The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Association between air pollutants and dementia risk in the elderly
Open accessAbstract
Background: The aging rate in Taiwan is the second highest in the world. As the population ages quickly, the prevalence of dementia increases rapidly. There are some studies that have explored the association between air pollution and cognitive decline, but the association between air pollution and dementia has not been directly evaluated. Methods: This was a case‐control study comprising 249 Alzheimer's disease (AD) patients, 125 vascular dementia (VaD) patients, and 497 controls from three teaching hospitals in northern Taiwan from 2007 to 2010. Data of particulate matter <10 μm in diameter (PM 10) and ozone were obtained from the Taiwan Environmental Protection Administration for 12 and 14 years, respectively. Blood samples were collected to determine the apolipoprotein E (APOE) ɛ4 haplotype. Bayesian maximum entropy was used to estimate the individual exposure level of air pollutants, which was then tertiled for analysis. Conditional logistic regression models were used to estimate adjusted odds ratios (AORs) and 95% confidence intervals between the association of PM 10 and ozone exposure with AD and VaD risk. Results: The highest tertile of PM 10 (≥49.23 μg/m 3) or ozone (≥21.56 ppb) exposure was associated with increased AD risk (highest vs. lowest tertile of PM 10: AOR = 4.17; highest vs. lowest tertile of ozone: AOR = 2.00). Similar finding was observed for VaD. The association with AD and VaD risk remained for the highest tertile PM 10 exposure after stratification by APOE ɛ4 status and gender. Conclusions: Long‐term exposure to the highest tertile of PM 10 or ozone was significantly associated with an increased risk of AD and VaD.
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“However, only a small portion of cognitively impaired elderly progress to dementia [19]; therefore, studies on cognitive impairment have been unable to fully”
BackgroundCorrelation Between Elevated Levels of Amyloid β-Peptide in the Brain and Cognitive Decline
Näslund, J. (2000) · JAMA · doi:10.1001/jama.283.12.1571 · Cited by 1,268
Air Pollution, Oxidative Stress, and Alzheimer's Disease
Moulton, P. V., & Yang, W. (2012) · Journal of Environmental and Public Health · doi:10.1155/2012/472751 · Cited by 265
Cited by
Cacciottolo, M., Wang, X., Driscoll, I., Woodward, N., Saffari, A., Reyes, J., Serre, M. L., Vizuete, W., Sioutas, C., Morgan, T. E., et al. (2017) · Translational Psychiatry · doi:10.1038/tp.2016.280 · Cited by 432
Self-citationSantos, C. Y., Snyder, P. J., Wu, W., Zhang, M., Echeverria, A., & Alber, J. (2017) · Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring · doi:10.1016/j.dadm.2017.01.005 · Cited by 431
Exposure to ambient air pollution and the incidence of dementia: a population-based cohort study
Chen, H., Kwong, J. C., Copes, R., Hystad, P., van Donkelaar, A., Tu, K., Brook, J. R., Goldberg, M. S., Martin, R. V., Murray, B. J., et al. (2017) · Environment International · doi:10.1016/j.envint.2017.08.020 · Cited by 394
Are noise and air pollution related to the incidence of dementia? A cohort study in London, England
Carey, I. M., Anderson, H. R., Atkinson, R. W., Beevers, S. D., Cook, D. G., Strachan, D. P., Dajnak, D., Gulliver, J., & Kelly, F. J. (2018) · BMJ Open · doi:10.1136/bmjopen-2018-022404 · Cited by 302
Shou, Y., Huang, Y., Zhu, X., Liu, C., Hu, Y., & Wang, H. (2019) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2019.02.086 · Cited by 303
Metadata
- Authors
- Wu, Y., Lin, Y., Yu, H., Chen, J., Chen, T., Sun, Y., Wen, L., Yip, P., Chu, Y., & Chen, Y.
- Venue
- Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
- Publisher
- Wiley
- Published
- 2015-05-14
- Volume
- 1
- Issue
- 2
- Pages
- 220-228
- ISSN
- 2352-8729 (ISSN-L)
- OpenAlex
- W1729934446
- Cited by
- 189
- References
- 4
- FWCI
- 8.62
- Type
- journal article
- Language
- en
- Open access
- gold
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- Wu, Y., Lin, Y., Yu, H., Chen, J., Chen, T., Sun, Y., Wen, L., Yip, P., Chu, Y., & Chen, Y. (2015). Association between air pollutants and dementia risk in the elderly. Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring. https://doi.org/10.1016/j.dadm.2014.11.015
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