Cited by 165Cellular transport and secretionMicrotubule and mitosis dynamicsNeurogenesis and neuroplasticity mechanisms

Pericentrosomal targeting of Rab6 secretory vesicles by Bicaudal-D-related protein 1 (BICDR-1) regulates neuritogenesis

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Schlager, Max A, Kapitein, Lukas C, Grigoriev, Ilya, Burzynski, Grzegorz M, Wulf, Phebe S, Keijzer, Nanda, de Graaff, Esther, Fukuda, Mitsunori +3 more·2010·The EMBO Journal

Abstract

Membrane and secretory trafficking are essential for proper neuronal development. However, the molecular mechanisms that organize secretory trafficking are poorly understood. Here, we identify Bicaudal-D-related protein 1 (BICDR-1) as an effector of the small GTPase Rab6 and key component of the molecular machinery that controls secretory vesicle transport in developing neurons. BICDR-1 interacts with kinesin motor Kif1C, the dynein/dynactin retrograde motor complex, regulates the pericentrosomal localization of Rab6-positive secretory vesicles and is required for neural development in zebrafish. BICDR-1 expression is high during early neuronal development and strongly declines during neurite outgrowth. In young neurons, BICDR-1 accumulates Rab6 secretory vesicles around the centrosome, restricts anterograde secretory transport and inhibits neuritogenesis. Later during development, BICDR-1 expression is strongly reduced, which permits anterograde secretory transport required for neurite outgrowth. These results indicate an important role for BICDR-1 as temporal regulator of secretory trafficking during the early phase of neuronal differentiation.

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Crossref · 10.1038/emboj.2010.51

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  • During neuronal development, BCDR-1 decreases significantly.

    “During neuronal development, BCDR-1 decreases significantly (Schlager et al., 2010).”

    From The Rab6-regulated KIF1C kinesin motor domain contributes to Golgi organization (2015) · cites this paper as Schlager et al., 2010

  • Additional Rab6A effectors BICDR-1 and myosin IIA interact at least indirectly with KIF1C.

    “In addition to the direct interaction between Rab6A and KIF1C described here, additional Rab6A effectors have been reported to interact at least indirectly with KIF1C. These include BICDR-1, which interacts in lysates and by yeast two-hybrid at the C-terminus of KIF1C (Schlager et al., 2010), and myosin IIA, which in lysates, interacts in the region before the C-terminus (residues 713–811; Kopp et”

    From The Rab6-regulated KIF1C kinesin motor domain contributes to Golgi organization (2015) · cites this paper as Schlager et al., 2010

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Authors
Schlager, M. A., Kapitein, L. C., Grigoriev, I., Burzynski, G. M., Wulf, P. S., Keijzer, N., de Graaff, E., Fukuda, M., Shepherd, I. T., Akhmanova, A., & Hoogenraad, C. C.
Affiliations
  • Erasmus MC (NL)
  • Emory University (US)
  • Tohoku University (JP)
Corresponding author
Hoogenraad, Casper C
Venue
The EMBO Journal
Published
2010-04-01
Volume
29
Issue
10
Pages
1637-1651
ISSN
  • 0261-4189 (ISSN-L)
  • 1460-2075
OpenAlex
W2029768388
Cited by
165
References
48
Citations by year
2026: 4 · 2025: 5 · 2024: 15 · 2023: 8 · 2022: 14 · 2021: 12 · 2020: 15 · 2019: 14 · 2018: 11 · 2017: 14 · 2016: 14 · 2015: 8 · 2014: 10 · 2013: 4 · 2012: 10
FWCI
2.94
Type
journal article
Language
en
Open access
Locations
  • The EMBO Journal (publishedVersion, cc-by-nc-sa)
  • PubMed Central (publishedVersion, cc-by-nc-sa)
  • PubMed (publishedVersion)
  • EUR Research Repository (Erasmus University Rotterdam) (publishedVersion)
  • EUR Research Repository (Erasmus University Rotterdam) (submittedVersion)
  • RePub (Erasmus University Rotterdam) (submittedVersion, other-oa)
  • RePub (Erasmus University Rotterdam) (submittedVersion)
Funders
Japan Society for the Promotion of Science
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Microtubule and mitosis dynamics
  • Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Keywords
Rab6, secretory vesicle transport, neurite outgrowth, neuronal differentiation, secretory trafficking, centrosome
MeSH terms
Animals, Brain, Cell Differentiation, Cell Membrane, Chlorocebus aethiops, Cytoskeletal Proteins, Humans, Kidney, Models, Biological, Neurons, Zebrafish, Kinesins, Centrosome, COS Cells, rab GTP-Binding Proteins, Adaptor Proteins, Vesicular Transport, Adaptor Proteins, Signal Transducing

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