The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Bmp Signaling Regulates Myocardial Differentiation from Cardiac Progenitors Through a MicroRNA-Mediated Mechanism
Open accessAbstract
Summary MicroRNAs (miRNA) are small, non-coding RNAs that regulate gene expression post-transcriptionally. We investigated the hypothesis that Bone Morphogenetic Protein (Bmp)-signaling regulates miRNAs in cardiac progenitor cells. Bmp2 and Bmp4 regulate OFT myocardial differentiation via regulation of the miRNA 17-92 cluster. In Bmp mutant embryos, myocardial differentiation was delayed and multiple miRNAs encoded by miRNA 17-92 were reduced. We uncovered functional miRNA17-92 seed sequences within the 3′ UTR of cardiac progenitor genes such as Isl1 and Tbx1. In both Bmp and miRNA 17-92 mutant embryos, Isl1and Tbx1 expression failed to be correctly downregulated. Transfection experiments indicated that miRNA 17 and miRNA 20a directly repressed Isl1and Tbx1. Genetic interaction studies uncovered a synergistic interaction between miRNA 17-92 cluster and Bmp4 providing direct in vivo evidence for the Bmp-miRNA 17-92 regulatory pathway. Our findings indicate that Bmp-signaling directly regulates a miRNA-mediated effector mechanism that downregulates cardiac progenitor genes and enhances myocardial differentiation.
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Cites
Evidence for Cardiomyocyte Renewal in Humans
Bergmann, O., Bhardwaj, R. D., Bernard, S., Zdunek, S., Barnabé-Heider, F., Walsh, S., Zupicich, J., Alkass, K., Buchholz, B. A., Druid, H., et al. (2009) · Science · doi:10.1126/science.1164680 · Cited by 3,130
miR-145 and miR-143 regulate smooth muscle cell fate and plasticity
Cordes, K. R., Sheehy, N. T., White, M. P., Berry, E. C., Morton, S. U., Muth, A. N., Lee, T.-H., Miano, J. M., Ivey, K. N., & Srivastava, D. (2009) · Nature · doi:10.1038/nature08195 · Cited by 1,585
Cited by
Mogilyansky, E., & Rigoutsos, I. (2013) · Cell Death & Differentiation · doi:10.1038/cdd.2013.125 · Cited by 889
Heart Fields and Cardiac Morphogenesis
Kelly, R. G., Buckingham, M. E., & Moorman, A. F. (2014) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a015750 · Cited by 283
Mechanisms of Cardiac Regeneration
Uygur, A., & Lee, R. T. (2016) · Developmental Cell · doi:10.1016/j.devcel.2016.01.018 · Cited by 286
The MicroRNA-17-92 Family of MicroRNA Clusters in Development and Disease
Concepcion, C. P., Bonetti, C., & Ventura, A. (2012) · The Cancer Journal · doi:10.1097/ppo.0b013e318258b60a · Cited by 285
Angiocrine Bmp2 signaling in murine liver controls normal iron homeostasis
Koch, P.-S., Olsavszky, V., Ulbrich, F., Sticht, C., Demory, A., Leibing, T., Henzler, T., Meyer, M., Zierow, J., Schneider, S., et al. (2017) · Blood · doi:10.1182/blood-2016-07-729822 · Cited by 161
Metadata
- Authors
- Wang, J., Greene, S. B., Bonilla-Claudio, M., Tao, Y., Zhang, J., Bai, Y., Huang, Z., Black, B. L., Wang, F., & Martin, J. F.
- Venue
- Developmental Cell
- Publisher
- Elsevier BV
- Published
- 2010-12
- Volume
- 19
- Issue
- 6
- Pages
- 903-912
- ISSN
- 1534-5807 (ISSN-L)
- OpenAlex
- W2069250218
- Cited by
- 180
- References
- 2
- FWCI
- 6.73
- Type
- journal article
- Language
- en
- Open access
- bronze
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