Cited by 361Cellular transport and secretionExtracellular vesicles in diseaseMicrotubule and mitosis dynamics

Rab6 regulates transport and targeting of exocytotic carriers

Open access
Grigoriev, Ilya, Splinter, Daniël, Keijzer, Nanda, Wulf, Phebe S., Demmers, Jeroen, Ohtsuka, Toshihisa, Modesti, Mauro, Maly, Ivan V. +3 more·2007·Developmental Cell

Abstract

Constitutive exocytosis delivers newly synthesized proteins, lipids, and other molecules from the Golgi apparatus to the cell surface. This process is mediated by vesicles, which bud off the trans-Golgi network, move along cytoskeletal filaments, and fuse with the plasma membrane. Here, we show that the small GTPase Rab6 marks exocytotic vesicles and, together with the microtubule plus-end-directed motor kinesin-1, stimulates their processive microtubule-based transport to the cell periphery. Furthermore, Rab6 directs targeting of secretory vesicles to plasma-membrane sites enriched in the cortical protein ELKS, a known Rab6 binding partner. Our data demonstrate that although Rab6 is not essential for secretion, it controls the organization of exocytosis within the cellular space.

Integrity signals

Registry

Crossref · 10.1016/j.devcel.2007.06.010

Cites

36 of 36 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Rab6A participates in the motility of post-Golgi, exocytic transport vesicles in cooperation with KIF5B and with cytoplasmic dynein via bicaudal D1 and D2 proteins.

    “Rab6A participates in the motility of post-Golgi, exocytic transport vesicles (Grigoriev et al., 2007) in cooperation with the kinesin motor, KIF5B, and with cytoplasmic dynein via its effector, bicaudal D1 and D2 proteins (Matanis et al., 2002).”

    From The Rab6-regulated KIF1C kinesin motor domain contributes to Golgi organization (2015) · cites this paper as Grigoriev et al., 2007

  • Depletion of KIF5B did not fully block the motility of Rab6A vesicles in previous work.

    “Depletion of KIF5B did not fully block the motility of Rab6A vesicles in previous work (Grigoriev et al., 2007), thus, KIF1C likely functions in conjunction with these motors to drive Rab6A vesicle motility.”

    From The Rab6-regulated KIF1C kinesin motor domain contributes to Golgi organization (2015) · cites this paper as Grigoriev et al., 2007

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Grigoriev, I., Splinter, D., Keijzer, N., Wulf, P. S., Demmers, J., Ohtsuka, T., Modesti, M., Maly, I. V., Grosveld, F., Hoogenraad, C. C., & Akhmanova, A.
Affiliations
  • Erasmus MC (NL)
  • University of Toyama (JP)
  • University of Pittsburgh (US)
Corresponding author
Akhmanova, Anna
Venue
Developmental Cell
Publisher
Elsevier BV
Published
2007-08
Volume
13
Issue
2
Pages
305-314
ISSN
1534-5807 (ISSN-L)
OpenAlex
W2091205354
Cited by
361
References
36
Citations by year
2026: 9 · 2025: 23 · 2024: 24 · 2023: 20 · 2022: 17 · 2021: 23 · 2020: 27 · 2019: 23 · 2018: 16 · 2017: 24 · 2016: 20 · 2015: 10 · 2014: 24 · 2013: 23 · 2012: 20
FWCI
5.50
Type
journal article
Language
en
Open access
Locations
  • Developmental Cell (publishedVersion)
  • PubMed (publishedVersion)
  • EUR Research Repository (Erasmus University Rotterdam) (publishedVersion)
  • EUR Research Repository (Erasmus University Rotterdam) (submittedVersion)
Funders
  • European Science Foundation
  • Nederlandse Organisatie voor Wetenschappelijk Onderzoek (814.02.005)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Extracellular vesicles in disease
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Microtubule and mitosis dynamics
Keywords
Rab6, secretory vesicle transport, microtubule transport, kinesin-1, trans-Golgi network, Golgi apparatus, elk, plasma membrane targeting, small GTPases, vesicle fusion
MeSH terms
Animals, Biological Transport, Cell Line, Cell Membrane, Cytoplasm, Dogs, Dyneins, Exocytosis, HeLa Cells, Humans, Membrane Fusion, Nerve Tissue Proteins, Biomarkers, Kinesins, rab GTP-Binding Proteins, Transport Vesicles, Adaptor Proteins, Signal Transducing, Rats

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review