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Cited by 78Neural and Behavioral Psychology StudiesNeurotransmitter Receptor Influence on BehaviorAdvanced MRI Techniques and Applications

In vivo evidence of neurophysiological maturation of the human adolescent striatum

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Larsen, Bart, Luna, Beatriz·2015·Developmental Cognitive Neuroscience
DOI 10.1016/j.dcn.2014.12.003PMC PMC4385446
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Abstract

Maturation of the striatum has been posited to play a primary role in observed increases in adolescent sensation-seeking. However, evidence of neurophysiological maturation in the human adolescent striatum is limited. We applied T2*-weighted imaging, reflecting indices of tissue-iron concentration, to provide direct in vivo evidence of neurophysiological development of the human adolescent striatum. Multivariate pattern analysis (MVPA) of striatal T2*-weighted signal generated age predictions that accounted for over 60% of the sample variance in 10-25 year olds, using both task-related and resting state fMRI. Dorsal and ventral striatum showed age related increases and decreases respectively of striatal neurophysiology suggesting qualitative differences in the maturation of limbic and executive striatal systems. In particular, the ventral striatum was found to show the greatest developmental differences and contribute most heavily to the multivariate age predictor. The relationship of the T2*-weighted signal to the striatal dopamine system is discussed. Together, results provide evidence for protracted maturation of the striatum through adolescence.

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  • Functional imaging studies indicate significant changes occur in the function of subcortical structures and in their relationship with cortical regions, notably in nuclei associated with reward and motivation.

    “Functional imaging studies further indicate that significant changes occur in the function of subcortical structures and in their relationship with cortical regions, notably in nuclei associated with reward and motivation [26–29].”

    From Adolescent nicotine exposure and persistent neurocircuitry changes: unveiling lifelong psychiatric risks (2025) · cites this paper as [28]

    The Introduction reports fMRI evidence of age-related differences in striatal responses to reward, and the Results (Whole-brain analysis) identify developmental changes in the ventral striatum, a reward-related region. The Discussion (T2* and the adolescent brain) discusses frontostriatal development, but the passages do not establish changes in the functional relationship between subcortical and cortical regions. (LLM, conf=0.82)

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Authors
Larsen, B., & Luna, B.
Affiliations
University of Pittsburgh (US)
Corresponding author
Larsen, Bart
ORCID
Larsen, Bart
Venue
Developmental Cognitive Neuroscience
Publisher
Elsevier BV
Published
2015-04
Volume
12
Pages
74-85
ISSN
1878-9293 (ISSN-L)
DOI
10.1016/j.dcn.2014.12.003
PMC
PMC4385446
OpenAlex
W1967924369
Cited by
78
References
13
Citations by year
2026: 4 · 2025: 7 · 2024: 5 · 2023: 7 · 2022: 12 · 2021: 5 · 2020: 9 · 2019: 2 · 2018: 15 · 2017: 7 · 2016: 3 · 2015: 2
FWCI
2.05
Type
journal article
Language
en
Open access
Licence
Locations
  • Developmental Cognitive Neuroscience (publishedVersion, cc-by-nc-nd)
  • PubMed Central (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
Funders
National Institutes of Health (5R01 MH080243)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
Keywords
striatum, adolescent brain development, ventral striatum, dorsal striatum, T2-weighted imaging, multivariate pattern analysis, age prediction, sensation seeking, dopaminergic system, resting-state fMRI, task-based fMRI
MeSH terms
Adolescent, Adult, Child, Corpus Striatum, Dopamine, Female, Humans, Limbic System, Magnetic Resonance Imaging, Male, Multivariate Analysis, Neostriatum, Young Adult

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