The WW Domain Protein Kibra Acts Upstream of Hippo in Drosophila

Inactivation of YAP oncoprotein by the Hippo pathway is involved in cell contact inhibition and tissue growth control

Zhao, B., Wei, X., Li, W., Udan, R. S., Yang, Q., Kim, J., Xie, J., Ikenoue, T., Yu, J., Li, L., et al. (2007) · Genes & Development · doi:10.1101/gad.1602907 · Cited by 3,092

A genome-wide transgenic RNAi library for conditional gene inactivation in Drosophila

Dietzl, G., Chen, D., Schnorrer, F., Su, K.-C., Barinova, Y., Fellner, M., Gasser, B., Kinsey, K., Oppel, S., Scheiblauer, S., et al. (2007) · Nature · doi:10.1038/nature05954 · Cited by 2,644

The Hippo Signaling Pathway Coordinately Regulates Cell Proliferation and Apoptosis by Inactivating Yorkie, the Drosophila Homolog of YAP

Huang, J., Wu, S., Barrera, J., Matthews, K., & Pan, D. (2005) · Cell · doi:10.1016/j.cell.2005.06.007 · Cited by 1,863

The Drosophila Mst Ortholog, hippo, Restricts Growth and Cell Proliferation and Promotes Apoptosis

Harvey, K. F., Pfleger, C. M., & Hariharan, I. K. (2003) · Cell · doi:10.1016/s0092-8674(03)00557-9 · Cited by 976

salvador Promotes Both Cell Cycle Exit and Apoptosis in Drosophila and Is Mutated in Human Cancer Cell Lines

Tapon, N., Harvey, K. F., Bell, D. W., Wahrer, D. C. R., Schiripo, T. A., Haber, D. A., & Hariharan, I. K. (2002) · Cell · doi:10.1016/s0092-8674(02)00824-3 · Cited by 856

Coordination of Growth and Cell Division in the Drosophila Wing

Neufeld, T. P., de la Cruz, A. F. A., Johnston, L. A., & Edgar, B. A. (1998) · Cell · doi:10.1016/s0092-8674(00)81462-2 · Cited by 769

The tumour-suppressor genes NF2/Merlin and Expanded act through Hippo signalling to regulate cell proliferation and apoptosis

Hamaratoglu, F., Willecke, M., Kango-Singh, M., Nolo, R., Hyun, E., Tao, C., Jafar-Nejad, H., & Halder, G. (2006) · Nature Cell Biology · doi:10.1038/ncb1339 · Cited by 767

Systematic generation of high-resolution deletion coverage of the Drosophila melanogaster genome

Parks, A. L., Cook, K. R., Belvin, M., Dompe, N. A., Fawcett, R., Huppert, K., Tan, L. R., Winter, C. G., Bogart, K. P., Deal, J. E., et al. (2004) · Nature Genetics · doi:10.1038/ng1312 · Cited by 755

Hippo promotes proliferation arrest and apoptosis in the Salvador/Warts pathway

Udan, R. S., Kango-Singh, M., Nolo, R., Tao, C., & Halder, G. (2003) · Nature Cell Biology · doi:10.1038/ncb1050 · Cited by 747

Hippo signaling in organ size control

Pan, D. (2007) · Genes & Development · doi:10.1101/gad.1536007 · Cited by 647

The TEAD/TEF Family Protein Scalloped Mediates Transcriptional Output of the Hippo Growth-Regulatory Pathway

Wu, S., Liu, Y., Zheng, Y., Dong, J., & Pan, D. (2008) · Developmental Cell · doi:10.1016/j.devcel.2008.01.007 · Cited by 640

The TEAD/TEF family of transcription factor Scalloped mediates Hippo signaling in organ size control

Zhang, L., Ren, F., Zhang, Q., Chen, Y., Wang, B., & Jiang, J. (2008) · Developmental Cell · doi:10.1016/j.devcel.2008.01.006 · Cited by 630

The Salvador–Warts–Hippo pathway — an emerging tumour-suppressor network

Harvey, K., & Tapon, N. (2007) · Nature Reviews Cancer · doi:10.1038/nrc2070 · Cited by 628

The Salvador partner Hippo promotes apoptosis and cell-cycle exit in Drosophila

Pantalacci, S., Tapon, N., & Léopold, P. (2003) · Nature Cell Biology · doi:10.1038/ncb1051 · Cited by 551

Protein interaction mapping: A Drosophila case study

Formstecher, E., Aresta, S., Collura, V., Hamburger, A., Meil, A., Trehin, A., Reverdy, C., Betin, V., Maire, S., Brun, C., et al. (2005) · Genome Research · doi:10.1101/gr.2659105 · Cited by 542

SCALLOPED Interacts with YORKIE, the Nuclear Effector of the Hippo Tumor-Suppressor Pathway in Drosophila

Goulev, Y., Fauny, J. D., Gonzalez-Marti, B., Flagiello, D., Silber, J., & Zider, A. (2008) · Current Biology · doi:10.1016/j.cub.2008.02.034 · Cited by 452

The FERM domain: a unique module involved in the linkage of cytoplasmic proteins to the membrane

Chishti, A. H., Kim, A. C., Marfatia, S. M., Lutchman, M., Hanspal, M., Jindal, H., Liu, S.-C., Low, P. S., Rouleau, G. A., Mohandas, N., et al. (1998) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(98)01237-7 · Cited by 448

The Emerging Role of the Hippo Pathway in Cell Contact Inhibition, Organ Size Control, and Cancer Development in Mammals

Zeng, Q., & Hong, W. (2008) · Cancer Cell · doi:10.1016/j.ccr.2008.02.011 · Cited by 435

Delineation of a Fat tumor suppressor pathway

Cho, E., Feng, Y., Rauskolb, C., Maitra, S., Fehon, R., & Irvine, K. D. (2006) · Nature Genetics · doi:10.1038/ng1887 · Cited by 432

Common Kibra Alleles Are Associated with Human Memory Performance

Papassotiropoulos, A., Stephan, D. A., Huentelman, M. J., Hoerndli, F. J., Craig, D. W., Pearson, J. V., Huynh, K.-D., Brunner, F., Corneveaux, J., Osborne, D., et al. (2006) · Science · doi:10.1126/science.1129837 · Cited by 409

In vivo regulation of Yorkie phosphorylation and localization

Oh, H., & Irvine, K. D. (2008) · Development · doi:10.1242/dev.015255 · Cited by 404

Kibra Is a Regulator of the Salvador/Warts/Hippo Signaling Network

Genevet, A., Wehr, M. C., Brain, R., Thompson, B. J., & Tapon, N. (2010) · Developmental Cell · doi:10.1016/j.devcel.2009.12.011 · Cited by 402

Filling out the Hippo pathway

Saucedo, L. J., & Edgar, B. A. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2221 · Cited by 363

Shar-pei mediates cell proliferation arrest during imaginal disc growth in Drosophila

Kango-Singh, M., Nolo, R., Tao, C., Verstreken, P., Hiesinger, P. R., Bellen, H. J., & Halder, G. (2002) · Development · doi:10.1242/dev.00168 · Cited by 348

From Cell Structure to Transcription: Hippo Forges a New Path

Edgar, B. A. (2006) · Cell · doi:10.1016/j.cell.2006.01.005 · Cited by 331

The Fat Cadherin Acts through the Hippo Tumor-Suppressor Pathway to Regulate Tissue Size

Willecke, M., Hamaratoglu, F., Kango-Singh, M., Udan, R., Chen, C.-L., Tao, C., Zhang, X., & Halder, G. (2006) · Current Biology · doi:10.1016/j.cub.2006.09.005 · Cited by 329

Fat Cadherin Modulates Organ Size in Drosophila via the Salvador/Warts/Hippo Signaling Pathway

Bennett, F. C., & Harvey, K. F. (2006) · Current Biology · doi:10.1016/j.cub.2006.09.045 · Cited by 314

Regulation of Imaginal Disc Growth by Tumor-Suppressor Genes in Drosophila

Hariharan, I. K., & Bilder, D. (2006) · Annual Review of Genetics · doi:10.1146/annurev.genet.39.073003.100738 · Cited by 237

The FERM-Domain Protein Expanded Regulates Hippo Pathway Activity via Direct Interactions with the Transcriptional Activator Yorkie

Badouel, C., Gardano, L., Amin, N., Garg, A., Rosenfeld, R., Le Bihan, T., & McNeill, H. (2009) · Developmental Cell · doi:10.1016/j.devcel.2009.01.010 · Cited by 210

Merlin and the ERM proteins – regulators of receptor distribution and signaling at the cell cortex

McClatchey, A. I., & Fehon, R. G. (2009) · Trends in Cell Biology · doi:10.1016/j.tcb.2009.02.006 · Cited by 206

Regulation of Cell Proliferation by a Morphogen Gradient

Rogulja, D., & Irvine, K. D. (2005) · Cell · doi:10.1016/j.cell.2005.08.030 · Cited by 203

The Fat and Warts signaling pathways: new insights into their regulation,mechanism and conservation

Reddy, B. V. V. G., & Irvine, K. D. (2008) · Development · doi:10.1242/dev.020974 · Cited by 187

Characterization of KIBRA, a novel WW domain-containing protein

Kremerskothen, J., Plaas, C., Büther, K., Finger, I., Veltel, S., Matanis, T., Liedtke, T., & Barnekow, A. (2003) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(02)02945-5 · Cited by 156

Phosphorylation-independent repression of Yorkie in Fat-Hippo signaling

Oh, H., Reddy, B. V. V. G., & Irvine, K. D. (2009) · Developmental Biology · doi:10.1016/j.ydbio.2009.08.026 · Cited by 114

Expanded and fat regulate growth and differentiation in the Drosophila eye through multiple signaling pathways

Tyler, D. M., & Baker, N. E. (2007) · Developmental Biology · doi:10.1016/j.ydbio.2007.02.004 · Cited by 111

KIBRA gene variants are associated with episodic memory in healthy elderly

Schaper, K., Kölsch, H., Popp, J., Wagner, M., & Jessen, F. (2007) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2007.02.001 · Cited by 110

The Drosophila tumor suppressors Expanded and Merlin differentially regulate cell cycle exit, apoptosis, and Wingless signaling

Pellock, B. J., Buff, E. M., White, K., & Hariharan, I. K. (2006) · Developmental Biology · doi:10.1016/j.ydbio.2006.12.021 · Cited by 100

An Overexpression Screen in Drosophila for Genes That Restrict Growth or Cell-Cycle Progression in the Developing Eye

Tseng, A.-S. K., & Hariharan, I. K. (2002) · Genetics · doi:10.1093/genetics/162.1.229 · Cited by 75

Yorkie and Scalloped: Partners in Growth Activation

Bandura, J. L., & Edgar, B. A. (2008) · Developmental Cell · doi:10.1016/j.devcel.2008.02.010 · Cited by 26

Hippo pathway in organ size control, tissue homeostasis, and cancer

Yu, F.-X., Zhao, B., & Guan, K.-L. (2015) · Cell · doi:10.1016/j.cell.2015.10.044 · Cited by 2,206

The Hippo pathway: regulators and regulations.

Yu, F.-X., & Guan, K.-L. (2013) · Genes & Development · doi:10.1101/gad.210773.112 · Cited by 1,231

The Hippo pathway in organ size control, tissue regeneration and stem cell self-renewal

Zhao, B., Tumaneng, K., & Guan, K.-L. (2011) · Nature Cell Biology · doi:10.1038/ncb2303 · Cited by 1,205

Yap1 acts downstream of α-catenin to control epidermal proliferation

Schlegelmilch, K., Mohseni, M., Kirak, O., Pruszak, J., Rodriguez, J. R., Zhou, D., Kreger, B. T., Vasioukhin, V., Avruch, J., Brummelkamp, T. R., et al. (2011) · Cell · doi:10.1016/j.cell.2011.02.031 · Cited by 1,036

Hippo–YAP/TAZ signalling in organ regeneration and regenerative medicine

Moya, I. M., & Halder, G. (2019) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-018-0086-y · Cited by 981