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Protein Synthesis during Sleep Consolidates Cortical Plasticity In Vivo
Open accessAbstract
Sleep consolidates experience-dependent brain plasticity, but the precise cellular mechanisms mediating this process are unknown [1]. De novo cortical protein synthesis is one possible mechanism. In support of this hypothesis, sleep is associated with increased brain protein synthesis [2, 3] and transcription of messenger RNAs (mRNAs) involved in protein synthesis regulation [4, 5]. Protein synthesis in turn is critical for memory consolidation and persistent forms of plasticity in vitro and in vivo [6, 7]. However, it is unknown whether cortical protein synthesis in sleep serves similar functions. We investigated the role of protein synthesis in the sleep-dependent consolidation of a classic form of cortical plasticity in vivo (ocular dominance plasticity, ODP; [8, 9]) in the cat visual cortex. We show that intracortical inhibition of mammalian target of rapamycin (mTOR)-dependent protein synthesis during sleep abolishes consolidation but has no effect on plasticity induced during wakefulness. Sleep also promotes phosphorylation of protein synthesis regulators (i.e., 4E-BP1 and eEF2) and the translation (but not transcription) of key plasticity related mRNAs (ARC and BDNF). These findings show that sleep promotes cortical mRNA translation. Interruption of this process has functional consequences, because it abolishes the consolidation of experience in the cortex.
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“Furthermore, phosphorylation of regulators of protein synthesis as well as translation of plasticity-related mRNAs (e.g., Arc and BDNF) was increased during sleep, overall speaking for the notion that sleep is a period of enhanced protein synthesis in these networks.”
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“Rapamycin had no effect on plasticity induced during wakefulness.”
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“Most recently, Seibt et al. (1060) demonstrated the critical dependence of ODP on protein synthesis during sleep, as respective plastic changes in visual cortex could be prevented by inhibition of mTOR-mediated protein synthesis through rapamycin.”
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REM sleep promotes bidirectional plasticity in developing visual cortex in vivo
Renouard, L., Hayworth, C. R., Rempe, M. J., Clegern, W. C., Wisor, J. P., & Frank, M. G. (2022) · Neurobiology of Sleep and Circadian Rhythms · doi:10.1016/j.nbscr.2022.100076 · Cited by 14
Self-citationRegulation of filial imprinting and structural plasticity by mTORC1 in newborn chickens
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Metadata
- Authors
- Seibt, J., Dumoulin, M. C., Aton, S. J., Coleman, T., Watson, A., Naidoo, N., & Frank, M. G.
- Affiliations
- University of Bern (CH)
- University of Pennsylvania (US)
- Corresponding author
- Frank, Marcos G.
- Venue
- Current Biology
- Publisher
- Elsevier BV
- Published
- 2012-04
- Volume
- 22
- Issue
- 8
- Pages
- 676-682
- ISSN
- 0960-9822 (ISSN-L)
- PMC
- PMC3350782
- OpenAlex
- W2017764061
- Cited by
- 162
- References
- 39
- Citations by year
- 2026: 3 · 2025: 8 · 2024: 7 · 2023: 6 · 2022: 11 · 2021: 9 · 2020: 14 · 2019: 18 · 2018: 19 · 2017: 16 · 2016: 4 · 2015: 6 · 2014: 13 · 2013: 16 · 2012: 12
- FWCI
- 7.69
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Current Biology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- University of Pennsylvania
- National Heart, Lung, and Blood Institute (T32HL007953)
- National Eye Institute (F32EY006831, R01EY019022, R00EY021503, R01-EY 019002, F32EY017766, K99EY021503, T32EY007143)
- National Institute of General Medical Sciences (T32GM07517, T32GM007517)
- National Institute of Neurological Disorders and Stroke (F31NS067935)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- sleep-dependent memory consolidation, protein synthesis, ocular dominance plasticity, visual cortex, mTOR inhibition, 4E-BP1, elongation factor 2, mRNA translation, Arc, brain-derived neurotrophic factor, cortical plasticity, cats
- MeSH terms
- Animals, Cats, Neuronal Plasticity, Phosphoproteins, Phosphorylation, Sleep, Transcription, Genetic, Protein Biosynthesis, Wakefulness, Brain-Derived Neurotrophic Factor, Dominance, Ocular, Mediator Complex, TOR Serine-Threonine Kinases
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