Cited by 211Circadian rhythm and melatoninMetabolomics and Mass Spectrometry StudiesDietary Effects on Health

Human blood metabolite timetable indicates internal body time

Open access
Kasukawa, Takeya, Sugimoto, Masahiro, Hida, Akiko, Minami, Yoichi, Mori, Masayo, Honma, Sato, Honma, Ken-ichi, Mishima, Kazuo +2 more·2012·Proceedings of the National Academy of Sciences

Abstract

A convenient way to estimate internal body time (BT) is essential for chronotherapy and time-restricted feeding, both of which use body-time information to maximize potency and minimize toxicity during drug administration and feeding, respectively. Previously, we proposed a molecular timetable based on circadian-oscillating substances in multiple mouse organs or blood to estimate internal body time from samples taken at only a few time points. Here we applied this molecular-timetable concept to estimate and evaluate internal body time in humans. We constructed a 1.5-d reference timetable of oscillating metabolites in human blood samples with 2-h sampling frequency while simultaneously controlling for the confounding effects of activity level, light, temperature, sleep, and food intake. By using this metabolite timetable as a reference, we accurately determined internal body time within 3 h from just two anti-phase blood samples. Our minimally invasive, molecular-timetable method with human blood enables highly optimized and personalized medicine.

Integrity signals

Registry

Crossref · 10.1073/pnas.1207768109

Cites

65 of 65 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Kasukawa, T., Sugimoto, M., Hida, A., Minami, Y., Mori, M., Honma, S., Honma, K.-I., Mishima, K., Soga, T., & Ueda, H. R.
Affiliations
  • Functional Genomics Unit, and
  • Kyoto University (JP)
  • National Center of Neurology and Psychiatry (JP)
  • RIKEN (JP)
  • Institute for Advanced Biosciences, Keio University (JP)
  • Hokkaido University (JP)
Venue
Proceedings of the National Academy of Sciences
Published
2012-08-27
Volume
109
Issue
37
Pages
15036-15041
ISSN
  • 0027-8424 (ISSN-L)
  • 1091-6490
OpenAlex
W2151299659
Cited by
211
References
65
Citations by year
2026: 7 · 2025: 7 · 2024: 12 · 2023: 10 · 2022: 13 · 2021: 17 · 2020: 19 · 2019: 12 · 2018: 15 · 2017: 17 · 2016: 19 · 2015: 31 · 2014: 13 · 2013: 17 · 2012: 2
FWCI
8.92
Type
journal article
Language
en
Open access
Locations
  • Proceedings of the National Academy of Sciences (publishedVersion)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
Japan Society for the Promotion of Science (23592784, 23115006, 21390064, 23560446)
Topics
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolomics and Mass Spectrometry Studies
  • Health Sciences › Medicine › Physiology › Dietary Effects on Health
Keywords
circadian rhythm, blood metabolites, chronotherapy, time-restricted feeding, personalized medicine
MeSH terms
Biological Clocks, Blood, Chromatography, Liquid, Eating, Humans, Male, Sleep, Mass Spectrometry, Temperature, Time Factors, Photoperiod, Chronotherapy, Metabolomics, Young Adult, Precision Medicine

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review