Cited by 26Adipose Tissue and MetabolismAdipokines, Inflammation, and Metabolic DiseasesFibroblast Growth Factor Research

Brown Adipose Tissue and Browning Agents: Irisin and FGF21 in the Development of Obesity in Children and Adolescents

Pyrżak, B., Demkow, U., Kucharska, A. M.·2015·Advances in experimental medicine and biology

Abstract

In the pediatric population, especially in early infancy, the activity of brown adipose tissue (BAT) is the highest. Further in life BAT is more active in individuals with a lower body mass index and one can expect that BAT is protective against childhood obesity. The development of BAT throughout the whole life can be regulated by genetic, endocrine, and environmental factors. Three distinct adipose depots have been identified: white, brown, and beige adipocytes. The process by which BAT can become beige is still unclear and is an area of intensive research. The "browning agents" increase energy expenditure through the production of heat. Numerous factors known as "browning agents" have currently been described. In humans, recent studies justify a notion of a role of novel myokines: irisin and fibroblast growth factor 21 (FGF21) in the metabolism and development of obesity. This review describes a possible role of irisin and FGF21 in the pathogenesis of obesity in children.

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Registry

Crossref · 10.1007/5584_2015_149

Cites

61 of 61 references verified0 citation errors · 0 not checkable

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  • Irisin glycopeptide triggers BDNF expression.

    “After cleavage of the signal peptide and cleavage of the site flanking the fibronectin domain, irisin glycopeptide is produced that triggers BDNF expression [189,190].”

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Authors
Pyrżak, B., Demkow, U., & Kucharska, A. M.
Affiliations
Medical University of Warsaw (PL)
Corresponding author
Pyrżak, B.
Venue
Advances in experimental medicine and biology
Published
2015
Volume
866
Pages
25-34
ISSN
  • 0065-2598 (ISSN-L)
  • 2214-8019
OpenAlex
W425878978
Cited by
26
References
61
Citations by year
2025: 2 · 2023: 2 · 2022: 2 · 2021: 5 · 2020: 4 · 2019: 1 · 2018: 4 · 2017: 3 · 2016: 1 · 2015: 2
FWCI
10.99
Type
book chapter
Language
en
Open access
closed
Locations
  • Advances in experimental medicine and biology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
  • Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fibroblast Growth Factor Research
Keywords
brown adipose tissue, irisin, FGF21, childhood obesity, adolescents, beige adipocytes, energy expenditure, myokines, obesity pathogenesis, adipose tissue development
MeSH terms
Uncoupling Protein 1, Adolescent, Adipose Tissue, Brown, Child, Fibroblast Growth Factors, Fibronectins, Humans, Ion Channels, Obesity, Maillard Reaction, Thermogenesis, Mitochondrial Proteins, Lipid Metabolism, Cell Transdifferentiation

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