The DOI matches its Crossref record; 35 of the 35 references it cites were found in a registry or an index.
Individual Oligodendrocytes Have Only a Few Hours in which to Generate New Myelin Sheaths In Vivo
Open accessAbstract
SUMMARY The number of myelin sheaths made by individual oligodendrocytes regulates the extent of myelination, which profoundly affects central nervous system function. It remains unknown when, during their life, individual oligodendrocytes can regulate myelin sheath number in vivo. We show, using live imaging in zebrafish, that oligodendrocytes make new myelin sheaths during a period of just 5 hr, with regulation of sheath number after this time limited to occasional retractions. We also show that activation and reduction of Fyn kinase in oligodendrocytes increases and decreases sheath number per cell, respectively. Interestingly, these oligodendrocytes also generate their new myelin sheaths within the same period, despite having vastly different extents of myelination. Our data demonstrate a restricted time window relative to the lifetime of the individual oligodendrocyte, during which myelin sheath formation occurs and the number of sheaths is determined.
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The Tol2kit: A multisite gateway‐based construction kit for Tol2 transposon transgenesis constructs
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Oligodendroglia metabolically support axons and contribute to neurodegeneration
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Self-citationGlycolytic oligodendrocytes maintain myelin and long-term axonal integrity
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Transparent Adult Zebrafish as a Tool for In Vivo Transplantation Analysis
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SLC24A5, a putative cation exchanger, affects pigmentation in zebrafish and humans
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Cited by
Myelination of the Nervous System: Mechanisms and Functions
Nave, K.-A., & Werner, H. B. (2014) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-100913-013101 · Cited by 983
A new mechanism of nervous system plasticity: activity-dependent myelination
Fields, R. D. (2015) · Nature Reviews Neuroscience · doi:10.1038/nrn4023 · Cited by 794
Green, A. J., Gelfand, J. M., Cree, B. A., Bevan, C., Boscardin, W. J., Mei, F., Inman, J., Arnow, S., Devereux, M., Abounasr, A., et al. (2017) · The Lancet · doi:10.1016/s0140-6736(17)32346-2 · Cited by 593
Preparing the ground for tissue regeneration: from mechanism to therapy
Forbes, S. J., & Rosenthal, N. (2014) · Nature Medicine · doi:10.1038/nm.3653 · Cited by 585
Oligodendrocyte Development and Plasticity
Bergles, D. E., & Richardson, W. D. (2016) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a020453 · Cited by 585
Metadata
- Authors
- Czopka, T., ffrench-Constant, C., & Lyons, D. A.
- Venue
- Developmental Cell
- Publisher
- Elsevier BV
- Published
- 2013-06
- Volume
- 25
- Issue
- 6
- Pages
- 599-609
- ISSN
- 1534-5807 (ISSN-L)
- OpenAlex
- W1973848776
- Cited by
- 342
- References
- 35
- FWCI
- 9.11
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Czopka, T., ffrench-Constant, C., & Lyons, D. A. (2013). Individual Oligodendrocytes Have Only a Few Hours in which to Generate New Myelin Sheaths In Vivo. Developmental Cell. https://doi.org/10.1016/j.devcel.2013.05.013
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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