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Cited by 219

The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.

On the Relationship of Protein and mRNA Dynamics in Vertebrate Embryonic Development

Open access
Peshkin, Leonid, Wühr, Martin, Pearl, Esther, Haas, Wilhelm, Freeman, Robert M., Gerhart, John C., Klein, Allon M., Horb, Marko, Gygi, Steven P., Kirschner, Marc W.·2015·Developmental Cell
DOI 10.1016/j.devcel.2015.10.010
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Abstract

Summary A biochemical explanation of development from the fertilized egg to the adult requires an understanding of the proteins and RNAs expressed over time during embryogenesis. We present a comprehensive characterization of protein and mRNA dynamics across early development in Xenopus. Surprisingly, we find that most protein levels change little and duplicated genes are expressed similarly. While the correlation between protein and mRNA levels is poor, a mass action kinetics model parameterized using protein synthesis and degradation rates regresses protein dynamics to RNA dynamics, corrected for initial protein concentration. This study provides detailed data for absolute levels of ∼10K proteins and ∼28K transcripts via a convenient web portal, a rich resource for developmental biologists. It underscores the lasting impact of maternal dowry, finds surprisingly few cases where degradation alone drives a change in protein level, and highlights the importance of transcription in shaping the dynamics of the embryonic proteome.

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Citations

Cites

Research works printed but not linked: 26

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Metadata

Authors
Peshkin, L., Wühr, M., Pearl, E., Haas, W., Freeman, R. M., Gerhart, J. C., Klein, A. M., Horb, M., Gygi, S. P., & Kirschner, M. W.
Venue
Developmental Cell
Publisher
Elsevier BV
Published
2015-11
Volume
35
Issue
3
Pages
383-394
ISSN
1534-5807 (ISSN-L)
DOI
10.1016/j.devcel.2015.10.010
OpenAlex
W2126441851
Cited by
219
References
6
FWCI
9.52
Type
journal article
Language
en
Open access
bronze
Licence

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