p53 and E2f: partners in life and death

Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

Donehower, L. A., Harvey, M., Slagle, B. L., McArthur, M. J., Montgomery, C. A., Butel, J. S., & Bradley, A. (1992) · Nature · doi:10.1038/356215a0 · Cited by 4,649 · see citing works

Tumor suppressor p53 is a direct transcriptional activator of the human bax gene

Toshiyuki, M., & Reed, J. C. (1995) · Cell · doi:10.1016/0092-8674(95)90412-3 · Cited by 4,063 · see citing works

Network motifs: theory and experimental approaches

Alon, U. (2007) · Nature Reviews Genetics · doi:10.1038/nrg2102 · Cited by 3,279 · see citing works

Live or let die: the cell's response to p53

Vousden, K. H., & Lü, X. (2002) · Nature reviews. Cancer · doi:10.1038/nrc864 · Cited by 3,177 · see citing works

A microRNA component of the p53 tumour suppressor network

He, L., He, X., Lim, L. P., de Stanchina, E., Xuan, Z., Liang, Y., Xue, W., Zender, L., Magnus, J., Ridzon, D., et al. (2007) · Nature · doi:10.1038/nature05939 · Cited by 2,692 · see citing works

PUMA, a Novel Proapoptotic Gene, Is Induced by p53

Nakano, K., & Vousden, K. H. (2001) · Molecular Cell · doi:10.1016/s1097-2765(01)00214-3 · Cited by 2,315 · see citing works

Noxa, a BH3-Only Member of the Bcl-2 Family and Candidate Mediator of p53-Induced Apoptosis

Oda, E., Ohki, R., Murasawa, H., Nemoto, J., Shibue, T., Yamashita, T., Tokino, T., Taniguchi, T., & Tanaka, †. N. (2000) · Science · doi:10.1126/science.288.5468.1053 · Cited by 2,112 · see citing works

Negative Control of p53 by Sir2α Promotes Cell Survival under Stress

Luo, J., Nikolaev, A. Y., Imai, S.-I., Chen, D., Su, F., Shiloh, A., Guarente, L., & Gu, W. (2001) · Cell · doi:10.1016/s0092-8674(01)00524-4 · Cited by 2,081 · see citing works

Tumor spectrum analysis in p53-mutant mice

Jacks, T., Remington, L., Williams, B. O., Schmitt, E. M., Halachmi, S., Bronson, R. T., & Weinberg, R. A. (1994) · Current Biology · doi:10.1016/s0960-9822(00)00002-6 · Cited by 2,051 · see citing works

Activation of the ATM Kinase by Ionizing Radiation and Phosphorylation of p53

Canman, C. E., Lim, D.-S., Cimprich, K. A., Taya, Y., Tamai, K., Sakaguchi, K., Appella, E., Kastan, M. B., & Siliciano, J. D. (1998) · Science · doi:10.1126/science.281.5383.1677 · Cited by 2,042 · see citing works

Enhanced Phosphorylation of p53 by ATM in Response to DNA Damage

Banin, S., Moyal, L., Shieh, S.-Y., Taya, Y., Anderson, C. W., Chessa, L., Smorodinsky, N. I., Prives, C., Reiss, Y., Shiloh, Y., et al. (1998) · Science · doi:10.1126/science.281.5383.1674 · Cited by 1,797 · see citing works

The RB and p53 pathways in cancer

Sherr, C. J., & McCormick, F. (2002) · Cancer Cell · doi:10.1016/s1535-6108(02)00102-2 · Cited by 1,690 · see citing works

A novel form of Epstein-Barr virus latency in normal B cells in vivo

Miyashita, E. M., Yang, B., Lam, K. M. C., Crawford, D., & Thorley‐Lawson, D. A. (1995) · Cell · doi:10.1016/0092-8674(95)90513-8 · Cited by 1,591 · see citing works

Tumor Suppression at the Mouse INK4a Locus Mediated by the Alternative Reading Frame Product p19

Kamijo, T., Zindy, F., Roussel, M. F., Quelle, D. E., Downing, J. R., Ashmun, R. A., Grosveld, G., & Sherr, C. J. (1997) · Cell · doi:10.1016/s0092-8674(00)80452-3 · Cited by 1,566 · see citing works

Transcriptional Activation of miR-34a Contributes to p53-Mediated Apoptosis

Raver-Shapira, N., Marciano, E., Meiri, E., Spector, Y., Rosenfeld, N., Moskovits, N. B.-C., Bentwich, Z., & Oren, M. (2007) · Molecular Cell · doi:10.1016/j.molcel.2007.05.017 · Cited by 1,352 · see citing works

The coordinate regulation of the p53 and mTOR pathways in cells

Feng, Z., Zhang, H., Levine, A. J., & Jin, S. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0502857102 · Cited by 1,235 · see citing works

p53AIP1, a Potential Mediator of p53-Dependent Apoptosis, and Its Regulation by Ser-46-Phosphorylated p53

Oda, K., Arakawa, H., Tanaka, T., Matsuda, K., Tanikawa, C., Mori, T., Nishimori, H., Tamai, K., Tokino, T., Nakamura, Y., et al. (2000) · Cell · doi:10.1016/s0092-8674(00)00073-8 · Cited by 1,162 · see citing works

Regulation of autophagy by cytoplasmic p53

Tasdemir, E., Maiuri, M. C., Galluzzi, L., Vitale, I., Djavaheri-Mergny, M., D'Amelio, M., Criollo, A., Morselli, E., Zhu, C., Harper, F., et al. (2008) · Nature Cell Biology · doi:10.1038/ncb1730 · Cited by 1,132 · see citing works

A Senescence Program Controlled by p53 and p16INK4a Contributes to the Outcome of Cancer Therapy

Schmitt, C. A., Fridman, J. S., Yang, M., Lee, S., Baranov, E., Hoffman, R. M., & Lowe, S. W. (2002) · Cell · doi:10.1016/s0092-8674(02)00734-1 · Cited by 1,050 · see citing works

The INK4a/ARF network in tumour suppression

Sherr, C. J. (2001) · Nature Reviews Molecular Cell Biology · doi:10.1038/35096061 · Cited by 984 · see citing works

Nucleolar Arf sequesters Mdm2 and activates p53

Weber, J. D., Taylor, L. J., Roussel, M. F., Sherr, C. J., & Bar-Sagi, D. (1999) · Nature Cell Biology · doi:10.1038/8991 · Cited by 940 · see citing works

p14ARF links the tumour suppressors RB and p53

Bates, S., Phillips, A. C., Clark, P. A., Stott, F., Peters, G., Ludwig, R. L., & Vousden, K. H. (1998) · Nature · doi:10.1038/25867 · Cited by 918 · see citing works

Tumor-suppressive miR-34a induces senescence-like growth arrest through modulation of the E2F pathway in human colon cancer cells

Tazawa, H., Tsuchiya, N., Izumiya, M., & Nakagama, H. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0707351104 · Cited by 902 · see citing works

UV Irradiation Stimulates Levels of p53 Cellular Tumor Antigen in Nontransformed Mouse Cells

Maltzman, W., & Czyzyk, L. (1984) · Molecular and Cellular Biology · doi:10.1128/mcb.4.9.1689 · Cited by 893 · see citing works

Human SIR2 deacetylates p53 and antagonizes PML/p53‐induced cellular senescence

Langley, E., Pearson, M., Faretta, M., Bauer, U., Frye, R. A., Minucci, S., Pelicci, P. G., & Kouzarides, T. (2002) · The EMBO Journal · doi:10.1093/emboj/21.10.2383 · Cited by 859 · see citing works

p53 and E2F-1 cooperate to mediate apoptosis.

Wu, X., & Levine, A. J. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.9.3602 · Cited by 836 · see citing works

MicroRNA-34a functions as a potential tumor suppressor by inducing apoptosis in neuroblastoma cells

Welch, C., Chen, Y., & Stallings, R. L. (2007) · Oncogene · doi:10.1038/sj.onc.1210293 · Cited by 805 · see citing works

Chk2/hCds1 functions as a DNA damage checkpoint in G₁by stabilizing p53

Chehab, N. H., Malikzay, A., Appel, M., & Halazonetis, T. D. (2000) · Genes & Development · doi:10.1101/gad.14.3.278 · Cited by 805 · see citing works

p63 and p73 are required for p53-dependent apoptosis in response to DNA damage

Flores, E. R., Tsai, K. Y., Crowley, D. G., Sengupta, S., Yang, A., McKeon, F., & Jacks, T. (2002) · Nature · doi:10.1038/416560a · Cited by 801 · see citing works

Mitochondrial p53 activates Bak and causes disruption of a Bak–Mcl1 complex

Leu, J. I.-J., Dumont, P., Hafey, M. J., Murphy, M. E., & George, D. L. (2004) · Nature Cell Biology · doi:10.1038/ncb1123 · Cited by 767 · see citing works

The p53–Mdm2 module and the ubiquitin system

Michael, D., & Oren, M. (2002) · Seminars in Cancer Biology · doi:10.1016/s1044-579x(02)00099-8 · Cited by 759 · see citing works

The E2F transcriptional network: old acquaintances with new faces

Dimova, D. K., & Dyson, N. J. (2005) · Oncogene · doi:10.1038/sj.onc.1208612 · Cited by 715 · see citing works

Role for the p53 homologue p73 in E2F-1-induced apoptosis

Irwin, M. S., Marín, M. C., Phillips, A. C., Seelan, R. S., Smith, D. I., Liu, W., Flores, E. R., Tsai, K. Y., Jacks, T., Vousden, K. H., et al. (2000) · Nature · doi:10.1038/35036614 · Cited by 710 · see citing works

Tumor suppression by Ink4a-Arf: progress and puzzles.

Lowe, S. W., & Sherr, C. J. (2003) · Current Opinion in Genetics & Development · doi:10.1016/s0959-437x(02)00013-8 · Cited by 699 · see citing works

Nutrient Availability Regulates SIRT1 Through a Forkhead-Dependent Pathway

Nemoto, S., Fergusson, M. M., & Finkel, T. (2004) · Science · doi:10.1126/science.1101731 · Cited by 671 · see citing works

ASPP Proteins Specifically Stimulate the Apoptotic Function of p53

Samuels-Lev, Y., O'Connor, D. J., Bergamaschi, D., Trigiante, G., Hsieh, J.-K., Zhong, S., Campargue, I., Naumovski, L., Crook, T., & Lu, X. (2001) · Molecular Cell · doi:10.1016/s1097-2765(01)00367-7 · Cited by 664 · see citing works

The E2F1–3 transcription factors are essential for cellular proliferation

Wu, L., Timmers, C. D., Maiti, B., Saavedra, H. I., Sang, L., Chong, G. T., Nuckolls, F., Giangrande, P. H., Wright, F. A., Field, S. J., et al. (2001) · Nature · doi:10.1038/35106593 · Cited by 620 · see citing works

Pocket proteins and cell cycle control

Cobrinik, D. (2005) · Oncogene · doi:10.1038/sj.onc.1208619 · Cited by 601 · see citing works

Apaf-1 is a transcriptional target for E2F and p53

Moroni, M. C., Hickman, E. S., Denchi, E. L., Caprara, G., Colli, E., Cecconi, F., Müller, H., & Helin, K. (2001) · Nature Cell Biology · doi:10.1038/35078527 · Cited by 593 · see citing works

Interaction between the retinoblastoma protein and the oncoprotein MDM2

Xiao, Z.-X., Chen, J., Levine, A. J., Modjtahedi, N., Xing, J. W., Sellers, W. R., & Livingston, D. M. (1995) · Nature · doi:10.1038/375694a0 · Cited by 586 · see citing works

Targeted disruption of the three Rb-related genes leads to loss of G ₁ control and immortalization

Sage, J., Mulligan, G. J., Attardi, L. D., Miller, A., Chen, S., Williams, B., Theodorou, E., & Jacks, T. (2000) · Genes & Development · doi:10.1101/gad.843200 · Cited by 582 · see citing works

Distinct and Overlapping Roles for E2F Family Members in Transcription, Proliferation and Apoptosis

DeGregori, J. V., & Johnson, D. G. (2006) · Current Molecular Medicine · doi:10.2174/1566524010606070739 · Cited by 499 · see citing works

Untitled work

(1993) · PubMed · Cited by 469 · see citing works

Stimulation of E2F1/DP1 transcriptional activity by MDM2 oncoprotein

Martin, K., Trouche, D., Hagemeier, C., Sørensen, T. S., Thangue, N. B. L., & Kouzarides, T. (1995) · Nature · doi:10.1038/375691a0 · Cited by 454 · see citing works

Interactions between E2F1 and SirT1 regulate apoptotic response to DNA damage

Wang, C., Chen, L., Hou, X., Li, Z., Kabra, N., Ma, Y., Nemoto, S., Finkel, T., Gu, W. J., Cress, W. D., et al. (2006) · Nature Cell Biology · doi:10.1038/ncb1468 · Cited by 447 · see citing works

Selective induction of E2F1 in response to DNA damage, mediated by ATM-dependent phosphorylation.

Lin, W.-C., Lin, F., & Nevins, J. R. (2001) · PubMed Central · Cited by 440 · see citing works

Expression of bbc3 , a pro-apoptotic BH3-only gene, is regulated by diverse cell death and survival signals

Han, J., Flemington, C., Houghton, A. B., Gu, Z., Zambetti, G. P., Lutz, R. J., Zhu, L., & Chittenden, T. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.201208798 · Cited by 428 · see citing works

Direct coupling of the cell cycle and cell death machinery by E2F

Nahle, Z., Polakoff, J., Davuluri, R. V., McCurrach, M. E., Jacobson, M. D., Narita, M., Zhang, M. Q., Lazebnik, Y., Bar-Sagi, D., & Lowe, S. W. (2002) · Nature Cell Biology · doi:10.1038/ncb868 · Cited by 421 · see citing works

A complex barcode underlies the heterogeneous response of p53 to stress

Murray-Zmijewski, F., Slee, E. A., & Lu, X. (2008) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2451 · Cited by 420 · see citing works

The prolyl isomerase Pin1 reveals a mechanism to control p53 functions after genotoxic insults

Zacchi, P., Gostissa, M., Uchida, T., Salvagno, C., Avolio, F., Volinia, S., Ronai, Z. A., Blandino, G., Schneider, C., & Sal, G. D. (2002) · Nature · doi:10.1038/nature01120 · Cited by 413 · see citing works

Ablation of the Retinoblastoma gene family deregulates G₁ control causing immortalization and increased cell turnover under growth-restricting conditions

Dannenberg, J.-H., van Rossum, A., Schuijff, L., & te Riele, H. (2000) · Genes & Development · doi:10.1101/gad.847700 · Cited by 413 · see citing works

Chk2 activates E2F-1 in response to DNA damage

Stevens, C., Smith, L. M., & Thangue, N. B. L. (2003) · Nature Cell Biology · doi:10.1038/ncb974 · Cited by 386 · see citing works

The prolyl isomerase Pin1 is a regulator of p53 in genotoxic response

Zheng, H., You, H., Zhou, X. Z., Murray, S. A., Uchida, T., Wulf, G. M., Gu, L., Tang, X., Lu, K. P., & Xiao, Z. J. (2002) · Nature · doi:10.1038/nature01116 · Cited by 384 · see citing works

Mutation of E2f-1 Suppresses Apoptosis and Inappropriate S Phase Entry and Extends Survival of Rb-Deficient Mouse Embryos

Tsai, K. Y., Hu, Y., Macleod, K. F., Crowley, D., Yamasaki, L., & Jacks, T. (1998) · Molecular Cell · doi:10.1016/s1097-2765(00)80274-9 · Cited by 372 · see citing works

<i>BNIP3</i> Is an RB/E2F Target Gene Required for Hypoxia-Induced Autophagy

Tracy, K., Dibling, B. C., Spike, B. T., Knabb, J. R., Schumacker, P., & Macleod, K. F. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.02246-06 · Cited by 369 · see citing works

The Human ARF Cell Cycle Regulatory Gene Promoter Is a CpG Island Which Can Be Silenced by DNA Methylation and Down-Regulated by Wild-Type p53

Robertson, K. D., & Jones, P. A. (1998) · Molecular and Cellular Biology · doi:10.1128/mcb.18.11.6457 · Cited by 352 · see citing works

Keeping p53 in check: essential and synergistic functions of Mdm2 and Mdm4

Marine, J.-C., Francoz, S., Maetens, M., Wahl, G., Toledo, F., & Lozano, G. (2006) · Cell Death &amp; Differentiation · doi:10.1038/sj.cdd.4401912 · Cited by 352 · see citing works

Role of the p53-homologue p73 in E2F1-induced apoptosis

Stiewe, T., & Pützer, B. M. (2000) · Nature Genetics · doi:10.1038/82617 · Cited by 351 · see citing works

E2f3 is critical for normal cellular proliferationPreprint

Humbert, P. O., Verona, R. I., Trimarchi, J. M., Rogers, C., Dandapani, S. V., & Lees, J. A. (2000) · Genes & Development · doi:10.1101/gad.14.6.690 · Cited by 334 · see citing works

A common E2F-1 and p73 pathway mediates cell death induced by TCR activation

Lissy, N. A., Davis, P. K., Irwin, M. S., Kaelin, W. G., & Dowdy, S. F. (2000) · Nature · doi:10.1038/35036608 · Cited by 330 · see citing works

Up-regulation of Bcl-2 Homology 3 (BH3)-only Proteins by E2F1 Mediates Apoptosis

Hershko, T., & Ginsberg, D. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m312866200 · Cited by 322 · see citing works

Life and death decisions by the E2F transcription factors

Iaquinta, P. J., & Lees, J. A. (2007) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2007.10.006 · Cited by 304 · see citing works

E2F – at the crossroads of life and death

Polager, S., & Ginsberg, D. (2008) · Trends in Cell Biology · doi:10.1016/j.tcb.2008.08.003 · Cited by 300 · see citing works

MDM2 Promotes Proteasome-Dependent Ubiquitin-Independent Degradation of Retinoblastoma Protein

Sdek, P., Ying, H., Chang, D. L. F., Qiu, W., Zheng, H., Touitou, R., Allday, M. J., & Jim Xiao, Z.-X. (2005) · Molecular Cell · doi:10.1016/j.molcel.2005.10.017 · Cited by 288 · see citing works

Loss of E2F-1 reduces tumorigenesis and extends the lifespan of Rb1(+/−) mice

Yamasaki, L., Bronson, R. T., Williams, B. O., Dyson, N. J., Harlow, E., & Jacks, T. (1998) · Nature Genetics · doi:10.1038/ng0498-360 · Cited by 283 · see citing works

Differential regulation of E2F1 apoptotic target genes in response to DNA damage

Pediconi, N., Ianari, A., Costanzo, A., Belloni, L., Gallo, R., Cimino, L., Porcellini, A., Screpanti, I., Balsano, C., Alesse, E., et al. (2003) · Nature Cell Biology · doi:10.1038/ncb998 · Cited by 266 · see citing works

E2F1 regulates autophagy and the transcription of autophagy genes

Polager, S., Ofir, M., & Ginsberg, D. (2008) · Oncogene · doi:10.1038/onc.2008.117 · Cited by 260 · see citing works

RB Regulates the Stability and the Apoptotic Function of p53 via MDM2

Hsieh, J.-K., Chan, F., O’Connor, D. J., Mittnacht, S., Zhong, S., & Lü, X. (1999) · Molecular Cell · doi:10.1016/s1097-2765(00)80309-3 · Cited by 255 · see citing works

PIN1 Is an E2F Target Gene Essential for Neu/Ras-Induced Transformation of Mammary Epithelial Cells

Ryo, A., Liou, Y.-C., Wulf, G. M., Nakamura, M., Lee, S. W., & Lu, K. P. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.15.5281-5295.2002 · Cited by 254 · see citing works

pRB plays an essential role in cell cycle arrest induced by DNA damage

Harrington, E. A., Bruce, J. L., Harlow, E., & Dyson, N. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.20.11945 · Cited by 242 · see citing works

Mdm2 Regulates p53 mRNA Translation through Inhibitory Interactions with Ribosomal Protein L26

Ofir-Rosenfeld, Y., Boggs, K., Michael, D., Kastan, M. B., & Oren, M. (2008) · Molecular Cell · doi:10.1016/j.molcel.2008.08.031 · Cited by 240 · see citing works

p73 induction after DNA damage is regulated by checkpoint kinases Chk1 and Chk2Preprint

Urist, M. J., Tanaka, T., Poyurovsky, M. V., & Prives, C. L. (2004) · Genes & Development · doi:10.1101/gad.1221004 · Cited by 234 · see citing works

The ups and downs of SIRT1

Kwon, H.-S., & Ott, M. (2008) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2008.08.001 · Cited by 227 · see citing works

Negative regulation of bcl-2 expression by p53 in hematopoietic cells

Wu, Y.-L., Mehew, J. W., Heckman, C. A., Arcinas, M., & Boxer, L. M. (2001) · Oncogene · doi:10.1038/sj.onc.1204067 · Cited by 221 · see citing works

Synergistic Function of E2F7 and E2F8 Is Essential for Cell Survival and Embryonic Development

Li, J., Ran, C., Li, E., Gordon, F., Comstock, G., Siddiqui, H., Cleghorn, W. M., Chen, H., Kornacker, K., Liu, C., et al. (2008) · Developmental Cell · doi:10.1016/j.devcel.2007.10.017 · Cited by 221 · see citing works

Transcription Factor E2F-1 Is Upregulated in Response to DNA Damage in a Manner Analogous to That of p53

Blattner, C., Sparks, A., & Lane, D. P. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.5.3704 · Cited by 213 · see citing works

The common mechanisms of transformation by the small DNA tumor viruses: The inactivation of tumor suppressor gene products: p53

Levine, A. J. (2008) · Virology · doi:10.1016/j.virol.2008.09.034 · Cited by 212 · see citing works

Transcription regulation by mutant p53

Weisz, L., Oren, M., & Rotter, V. (2007) · Oncogene · doi:10.1038/sj.onc.1210294 · Cited by 207 · see citing works

E2F3 contributes both to the inappropriate proliferation and to the apoptosis arising in <i>Rb</i> mutant embryos

Ziebold, U., Reza, T., Caron, A., & Lees, J. A. (2001) · Genes &amp; Development · doi:10.1101/gad.858801 · Cited by 200 · see citing works

Repression of the Arf tumor suppressor by E2F3 is required for normal cell cycle kineticsPreprint

Aslanian, A., Iaquinta, P. J., Verona, R. I., & Lees, J. A. (2004) · Genes & Development · doi:10.1101/gad.1196704 · Cited by 170 · see citing works

Amplification and overexpression of E2F3 in human bladder cancer

Feber, A., Clark, J., Goodwin, G. H., Dodson, A. R., Smith, P. H., Fletcher, A. L., Edwards, S. M., Flohr, P., Falconer, A., Roe, T., et al. (2003) · Oncogene · doi:10.1038/sj.onc.1207274 · Cited by 169 · see citing works

Bcl-2 is an apoptotic target suppressed by both c-Myc and E2F-1

Eischen, C. M., Packham, G., Nip, J., Fee, B. E., Hiebert, S. W., Zambetti, G. P., & Cleveland, J. L. (2001) · Oncogene · doi:10.1038/sj.onc.1204892 · Cited by 167 · see citing works

p19ARF targets certain E2F species for degradation

Martelli, F., Hamilton, T., Silver, D. P., Sharpless, N. E., Bardeesy, N. M., Rokas, M., DePinho, R. A., Livingston, D. M., & Grossman, S. R. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.081061398 · Cited by 167 · see citing works

E2F3 amplification and overexpression is associated with invasive tumor growth and rapid tumor cell proliferation in urinary bladder cancer

Oeggerli, M., Tomovska, S., Schraml, P., Calvano-Forte, D., Schafroth, S., Simon, R., Gasser, T., Mihatsch, M. J., & Sauter, G. (2004) · Oncogene · doi:10.1038/sj.onc.1207749 · Cited by 164 · see citing works

Mouse double minute antagonist Nutlin-3a enhances chemotherapy-induced apoptosis in cancer cells with mutant p53 by activating E2F1

Ambrosini, G., Sambol, E. B., Carvajal, D., Vassilev, L. T., Singer, S., & Schwartz, G. K. (2007) · Oncogene · doi:10.1038/sj.onc.1210136 · Cited by 163 · see citing works

Putting the Oncogenic and Tumor Suppressive Activities of E2F into Context

Johnson, D. G., & DeGregori, J. V. (2006) · Current Molecular Medicine · doi:10.2174/1566524010606070731 · Cited by 162 · see citing works

Human ARF binds E2F1 and inhibits its transcriptional activity

Eymin, B., Karayan, L., Seité, P., Brambilla, C., Brambilla, E. M., Larsen, C., & Gazzéri, S. (2001) · Oncogene · doi:10.1038/sj.onc.1204220 · Cited by 161 · see citing works

p53 Regulation of G ₂ Checkpoint Is Retinoblastoma Protein Dependent

Flatt, P. M., Tang, L. J., Scatena, C. D., Szak, S. T., & Pietenpol, J. A. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.12.4210-4223.2000 · Cited by 161 · see citing works

Increased E2F1 activity induces skin tumors in mice heterozygous and nullizygous for p53

Pierce, A. M., Gimenez-Conti, I. B., Schneider‐Broussard, R., Martinez, L. A., Conti, C. J., & Johnson, D. G. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.15.8858 · Cited by 156 · see citing works

Transcription factor E2F3 overexpressed in prostate cancer independently predicts clinical outcome

Foster, C. S., Falconer, A., Dodson, A. R., Norman, A. R., Dennis, N. M., Fletcher, A., Southgate, C., Dowe, A., Dearnaley, D. P., Jhavar, S. G., et al. (2004) · Oncogene · doi:10.1038/sj.onc.1207800 · Cited by 152 · see citing works

p53‐repressed miRNAs are involved with E2F in a feed‐forward loop promoting proliferation

Brosh, R., Shalgi, R., Liran, A., Landan, G., Korotayev, K., Nguyen, G. H., Enerly, E., Johnsen, H., Buganim, Y., Solomon, H., et al. (2008) · Molecular Systems Biology · doi:10.1038/msb.2008.65 · Cited by 152 · see citing works

The prolyl isomerase Pin1 orchestrates p53 acetylation and dissociation from the apoptosis inhibitor iASPP

Mantovani, F., Tocco, F., Girardini, J. E., Smith, P., Gasco, M., Lü, X., Crook, T., & Sal, G. D. (2007) · Nature Structural & Molecular Biology · doi:10.1038/nsmb1306 · Cited by 150 · see citing works

E2F1 Uses the ATM Signaling Pathway to Induce p53 and Chk2 Phosphorylation and Apoptosis

Powers, J. T., Hong, S., Mayhew, C. N., Rogers, P. M., Knudsen, E. S., & Johnson, D. G. (2004) · Molecular Cancer Research · doi:10.1158/1541-7786.203.2.4 · Cited by 149 · see citing works

Direct repression of the Mcl-1 promoter by E2F1

Croxton, R., Ma, Y., Song, L., Haura, E. B., & Cress, W. D. (2002) · Oncogene · doi:10.1038/sj.onc.1205157 · Cited by 146 · see citing works

Stabilization of E2F1 protein by MDM2 through the E2F1 ubiquitination pathway

Zhang, Z., Wang, H., Li, M., Rayburn, E. R., Agrawal, S., & Zhang, R. (2005) · Oncogene · doi:10.1038/sj.onc.1208814 · Cited by 139 · see citing works

F-box protein Skp2: a novel transcriptional target of E2F

Zhang, L., & Wang, C. (2005) · Oncogene · doi:10.1038/sj.onc.1209286 · Cited by 136 · see citing works

Deregulated expression of E2F1 induces hyperplasia and cooperates with ras in skin tumor development

Pierce, A. M., FISHER, S. M., Conti, C. J., & Johnson, D. G. (1998) · Oncogene · doi:10.1038/sj.onc.1201666 · Cited by 136 · see citing works

Skp2 Suppresses p53-Dependent Apoptosis by Inhibiting p300

Kitagawa, M., Lee, S. H., & McCormick, F. P. (2008) · Molecular Cell · doi:10.1016/j.molcel.2007.11.036 · Cited by 129 · see citing works

Dual-specificity phosphatase 5 (DUSP5) as a direct transcriptional target of tumor suppressor p53

Ueda, K., Arakawa, H., & Nakamura, Y. (2003) · Oncogene · doi:10.1038/sj.onc.1206845 · Cited by 126 · see citing works

Classic and novel roles of p53: prospects for anticancer therapy

Fuster, J. J., Sanz-Gonzalez, S. M., Moll, U. M., & Andrés, V. (2007) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2007.03.002 · Cited by 126 · see citing works

Apoptosis Associated with Deregulated E2F Activity Is Dependent on E2F1 and Atm/Nbs1/Chk2

Rogoff, H. A., Pickering, M., Frame, F. M., Debatis, M. E., Sánchez, Y., Jones, S. N., & Kowalik, T. F. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.7.2968-2977.2004 · Cited by 123 · see citing works

E2F transcriptional repressor complexes are critical downstream targets of p19ARF/p53-induced proliferative arrest

Rowland, B. D., Denissov, S. G., Douma, S., Stunnenberg, H. G., Bernards, R., & Peeper, D. S. (2002) · Cancer Cell · doi:10.1016/s1535-6108(02)00085-5 · Cited by 120 · see citing works

ATM is a target for positive regulation by E2F-1

Berkovich, E., & Ginsberg, D. (2003) · Oncogene · doi:10.1038/sj.onc.1206144 · Cited by 117 · see citing works

E2F1-induced apoptosis: turning killers into therapeutics

Stanelle, J., & Pützer, B. M. (2006) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2006.02.002 · Cited by 112 · see citing works

Novel Function of the Cyclin A Binding Site of E2F in Regulating p53-Induced Apoptosis in Response to DNA Damage

Hsieh, J.-K., Yap, D., O’Connor, D. J., Fogal, V., Fallis, L., Chan, F., Zhong, S., & Lü, X. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.1.78-93.2002 · Cited by 112 · see citing works

E2F1 Induces Phosphorylation of p53 That Is Coincident with p53 Accumulation and Apoptosis

Rogoff, H. A., Pickering, M., Debatis, M. E., Jones, S. N., & Kowalik, T. F. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.15.5308-5318.2002 · Cited by 111 · see citing works

p130/E2F4 Binds to and Represses the cdc2 Promoter in Response to p53

Taylor, W. R., Schönthal, A. H., Galante, J., & Stark, G. R. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m005101200 · Cited by 110 · see citing works

Constitutive expression of E2F-1 leads to p21-dependent cell cycle arrest in S phase of the cell cycle

Radhakrishnan, S. K., Feliciano, C. S., Najmabadi, F., Haegebarth, A., Kandel, E., Tyner, A. L., & Gartel, A. L. (2004) · Oncogene · doi:10.1038/sj.onc.1207571 · Cited by 109 · see citing works

Specificity of E2F1, E2F2, and E2F3 in mediating phenotypes induced by loss of Rb.

Saavedra, H. I., Wu, L., de Bruin, A., Timmers, C. D., Rosol, T. J., Weinstein, M. B., Robinson, M. L., & Leone, G. W. (2002) · PubMed · Cited by 108 · see citing works

Novel link between E2F and p53: proapoptotic cofactors of p53 are transcriptionally upregulated by E2F

Hershko, T., Chaussepied, M., Oren, M., & Ginsberg, D. (2005) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4401575 · Cited by 107 · see citing works

The candidate tumor suppressor BTG3 is a transcriptional target of p53 that inhibits E2F1

Ou, Y.-H., Chung, P.-H., Hsu, F., Sun, T.-P., Chang, W.-Y., & Shieh, S.-Y. (2007) · The EMBO Journal · doi:10.1038/sj.emboj.7601825 · Cited by 107 · see citing works

E2f1, E2f2, and E2f3 Control E2F Target Expression and Cellular Proliferation via a p53-Dependent Negative Feedback Loop

Timmers, C. D., Sharma, N., Opavský, R., Maiti, B., Wu, L., Wu, J. S., Orringer, D. A., Trikha, P., Saavedra, H. I., & Leone, G. W. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.02147-05 · Cited by 106 · see citing works

Specific Role for p300/CREB-binding Protein-associated Factor Activity in E2F1 Stabilization in Response to DNA Damage

Ianari, A., Gallo, R., Palma, M., Alesse, E., & Gulino, A. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m402403200 · Cited by 102 · see citing works

p73 regulates DRAM-independent autophagy that does not contribute to programmed cell death

Crighton, D., O’Prey, J., Bell, H. S., & Ryan, K. M. (2007) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4402108 · Cited by 101 · see citing works

Apoptotic and Growth-Promoting Activity of E2F Modulated by MDM2

Loughran, Ö., & Thangue, N. B. L. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.6.2186-2197.2000 · Cited by 90 · see citing works

Control of the p53-p21CIP1 Axis by E2f1, E2f2, and E2f3 Is Essential for G1/S Progression and Cellular Transformation

Sharma, N., Timmers, C. D., Trikha, P., Saavedra, H. I., Obery, A., & Leone, G. W. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m604152200 · Cited by 89 · see citing works

E2F-1 transcriptional activity is a critical determinant of Mdm2 antagonist-induced apoptosis in human tumor cell lines

Kitagawa, M., Aonuma, M., Lee, S. H., Fukutake, S., & McCormick, F. P. (2008) · Oncogene · doi:10.1038/onc.2008.164 · Cited by 88 · see citing works

p19ARF Is Dispensable for Oncogenic Stress-Induced p53-Mediated Apoptosis and Tumor Suppression In Vivo

Tolbert, D., Lu, X., Yin, C., Tantama, M., & Dyke, T. V. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.1.370-377.2002 · Cited by 85 · see citing works

The Proapoptotic Gene SIVA Is a Direct Transcriptional Target for the Tumor Suppressors p53 and E2F1

Fortin, A., MacLaurin, J. G., Arbour, N., Cregan, S. P., Kushwaha, N., Callaghan, S. M., Park, D. S., Albert, P. R., & Slack, R. S. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m400376200 · Cited by 84 · see citing works

Distinct E2F‐mediated transcriptional program regulates p14 ARF gene expression

Komori, H., Enomoto, M., Nakamura, M., Iwanaga, R., & Ohtani, K. (2005) · The EMBO Journal · doi:10.1038/sj.emboj.7600836 · Cited by 82 · see citing works

Drosophila E2F1 Has Context-Specific Pro- and Antiapoptotic Properties during Development

Moon, N.-S., Frolov, M. V., Kwon, E.-J., Stefano, L. D., Dimova, D. K., Morris, E. J., Taylor‐Harding, B., White, K., & Dyson, N. J. (2005) · Developmental Cell · doi:10.1016/j.devcel.2005.08.015 · Cited by 76 · see citing works

Stress signals induce transcriptionally inactive E2F-1 independently of p53 and Rb

O’Connor, D. J., & Lü, X. (2000) · Oncogene · doi:10.1038/sj.onc.1203540 · Cited by 74 · see citing works

The Central Acidic Domain of MDM2 Is Critical in Inhibition of Retinoblastoma-mediated Suppression of E2F and Cell Growth

Sdek, P., Ying, H., Zheng, H., Margulis, A. R., Tang, X., Tian, K., & Xiao, Z. J. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m406062200 · Cited by 74 · see citing works

ARF Differentially Modulates Apoptosis Induced by E2F1 and Myc

Russell, J. L., Powers, J. T., Rounbehler, R. J., Rogers, P. M., Conti, C. J., & Johnson, D. G. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.5.1360-1368.2002 · Cited by 71 · see citing works

E2F Mediates Sustained G2 Arrest and Down-regulation of Stathmin and AIM-1 Expression in Response to Genotoxic Stress

Polager, S., & Ginsberg, D. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m210327200 · Cited by 70 · see citing works

The MDM2 antagonist nutlin-3 sensitizes p53-null neuroblastoma cells to doxorubicin via E2F1 and TAp73

Peirce (2009) · International Journal of Oncology · doi:10.3892/ijo_00000267 · Cited by 67 · see citing works

Retinoblastoma Pathway Defects Show Differential Ability to Activate the Constitutive DNA Damage Response in Human Tumorigenesis

Tort, F., Bártková, J., Sehested, M., Orntoft, T. F., Lukas, J., & Bártek, J. (2006) · Cancer Research · doi:10.1158/0008-5472.can-06-2178 · Cited by 66 · see citing works

Regulation of E2F-1 after DNA Damage by p300-Mediated Acetylation and Ubiquitination

Galbiati, L., Mendoza-Maldonado, R., Gutiérrez, M. I., & Giacca, M. (2005) · Cell Cycle · doi:10.4161/cc.4.7.1784 · Cited by 65 · see citing works

Cell cycle‐dependent nuclear retention of p53 by E2F1 requires phosphorylation of p53 at Ser315

Fogal, V., Hsieh, J.-K., Royer, C., Zhong, S., & Lü, X. (2005) · The EMBO Journal · doi:10.1038/sj.emboj.7600735 · Cited by 64 · see citing works

ARF Is Not Required for Apoptosis in Rb Mutant Mouse Embryos

Tsai, K. Y., MacPherson, D. P., Rubinson, D. A., Crowley, D. G., & Jacks, T. (2002) · Current Biology · doi:10.1016/s0960-9822(01)00659-5 · Cited by 63 · see citing works

p14ARF regulates E2F activity

Mason, S., Loughran, Ö., & Thangue, N. B. L. (2002) · Oncogene · doi:10.1038/sj.onc.1205524 · Cited by 62 · see citing works

Apoptosis-stimulating protein of p53-2 (ASPP2/53BP2L) is an E2F target gene

Chen, D., Padiernos, E., Ding, F., Lossos, I. S., & Lopez, C. D. (2004) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4401536 · Cited by 59 · see citing works

E2F1 Modulates p38 MAPK Phosphorylation via Transcriptional Regulation of ASK1 and Wip1

Hershko, T., Korotayev, K., Polager, S., & Ginsberg, D. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m601758200 · Cited by 58 · see citing works

ASPP1 and ASPP2 are new transcriptional targets of E2F

Fogal, V., Kartasheva, N. N., Trigiante, G., Llanos, S., Yap, D., Vousden, K. H., & Lü, X. (2005) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4401562 · Cited by 57 · see citing works

E2F3 is the main target gene of the 6p22 amplicon with high specificity for human bladder cancer

Oeggerli, M., Schraml, P., Ruiz, C. F., Bloch, M., Novotny, H., Mirlacher, M., Sauter, G., & Simon, R. (2006) · Oncogene · doi:10.1038/sj.onc.1209946 · Cited by 50 · see citing works

Mutant p53: one name, many proteinsPreprint

Freed-Pastor, W. A., & Prives, C. L. (2012) · Genes & Development · doi:10.1101/gad.190678.112 · Cited by 1,246 · see citing works

MicroRNA and cancer

Jansson, M., & Lund, A. H. (2012) · Molecular Oncology · doi:10.1016/j.molonc.2012.09.006 · Cited by 1,120 · see citing works

Census and evaluation of p53 target genes

Fischer, M. (2017) · Oncogene · doi:10.1038/onc.2016.502 · Cited by 971 · see citing works

Integrated Analysis of TP53 Gene and Pathway Alterations in The Cancer Genome Atlas

Donehower, L. A., Soussi, T., Korkut, A., Liu, Y., Schultz, A., Cardenas, M., Li, X., Babur, Ö., Hsu, T., Lichtarge, O., et al. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.07.001 · Cited by 707 · see citing works

The role of nuclear lamin B1 in cell proliferation and senescence

Shimi, T., Butin-Israeli, V., Adam, S. A., Hamanaka, R. B., Goldman, A. E., Lucas, C. A., Shumaker, D. K., Kosak, S. T., Chandel, N. S., & Goldman, R. D. (2011) · Genes &amp; Development · doi:10.1101/gad.179515.111 · Cited by 547 · see citing works

The return of the nucleus: transcriptional and epigenetic control of autophagy

Füllgrabe, J., Klionsky, D. J., & Joseph, B. (2013) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3716 · Cited by 463 · see citing works

Autophagy

Hale, A. N., Ledbetter, D., Gawriluk, T. R., & Rucker, E. B. (2013) · Autophagy · doi:10.4161/auto.24273 · Cited by 336 · see citing works

Senescence from G2 arrest, revisited

Gire, V., & Dulić, V. (2015) · Cell Cycle · doi:10.1080/15384101.2014.1000134 · Cited by 300 · see citing works

Exploiting replicative stress to treat cancer

Dobbelstein, M., & Sørensen, C. S. (2015) · Nature Reviews Drug Discovery · doi:10.1038/nrd4553 · Cited by 300 · see citing works

M. tuberculosis Reprograms Hematopoietic Stem Cells to Limit Myelopoiesis and Impair Trained Immunity

Khan, N., Downey, J., Sanz, J., Kaufmann, E., Blankenhaus, B., Pacis, A., Pernet, E., Ahmed, E. A., Cardoso, S., Nijnik, A., et al. (2020) · Cell · doi:10.1016/j.cell.2020.09.062 · Cited by 296 · see citing works

Microsporidian genome analysis reveals evolutionary strategies for obligate intracellular growthPreprint

Cuomo, C. A., Desjardins, C. A., Bakowski, M. A., Goldberg, J. M., Ma, A. T., Becnel, J. J., Didier, E. S., Fan, L., Heiman, D. I., Levin, J. Z., et al. (2012) · Genome Research · doi:10.1101/gr.142802.112 · Cited by 273 · see citing works

Specific ablation of Nampt in adult neural stem cells recapitulates their functional defects during aging

Stein, L. R., & Imai, S. (2014) · The EMBO Journal · doi:10.1002/embj.201386917 · Cited by 265 · see citing works

A threshold mechanism mediates p53 cell fate decision between growth arrest and apoptosis.

Kracikova, M., Akiri, G., George, A., Sachidanandam, R., & Aaronson, S. A. (2013) · Cell Death &amp; Differentiation · doi:10.1038/cdd.2012.155 · Cited by 261 · see citing works

Oncogene-induced senescence: the bright and dark side of the response

Gorgoulis, V. G., & Halazonetis, T. D. (2010) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2010.07.013 · Cited by 257 · see citing works

The intersection between DNA damage response and cell death pathways.

Nowsheen, S., & Yang, E. S.-H. (2012) · PubMed · Cited by 219 · see citing works

Autophagy and the Cell Cycle: A Complex Landscape

Mathiassen, S. G., Zio, D. D., & Cecconi, F. (2017) · Frontiers in Oncology · doi:10.3389/fonc.2017.00051 · Cited by 210 · see citing works

E2F1-inducible microRNA 449a/b suppresses cell proliferation and promotes apoptosis

Lizé, M., Pilarski, S. M., & Dobbelstein, M. (2009) · Cell Death and Differentiation · doi:10.1038/cdd.2009.188 · Cited by 206 · see citing works

Integrative Analysis Reveals an Outcome-Associated and Targetable Pattern of p53 and Cell Cycle Deregulation in Diffuse Large B Cell Lymphoma

Monti, S., Chapuy, B., Takeyama, K., Rodig, S. J., Hao, Y., Yeda, K. T., Inguilizian, H., Mermel, C. H., Currie, T., Doǧan, A., et al. (2012) · Cancer Cell · doi:10.1016/j.ccr.2012.07.014 · Cited by 205 · see citing works

Targeting the RB-pathway in Cancer Therapy

Knudsen, E. S., & Wang, J. Y. J. (2010) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-09-0787 · Cited by 204 · see citing works

Transcriptional regulation of mammalian autophagy at a glance

Füllgrabe, J., Ghislat, G., Cho, D., & Rubinsztein, D. C. (2016) · Journal of Cell Science · doi:10.1242/jcs.188920 · Cited by 195 · see citing works

Multifaceted role of prohibitin in cell survival and apoptosis

Peng, Y., Chen, P., Ouyang, R., & Song, L. (2015) · APOPTOSIS · doi:10.1007/s10495-015-1143-z · Cited by 195 · see citing works

20 years studying p53 functions in genetically engineered mice

Donehower, L. A., & Lozano, G. (2009) · Nature reviews. Cancer · doi:10.1038/nrc2731 · Cited by 193 · see citing works

Clinical update on cancer: molecular oncology of head and neck cancer

Suh, Y., Amelio, I., Urbano, T. G., & Tavassoli, M. (2014) · Cell Death and Disease · doi:10.1038/cddis.2013.548 · Cited by 190 · see citing works

Mitochondrial Stress Engages E2F1 Apoptotic Signaling to Cause Deafness

Raimundo, N., Song, L., Shutt, T. E., McKay, S. E., Cotney, J. L., Guan, M., Gilliland, T., Hohuan, D., Santos‐Sacchi, J., & Shadel, G. S. (2012) · Cell · doi:10.1016/j.cell.2011.12.027 · Cited by 185 · see citing works

Merkel Cell Polyomavirus Infection, Large T Antigen, Retinoblastoma Protein and Outcome in Merkel Cell Carcinoma

Sihto, H. J., Kukko, H., Koljonen, V., Sankila, R. J., Böhling, T., & Joensuu, H. (2011) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-10-3363 · Cited by 184 · see citing works

ATM and p53 Regulate FOXM1 Expression via E2F in Breast Cancer Epirubicin Treatment and Resistance

Millour, J., de Olano, N., Horimoto, Y., Monteiro, L. J., Langer, J. K., Aligué, R., Hajji, N., & Lam, E. W. ‐. (2011) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-11-0024 · Cited by 183 · see citing works

miR-15 and miR-16 Are Direct Transcriptional Targets of E2F1 that Limit E2F-Induced Proliferation by Targeting Cyclin E

Ofir, M., Hacohen, D., & Ginsberg, D. (2011) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-10-0344 · Cited by 183 · see citing works

Mad2 Is a Critical Mediator of the Chromosome Instability Observed upon Rb and p53 Pathway Inhibition

Schvartzman, J.-M., Duijf, P. H. G., Sotillo, R., Coker, C., & Benezra, R. (2011) · Cancer Cell · doi:10.1016/j.ccr.2011.04.017 · Cited by 181 · see citing works

let‐7 and miR‐17‐92: Small‐sized major players in lung cancer development

Osada, H., & Takahashi, T. (2010) · Cancer Science · doi:10.1111/j.1349-7006.2010.01707.x · Cited by 180 · see citing works

Cell Cycle Regulation During Viral Infection

Bagga, S., & Bouchard, M. J. (2014) · Methods in molecular biology · doi:10.1007/978-1-4939-0888-2_10 · Cited by 180 · see citing works

Insights into p53 transcriptional function via genome-wide chromatin occupancy and gene expression analysis

Nikulenkov, F., Spinnler, C., Li, H., Tonelli, C., Shi, Y., Turunen, M. M., Kivioja, T., Ignatiev, I., Kel, A. E., Taipale, J., et al. (2012) · Cell Death and Differentiation · doi:10.1038/cdd.2012.89 · Cited by 178 · see citing works

The SnRK1 Energy Sensor in Plant Biotic Interactions

Hulsmans, S., Rodríguez, M., Coninck, B. D., & Rolland, F. (2016) · Trends in Plant Science · doi:10.1016/j.tplants.2016.04.008 · Cited by 176 · see citing works

The Transcription Factor FOXM1 (Forkhead box M1)

Wierstra, I. (2013) · Advances in cancer research · doi:10.1016/b978-0-12-407173-5.00004-2 · Cited by 174 · see citing works

Oncosuppressive role of p53‐induced miR‐205 in triple negative breast cancer

Piovan, C., Palmieri, D., Leva, G. D., Braccioli, L., Casalini, P., Nuovo, G. J., Tortoreto, M., Sasso, M., Plantamura, I., Triulzi, T., et al. (2012) · Molecular Oncology · doi:10.1016/j.molonc.2012.03.003 · Cited by 166 · see citing works

Vascular endothelial growth factor regulates adult hippocampal cell proliferation through MEK/ERK- and PI3K/Akt-dependent signaling

Fournier, N. M., Lee, B., Banasr, M., Elsayed, M., & Duman, R. S. (2012) · Neuropharmacology · doi:10.1016/j.neuropharm.2012.04.033 · Cited by 164 · see citing works

RB1 dual role in proliferation and apoptosis: Cell fate control and implications for cancer therapy

Indovina, P., Pentimalli, F., Casini, N., Vocca, I., & Giordano, A. (2015) · Oncotarget · doi:10.18632/oncotarget.4286 · Cited by 162 · see citing works

Functional analyses of coronary artery disease associated variation on chromosome 9p21 in vascular smooth muscle cells

Motterle, A., Pu, X., Wood, H., Xiao, Q., Gor, S., Liang Ng, F., Chan, K., Cross, F., Shohreh, B., Poston, R. N., et al. (2012) · Human Molecular Genetics · doi:10.1093/hmg/dds224 · Cited by 160 · see citing works

Stearoyl CoA desaturase-1: New insights into a central regulator of cancer metabolism

Igal, R. A. (2016) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2016.09.009 · Cited by 159 · see citing works

A genome-wide SNP-association study confirms a sequence variant (g.66493737C>T) in the equine myostatin (MSTN) gene as the most powerful predictor of optimum racing distance for Thoroughbred racehorses

Hill, E. W., McGivney, B. A., Gu, J., Whiston, R., & MacHugh, D. E. (2010) · BMC Genomics · doi:10.1186/1471-2164-11-552 · Cited by 158 · see citing works

miR-15a and miR-16-1 downregulate CCND1 and induce apoptosis and cell cycle arrest in osteosarcoma

Cai, C., ZHAO, G.-Y., Tian, L., LIU, L., YAN, K., Ma, Y., Ji, Z., Li, X., Han, K., Gao, J., et al. (2012) · Oncology Reports · doi:10.3892/or.2012.1995 · Cited by 147 · see citing works

Adenovirus DNA ReplicationPreprint

Hoeben, R. C., & Uil, T. G. (2013) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a013003 · Cited by 144 · see citing works

Ribosomal Proteins Control or Bypass p53 during Nucleolar Stress

Russo, A., & Russo, G. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18010140 · Cited by 143 · see citing works

Role of Cell Cycle Re-Entry in Neurons: A Common Apoptotic Mechanism of Neuronal Cell Death

Folch, J., Junyent, F., Verdaguer, E., Auladell, C., Pizarro, J. G., Beas‐Zárate, C., Pallàs, M., & Camins, A. (2011) · Neurotoxicity Research · doi:10.1007/s12640-011-9277-4 · Cited by 138 · see citing works

Senescence Sensitivity of Breast Cancer Cells Is Defined by Positive Feedback Loop between CIP2A and E2F1

Laine, A., Sihto, H., Come, C., Rosenfeldt, M. T., Zwolinska, A., Niemelä, M., Khanna, A., Chan, E. K., Kähäri, V.-M., Kellokumpu-Lehtinen, P.-L., et al. (2013) · Cancer Discovery · doi:10.1158/2159-8290.cd-12-0292 · Cited by 130 · see citing works

A Noncanonical Role for the CKI-RB-E2F Cell-Cycle Signaling Pathway in Plant Effector-Triggered Immunity

Wang, S., Gu, Y., Zebell, S. G., Anderson, L. K., Wang, W., Mohan, R., & Dong, X. (2014) · Cell Host & Microbe · doi:10.1016/j.chom.2014.10.005 · Cited by 125 · see citing works

Identifying disease genes and module biomarkers by differential interactions

Liu, X., Liu, Z.-P., Zhao, X., & Chen, L. (2011) · Journal of the American Medical Informatics Association · doi:10.1136/amiajnl-2011-000658 · Cited by 118 · see citing works

H19 Noncoding RNA, an Independent Prognostic Factor, Regulates Essential Rb-E2F and CDK8-β-Catenin Signaling in Colorectal Cancer

Ohtsuka, M., Ling, H. Y., Ivan, C., Pichler, M., Matsushita, D., Goblirsch, M. J., Stiegelbauer, V., Shigeyasu, K., Zhang, X., Chen, M., et al. (2016) · EBioMedicine · doi:10.1016/j.ebiom.2016.10.026 · Cited by 113 · see citing works

Recent trends in targeting miRNAs for cancer therapy

Shah, V., & Shah, J. (2020) · Journal of Pharmacy and Pharmacology · doi:10.1111/jphp.13351 · Cited by 113 · see citing works

Dioxin toxicity, aryl hydrocarbon receptor signaling, and apoptosis—Persistent pollutants affect programmed cell death

Chopra, M., & Schrenk, D. (2011) · Critical Reviews in Toxicology · doi:10.3109/10408444.2010.524635 · Cited by 113 · see citing works

Apigenin induces apoptosis via extrinsic pathway, inducing p53 and inhibiting STAT3 and NFκB signaling in HER2-overexpressing breast cancer cells

Seo, H., Choi, H., Kim, S.-R., Choi, Y. K., Woo, S., Shin, I., Woo, J. K., Park, S., Shin, Y. C., & Ko, S.-K. (2012) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-012-1310-2 · Cited by 112 · see citing works

Causes and consequences of nuclear envelope alterations in tumour progression

Bell, E. S., & Lammerding, J. (2016) · European Journal of Cell Biology · doi:10.1016/j.ejcb.2016.06.007 · Cited by 110 · see citing works

The Role of the Apoptotic Machinery in Tumor SuppressionPreprint

Delbridge, A. R. D., Valente, L. J., & Strasser, A. (2012) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a008789 · Cited by 103 · see citing works

Transcriptional and epigenetic regulation of the p53 tumor suppressor gene

Saldaña-Meyer, R., & Targa, F. R. (2011) · Epigenetics · doi:10.4161/epi.6.9.16683 · Cited by 101 · see citing works

Tumor Protein 53-Induced Nuclear Protein 1 Enhances p53 Function and Represses Tumorigenesis

Shahbazi, J., Lock, R. B., & Liu, T. (2013) · Frontiers in Genetics · doi:10.3389/fgene.2013.00080 · Cited by 98 · see citing works

Specific Acetylation of p53 by HDAC Inhibition Prevents DNA Damage-Induced Apoptosis in Neurons

Brochier, C., Dennis, G., Rivieccio, M. A., McLaughlin, K., Coppola, G., Ratan, R. R., & Langley, B. C. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.5214-12.2013 · Cited by 97 · see citing works

The JmjC domain‐containing histone demethylase KDM3A is a positive regulator of the G 1 /S transition in cancer cells via transcriptional regulation of the HOXA1 gene

Cho, H., Toyokawa, G., Daigo, Y., Hayami, S., Masuda, K., Ikawa, N., Yamane, Y., Maejima, K., Tsunoda, T., Field, H. I., et al. (2011) · International Journal of Cancer · doi:10.1002/ijc.26501 · Cited by 96 · see citing works

Single-walled carbon nanotube induction of rat aortic endothelial cell apoptosis: Reactive oxygen species are involved in the mitochondrial pathway

Cheng, W., Lin, Z., Wei, B.-F., Zeng, Q., Han, B., Wei, C., Xian-jun, F., Hu, C., Liu, L.-H., Huang, J., et al. (2010) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2010.12.013 · Cited by 94 · see citing works

Multi-omics analysis of human mesenchymal stem cells shows cell aging that alters immunomodulatory activity through the downregulation of PD-L1

Gao, Y., Chi, Y., Chen, Y., Wang, W., Li, H., Zheng, W., Zhu, P., An, J., Duan, Y., Sun, T., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-39958-5 · Cited by 92 · see citing works

Proteogenomic analysis of chemo-refractory high-grade serous ovarian cancer

Chowdhury, S., Kennedy, J. J., Ivey, R. G., Murillo, O. D., Hosseini, N., Song, X., Petralia, F., Calinawan, A. P., Savage, S. R., Berry, A. B., et al. (2023) · Cell · doi:10.1016/j.cell.2023.07.004 · Cited by 91 · see citing works

PERK Integrates Oncogenic Signaling and Cell Survival During Cancer Development

Bu, Y., & Diehl, J. A. (2016) · Journal of Cellular Physiology · doi:10.1002/jcp.25336 · Cited by 90 · see citing works

Inferring transcriptional and microRNA‐mediated regulatory programs in glioblastoma

Setty, M. N., Helmy, K. Y., Khan, A. A., Silber, J., Arvey, A. J., Neezen, F., Agius, P., Huse, J. T., Holland, E. C., & Leslie, C. S. (2012) · Molecular Systems Biology · doi:10.1038/msb.2012.37 · Cited by 89 · see citing works

C. elegans germ cells show temperature and age-dependent expression of Cer1, a Gypsy/Ty3-related retrotransposon

Dennis, S., Sheth, U., Feldman, J. L., English, K. A., & Priess, J. R. (2012) · PLoS Pathogens · doi:10.1371/journal.ppat.1002591 · Cited by 88 · see citing works

Transcriptional Regulation of Energy Metabolism in Cancer Cells

Rodríguez‐Enríquez, S., Marín‐Hernández, Á., Gallardo‐Pérez, J. C., Pacheco-Velázquez, S. C., Belmont-Díaz, J., Robledo‐Cadena, D. X., Vargas-Navarro, J. L., de la Peña, N. A. C., Saavedra, E., & Moreno‐Sánchez, R. (2019) · Cells · doi:10.3390/cells8101225 · Cited by 86 · see citing works

Effects of TP53 mutational status on gene expression patterns across 10 human cancer types

Parikh, N., Hilsenbeck, S. G., Creighton, C. J., Dayaram, T., Shuck, R. L., Shinbrot, E., Liu, X., Gibbs, R. A., Wheeler, D. A., & Donehower, L. A. (2013) · The Journal of Pathology · doi:10.1002/path.4321 · Cited by 86 · see citing works

Going out of the brain: Non-nervous system physiological and pathological functions of Cdk5

Contreras-Vallejos, E., Utreras, E., & González-Billault, C. E. (2011) · Cellular Signalling · doi:10.1016/j.cellsig.2011.08.022 · Cited by 85 · see citing works

Evaluating the physiological reserves of older patients with cancer: The value of potential biomarkers of aging?

Pallis, A. G., Hatse, S., Brouwers, B. A. H., Pawelec, G., Falandry, C., Wedding, U., Lago, L. D., Repetto, L., Ring, A. E., & Wildiers, H. P. M. W. (2013) · Journal of Geriatric Oncology · doi:10.1016/j.jgo.2013.09.001 · Cited by 84 · see citing works

E2F1 apoptosis counterattacked: evil strikes back

Pützer, B. M., & Engelmann, D. (2012) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2012.10.009 · Cited by 84 · see citing works

MiR-106a inhibits glioma cell growth by targeting E2F1 independent of p53 status

Yang, G., Zhang, R., Chen, X., Mu, Y., Ai, J., Chen, S., Liu, Y., Shi, C., Sun, L., Rainov, N. G., et al. (2011) · Journal of Molecular Medicine · doi:10.1007/s00109-011-0775-x · Cited by 83 · see citing works

The PI3K/Akt/mTOR pathway regulates the replicative senescence of human VSMCs

Tan, P., Wang, Y., Li, S., Wang, Y., He, J., Chen, Y., Deng, H., Huang, W., Zhan, J., & Liu, Y. (2016) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-016-2796-9 · Cited by 79 · see citing works

Emerging Role of the Nucleolar Stress Response in Autophagy

Pfister, A. S. (2019) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2019.00156 · Cited by 77 · see citing works

Deletion of Rb Accelerates Pancreatic Carcinogenesis by Oncogenic Kras and Impairs Senescence in Premalignant Lesions

Carrière, C., Gore, A. J., Norris, A. M., Gunn, J. R., Young, A. L., Longnecker, D. S., & Korc, M. (2011) · Gastroenterology · doi:10.1053/j.gastro.2011.05.041 · Cited by 75 · see citing works

Smyd3-associated regulatory pathways in cancer

Giakountis, A., Moulos, P., Sarris, M. E., Hatzis, P., & Talianidis, I. (2016) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2016.08.008 · Cited by 74 · see citing works

Modeling epigenetic lesions that cause gliomas

Rahme, G. J., Javed, N. M., Puorro, K. L., Xin, S., Hovestadt, V., Johnstone, S. E., & Bernstein, B. (2023) · Cell · doi:10.1016/j.cell.2023.06.022 · Cited by 73 · see citing works

COMMD9 promotes TFDP1/E2F1 transcriptional activity via interaction with TFDP1 in non-small cell lung cancer

Zhan, W., Wang, W., Han, T., Xie, C., Zhang, T., Gan, M., & Wang, J.-B. (2016) · Cellular Signalling · doi:10.1016/j.cellsig.2016.11.016 · Cited by 72 · see citing works

Complex Cartography: Regulation of E2F Transcription Factors by Cyclin F and Ubiquitin

Emanuele, M. J., Enrico, T. P., Mouery, R. D., Wasserman, D., Nachum, S., & Tzur, A. (2020) · Trends in Cell Biology · doi:10.1016/j.tcb.2020.05.002 · Cited by 72 · see citing works

miR-34a Induces the Downregulation of Both E2F1 and B-Myb Oncogenes in Leukemic Cells

Zauli, G., Voltan, R., di Iasio, M. G., Bosco, R., Melloni, E., Sana, M. E., & Secchiero, P. (2011) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-10-3244 · Cited by 72 · see citing works

The long non-coding RNA ERIC is regulated by E2F and modulates the cellular response to DNA damage

Feldstein, O., Nizri, T., Doniger, T., Jacob, J., Rechavi, G., & Ginsberg, D. (2013) · Molecular Cancer · doi:10.1186/1476-4598-12-131 · Cited by 72 · see citing works

Novel insights into RB1 mutation

Yao, Y., Gu, X., Xu, X., Ge, S., & Jia, R. (2022) · Cancer Letters · doi:10.1016/j.canlet.2022.215870 · Cited by 71 · see citing works

Metallothionein 1G functions as a tumor suppressor in thyroid cancer through modulating the PI3K/Akt signaling pathway

Fu, J., Lv, H., Guan, H., Ma, X., Ji, M., He, N., Shi, B., & Hou, P. (2013) · BMC Cancer · doi:10.1186/1471-2407-13-462 · Cited by 70 · see citing works

Synergistic functions of E2F7 and E2F8 are critical to suppress stress-induced skin cancer

Thurlings, I., Martínez-López, L. M., Westendorp, B., Zijp, M., Kuiper, R., Tooten, P. C. J., Kent, L. N., Leone, G. W., Vos, H. R., Burgering, B. M. T., et al. (2016) · Oncogene · doi:10.1038/onc.2016.251 · Cited by 70 · see citing works

Redundancy: A Critical Obstacle to Improving Cancer Therapy

Lavi, O. (2015) · Cancer Research · doi:10.1158/0008-5472.can-14-3256 · Cited by 68 · see citing works

E2F1: Cause and Consequence of DNA Replication Stress

Fouad, S., Hauton, D., & D’Angiolella, V. (2021) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2020.599332 · Cited by 67 · see citing works

Revisiting the Female Germline and Its Expanding Toolbox

Pinto, S. C., Mendes, M. A., Coimbra, S., & Tucker, M. R. (2019) · Trends in Plant Science · doi:10.1016/j.tplants.2019.02.003 · Cited by 66 · see citing works

Dual Programmed Cell Death Pathways Induced by p53 Transactivation Overcome Resistance to Oncolytic Adenovirus in Human Osteosarcoma Cells

Hasei, J., Sasaki, T., Tazawa, H., Osaki, S., Yamakawa, Y., Kunisada, T., Yoshida, A., Hashimoto, Y., Onishi, T., Uno, F., et al. (2013) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-12-0869 · Cited by 65 · see citing works

Translating DNA damage into cancer cell death—A roadmap for E2F1 apoptotic signalling and opportunities for new drug combinations to overcome chemoresistance

Engelmann, D., & Pützer, B. M. (2010) · Drug Resistance Updates · doi:10.1016/j.drup.2010.06.001 · Cited by 64 · see citing works

p53 is essential for DNA methylation homeostasis in naïve embryonic stem cells, and its loss promotes clonal heterogeneityPreprint

Tovy, A., Spiro, A., McCarthy, R. L., Shipony, Z., Aylon, Y., Allton, K. L., Ainbinder, E., Furth, N., Tanay, A., Barton, M. C., et al. (2017) · Genes & Development · doi:10.1101/gad.299198.117 · Cited by 64 · see citing works

Epigenetic Alterations in Blood Mirror Age-Associated Dna Methylation and Gene Expression Changes in Human Liver

Bysani, M., Perfilyev, A., de Mello, V. D., Rönn, T., Nilsson, E., Pihlajamäki, J., & Ling, C. (2016) · Epigenomics · doi:10.2217/epi-2016-0087 · Cited by 63 · see citing works

Xanthatin Induces Cell Cycle Arrest at G2/M Checkpoint and Apoptosis via Disrupting NF-κB Pathway in A549 Non-Small-Cell Lung Cancer Cells

Zhang, L., Ruan, J., Yan, L., Li, W., Wu, Y. C., Li, T., Zhang, F., Zheng, S., Wang, A., & Lu, Y. (2012) · Molecules · doi:10.3390/molecules17043736 · Cited by 62 · see citing works

The E2F1/Rb and p53/MDM2 Pathways in DNA Repair and Apoptosis: Understanding the Crosstalk to Develop Novel Strategies for Prostate Cancer Radiotherapy

Udayakumar, T. S., Shareef, M. M., Diaz, D. A., Ahmed, M. M., & Pollack, A. S. (2010) · Seminars in Radiation Oncology · doi:10.1016/j.semradonc.2010.05.007 · Cited by 62 · see citing works

Starvation, detoxification, and multidrug resistance in cancer therapy

Lee, C. D., Raffaghello, L., & Longo, V. D. (2012) · Drug Resistance Updates · doi:10.1016/j.drup.2012.01.004 · Cited by 62 · see citing works

Chromatin Remodeling Factor LSH is Upregulated by the LRP6-GSK3β-E2F1 Axis Linking Reversely with Survival in Gliomas

Xiao, D., Huang, J. X., Pan, Y., Li, H. R., Fu, C., Mao, C., Cheng, Y., Shi, Y., Chen, L., Jiang, Y., et al. (2016) · Theranostics · doi:10.7150/thno.17032 · Cited by 62 · see citing works

PARP‐1 regulates DNA repair factor availability

Schiewer, M. J., Mandigo, A. C., Gordon, N., Huang, F., Gaur, S., de Leeuw, R., Zhao, S. G., Evans, J. R., Han, S., Parsons, T., et al. (2018) · EMBO Molecular Medicine · doi:10.15252/emmm.201708816 · Cited by 62 · see citing works

A Bovine Lymphosarcoma Cell Line Infected with Theileria annulata Exhibits an Irreversible Reconfiguration of Host Cell Gene Expression

Kinnaird, J. H., Weir, W., Durrani, Z., Pillai, S. S., Baird, M., & Shiels, B. R. (2013) · PLoS ONE · doi:10.1371/journal.pone.0066833 · Cited by 59 · see citing works

Sarcomas of Bone

Anderson, M. E., Randall, R. L., Springfield, D. S., & Gebhardt, M. C. (2014) · Elsevier eBooks · doi:10.1016/b978-1-4557-2865-7.00092-8 · Cited by 59 · see citing works

Checkpoint Kinase 1 Inhibition Enhances Cisplatin Cytotoxicity and Overcomes Cisplatin Resistance in SCLC by Promoting Mitotic Cell Death

Hsu, W., Zhao, X., Zhu, J., Kim, I., Rao, G., McCutcheon, J. N., Hsu, S.-T., Teicher, B. A., Kallakury, B., Dowlati, A., et al. (2019) · Journal of Thoracic Oncology · doi:10.1016/j.jtho.2019.01.028 · Cited by 59 · see citing works

Non-Coding microRNAs as Novel Potential Tumor Markers in Testicular Cancer

Regouc, M., Belge, G., Lorch, A., Dieckmann, K., & Pichler, M. (2020) · Cancers · doi:10.3390/cancers12030749 · Cited by 58 · see citing works

The dual role of p53: DNA protection and antioxidant

Borrás, C., Gómez‐Cabrera, M. C., & Viña, J. (2011) · Free Radical Research · doi:10.3109/10715762.2011.571685 · Cited by 58 · see citing works

KMTase Set7/9 is a critical regulator of E2F1 activity upon genotoxic stress

Lezina, L., Aksenova, V., Ivanova, T., Purmessur, N. S., Antonov, A. V., Tentler, D., Fedorova, O., Garabadgiu, A. V., Talianidis, I., Melino, G., et al. (2014) · Cell Death and Differentiation · doi:10.1038/cdd.2014.108 · Cited by 58 · see citing works

miR-15/16 complex targets p70S6 kinase1 and controls cell proliferation in MDA-MB-231 breast cancer cells

Ramaiah, M. J., Lavanya, A., Honarpisheh, M. M., Zarea, M., Bhadra, U., & Bhadra, M. P. (2014) · Gene · doi:10.1016/j.gene.2014.09.052 · Cited by 57 · see citing works

Kinetic Modeling–Based Detection of Genetic Signatures That Provide Chemoresistance via the E2F1-p73/DNp73-miR-205 Network

Vera, J., Schmitz, U., Lai, X., Engelmann, D., Khan, F. M., Wolkenhauer, O., & Pützer, B. M. (2013) · Cancer Research · doi:10.1158/0008-5472.can-12-4095 · Cited by 57 · see citing works

Expanding Roles of the E2F-RB-p53 Pathway in Tumor Suppression

Zhou, Y., Nakajima, R., Shirasawa, M., Fikriyanti, M., Zhao, L., Iwanaga, R., Bradford, A. P., Kurayoshi, K., Araki, K., & Ohtani, K. (2023) · Biology · doi:10.3390/biology12121511 · Cited by 49 · see citing works

Role of the RB Tumor Suppressor in Cancer

Yamasaki, L. (2006) · Kluwer Academic Publishers eBooks · doi:10.1007/0-306-48158-8_9 · Cited by 85 · see citing works

E2F and p53 make a nice couple: converging pathways in apoptosis

Dynlacht, B. D. (2005) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4401612 · Cited by 10 · see citing works

E2F and the molecular mechanisms of early cell-cycle control

Thangue, N. B. L. (1996) · Biochemical Society Transactions · doi:10.1042/bst0240054 · Cited by 72 · see citing works

Integration of the PRB and P53 Cell Cycle Control Pathways

Stewart, C. L., Soria, A. M., & Hamel, P. A. (2001) · Journal of Neuro-Oncology · doi:10.1023/a:1010615822317 · Cited by 26 · see citing works