The DOI matches its Crossref record; 52 of the 52 references it cites were found in a registry or an index.
Sox9 Directs Hypertrophic Maturation and Blocks Osteoblast Differentiation of Growth Plate Chondrocytes
Open accessAbstract
SUMMARY The transcription factor Sox9 is necessary for early chondrogenesis, but its subsequent roles in the cartilage growth plate, a highly specialized structure that drives skeletal growth and endochondral ossification, remain unclear. Using a doxycycline-inducible Cre transgene and Sox9 conditional null alleles in the mouse, we show that Sox9 is required to maintain chondrocyte columnar proliferation and generate cell hypertrophy, two key features of functional growth plates. Sox9 keeps Runx2 expression and β-catenin signaling in check, and thereby inhibits not only progression from proliferation to prehypertrophy, but also subsequent acquisition of an osteoblastic phenotype. Sox9 protein outlives Sox9 RNA in upper hypertrophic chondrocytes, where it contributes with Mef2c to directly activate the major marker of these cells, Col10a1. These findings thus reveal that Sox9 remains a central determinant of the lineage fate and multi-step differentiation program of growth plate chondrocytes, and thereby illuminate our understanding of key molecular mechanisms underlying skeletogenesis.
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Cites
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Cited by
Stöckl, S., Göttl, C., Grifka, J., & Grässel, S. (2013) · Cellular Physiology and Biochemistry · doi:10.1159/000350089 · Cited by 4,656
Cellular biology of fracture healing
Bahney, C. S., Zondervan, R. L., Allison, P., Theologis, A., Ashley, J. W., Ahn, J., Miclau, T., Marcucio, R. S., & Hankenson, K. D. (2019) · Journal of Orthopaedic Research · doi:10.1002/jor.24170 · Cited by 577
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Self-citationSOX9 in cartilage development and disease
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Self-citationDistinct Transcriptional Programs Underlie Sox9 Regulation of the Mammalian Chondrocyte
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The cartilage extracellular matrix as a transient developmental scaffold for growth plate maturation
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Metadata
- Authors
- Dy, P., Wang, W., Bhattaram, P., Wang, Q., Wang, L., Ballock, R. T., & Lefebvre, V.
- Venue
- Developmental Cell
- Publisher
- Elsevier BV
- Published
- 2012-03
- Volume
- 22
- Issue
- 3
- Pages
- 597-609
- ISSN
- 1534-5807 (ISSN-L)
- OpenAlex
- W2011576192
- Cited by
- 400
- References
- 52
- FWCI
- 20.25
- Type
- journal article
- Language
- en
- Open access
- bronze
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