Cited by 550Neural and Behavioral Psychology StudiesNeurotransmitter Receptor Influence on BehaviorFunctional Brain Connectivity Studies

An Integrative Model of the Maturation of Cognitive Control

Open access
Luna, Beatriz, Marek, Scott, Larsen, Bart, Tervo-Clemmens, Brenden, Chahal, Rajpreet·2015·Annual Review of Neuroscience

Abstract

Brains systems undergo unique and specific dynamic changes at the cellular, circuit, and systems level that underlie the transition to adult-level cognitive control. We integrate literature from these different levels of analyses to propose a novel model of the brain basis of the development of cognitive control. The ability to consistently exert cognitive control improves into adulthood as the flexible integration of component processes, including inhibitory control, performance monitoring, and working memory, increases. Unique maturational changes in brain structure, supported by interactions between dopaminergic and GABAergic systems, contribute to enhanced network synchronization and an improved signal-to-noise ratio. In turn, these factors facilitate the specialization and strengthening of connectivity in networks supporting the transition to adult levels of cognitive control. This model provides a novel understanding of the adolescent period as an adaptive period of heightened experience-seeking necessary for the specialization of brain systems supporting cognitive control.

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Crossref · 10.1146/annurev-neuro-071714-034054

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144 of 144 references verified0 citation errors · 0 not checkable

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  • Cognitive skills such as planning, future thinking, inhibiting inappropriate behaviour, emotion regulation, decision making, and particular forms of memory continue to improve during adolescence.

    “At the same time, cognitive skills such as planning, future thinking, inhibiting inappropriate behaviour, emotion regulation, decision making, and particular forms of memory continue to improve during adolescence (figure 2). 144-149”

    From The Lancet Psychiatry Commission on youth mental health (2024) · cites this paper as [147]

    The Introduction and the sections on Inhibitory Control and Working Memory report continued improvement in cognitive control, response inhibition, and working memory during adolescence. The passages do not establish the same developmental claim specifically for planning, future thinking, emotion regulation, or decision making. (LLM, conf=0.86)

    Experimental — accuracy not yet measured
  • Resting-state functional brain networks, especially those supporting executive function, develop rapidly during typical adolescence.

    “Resting-state functional brain networks, especially those that subserve executive function, are rapidly developing during typical adolescence (21–23)”

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Research works printed but not linked: 2

  1. Baddeley A 1986 Working Memory New York Oxford Univ. Press
  2. Yakovlev PI Lecours AR Minkowski A 1967 The myelogenetic cycles of regional maturation of the brain Regional Development of the Brain in Early Life Minkowski A 3 70 Oxford, UK Blackwell Sci

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Authors
Luna, B., Marek, S., Larsen, B., Tervo-Clemmens, B., & Chahal, R.
Affiliations
  • Department of Psychiatry,
  • University of Pittsburgh (US)
  • Department of Psychology, and
Venue
Annual Review of Neuroscience
Published
2015-07-08
Volume
38
Issue
1
Pages
151-170
ISSN
  • 0147-006X (ISSN-L)
  • 1545-4126
OpenAlex
W2139752141
Cited by
550
References
144
Citations by year
2026: 66 · 2025: 55 · 2024: 70 · 2023: 70 · 2022: 52 · 2021: 50 · 2020: 45 · 2019: 41 · 2018: 46 · 2017: 32 · 2016: 21 · 2015: 1 · 2012: 1
FWCI
3.25
Type
journal article
Language
en
Open access
Locations
  • Annual Review of Neuroscience (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institutes of Health
  • National Institute of Mental Health (R01MH080243, MH-067924, MH080243, R37MH080243, R01MH067924)
  • National Institute on Drug Abuse (T90DA022761)
  • Eunice Kennedy Shriver National Institute of Child Health and Human Development (R21HD074850)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
Keywords
cognitive control, brain maturation, inhibitory control, performance monitoring, working memory, dopaminergic system, GABAergic system, network synchronization, signal-to-noise ratio, brain network connectivity, adolescence, experience seeking, coming of age
MeSH terms
Animals, Brain, Cognition, Humans, Models, Neurological, Neural Pathways, Dopaminergic Neurons, GABAergic Neurons

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