The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
Polyploidization and Cell Fusion Contribute to Wound Healing in the Adult Drosophila Epithelium
Open accessAbstract
Summary Background Re-establishing epithelial integrity and biosynthetic capacity is critically important following tissue damage. The adult Drosophila abdominal epithelium provides an attractive new system to address how post-mitotic diploid cells contribute to repair. Results Puncture wounds to the adult Drosophila epidermis close initially by forming a melanized scab. We found that epithelial cells near the wound site fuse to form a giant syncytium, which sends lamellae under the scab to re-epithelialize the damaged site. Other large cells arise more peripherally by initiating endocycles and becoming polyploid, or by cell fusion. Rac GTPase activity is needed for syncytium formation, while the Hippo signaling effector Yorkie modulates both polyploidization and cell fusion. Large cell formation is functionally important because when both polyploidization and fusion are blocked, wounds do not re-epithelialize. Conclusions Our observations indicate that cell mass lost upon wounding can be replaced by polyploidization instead of mitotic proliferation. We propose that large cells generated by polyploidization or cell fusion are essential because they are better able than diploid cells to mechanically stabilize wounds, especially those containing permanent acellular structures, such as scar tissue.
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Reinke, J. M., & Sorg, H. (2012) · European Surgical Research · doi:10.1159/000339613 · Cited by 1,898
A GAL4-Driver Line Resource for Drosophila Neurobiology
Jenett, A., Rubin, G. M., Ngo, T.-T. B., Shepherd, D., Murphy, C., Dionne, H., Pfeiffer, B. D., Cavallaro, A., Hall, D., Jeter, J., et al. (2012) · Cell Reports · doi:10.1016/j.celrep.2012.09.011 · Cited by 1,449
Mammalian heart renewal by pre-existing cardiomyocytes
Senyo, S. E., Steinhauser, M. L., Pizzimenti, C. L., Yang, V. K., Cai, L., Wang, M., Wu, T.-D., Guerquin-Kern, J.-L., Lechene, C. P., & Lee, R. T. (2013) · Nature · doi:10.1038/nature11682 · Cited by 1,343
The Hippo pathway in organ size control, tissue regeneration and stem cell self-renewal
Zhao, B., Tumaneng, K., & Guan, K.-L. (2011) · Nature Cell Biology · doi:10.1038/ncb2303 · Cited by 1,205
Fibroblasts and myofibroblasts in wound healing: Force generation and measurement
Li, B., & Wang, J. H.-C. (2011) · Journal of Tissue Viability · doi:10.1016/j.jtv.2009.11.004 · Cited by 594
Wound healing recapitulates morphogenesis in Drosophila embryos
Wood, W., Jacinto, A., Grose, R., Woolner, S., Gale, J., Wilson, C., & Martin, P. (2002) · Nature Cell Biology · doi:10.1038/ncb875 · Cited by 435
Diril, M. K., Ratnacaram, C. K., Padmakumar, V. C., Du, T., Wasser, M., Coppola, V., Tessarollo, L., & Kaldis, P. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1115201109 · Cited by 385
JNK Signaling Pathway Is Required for Efficient Wound Healing in Drosophila
Rämet, M., Lanot, R., Zachary, D., & Manfruelli, P. (2002) · Developmental Biology · doi:10.1006/dbio.2001.0502 · Cited by 313
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Endocycles: a recurrent evolutionary innovation for post-mitotic cell growth
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González-Rosa, J. M., Sharpe, M., Field, D., Soonpaa, M. H., Field, L. J., Burns, C. E., & Burns, C. G. (2018) · Developmental Cell · doi:10.1016/j.devcel.2018.01.021 · Cited by 264
Haensel, D., & Dai, X. (2018) · Developmental Dynamics · doi:10.1002/dvdy.24561 · Cited by 232
Polyploidy in liver development, homeostasis and disease
Donne, R., Saroul-Aïnama, M., Cordier, P., Celton-Morizur, S., & Desdouets, C. (2020) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-020-0284-x · Cited by 188
Metadata
- Authors
- Losick, V. P., Fox, D. T., & Spradling, A. C.
- Venue
- Current Biology
- Publisher
- Elsevier BV
- Published
- 2013-11
- Volume
- 23
- Issue
- 22
- Pages
- 2224-2232
- ISSN
- 0960-9822 (ISSN-L)
- OpenAlex
- W2040377035
- Cited by
- 207
- References
- 8
- FWCI
- 10.81
- Type
- journal article
- Language
- en
- Open access
- bronze
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