Loss of dE2F compromises mitochondrial function
Open accessAbstract
E2F/DP transcription factors regulate cell proliferation and apoptosis. Here, we investigated the mechanism of the resistance of Drosophila dDP mutants to irradiation-induced apoptosis. Contrary to the prevailing view, this is not due to an inability to induce the apoptotic transcriptional program, because we show that this program is induced; rather, this is due to a mitochondrial dysfunction of dDP mutants. We attribute this defect to E2F/DP-dependent control of expression of mitochondria-associated genes. Genetic attenuation of several of these E2F/DP targets mimics the dDP mutant mitochondrial phenotype and protects against irradiation-induced apoptosis. Significantly, the role of E2F/DP in the regulation of mitochondrial function is conserved between flies and humans. Thus, our results uncover a role of E2F/DP in the regulation of mitochondrial function and demonstrate that this aspect of E2F regulation is critical for the normal induction of apoptosis in response to irradiation.
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Cell cycle transcription factors, such as MYC and E2F, have been shown to promote metabolic and mitochondrial gene expression.
“Cell cycle transcription factors, such as MYC and E2F, have been shown to promote metabolic and mitochondrial gene expression.”
From Metabolic reprogramming during neuronal differentiation from aerobic glycolysis to neuronal oxidative phosphorylation (2016) · cites this paper as Ambrus et al., 2013
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Cites
Databases on transcriptional regulation: TRANSFAC, TRRD and COMPEL
Heinemeyer, T. (1998) · Nucleic Acids Research · doi:10.1093/nar/26.1.362 · Cited by 1,462 · see citing works
Müller, H., Bracken, A. P., Vernell, R., Moroni, M. C., Christians, F. C., Grassilli, E., Prosperini, E., Vigo, E., Oliner, J. D., & Helin, K. (2001) · Genes & Development · doi:10.1101/gad.864201 · Cited by 752 · see citing works
Role for the p53 homologue p73 in E2F-1-induced apoptosis
Irwin, M. S., Marín, M. C., Phillips, A. C., Seelan, R. S., Smith, D. I., Liu, W., Flores, E. R., Tsai, K. Y., Jacks, T., Vousden, K. H., et al. (2000) · Nature · doi:10.1038/35036614 · Cited by 710 · see citing works
Distinct roles for E2F proteins in cell growth control and apoptosis
DeGregori, J. V., Leone, G. W., Miron, A., Jakoi, L., & Nevins, J. R. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.14.7245 · Cited by 704 · see citing works
Wang, S. L., Hawkins, C. J., Yoo, S. J., Müller, H. ‐. J., & Hay, B. A. (1999) · Cell · doi:10.1016/s0092-8674(00)81974-1 · Cited by 505 · see citing works
p53 and E2f: partners in life and death
Polager, S., & Ginsberg, D. (2009) · Nature Reviews Cancer · doi:10.1038/nrc2718 · Cited by 498 · see citing works
Drosophila p53 Binds a Damage Response Element at the reaper Locus
Brodsky, M. H., Nordstrom, W., Tsang, G., Kwan, E., Rubin, G. M., & Abrams, J. (2000) · Cell · doi:10.1016/s0092-8674(00)80627-3 · Cited by 467 · see citing works
Tsai, K. Y., Hu, Y., Macleod, K. F., Crowley, D., Yamasaki, L., & Jacks, T. (1998) · Molecular Cell · doi:10.1016/s1097-2765(00)80274-9 · Cited by 372 · see citing works
Vo, T.-T. T., Ryan, J. A., Carrasco, R. D., Neuberg, D. S., Rossi, D. J., Stone, R. M., DeAngelo, D. J., Frattini, M. G., & Letai, A. G. (2012) · Cell · doi:10.1016/j.cell.2012.08.038 · Cited by 348 · see citing works
E2F transcription factor-1 regulates oxidative metabolism
Blanchet, É., Annicotte, J., Lagarrigue, S., Aguilar, V. M., Clapé, C., Carine Chavey, A., Fritz, V., Casas, F., Apparailly, F., Auwerx, J. H., et al. (2011) · Nature Cell Biology · doi:10.1038/ncb2309 · Cited by 272 · see citing works
Regulation of apoptosis in Drosophila
Steller, H. (2008) · Cell Death and Differentiation · doi:10.1038/cdd.2008.50 · Cited by 268 · see citing works
Differential regulation of E2F1 apoptotic target genes in response to DNA damage
Pediconi, N., Ianari, A., Costanzo, A., Belloni, L., Gallo, R., Cimino, L., Porcellini, A., Screpanti, I., Balsano, C., Alesse, E., et al. (2003) · Nature Cell Biology · doi:10.1038/ncb998 · Cited by 266 · see citing works
Gitools: Analysis and Visualisation of Genomic Data Using Interactive Heat-Maps
Perez-Llamas, C., & López-Bigas, N. (2011) · PLoS ONE · doi:10.1371/journal.pone.0019541 · Cited by 265 · see citing works
Dimova, D. K., Nolan-Stevaux, O., Frolov, M. V., & Dyson, N. J. (2003) · Genes & Development · doi:10.1101/gad.1116703 · Cited by 235 · see citing works
Self-citationCaspase-Dependent Cell Death inDrosophila
Hay, B. A., & Guo, M. (2006) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.21.012804.093845 · Cited by 201 · see citing works
Transcriptional and Nontranscriptional Functions of E2F1 in Response to DNA Damage
Biswas, A., & Johnson, D. G. (2011) · Cancer Research · doi:10.1158/0008-5472.can-11-2196 · Cited by 180 · see citing works
Repression of the Arf tumor suppressor by E2F3 is required for normal cell cycle kineticsPreprint
Aslanian, A., Iaquinta, P. J., Verona, R. I., & Lees, J. A. (2004) · Genes & Development · doi:10.1101/gad.1196704 · Cited by 170 · see citing works
Mitochondrial Disruption in Drosophila Apoptosis
Abdelwahid, E., Yokokura, T., Krieser, R. J., Balasundaram, S., Fowle, W. H., & White, K. (2007) · Developmental Cell · doi:10.1016/j.devcel.2007.04.004 · Cited by 165 · see citing works
Royzman, I., Whittaker, A. J., & Orr‐Weaver, T. L. (1997) · Genes & Development · doi:10.1101/gad.11.15.1999 · Cited by 158 · see citing works
The Apical Caspase dronc Governs Programmed and Unprogrammed Cell Death in Drosophila
Chew, S. K., Akdemir, F., Chen, P., Lu, W.-J., Mills, K., Daish, T., Kumar, S., Rodriguez, A., & Abrams, J. (2004) · Developmental Cell · doi:10.1016/j.devcel.2004.09.016 · Cited by 153 · see citing works
Ectopic E2F expression induces S phase and apoptosis in Drosophila imaginal discs.Preprint
Asano, M., Nevins, J. R., & Wharton, R. P. (1996) · Genes & Development · doi:10.1101/gad.10.11.1422 · Cited by 152 · see citing works
Georlette, D., Ahn, S., MacAlpine, D. M., Cheung, E. J., Lewis, P. W., Beall, E. L., Bell, S. P., Speed, T. P., Manak, J. R., & Botchan, M. R. (2007) · Genes & Development · doi:10.1101/gad.1600107 · Cited by 142 · see citing works
Expression of Dominant-Negative Mutant DP-1 Blocks Cell Cycle Progression in G 1
Wu, C., Classon, M., Dyson, N. J., & Harlow, E. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.7.3698 · Cited by 139 · see citing works
López-Bigas, N., Kisiel, T. A., DeWaal, D. C., Holmes, K. B., Volkert, T. L., Gupta, S., Love, J. A., Murray, H. L., Young, R. A., & Benevolenskaya, E. V. (2008) · Molecular Cell · doi:10.1016/j.molcel.2008.08.004 · Cited by 134 · see citing works
Self-citationSankaran, V. G., Orkin, & Walkley, C. R. (2008) · Genes & Development · doi:10.1101/gad.1627208 · Cited by 133 · see citing works
The retinoblastoma protein induces apoptosis directly at the mitochondriaPreprint
Hilgendorf, K. I., Leshchiner, E. S., Nedelcu, S., Maynard, M. A., Calo, E., Ianari, A., Walensky, L. D., & Lees, J. A. (2013) · Genes & Development · doi:10.1101/gad.211326.112 · Cited by 131 · see citing works
Role of Mitochondrial Remodeling in Programmed Cell Death in Drosophila melanogaster
Goyal, G., Fell, B., Sarin, A., Youle, R. J., & Sriram, V. (2007) · Developmental Cell · doi:10.1016/j.devcel.2007.02.002 · Cited by 124 · see citing works
A Genetic Analysis of the E2F1 Gene Distinguishes Regulation by Rb, p107, and Adenovirus E4
Cress, W. D., Johnson, D. G., & Nevins, J. R. (1993) · Molecular and Cellular Biology · doi:10.1128/mcb.13.10.6314 · Cited by 115 · see citing works
Pyicos: a versatile toolkit for the analysis of high-throughput sequencing data
Althammer, S., González‐Vallinas, J., Ballaré, C., Beato, M., & Eyras, E. (2011) · Bioinformatics · doi:10.1093/bioinformatics/btr570 · Cited by 90 · see citing works
Loss of RBF1 changes glutamine catabolismPreprint
Nicolay, B., Gameiro, P. A., Tschöp, K., Korenjak, M., Heilmann, A. M. F., Asara, J. M., Stephanopoulos, G. N., Iliopoulos, O., & Dyson, N. J. (2013) · Genes & Development · doi:10.1101/gad.206227.112 · Cited by 85 · see citing works
Coordinated repression of cell cycle genes by KDM5A and E2F4 during differentiation
Beshiri, M. L., Holmes, K. B., Richter, W. F., Hess, S., Islam, A. B. M. M. K., Yan, Q., Plante, L., Litovchick, L., Gévry, N. Y., López-Bigas, N., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1216724109 · Cited by 82 · see citing works
Self-citationGH3, a novel proapoptotic domain in Drosophila Grim, promotes a mitochondrial death pathway
Claverı́a, C., Caminero, E., Martínez‐A, C., Campuzano, S., & Torres, M. (2002) · The EMBO Journal · doi:10.1093/emboj/cdf354 · Cited by 78 · see citing works
Drosophila E2F1 Has Context-Specific Pro- and Antiapoptotic Properties during Development
Moon, N.-S., Frolov, M. V., Kwon, E.-J., Stefano, L. D., Dimova, D. K., Morris, E. J., Taylor‐Harding, B., White, K., & Dyson, N. J. (2005) · Developmental Cell · doi:10.1016/j.devcel.2005.08.015 · Cited by 76 · see citing works
Self-citationDrosophila IAP antagonists form multimeric complexes to promote cell death
Sandu, C., Ryoo, H. D., & Steller, H. (2010) · The Journal of Cell Biology · doi:10.1083/jcb.201004086 · Cited by 72 · see citing works
Moon, N.-S., Stefano, L. D., Morris, E. J., Patel, R. G., White, K., & Dyson, N. J. (2008) · PLoS Genetics · doi:10.1371/journal.pgen.1000153 · Cited by 64 · see citing works
Self-citationRegulation of apoptosis of rbf mutant cells during Drosophila development
Tanaka‐Matakatsu, M., Xu, J., Cheng, L., & Du, W. (2008) · Developmental Biology · doi:10.1016/j.ydbio.2008.11.035 · Cited by 61 · see citing works
Mitochondrial involvement in cell death of non-mammalian eukaryotes
Abdelwahid, E., Rolland, S. G. M., Teng, X., Conradt, B., Hardwick, J. M., & White, K. (2010) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2010.10.008 · Cited by 55 · see citing works
Korenjak, M., Anderssen, E., Ramaswamy, S., Whetstine, J. R., & Dyson, N. J. (2012) · Molecular and Cellular Biology · doi:10.1128/mcb.00536-12 · Cited by 54 · see citing works
Nicolay, B., Bayarmagnai, B., Islam, A. B. M. M. K., López-Bigas, N., & Frolov, M. V. (2011) · Genes & Development · doi:10.1101/gad.1999211 · Cited by 52 · see citing works
Self-citationmir-11 limits the proapoptotic function of its host gene, dE2f1Preprint
Truscott, M., Islam, A. B. M. M. K., López-Bigas, N., & Frolov, M. V. (2011) · Genes & Development · doi:10.1101/gad.16947411 · Cited by 43 · see citing works
Self-citationdDP Is Needed for Normal Cell Proliferation
Frolov, M. V., Moon, N.-S., & Dyson, N. J. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.8.3027-3039.2005 · Cited by 39 · see citing works
Self-citationMed24 and Mdh2 are required for Drosophila larval salivary gland cell death
Wang, L., Lam, G., & Thummel, C. S. (2010) · Developmental Dynamics · doi:10.1002/dvdy.22213 · Cited by 35 · see citing works
dE2F2-Independent Rescue of Proliferation in Cells Lacking an Activator dE2F1
Ambrus, A., Nicolay, B., Rasheva, V. I., Suckling, R. J., & Frolov, M. V. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.01068-07 · Cited by 19 · see citing works
Self-citationS Phase–Coupled E2f1 Destruction Ensures Homeostasis in Proliferating Tissues
Davidson, J. M., & Duronio, R. J. (2012) · PLoS Genetics · doi:10.1371/journal.pgen.1002831 · Cited by 16 · see citing works
Genome-wide Analysis using ChIP to Identify Isoform-specific Gene Targets
Beshiri, M. L., Islam, A. B. M. M. K., DeWaal, D. C., Richter, W. F., Love, J. A., López-Bigas, N., & Benevolenskaya, E. V. (2010) · Journal of Visualized Experiments · doi:10.3791/2101 · Cited by 13 · see citing works
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The broken cycle: E2F dysfunction in cancer
Kent, L. N., & Leone, G. W. (2019) · Nature reviews. Cancer · doi:10.1038/s41568-019-0143-7 · Cited by 786 · see citing works
Zheng, X., Boyer, L., Jin, M., Mertens, J., Kim, Y., Ma, L., Ma, L., Hamm, M., Gage, F. H., & Hunter, T. (2016) · eLife · doi:10.7554/elife.13374 · Cited by 671 · see citing works
“E2F also upregulates mitochondrial genes, a function conserved from flies to mammals (Ambrus et al., 2013).”
BackgroundRB1 : a prototype tumor suppressor and an enigmaPreprint
Dyson, N. J. (2016) · Genes & Development · doi:10.1101/gad.282145.116 · Cited by 437 · see citing works
Franco, J., Balaji, U., Freinkman, E., Witkiewicz, A. K., & Knudsen, E. S. (2016) · Cell Reports · doi:10.1016/j.celrep.2015.12.094 · Cited by 199 · see citing works
RB1 deficiency in triple-negative breast cancer induces mitochondrial protein translation
Jones, R. A., Robinson, T., Liu, J. C., Shrestha, M., Voisin, V., Ju, Y., Chung, P. E. D., Pellecchia, G., Fell, V. L., Bae, S., et al. (2016) · Journal of Clinical Investigation · doi:10.1172/jci81568 · Cited by 145 · see citing works
To live or let die – complexity within the E2F1 pathway
Roworth, A. P., Ghari, F., & Thangue, N. B. L. (2015) · Molecular & Cellular Oncology · doi:10.4161/23723548.2014.970480 · Cited by 113 · see citing works
Cell cycle regulation of mitochondrial function
López‐Mejía, I. C., & Lluis Fajas, A. (2014) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2014.10.006 · Cited by 89 · see citing works
Transcriptional Regulation of Energy Metabolism in Cancer Cells
Rodríguez‐Enríquez, S., Marín‐Hernández, Á., Gallardo‐Pérez, J. C., Pacheco-Velázquez, S. C., Belmont-Díaz, J., Robledo‐Cadena, D. X., Vargas-Navarro, J. L., de la Peña, N. A. C., Saavedra, E., & Moreno‐Sánchez, R. (2019) · Cells · doi:10.3390/cells8101225 · Cited by 86 · see citing works
Cell size homeostasis: Metabolic control of growth and cell division
Björklund, M. (2018) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2018.10.002 · Cited by 84 · see citing works
Deregulated transcription factors in cancer cell metabolisms and reprogramming
Kant, R., Manne, R., Anas, M., Penugurti, V., Chen, T., Pan, B., Hsu, C.-C., & Lin, H. (2022) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2022.10.001 · Cited by 72 · see citing works
HPV/E7 induces chemotherapy‐mediated tumor suppression by ceramide‐dependent mitophagy
Thomas, R. J., Oleinik, N. V., Selvam, S. P., Vaena, S. G., Dany, M., Nganga, R., Palma, R. M. D., Baron, K. D., Kim, J., Szulc, Z. M., et al. (2017) · EMBO Molecular Medicine · doi:10.15252/emmm.201607088 · Cited by 60 · see citing works
Emerging Links between E2F Control and Mitochondrial Function
Benevolenskaya, E. V., & Frolov, M. V. (2015) · Cancer Research · doi:10.1158/0008-5472.can-14-2173 · Cited by 54 · see citing works
Self-citationE2F function in muscle growth is necessary and sufficient for viability in Drosophila
Zappia, M. P., & Frolov, M. V. (2016) · Nature Communications · doi:10.1038/ncomms10509 · Cited by 54 · see citing works
Self-citationSõber, S., Rull, K., Reiman, M., Ilisson, P., Mattila, P., & Laan, M. (2016) · Scientific Reports · doi:10.1038/srep38439 · Cited by 52 · see citing works
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Hauck, L., Stanley-Hasnain, S., Fung, A., Grothe, D., Rao, V., Mak, T. W., & Billia, F. (2017) · PLoS ONE · doi:10.1371/journal.pone.0189861 · Cited by 44 · see citing works
Transcriptional responses to DNA damage
Silva, E., & Ideker, T. (2019) · DNA repair · doi:10.1016/j.dnarep.2019.05.002 · Cited by 31 · see citing works
Zhao, M., Liu, Y., Chang, J., Jin, Q., Liu, R., Hou, Y., Wang, Y., Zhang, X., Qiao, L., & Ren, L. (2019) · Cancer Biology and Medicine · doi:10.20892/j.issn.2095-3941.2019.0050 · Cited by 29 · see citing works
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Choo, A., O’Keefe, L. V., Lee, C. S., Gregory, S. L., Shaukat, Z., Colella, A. D., Lee, K., Denton, D., & Richards, R. I. (2015) · Genes Chromosomes and Cancer · doi:10.1002/gcc.22286 · Cited by 25 · see citing works
E2F/DP Prevents Cell-Cycle Progression in Endocycling Fat Body Cells by Suppressing dATM Expression
Guarner, A., Morris, R. T., Korenjak, M., Boukhali, M., Zappia, M. P., Rechem, C. V., Whetstine, J. R., Ramaswamy, S., Zou, L., Frolov, M. V., et al. (2017) · Developmental Cell · doi:10.1016/j.devcel.2017.11.008 · Cited by 21 · see citing works
Self-citationde la Maza, D. S., Hof‐Michel, S., Phillimore, L., Bökel, C., & Amoyel, M. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.110774 · Cited by 21 · see citing works
Clavier, A., Ruby, V., Rincheval‐Arnold, A., Mignotte, B., & Guénal, I. (2015) · Journal of Cell Science · doi:10.1242/jcs.169896 · Cited by 20 · see citing works
Liposome-Imipramine Blue Inhibits Sonic Hedgehog Medulloblastoma In Vivo
MacDonald, T. J., Liu, J., Yu, B., Malhotra, A., Munson, J., Park, J. C., Wang, K., Fei, B., Bellamkonda, R. V., & Arbiser, J. L. (2021) · Cancers · doi:10.3390/cancers13061220 · Cited by 15 · see citing works
Wei, Y., Mondal, S. S., Mouawad, R., Wilczyński, B., Henry, R. W., & Arnosti, D. N. (2015) · G3 Genes Genomes Genetics · doi:10.1534/g3.115.019166 · Cited by 14 · see citing works
Yang, R., Wu, L., Chen, J., Chen, W., Zhang, L., Zhang, L., You, R., Yin, L., Li, C., & Guan, Y. (2016) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.6b10377 · Cited by 12 · see citing works
Fujiwara, T., Hirooka, S., Yamashita, S., Yagisawa, F., & Miyagishima, S. (2024) · PLANT PHYSIOLOGY · doi:10.1093/plphys/kiae316 · Cited by 10 · see citing works
Uchiumi, F., Larsen, S. H., & Tanuma, S. (2015) · InTech eBooks · doi:10.5772/59588 · Cited by 10 · see citing works
Cellular signals integrate cell cycle and metabolic control in cancer
Akekawatchai, C., & Jitrapakdee, S. (2023) · Advances in protein chemistry and structural biology · doi:10.1016/bs.apcsb.2023.01.002 · Cited by 3 · see citing works
Minton, K. (2013) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3726 · Cited by 1 · see citing works
de la Maza, D. S., Hof‐Michel, S., Phillimore, L., Bökel, C., & Amoyel, M. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.01.12.426342 · Cited by 1 · see citing works
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Das, A., Li, Y., Fan, Y., & Moon, N.-S. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.06.02.657344
Self-citationDas, A., Li, Y.-N., Fan, Y., & Moon, N.-S. (2025) · Genetics · doi:10.1093/genetics/iyaf190 · Cited by 1 · see citing works
Self-citationConserved DNA architect couples chloroplast development to cell cycle in developing cotyledons
Wang, X., Zhang, Z., Cao, T., An, W., Zhang, J., Feng, J., Guo, Y., Chai, X., Ji, D., Ma, J., et al. (2026) · Nature Plants · doi:10.1038/s41477-026-02280-1
- Authors
- Ambrus, A. M., Islam, A. B. M. M. K., Holmes, K. B., Moon, N. S., Lopez-Bigas, N., Benevolenskaya, E. V., & Frolov, M. V.
- Affiliations
- University of Illinois Chicago (US)
- Universitat Pompeu Fabra (ES)
- McGill University (CA)
- Corresponding author
- Frolov, Maxim V.
- Venue
- Developmental Cell
- Publisher
- Elsevier BV
- Published
- 2013-11
- Volume
- 27
- Issue
- 4
- Pages
- 438-451
- ISSN
- 1534-5807 (ISSN-L)
- PMC
- PMC3866969
- OpenAlex
- W2003553263
- Cited by
- 34
- References
- 45
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 1 · 2023: 1 · 2022: 3 · 2021: 2 · 2019: 4 · 2018: 2 · 2017: 3 · 2016: 7 · 2015: 6 · 2014: 1 · 2013: 1
- FWCI
- 2.24
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Developmental Cell (publishedVersion)
- PubMed (publishedVersion)
- Repositori digital de la UPF (Universitat Pompeu Fabra) (publishedVersion, other-oa)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- RECERCAT (Consorci de Serveis Universitaris de Catalunya) (submittedVersion, other-oa)
- Funders
- National Institutes of Health
- National Cancer Institute (R01CA138631, CA138631)
- National Institute of General Medical Sciences (R01GM093827, GM93827)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
- Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Keywords
- cisplatin, mitochondrial dysfunction, radiation-induced apoptosis, radioresistance (biology), mitochondrial gene expression, Drosophila, apoptosis regulation, transcriptional attenuation
- MeSH terms
- Animals, Bone Neoplasms, Cell Cycle, DNA Damage, Drosophila melanogaster, Fluorescent Antibody Technique, Gamma Rays, Humans, Immunoenzyme Techniques, Mitochondria, Phenotype, Osteosarcoma, Transcription Factors, Tumor Cells, Cultured, Blotting, Western, Trans-Activators, Apoptosis, Drosophila Proteins, Animals, Genetically Modified, Chromatin Immunoprecipitation, Cell Proliferation, E2F Transcription Factors
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