 · see citing works
Effect of Light on Human Circadian Physiology
Duffy, J. F., & Czeisler, C. A. (2009) · Sleep Medicine Clinics · doi:10.1016/j.jsmc.2009.01.004 · Cited by 477 · see citing works
REV-ERBα Participates in Circadian SREBP Signaling and Bile Acid Homeostasis
Martelot, G. L., Claudel, T., Gatfield, D., Schaad, O., Kornmann, B., Sasso, G. L., Moschetta, A., & Schibler, U. (2009) · PLoS Biology · doi:10.1371/journal.pbio.1000181 · Cited by 448 · see citing works
Wilson, I. D., Nicholson, J. K., Castro‐Perez, J. M., Granger, J. H., Johnson, K. A., Smith, B. W., & Plumb, R. S. (2005) · Journal of Proteome Research · doi:10.1021/pr049769r · Cited by 421 · see citing works
Metabolism and the Control of Circadian Rhythms
Rutter, J. P., Reick, M., & McKnight, S. L. (2002) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.71.090501.142857 · Cited by 401 · see citing works
Circadian Timing of Cancer Chemotherapy
Hrushesky, W. J. M. (1985) · Science · doi:10.1126/science.3883493 · Cited by 372 · see citing works
Coordination of the transcriptome and metabolome by the circadian clock
Eckel‐Mahan, K. L., Patel, V. R., Mohney, R. P., Vignola, K. S., Baldi, P., & Sassone‐Corsi, P. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1118726109 · Cited by 370 · see citing works
The Period Length of Fibroblast Circadian Gene Expression Varies Widely among Human Individuals
Brown, S. A., Fleury-Olela, F., Nagoshi, E., Hauser, C., Juge-Aubry, C. E., Meier, C. A., Chicheportiche, R., Dayer, J., Albrecht, U., & Schibler, U. (2005) · PLoS Biology · doi:10.1371/journal.pbio.0030338 · Cited by 315 · see citing works
Nuclear receptor corepressor and histone deacetylase 3 govern circadian metabolic physiology
Alenghat, T., Meyers, K. C., Mullican, S. E., Leitner, K., Adeniji‐Adele, A., Avila, J. L., Bućan, M., Ahima, R. S., Kaestner, K. H., & Lazar, M. A. (2008) · Nature · doi:10.1038/nature07541 · Cited by 293 · see citing works
The relationship between nutrition and circadian rhythms in mammals
Froy, O. (2007) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2007.03.001 · Cited by 286 · see citing works
Adaptation to abrupt time shifts of the oscillator(s) controlling human circadian rhythms.
Mills, J. N., Minors, D. S., & Waterhouse, J. M. (1978) · The Journal of Physiology · doi:10.1113/jphysiol.1978.sp012582 · Cited by 285 · see citing works
Molecular insights into human daily behavior
Brown, S. A., Kunz, D., Dumas, A., Westermark, P. O., Vanselow, K., Tilmann-Wahnschaffe, A., Herzel, H., & Kramer, A. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0707772105 · Cited by 270 · see citing works
Measurement of internal body time by blood metabolomics
Minami, Y., Kasukawa, T., Kakazu, Y., Iigo, M., Sugimoto, M., Ikeda, S., Yasui, A., van der Horst, G. T. J., Soga, T., & Ueda, H. R. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0900617106 · Cited by 261 · see citing works
Self-citationTolstikov, V., Lommen, A., Nakanishi, K., Tanaka, N., & Fiehn, O. (2003) · Analytical Chemistry · doi:10.1021/ac034716z · Cited by 260 · see citing works
Reinberg, A., & Halberg, F. E. (1971) · Annual Review of Pharmacology · doi:10.1146/annurev.pa.11.040171.002323 · Cited by 223 · see citing works
Wright, K. P., Gronfier, C., Duffy, J. F., & Czeisler, C. A. (2005) · Journal of Biological Rhythms · doi:10.1177/0748730404274265 · Cited by 217 · see citing works
Changing the dosing schedule minimizes the disruptive effects of interferon on clock function
Ohdo, S., Koyanagi, S., Suyama, H., Higuchi, S., & Aramaki, H. (2001) · Nature Medicine · doi:10.1038/85507 · Cited by 205 · see citing works
Noninvasive method for assessing the human circadian clock using hair follicle cells
Akashi, M., Soma, H., Yamamoto, T., Tsugitomi, A., Yamashita, S., Yamamoto, T., Nishida, E., Yasuda, A., Liao, J. K., & Node, K. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1003878107 · Cited by 192 · see citing works
Cellular Circadian Pacemaking and the Role of Cytosolic Rhythms
Hastings, M. H., Maywood, E. S., & O'Neill, J. S. (2008) · Current Biology · doi:10.1016/j.cub.2008.07.021 · Cited by 156 · see citing works
Plumb, R. S., Granger, J. H., Stumpf, C. L., Wilson, I. D., Evans, J. A., & Lenz, E. M. (2003) · The Analyst · doi:10.1039/b304296k · Cited by 146 · see citing works
Biological rhythms in the absorption, distribution, metabolism and excretion of drugs
Labrecque, G., & Bélanger, P. M. (1991) · Pharmacology & Therapeutics · doi:10.1016/0163-7258(91)90088-4 · Cited by 137 · see citing works
Horowitz, T. S., Cade, B. E., Wolfe, J. M., & Czeisler, C. A. (2001) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.2001.281.2.e384 · Cited by 133 · see citing works
Ueda, H. R., Chen, W., Minami, Y., Honma, S., Honma, K., Iino, M., & Hashimoto, S. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0401882101 · Cited by 132 · see citing works
Self-citationMelatonin in mice: rhythms, response to light, adrenergic stimulation, and metabolism
Kennaway, D. J., Voultsios, A., Varcoe, T. J., & Moyer, R. W. (2002) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00360.2001 · Cited by 131 · see citing works
Brain neurosteroids during the mouse oestrous cycle
Corpechot, C., Collins, B., Carey, M. P., Tsouros, A. E., Röbel, P., & Fry, J. P. (1997) · Brain Research · doi:10.1016/s0006-8993(97)00749-x · Cited by 118 · see citing works
Acute Induction of Eya3 by Late-Night Light Stimulation Triggers TSHβ Expression in Photoperiodism
Masumoto, K.-H., Ukai-Tadenuma, M., Kasukawa, T., Nagano, M., Uno, K. D., Tsujino, K., Horikawa, K., Shigeyoshi, Y., & Ueda, H. R. (2010) · Current Biology · doi:10.1016/j.cub.2010.11.038 · Cited by 118 · see citing works
Rhythmic Nucleotide Synthesis in the Liver: Temporal Segregation of Metabolites
Fustin, J., Doi, M., Yamada, H., Komatsu, R., Shimba, S., & Okamura, H. (2012) · Cell Reports · doi:10.1016/j.celrep.2012.03.001 · Cited by 108 · see citing works
Schwartz, M. D., Nunez, A. A., & Smale, L. (2004) · Neuroscience · doi:10.1016/j.neuroscience.2004.04.049 · Cited by 84 · see citing works
Chronopharmacokinetics and Chronopharmacodynamics of Cardiovascular Active Drugs
Lemmer, B., Scheidel, B., & Behne, S. (1991) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1991.tb27245.x · Cited by 79 · see citing works
Núñez, A. A., Bult, A., McElhinny, T. L., & Smale, L. (1999) · Journal of Biological Rhythms · doi:10.1177/074873099129000713 · Cited by 72 · see citing works
Hasan, S., Santhi, N., Lazar, A. S., Slak, A., Lo, J., von Schantz, M., Archer, S. N., Johnston, J. D., & Dijk, D. (2012) · The FASEB Journal · doi:10.1096/fj.11-201699 · Cited by 68 · see citing works
Chronobiology: Biological Timekeeping
Giebultowicz, J. M. (2004) · Integrative and Comparative Biology · doi:10.1093/icb/44.3.266 · Cited by 68 · see citing works
Effect of naloxone therapy on depersonalization: a pilot study
Nuller, Y. L., Morozova, M. G., Kushnir, O. N., & Hamper, N. (2001) · Journal of Psychopharmacology · doi:10.1177/026988110101500205 · Cited by 67 · see citing works
Smith, M. R., & Eastman, C. I. (2008) · SLEEP · doi:10.1093/sleep/31.12.1639 · Cited by 64 · see citing works
Reversal of multiunit activity within and outside the suprachiasmatic nucleus in the rat
Kubota, A., Inouye, S. T., & Kawamura, H. (1981) · Neuroscience Letters · doi:10.1016/0304-3940(81)90447-x · Cited by 56 · see citing works
Systems Biology of Mammalian Circadian ClocksPreprint
Ueda, H. R. (2007) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.2007.72.047 · Cited by 42 · see citing works
Self-citationReijenga, J. C., Martens, J., Giuliani, A., et al. (2002) · Journal of Chromatography B · doi:10.1016/s0378-4347(01)00527-8 · Cited by 42 · see citing works
Ramanathan, C., Núñez, A. A., Martínez, G. S., Schwartz, M. D., & Smale, L. (2006) · Brain Research · doi:10.1016/j.brainres.2005.11.082 · Cited by 41 · see citing works
Ramanathan, C., Stowie, A. C., Smale, L., & Nunez, A. A. (2010) · Neuroscience · doi:10.1016/j.neuroscience.2010.07.053 · Cited by 36 · see citing works
Administration of Interferon at Night May Increase its Therapeutic Index
Bocci, V. A. (1985) · Cancer Drug Delivery · doi:10.1089/cdd.1985.2.313 · Cited by 35 · see citing works
Aspects of clinical chronopharmacology
Reinberg, A., Smolensky, M. H., & Lévi, F. A. (1983) · Cephalalgia · doi:10.1177/03331024830030s108 · Cited by 11 · see citing works
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Time for food: the intimate interplay between nutrition, metabolism, and the circadian clock
Asher, G., & Sassone-Corsi, P. (2015) · Cell · doi:10.1016/j.cell.2015.03.015 · Cited by 844 · see citing works
Möller-Levet, C. S., Archer, S. N., Bucca, G., Laing, E. E., Slak, A., Kabiljo, R., Lo, J. C. Y., Santhi, N., von Schantz, M., Smith, C. P., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1217154110 · Cited by 576 · see citing works
Effect of sleep deprivation on the human metabolome
Davies, S. K., Ang, J. E., Revell, V. L., Holmes, B., Mann, A., Robertson, F. P., Cui, N., Middleton, B., Ackermann, K., Kayser, M., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1402663111 · Cited by 527 · see citing works
Circadian Clocks and Feeding Time Regulate the Oscillations and Levels of Hepatic Triglycerides
Adamovich, Y., Rousso-Noori, L., Zwighaft, Z., Neufeld-Cohen, A., Golik, M., Kraut-Cohen, J., Wang, M., Han, X., & Asher, G. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2013.12.016 · Cited by 410 · see citing works
Circadian rhythms, sleep deprivation, and human performance
Goel, N., Basner, M., Rao, H., & Dinges, D. F. (2013) · Progress in Molecular Biology and Translational Science · doi:10.1016/b978-0-12-396971-2.00007-5 · Cited by 400 · see citing works
“were used to form a circadian timetable, could subsequently be used to predict internal time within a 3-h interval using only two blood samples.(80)”
Neufeld-Cohen, A., Robles, M. S., Aviram, R., Manella, G., Adamovich, Y., Ladeuix, B., Nir, D., Rousso-Noori, L., Kuperman, Y., Golik, M., et al. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1519650113 · Cited by 262 · see citing works
Chronotype: Implications for Epidemiologic Studies on Chrono-Nutrition and Cardiometabolic Health
Almoosawi, S., Vingeliene, S., Gachon, F., Voortman, T., Palla, L., Johnston, J. D., Van Dam, R. M., Darimont, C., & Karagounis, L. G. (2019) · Advances in Nutrition · doi:10.1093/advances/nmy070 · Cited by 247 · see citing works
Circadian timing of metabolism in animal models and humans
Dibner, C., & Schibler, U. (2015) · Journal of Internal Medicine · doi:10.1111/joim.12347 · Cited by 237 · see citing works
Chua, E. C.-P., Shui, G., Lee, I. T.-G., Lau, P., Tan, L.-C., Yeo, S.-C., Lam, B. D., Bulchand, S., Summers, S. A., Puvanendran, K., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1222647110 · Cited by 221 · see citing works
Skene, D. J., Skornyakov, E., Chowdhury, N. R., Gajula, R. P., Middleton, B., Satterfield, B. C., Porter, K. I., Van Dongen, H. P. A., & Gaddameedhi, S. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1801183115 · Cited by 176 · see citing works
Oxalic acid and diacylglycerol 36:3 are cross-species markers of sleep debt
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Mullington, J. M., Abbott, S. M., Carroll, J. E., Davis, C. J., Dijk, D.-J., Dinges, D. F., Gehrman, P. R., Ginsburg, G. S., Gozal, D., Haack, M., et al. (2016) · Sleep · doi:10.5665/sleep.5616 · Cited by 105 · see citing works
MahmoudianDehkordi, S., Ahmed, A. T., Bhattacharyya, S., Han, X., Baillie, R. A., Arnold, M., Skime, M. K., John-Williams, L. S., Moseley, M. A., Thompson, J. W., et al. (2021) · Translational Psychiatry · doi:10.1038/s41398-020-01097-6 · Cited by 95 · see citing works
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- Authors
- Kasukawa, T., Sugimoto, M., Hida, A., Minami, Y., Mori, M., Honma, S., Honma, K.-I., Mishima, K., Soga, T., & Ueda, H. R.
- Affiliations
- Functional Genomics Unit, and
- Kyoto University (JP)
- National Center of Neurology and Psychiatry (JP)
- RIKEN (JP)
- Institute for Advanced Biosciences, Keio University (JP)
- Hokkaido University (JP)
- ORCID
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2012-08-27
- Volume
- 109
- Issue
- 37
- Pages
- 15036-15041
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC3443163
- OpenAlex
- W2151299659
- Cited by
- 211
- References
- 65
- Citations by year
- 2026: 7 · 2025: 7 · 2024: 12 · 2023: 10 · 2022: 13 · 2021: 17 · 2020: 19 · 2019: 12 · 2018: 15 · 2017: 17 · 2016: 19 · 2015: 31 · 2014: 13 · 2013: 17 · 2012: 2
- FWCI
- 8.92
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Japan Society for the Promotion of Science (23592784, 23115006, 21390064, 23560446)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolomics and Mass Spectrometry Studies
- Health Sciences › Medicine › Physiology › Dietary Effects on Health
- Keywords
- circadian rhythm, blood metabolites, chronotherapy, time-restricted feeding, personalized medicine
- MeSH terms
- Biological Clocks, Blood, Chromatography, Liquid, Eating, Humans, Male, Sleep, Mass Spectrometry, Temperature, Time Factors, Photoperiod, Chronotherapy, Metabolomics, Young Adult, Precision Medicine
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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