The DOI matches its Crossref record; 39 of the 39 references it cites were found in a registry or an index.
Protein Synthesis during Sleep Consolidates Cortical Plasticity In Vivo
Open accessAbstract
Sleep consolidates experience-dependent brain plasticity, but the precise cellular mechanisms mediating this process are unknown [1]. De novo cortical protein synthesis is one possible mechanism. In support of this hypothesis, sleep is associated with increased brain protein synthesis [2, 3] and transcription of messenger RNAs (mRNAs) involved in protein synthesis regulation [4, 5]. Protein synthesis in turn is critical for memory consolidation and persistent forms of plasticity in vitro and in vivo [6, 7]. However, it is unknown whether cortical protein synthesis in sleep serves similar functions. We investigated the role of protein synthesis in the sleep-dependent consolidation of a classic form of cortical plasticity in vivo (ocular dominance plasticity, ODP; [8, 9]) in the cat visual cortex. We show that intracortical inhibition of mammalian target of rapamycin (mTOR)-dependent protein synthesis during sleep abolishes consolidation but has no effect on plasticity induced during wakefulness. Sleep also promotes phosphorylation of protein synthesis regulators (i.e., 4E-BP1 and eEF2) and the translation (but not transcription) of key plasticity related mRNAs (ARC and BDNF). These findings show that sleep promotes cortical mRNA translation. Interruption of this process has functional consequences, because it abolishes the consolidation of experience in the cortex.
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“Furthermore, phosphorylation of regulators of protein synthesis as well as translation of plasticity-related mRNAs (e.g., Arc and BDNF) was increased during sleep, overall speaking for the notion that sleep is a period of enhanced protein synthesis in these networks.”
From About Sleep's Role in Memory (2013) · cites this paper as [1060]
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“Rapamycin had no effect on plasticity induced during wakefulness.”
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“Most recently, Seibt et al. (1060) demonstrated the critical dependence of ODP on protein synthesis during sleep, as respective plastic changes in visual cortex could be prevented by inhibition of mTOR-mediated protein synthesis through rapamycin.”
From About Sleep's Role in Memory (2013) · cites this paper as [1060]
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Cites
Molecular mechanisms of mTOR-mediated translational control
Ma, X. M., & Blenis, J. (2009) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2672 · Cited by 2,558
Prolonged Rapamycin Treatment Inhibits mTORC2 Assembly and Akt/PKB
Sarbassov, D. D., Ali, S. M., Sengupta, S., Sheen, J.-H., Hsu, P. P., Bagley, A. F., Markhard, A. L., & Sabatini, D. M. (2006) · Molecular Cell · doi:10.1016/j.molcel.2006.03.029 · Cited by 2,365
Wiesel, T. N., & Hubel, D. H. (1965) · Journal of Neurophysiology · doi:10.1152/jn.1965.28.6.1029 · Cited by 1,598
mTOR signaling: At the crossroads of plasticity, memory and disease
Hoeffer, C. A., & Klann, E. (2010) · Trends in Neurosciences · doi:10.1016/j.tins.2009.11.003 · Cited by 1,128
Translational control of long-lasting synaptic plasticity and memory
Costa-Mattioli, M., Sossin, W. S., Klann, E., & Sonenberg, N. (2009) · Neuron · doi:10.1016/j.neuron.2008.10.055 · Cited by 944
Regulation of elongation factor 2 kinase by p90RSK1 and p70 S6 kinase
Wang, X.-M., Li, W., Williams, M. R., Terada, N., Alessi, D., & Proud, C. G. (2001) · EMBO Journal · doi:10.1093/emboj/20.16.4370 · Cited by 862
A simple role for BDNF in learning and memory?
Cunha, C. (2010) · Frontiers in Molecular Neuroscience · doi:10.3389/neuro.02.001.2010 · Cited by 830
mTOR·RICTOR Is the Ser473 Kinase for Akt/Protein Kinase B in 3T3-L1 Adipocytes
Hresko, R. C., & Mueckler, M. M. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m508361200 · Cited by 642
Extensive and divergent effects of sleep and wakefulness on brain gene expression
Cirelli, C., Gutierrez, C. M., & Tononi, G. (2004) · Neuron · doi:10.1016/s0896-6273(03)00814-6 · Cited by 627
Sleep Enhances Plasticity in the Developing Visual Cortex
Frank, M. G., Issa, N. P., & Stryker, M. P. (2001) · Neuron · doi:10.1016/s0896-6273(01)00279-3 · Cited by 523
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Rasch, B., & Born, J. (2013) · Physiological Reviews · doi:10.1152/physrev.00032.2012 · Cited by 2,783
Lipton, J. O., & Şahin, M. (2014) · Neuron · doi:10.1016/j.neuron.2014.09.034 · Cited by 771
Sleep promotes branch-specific formation of dendritic spines after learning
Yang, G., Lai, C. S. W., Cichon, J., Ma, L., Li, W., & Gan, W.-B. (2014) · Science · doi:10.1126/science.1249098 · Cited by 616
Sleep, Plasticity and Memory from Molecules to Whole-Brain Networks
Abel, T. G., Havekes, R., Saletin, J., & Walker, M. P. (2013) · Current Biology · doi:10.1016/j.cub.2013.07.025 · Cited by 585
Sleep function: Toward elucidating an enigma
Krueger, J. M., Frank, M. G., Wisor, J. P., & Roy, S. (2016) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2015.08.005 · Cited by 440
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Metadata
- Authors
- Seibt, J., Dumoulin, M. C., Aton, S. J., Coleman, T., Watson, A., Naidoo, N., & Frank, M. G.
- Affiliations
- University of Bern (CH)
- University of Pennsylvania (US)
- Corresponding author
- Frank, Marcos G.
- Venue
- Current Biology
- Publisher
- Elsevier BV
- Published
- 2012-04
- Volume
- 22
- Issue
- 8
- Pages
- 676-682
- ISSN
- 0960-9822 (ISSN-L)
- PMC
- PMC3350782
- OpenAlex
- W2017764061
- Cited by
- 162
- References
- 39
- Citations by year
- 2026: 3 · 2025: 8 · 2024: 7 · 2023: 6 · 2022: 11 · 2021: 9 · 2020: 14 · 2019: 18 · 2018: 19 · 2017: 16 · 2016: 4 · 2015: 6 · 2014: 13 · 2013: 16 · 2012: 12
- FWCI
- 7.69
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Current Biology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- University of Pennsylvania
- National Heart, Lung, and Blood Institute (T32HL007953)
- National Eye Institute (F32EY006831, R01EY019022, R00EY021503, R01-EY 019002, F32EY017766, K99EY021503, T32EY007143)
- National Institute of General Medical Sciences (T32GM07517, T32GM007517)
- National Institute of Neurological Disorders and Stroke (F31NS067935)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- sleep-dependent memory consolidation, protein synthesis, ocular dominance plasticity, visual cortex, mTOR inhibition, 4E-BP1, elongation factor 2, mRNA translation, Arc, brain-derived neurotrophic factor, cortical plasticity, cats
- MeSH terms
- Animals, Cats, Neuronal Plasticity, Phosphoproteins, Phosphorylation, Sleep, Transcription, Genetic, Protein Biosynthesis, Wakefulness, Brain-Derived Neurotrophic Factor, Dominance, Ocular, Mediator Complex, TOR Serine-Threonine Kinases
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