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A Neuronal Hub Binding Sleep Initiation and Body Cooling in Response to a Warm External Stimulus
Open accessAbstract
Mammals, including humans, prepare for sleep by nesting and/or curling up, creating microclimates of skin warmth. To address whether external warmth induces sleep through defined circuitry, we used c-Fos-dependent activity tagging, which captures populations of activated cells and allows them to be reactivated to test their physiological role. External warming tagged two principal groups of neurons in the median preoptic (MnPO)/medial preoptic (MPO) hypothalamic area. GABA neurons located mainly in MPO produced non-rapid eye movement (NREM) sleep but no body temperature decrease. Nitrergic-glutamatergic neurons in MnPO-MPO induced both body cooling and NREM sleep. This circuitry explains how skin warming induces sleep and why the maximal rate of core body cooling positively correlates with sleep onset. Thus, the pathways that promote NREM sleep, reduced energy expenditure, and body cooling are inextricably linked, commanded by the same neurons. This implies that one function of NREM sleep is to lower brain temperature and/or conserve energy.
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“anesthetics may rely on molecular targets with intrinsic temperature sensing ability such as the K2P channels or mitochondrial targets in critical cellular populations to inextricably link reductions in body temperature with decreased metabolism as occurs with endogenous sleep [111].”
From The Biology of General Anesthesia from Paramecium to Primate (2019) · cites this paper as [111]
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Metadata
- Authors
- Harding, E. C., Yu, X., Miao, A., Andrews, N., Ma, Y., Ye, Z., Lignos, L., Miracca, G., Ba, W., Yustos, R., Vyssotski, A. L., Wisden, W., & Franks, N. P.
- Affiliations
- Imperial College London (GB)
- UK Dementia Research Institute (GB)
- University of Zurich (CH)
- Corresponding author
- Wisden, William
- Franks, Nicholas P.
- ORCID
- Venue
- Current Biology
- Publisher
- Elsevier BV
- Published
- 2018-07
- Volume
- 28
- Issue
- 14
- Pages
- 2263-2273.e4
- ISSN
- 0960-9822 (ISSN-L)
- PMC
- PMC6078908
- OpenAlex
- W2883713442
- Cited by
- 136
- References
- 56
- Citations by year
- 2026: 18 · 2025: 15 · 2024: 10 · 2023: 16 · 2022: 19 · 2021: 28 · 2020: 12 · 2019: 15 · 2018: 3
- FWCI
- 8.62
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Current Biology (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Spiral (Imperial College London) (submittedVersion, cc-by)
- Repository for Publications and Research Data (ETH Zurich) (submittedVersion, cc-by)
- ETH Zürich Research Collection (cc-by)
- Funders
- BBSRC (BB/F017324/1, 00093987, 2016/ALW/00093987, BB/L015129/1)
- Netherlands Organisation for Scientific Research (019.161LW.010)
- UK Dementia Research Institute
- UK Medical Research Council
- Alzheimer's Society
- Alzheimer’s Research UK
- UK Dementia
- Wellcome Trust (107839/Z/15/Z, 107841/Z/15/Z, 104931/Z/14/Z)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroscience of respiration and sleep
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Keywords
- sleep initiation, NREM sleep, body cooling, preoptic hypothalamus, GABAergic neurons, neural circuits, energy conservation, brain temperature
- MeSH terms
- Adaptation, Physiological, Animals, Body Temperature Regulation, Cold Temperature, Hot Temperature, Male, Mice, Inbred C57BL, Neurons, Preoptic Area, Sleep, Proto-Oncogene Proteins c-fos, Mice
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