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The adaptor molecule Disabled‐2 links the transforming growth factor β receptors to the Smad pathway
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Dab2 serves as an adaptor linking TGF-beta receptors with Smad family proteins, facilitating TGF-beta signal transduction.
“It was reported that Dab2 serves as an adaptor linking the transforming growth factor beta (TGF-beta) receptors with the Smad family proteins, facilitating TGF-beta signal transduction pathway (Hocevar et al., 2001).”
From Endocytosis and Physiology: Insights from Disabled-2 Deficient Mice (2016) · cites this paper as Hocevar et al., 2001
The Dab2 PTB domain directly associates with Smad2/3.
“Direct association of the Dab2 PTB domain with Smad2/3 has been reported (Hocevar et al., 2001).”
From Disabled‐2 exhibits the properties of a cargo‐selective endocytic clathrin adaptor (2002) · cites this paper as Hocevar et al., 2001
Dab2 is implicated in TGF-beta receptor activation and downstream Smad activation.
“Dab2 is also implicated in transforming growth factor b (TGF-b) receptor activation and downstream Smad activation (Hocevar et al., 2001).”
From Disabled‐2 exhibits the properties of a cargo‐selective endocytic clathrin adaptor (2002) · cites this paper as Hocevar et al., 2001
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Metadata
- Authors
- Hocevar, B. A., Smine, A., Xu, X., & Howe, P. H.
- Venue
- The EMBO Journal
- Published
- 2001-06-01
- Volume
- 20
- Issue
- 11
- Pages
- 2789-2801
- ISSN
- 0261-4189
- 1460-2075
- Cited by
- 213
- References
- 2
- Language
- en
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