The DOI matches its Crossref record; 125 of the 125 references it cites were found in a registry or an index.
A Comprehensive Roadmap of Murine Spermatogenesis Defined by Single-Cell RNA-Seq
Open accessAbstract
Summary: Spermatogenesis requires intricate interactions between the germline and somatic cells. Within a given cross-section of a seminiferous tubule, multiple germ and somatic cell types co-occur. This cellular heterogeneity has made it difficult to profile distinct cell types at different stages of development. To address this challenge, we collected single-cell RNA sequencing data from ~35K cells from the adult mouse testis, and identified all known germ and somatic cells, as well as two unexpected somatic cell types. Our analysis revealed a continuous developmental trajectory of germ cells from spermatogonia to spermatids, and identified novel candidate transcriptional regulators at several transition points during differentiation. Focused analyses delineated four subtypes of spermatogonia and nine subtypes of Sertoli cells, the latter linked to histologically defined developmental stages over the seminiferous epithelial cycle. Overall, this high-resolution cellular atlas represents a community resource and foundation of knowledge to study germ cell development and in vivo gametogenesis.
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Cited by
The adult human testis transcriptional cell atlas
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Context-dependent functional compensation between Ythdf m6A reader proteins
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Epigenetic inheritance of diet-induced and sperm-borne mitochondrial RNAs
Tomar, A., Gomez-Velazquez, M., Gerlini, R., Comas-Armangué, G., Makharadze, L., Kolbe, T., Boersma, A., Dahlhoff, M., Burgstaller, J. P., Lassi, M., et al. (2024) · Nature · doi:10.1038/s41586-024-07472-3 · Cited by 216
Metadata
- Authors
- Green, C. D., Ma, Q., Manske, G. L., Shami, A. N., Zheng, X., Marini, S., Moritz, L., Sultan, C., Gurczynski, S. J., Moore, B. B., Tallquist, M. D., Li, J. Z., & Hammoud, S. S.
- Venue
- Developmental Cell
- Publisher
- Elsevier BV
- Published
- 2018-09
- Volume
- 46
- Issue
- 5
- Pages
- 651-667.e10
- ISSN
- 1534-5807 (ISSN-L)
- OpenAlex
- W2888403713
- Cited by
- 521
- References
- 125
- FWCI
- 36.15
- Type
- journal article
- Language
- en
- Open access
- bronze
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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