Helping Wingless take flight: how WNT proteins are secreted
Abstract
How functional WNT proteins are made and how their secretion is regulated is becoming a focal point for the WNT-signalling field. Recently, lipoprotein particles, WNT lipid modifications, the conserved transmembrane protein Wntless (WLS; also known as EVI and SRT) and the retromer complex have been implicated in WNT secretion. Our aim is to synthesize ideas from these new findings for the mechanisms that underlie WNT secretion.
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The porcupine protein plays an important role in the palmitolation of the Wnt proteins, and their secretion is regulated by the wntless or evenness interrupted proteins and the retromer complex.
“The porcupine protein has been shown to play an important role in the palmitolation of the Wnt proteins, and their secretion is regulated by the wntless or evenness interrupted proteins and the retromer complex.11–14”
From Wnt signal transduction pathways (2008) · cites this paper as [13]
Cites
Wnt/β-Catenin Signaling in Development and Disease
Clevers, H. (2006) · Cell · doi:10.1016/j.cell.2006.10.018 · Cited by 5,568 · see citing works
The Wnt Signaling Pathway in Development and Disease
Logan, C. Y., & Nusse, R. (2004) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.20.010403.113126 · Cited by 5,325 · see citing works
Wnt proteins are lipid-modified and can act as stem cell growth factors
Willert, K., Brown, J. D., Danenberg, E., Duncan, A. W., Weissman, I. L., Reya, T., Yates, J. R., & Nusse, R. (2003) · Nature · doi:10.1038/nature01611 · Cited by 2,257 · see citing works
Nusse, R., & VARMUS, H. E. (1982) · Cell · doi:10.1016/0092-8674(82)90409-3 · Cited by 1,864 · see citing works
Veeman, M. T., Axelrod, J. D., & Moon, R. T. (2003) · Developmental Cell · doi:10.1016/s1534-5807(03)00266-1 · Cited by 1,359 · see citing works
Rijsewijk, F. A. M., Schuermann, M., Wagenaar, E., Parren, P. W. H. I., Weigel, D., & Nusse, R. (1987) · Cell · doi:10.1016/0092-8674(87)90038-9 · Cited by 931 · see citing works
Monounsaturated fatty acid modification of Wnt protein: its role in Wnt secretion.
Takada, R., Satomi, Y., Kurata, T., Ueno, N., Norioka, S., Kondoh, H., Takao, T., & Takada, S. (2006) · Developmental Cell · doi:10.1016/j.devcel.2006.10.003 · Cited by 807 · see citing works
Bänziger, C., Soldini, D., Schütt, C., Zipperlen, P., Hausmann, G., & Basler, K. (2006) · Cell · doi:10.1016/j.cell.2006.02.049 · Cited by 764 · see citing works
Self-citationDirect and Long-Range Action of a Wingless Morphogen Gradient
Zecca, M., Basler, K., & Struhl, G. (1996) · Cell · doi:10.1016/s0092-8674(00)81991-1 · Cited by 732 · see citing works
Self-citationLipoprotein particles are required for Hedgehog and Wingless signalling
Panáková, D., Sprong, H., Marois, É., Thiele, C., & Eaton, S. (2005) · Nature · doi:10.1038/nature03504 · Cited by 703 · see citing works
Organization of vesicular trafficking in epithelia
Rodriguez-Boulan, E., Kreitzer, G., & Müsch, A. (2005) · Nature reviews. Molecular cell biology · doi:10.1038/nrm1593 · Cited by 644 · see citing works
Role of the mammalian retromer in sorting of the cation-independent mannose 6-phosphate receptor
Arighi, C. N., Hartnell, L. M., Aguilar, R. C., Haft, C. R., & Bonifacino, J. S. (2004) · The Journal of Cell Biology · doi:10.1083/jcb.200312055 · Cited by 601 · see citing works
Unexpected complexity of the Wnt gene family in a sea anemone
Kusserow, A., Pang, K., Sturm, C., Hrouda, M., Lentfer, J., Schmidt, H. A., Technau, U., von Haeseler, A., Hobmayer, B., Martindale, M. Q., et al. (2005) · Nature · doi:10.1038/nature03158 · Cited by 599 · see citing works
Secretion of Wnt Ligands Requires Evi, a Conserved Transmembrane Protein
Bartscherer, K., Pelte, N., Ingelfinger, D., & Boutros, M. (2006) · Cell · doi:10.1016/j.cell.2006.04.009 · Cited by 580 · see citing works
Burke, R., Anthamatten, D., Bellotto, M., Hafen, E., Senti, K.-A., Dickson, B. J., & Basler, K. (1999) · Cell · doi:10.1016/s0092-8674(00)81677-3 · Cited by 579 · see citing works
Self-citationSIGNALING PATHWAYS IN INTESTINAL DEVELOPMENT AND CANCER
Sancho, E., Batlle, E., & Clevers, H. C. (2004) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.20.010403.092805 · Cited by 531 · see citing works
Kiecker, C. M., & Niehrs, C. (2001) · Development · doi:10.1242/dev.128.21.4189 · Cited by 515 · see citing works
Wnt Signaling Polarizes an Early C. elegans Blastomere to Distinguish Endoderm from Mesoderm
Thorpe, C. J., Schlesinger, A., Carter, J. C., & Bowerman, B. A. (1997) · Cell · doi:10.1016/s0092-8674(00)80530-9 · Cited by 514 · see citing works
A superfamily of membrane-bound O -acyltransferases with implications for Wnt signaling
Hofmann, K. (2000) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(99)01539-x · Cited by 495 · see citing works
Wingless gradient formation in the Drosophila wing
Strigini, M., & Cohen, S. M. (2000) · Current Biology · doi:10.1016/s0960-9822(00)00378-x · Cited by 454 · see citing works
van den Heuvel, M., Nusse, R., Johnston, P., & Lawrence, P. A. (1989) · Cell · doi:10.1016/0092-8674(89)90020-2 · Cited by 444 · see citing works
Ang, A. L., Taguchi, T., Francis, S., Fölsch, H., Murrells, L. J., Pypaert, M., Warren, G., & Mellman, I. (2004) · The Journal of Cell Biology · doi:10.1083/jcb.200408165 · Cited by 432 · see citing works
Long-range action of Wingless organizes the dorsal-ventral axis of the Drosophila wing
Neumann, C. J., & Cohen, S. M. (1997) · Development · doi:10.1242/dev.124.4.871 · Cited by 428 · see citing works
Chen, M.-H., Li, Y.-J., Kawakami, T., Xu, S.-M., & Chuang, P.-T. (2004) · Genes & Development · doi:10.1101/gad.1185804 · Cited by 407 · see citing works
Functional genomics reveals genes involved in protein secretion and Golgi organization
Bard, F., Casano, L., Mallabiabarrena, A., Wallace, E., Saito, K., Kitayama, H., Guizzunti, G., Hu, Y., Wendler, F., DasGupta, R., et al. (2006) · Nature · doi:10.1038/nature04377 · Cited by 372 · see citing works
Kadowaki, T., Wilder, E. L., Klingensmith, J., Zachary, K., & Perrimon, N. (1996) · Genes & Development · doi:10.1101/gad.10.24.3116 · Cited by 348 · see citing works
Nusse, R. (2003) · Development · doi:10.1242/dev.00821 · Cited by 337 · see citing works
Novel Lipid Modifications of Secreted Protein Signals
Mann, R. K., & Beachy, P. A. (2004) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.73.011303.073933 · Cited by 322 · see citing works
A Wnt canon orchestrating osteoblastogenesis
Hartmann, C. (2006) · Trends in Cell Biology · doi:10.1016/j.tcb.2006.01.001 · Cited by 314 · see citing works
Homozygous WNT3 Mutation Causes Tetra-Amelia in a Large Consanguineous Family
Niemann, S., Zhao, C., Pascu, F., Stahl, U., Aulepp, U., Niswander, L. A., Weber, J. L., & Müller, U. (2004) · The American Journal of Human Genetics · doi:10.1086/382196 · Cited by 311 · see citing works
Recycle your receptors with retromer
Seaman, M. N. J. (2005) · Trends in Cell Biology · doi:10.1016/j.tcb.2004.12.004 · Cited by 309 · see citing works
Differential Transformation of Mammary Epithelial Cells by Wnt Genes
Wong, G. T., Gavin, B. J., & McMahon, A. P. (1994) · Molecular and Cellular Biology · doi:10.1128/mcb.14.9.6278-6286.1994 · Cited by 302 · see citing works
van den Heuvel, M., Samos, C. H., Klingensmith, J., Perrimon, N., & Nusse, R. (1993) · The EMBO Journal · doi:10.1002/j.1460-2075.1993.tb06225.x · Cited by 261 · see citing works
Phenocopies induced with antisense RNA identify the wingless gene
Cabrera, C. V., Alonso, M. C., Johnston, P., Phillips, R., & Lawrence, P. A. (1987) · Cell · doi:10.1016/0092-8674(87)90039-0 · Cited by 260 · see citing works
Wnt Gradient Formation Requires Retromer Function in Wnt-Producing Cells
Coudreuse, D. Y. M., Roël, G., Betist, M. C., Destrée, O., & Korswagen, H. C. (2006) · Science · doi:10.1126/science.1124856 · Cited by 252 · see citing works
Differential transformation of mammary epithelial cells by Wnt genes.
Wong, G. T., Gavin, B. J., & McMahon, A. P. (1994) · Molecular and Cellular Biology · doi:10.1128/mcb.14.9.6278 · Cited by 249 · see citing works
Zhai, L., Chaturvedi, D., & Cumberledge, S. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m403407200 · Cited by 247 · see citing works
Sprinter: a novel transmembrane protein required for Wg secretion and signaling
Goodman, R. M., Thombre, S., Karagonlar, Z. F., Gray, D., Betts, D., Roebuck, J., Spana, E. P., & Selva, E. M. (2006) · Development · doi:10.1242/dev.02674 · Cited by 222 · see citing works
Wnt signaling establishes anteroposterior neuronal polarity and requires retromer in C. elegans
Prasad, B. C., & Clark, S. G. (2006) · Development · doi:10.1242/dev.02357 · Cited by 219 · see citing works
The Formation of TGN-to-Plasma-Membrane Transport Carriers
Bard, F., & Malhotra, V. (2006) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.21.012704.133126 · Cited by 209 · see citing works
Common principles in clathrin-mediated sorting at the Golgi and the plasma membrane
Traub, L. M. (2005) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2005.04.005 · Cited by 205 · see citing works
Secrets of caveolae- and lipid raft-mediated endocytosis revealed by mammalian viruses
Pelkmans, L. (2005) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2005.06.009 · Cited by 181 · see citing works
Wistrand, M., Käll, L., & Sonnhammer, E. L. L. (2006) · Protein Science · doi:10.1110/ps.051745906 · Cited by 181 · see citing works
Tanaka, K., Kitagawa, Y., & Kadowaki, T. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m200187200 · Cited by 177 · see citing works
The endocytic pathway and formation of the Wingless morphogen gradient
Marois, É., Mahmoud, A., & Eaton, S. (2005) · Development · doi:10.1242/dev.02197 · Cited by 177 · see citing works
Futter, C. E., Connolly, C. N., Cutler, D. F., & Hopkins, C. R. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.18.10999 · Cited by 172 · see citing works
Intracellular sorting and transport of proteins
van Vliet, C., Thomas, E. C., Merino‐Trigo, A., Teasdale, R. D., & Gleeson, P. A. (2003) · Progress in Biophysics and Molecular Biology · doi:10.1016/s0079-6107(03)00019-1 · Cited by 148 · see citing works
The mammalian retromer regulates transcytosis of the polymeric immunoglobulin receptor
Vergés, M., Luton, F., Gruber‐Traub, C., Tiemann, F., Reinders, L. G., Huang, L., Burlingame, A. L., Haft, C. R., & Mostov, K. E. (2004) · Nature Cell Biology · doi:10.1038/ncb1153 · Cited by 142 · see citing works
Molecular causes of colon cancer
Oving, I. M., & Clevers, H. C. (2002) · European Journal of Clinical Investigation · doi:10.1046/j.1365-2362.2002.01004.x · Cited by 135 · see citing works
The evolutionarily conserved porcupine gene family is involved in the processing of the Wnt family
Tanaka, K., Okabayashi, K., Asashima, M., Perrimon, N., & Kadowaki, T. (2000) · European Journal of Biochemistry · doi:10.1046/j.1432-1033.2000.01478.x · Cited by 128 · see citing works
Vesicle Formation at the Plasma Membrane and Trans-Golgi Network: The Same but Different
McNiven, M. A., & Thompson, H. M. (2006) · Science · doi:10.1126/science.1118133 · Cited by 120 · see citing works
Producing Cells Retain and Recycle Wingless in Drosophila Embryos
Pfeiffer, S., Ricardo, S. A. V., Manneville, J., Alexandre, C., & Vincent, J. (2002) · Current Biology · doi:10.1016/s0960-9822(02)00867-9 · Cited by 107 · see citing works
Domains of the TGN: Coats, Tethers and G Proteins
Gleeson, P. A., Lock, J. G., Luke, M. R., & Stow, J. L. (2004) · Traffic · doi:10.1111/j.1398-9219.2004.00182.x · Cited by 106 · see citing works
Morphogen Transport along Epithelia, an Integrated Trafficking Problem
Vincent, J., & Dubois, L. (2002) · Developmental Cell · doi:10.1016/s1534-5807(02)00323-4 · Cited by 82 · see citing works
The Wnt-dependent signaling pathways as target in oncology drug discovery
Janssens, N., Janicot, M., & Perera, T. (2006) · Investigational New Drugs · doi:10.1007/s10637-005-5199-4 · Cited by 72 · see citing works
Release and trafficking of lipid-linked morphogens
Eaton, S. (2005) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2005.12.006 · Cited by 68 · see citing works
Morphogens: how big is the big picture?
Lawrence, P. A. (2001) · Nature Cell Biology · doi:10.1038/35083096 · Cited by 61 · see citing works
Caricasole, A., Ferraro, T., Rimland, J. M., & Terstappen, G. C. (2002) · Gene · doi:10.1016/s0378-1119(02)00467-5 · Cited by 61 · see citing works
The Wnt Signaling Pathway in Retinal Degenerations
Hackam, A. S. (2005) · IUBMB Life · doi:10.1080/15216540500137586 · Cited by 58 · see citing works
Membrane transport: Retromer to the rescue
Pfeffer, S. R. (2001) · Current Biology · doi:10.1016/s0960-9822(01)00042-2 · Cited by 38 · see citing works
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Self-citationWnt Signaling Requires Retromer-Dependent Recycling of MIG-14/Wntless in Wnt-Producing Cells
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Franch‐Marro, X., Wendler, F., Guidato, S., Griffith, J. M., Baena-López, L. A., Itasaki, N., Maurice, M. M., & Vincent, J. (2008) · Nature Cell Biology · doi:10.1038/ncb1678 · Cited by 251 · see citing works
Wnt and the Wnt signaling pathway in bone development and disease
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Coombs, G., Yu, J., Canning, C., Veltri, C. A., Covey, T. M., Cheong, J. K., Utomo, V., Banerjee, N., Zhang, Z., Jadulco, R. C., et al. (2010) · Journal of Cell Science · doi:10.1242/jcs.072132 · Cited by 191 · see citing works
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Katanaev, V. L., Solis, G. P., Hausmann, G., Buestorf, S., Katanayeva, N., Schrock, Y., Stuermer, C. A. O., & Basler, K. (2008) · The EMBO Journal · doi:10.1038/sj.emboj.7601981 · Cited by 115 · see citing works
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Galli, L. M., Barnes, T. L., Secrest, S. S., Kadowaki, T., & Burrus, L. W. (2007) · Development · doi:10.1242/dev.02881 · Cited by 96 · see citing works
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Yuan, G., Regel, I., Lian, F., Friedrich, T., Hitkova, I., Hofheinz, R., Ströbel, P., Langer, R., Keller, G., Röcken, C., et al. (2012) · Oncogene · doi:10.1038/onc.2012.40 · Cited by 93 · see citing works
Eaton, S. (2008) · Developmental Cell · doi:10.1016/j.devcel.2007.12.014 · Cited by 90 · see citing works
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From endosomes to the trans-Golgi network
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Jin, J., Kittanakom, S., Wong, V., Reyes, B. A. S., Bockstaele, E. J. V., Štagljar, I., Berrettini, W. H., & Levenson, R. G. (2010) · BMC Neuroscience · doi:10.1186/1471-2202-11-33 · Cited by 60 · see citing works
Role of Adhesion in Arthropod Immune Recognition
Schmidt, O., Söderhäll, K., Theopold, U., & Faye, I. (2009) · Annual Review of Entomology · doi:10.1146/annurev.ento.54.110807.090618 · Cited by 58 · see citing works
Gasnereau, I., Herr, P., Chia, P. Z. C., Basler, K., & Gleeson, P. A. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.307231 · Cited by 57 · see citing works
Self-citationLeibold, J., Ruscetti, M. A., Cao, Z., Ho, Y.-J., Baslan, T., Zou, M., Abida, W. M., Feucht, J., Han, T., Barriga, F. M., et al. (2020) · Cancer Discovery · doi:10.1158/2159-8290.cd-19-1242 · Cited by 54 · see citing works
Motoneuron Wnts regulate neuromuscular junction development
Shen, C., Li, L., Zhao, K., Bai, L., Wang, A., Shu, X., Xiao, Y., Zhang, J., Zhang, K., Hui, T., et al. (2018) · eLife · doi:10.7554/elife.34625 · Cited by 53 · see citing works
The use of porcupine inhibitors to target Wnt-driven cancers
Ho, S. Y., & Keller, T. H. (2015) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2015.10.032 · Cited by 54 · see citing works
Trimeric G protein-dependent signaling by Frizzled receptors in animal development
Egger‐Adam, D. (2008) · Frontiers in bioscience · doi:10.2741/3036 · Cited by 48 · see citing works
Wnt Signaling Is Regulated by Endoplasmic Reticulum Retention
Zoltewicz, J. S., Ashique, A. M., Choe, Y., Lee, G., Taylor, S., Phamluong, K., Solloway, M. J., & Peterson, A. S. (2009) · PLoS ONE · doi:10.1371/journal.pone.0006191 · Cited by 48 · see citing works
Carboxypeptidase E: a negative regulator of the canonical Wnt signaling pathway
Skalka, N., Caspi, M., Caspi, E., Loh, Y. P., & Rosin‐Arbesfeld, R. (2012) · Oncogene · doi:10.1038/onc.2012.308 · Cited by 47 · see citing works
Wang, W., Xu, L., Liu, P., Jairam, K., Yin, Y., Chen, K., Sprengers, D., Peppelenbosch, M. P., Pan, Q., & Smits, R. (2016) · Neoplasia · doi:10.1016/j.neo.2016.10.004 · Cited by 47 · see citing works
Liu, L., Tang, L., Chen, D., Zheng, L., & Ma, X. (2024) · Frontiers in Endocrinology · doi:10.3389/fendo.2024.1486608 · Cited by 47 · see citing works
Synaptic Activity-Regulated Wnt Signaling in Synaptic Plasticity, Glial Function and Chronic Pain
Tang, S. (2014) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1871527312666131223114457 · Cited by 43 · see citing works
Take the Wnt out of the inflammatory sails: modulatory effects of Wnt in airway diseases
Reuter, S., Beckert, H., & Taube, C. (2015) · Laboratory Investigation · doi:10.1038/labinvest.2015.143 · Cited by 42 · see citing works
Osteogenesis and Bone Regeneration
Yang, H. (2019) · IntechOpen eBooks · doi:10.5772/intechopen.73955 · Cited by 42 · see citing works
Wnt signaling and neurite outgrowth: Insights and questions
Endo, Y., & Rubin, J. S. (2007) · Cancer Science · doi:10.1111/j.1349-7006.2007.00536.x · Cited by 40 · see citing works
Karnam, A., Bonam, S. R., Rambabu, N., Wong, S. S. W., Aimanianda, V., & Bayry, J. (2021) · mBio · doi:10.1128/mbio.02824-21 · Cited by 38 · see citing works
Zhang, Y., Chen, D., & Wang, Z. (2009) · Human Molecular Genetics · doi:10.1093/hmg/ddp332 · Cited by 37 · see citing works
Expression of Gpr177, a Wnt trafficking regulator, in mouse embryogenesis
Yu, H. I., Jin, Y., Fu, J., & Hsu, W. (2010) · Developmental Dynamics · doi:10.1002/dvdy.22336 · Cited by 34 · see citing works
Tarr, J. T., Lambi, A. G., Bradley, J. P., Barbe, M. F., & Popoff, S. N. (2018) · Journal of Developmental Biology · doi:10.3390/jdb6030018 · Cited by 34 · see citing works
Vargas, P. P., & Salinas, P. C. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.692888 · Cited by 33 · see citing works
Wnt Secretion and Gradient Formation
Solis, G. P., Lüchtenborg, A., & Katanaev, V. (2013) · International Journal of Molecular Sciences · doi:10.3390/ijms14035130 · Cited by 34 · see citing works
The long and the short of Wnt signaling in C. elegans
Hardin, J. D., & King, R. S. (2008) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2008.06.006 · Cited by 32 · see citing works
β-Catenin: A Key Molecule in Osteoblast Differentiation
Wróbel, E., Wojdasiewicz, P., Mikulska, A., & Szukiewicz, D. (2025) · Biomolecules · doi:10.3390/biom15071043 · Cited by 32 · see citing works
Wippermann, A., Klausing, S., Rupp, O., Albaum, S. P., Büntemeyer, H., Noll, T., & Hoffrogge, R. (2013) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-013-5282-2 · Cited by 28 · see citing works
Mesenchymal Wnt signaling promotes formation of sternum and thoracic body wall
Snowball, J. M., Ambalavanan, M. S., Cornett, B., Lang, R. A., Whitsett, J. A., & Sinner, D. I. (2015) · Developmental Biology · doi:10.1016/j.ydbio.2015.02.014 · Cited by 27 · see citing works
Secretion of Hedgehog-Related Peptides and WNT DuringCaenorhabditis elegansDevelopment
Kolotuev, I., Apaydin, A., & Labouesse, M. (2009) · Traffic · doi:10.1111/j.1600-0854.2008.00871.x · Cited by 27 · see citing works
Wnt-expressing cells in the intestines: guides for tissue remodeling
Miyoshi, H. (2016) · The Journal of Biochemistry · doi:10.1093/jb/mvw070 · Cited by 27 · see citing works
Wls promotes the proliferation of breast cancer cells via Wnt signaling
Lu, D., Li, Y., Liu, Q., Wu, Q., Zhang, H., Xie, P., & Wang, Q. (2015) · Medical Oncology · doi:10.1007/s12032-015-0585-z · Cited by 25 · see citing works
Petko, J., Justice-Bitner, S., Jin, J., Wong, V., Kittanakom, S., Ferraro, T. N., Štagljar, I., & Levenson, R. G. (2013) · PLoS ONE · doi:10.1371/journal.pone.0067608 · Cited by 24 · see citing works
Rab8 attenuates Wnt signaling and is required for mesenchymal differentiation into adipocytes
Stypulkowski, E., Feng, Q., Joseph, I., Farrell, V., Flores, J., Yu, S., Sakamori, R., Sun, J., Bandyopadhyay, S., Das, S., et al. (2021) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2021.100488 · Cited by 22 · see citing works
Lipid modification in Wnt structure and function
Ke, J., Xu, H. E., & Williams, B. O. (2013) · Current Opinion in Lipidology · doi:10.1097/mol.0b013e32835df2bf · Cited by 23 · see citing works
Ye, W., Wang, J., Huang, J., He, X. D., Ma, Z., Li, X., Huang, X., Li, F., Huang, S., Pan, J., et al. (2023) · Frontiers of Medicine · doi:10.1007/s11684-022-0942-1 · Cited by 20 · see citing works
Low expression of D2R and Wntless correlates with high motivation for heroin.
Tacelosky, D. M., Alexander, D. N., Morse, M., Hajnal, A. S., Berg, A. S., Levenson, R. G., & Grigson, P. S. (2015) · Behavioral Neuroscience · doi:10.1037/bne0000104 · Cited by 20 · see citing works
Chiou, S., Wang, L., Huang, S., Chai, C., Wang, S., Liao, Y., Lin, P., Liu, K.-Y., & Hsu, S. (2014) · Carcinogenesis · doi:10.1093/carcin/bgu166 · Cited by 19 · see citing works
Wnt3 Is Lipidated at Conserved Cysteine and Serine Residues in Zebrafish Neural Tissue
Dhasmana, D., Veerapathiran, S., Azbazdar, Y., Nelanuthala, A. V. S., Teh, C., Özhan, G., & Wohland, T. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.671218 · Cited by 17 · see citing works
Hang, K., Li, Y., Bai, J., Wang, Y., Kuang, Z., Xue, D., & Pan, Z. (2021) · Stem Cell Research & Therapy · doi:10.1186/s13287-021-02581-6 · Cited by 17 · see citing works
Gpr177 Deficiency Impairs Mammary Development and Prohibits Wnt-Induced Tumorigenesis
Maruyama, E. O., Yu, H., Jiang, M., Fu, J., & Hsu, W. (2013) · PLoS ONE · doi:10.1371/journal.pone.0056644 · Cited by 16 · see citing works
A sandwich ELISA for the detection of Wnt5a
Kummitha, C. M., Mayle, K. M., Christman, M. A., Deosarkar, S. P., Schwartz, A. L., McCall, K. D., Kohn, L. D., Malgor, R., & Goetz, D. J. (2009) · Journal of Immunological Methods · doi:10.1016/j.jim.2009.11.005 · Cited by 16 · see citing works
Mellado-López, M., Cuartero, Y., Brugada, R., & Vergés, M. (2014) · Biology of the Cell · doi:10.1111/boc.201400011 · Cited by 15 · see citing works
Varshini, M. S., Reddy, R. A., Krishnamurthy, P. T., & Wadhwani, A. (2024) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2024.105863 · Cited by 14 · see citing works
Retromer in Polarized Protein Transport
Vergés, M. (2016) · International review of cytology · doi:10.1016/bs.ircmb.2015.12.005 · Cited by 13 · see citing works
Suga, K., Suto, A., Tanaka, S., Sugawara, Y., Kageyama, T., Ishikawa, J., Sanayama, Y., Ikeda, K., Furuta, S., Kagami, S., et al. (2023) · JCI Insight · doi:10.1172/jci.insight.164778 · Cited by 14 · see citing works
Mutations in the WLS are associated with dental anomalies, torus palatinus, and torus mandibularis
Kantaputra, P. N., Tripuwabhrut, K., Jatooratthawichot, P., Adisornkanj, P., Hatsadaloi, A., Porntrakoolsaree, N., Kaewgaya, M., Olsen, B. R., Tongsima, S., Ngamphiw, C., et al. (2022) · European Journal of Orthodontics · doi:10.1093/ejo/cjac068 · Cited by 13 · see citing works
Krawetz, R. J., & Kelly, G. M. (2009) · Biochemistry and Cell Biology · doi:10.1139/o09-014 · Cited by 13 · see citing works
Ayansola, H., Mayorga, E. J., & Jin, Y. (2024) · Biomedicines · doi:10.3390/biomedicines12030668 · Cited by 12 · see citing works
Vergés, M. (2008) · International review of cytology · doi:10.1016/s1937-6448(08)01204-5 · Cited by 12 · see citing works
Drosophila long-chain acyl-CoA synthetase acts like a gap gene in embryonic segmentation
Zhang, Y., Zhang, Y., Gao, Y., Zhao, X., & Wang, Z. (2011) · Developmental Biology · doi:10.1016/j.ydbio.2011.02.030 · Cited by 12 · see citing works
High-Throughput RNAi Screen in Drosophila
DasGupta, R., & Gonsalves, F. C. (2008) · Methods in molecular biology · doi:10.1007/978-1-60327-469-2_13 · Cited by 12 · see citing works
The role of Bro1- domain-containing protein Myopic in endosomal trafficking of Wnt/Wingless
Pradhan‐Sundd, T., & Verheyen, E. M. (2014) · Developmental Biology · doi:10.1016/j.ydbio.2014.04.019 · Cited by 11 · see citing works
The interaction of Wnt-11 and signalling cascades in prostate cancer
Koushyar, S., Grant, G. H., & Onganer, P. U. (2016) · Tumor Biology · doi:10.1007/s13277-016-5263-z · Cited by 10 · see citing works
Role and Function of Wnts in the Regulation of Myogenesis: When Wnt Meets Myostatin
Fédon, Y., Bonnieu, A., Gay, S., Vernus, B., Bacou, F., & Bernardi, H. (2012) · InTech eBooks · doi:10.5772/48330 · Cited by 9 · see citing works
Therapeutic potential of ADSCs in diabetic wounds: a proteomics-based approach
Gu, Y., Mu, Z., Chen, Y., Wu, C., Shi, J., & Bai, N. (2024) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2024.1468220 · Cited by 8 · see citing works
Wntless (Wls): A Prognostic Index for Progression and Patient Survival of Breast Cancer
Zheng, D., Jiang, C., Yan, N., Miao, Y., Wang, K., Gao, G., Jiao, Y., Zhang, X., He, M., & Yang, Z. (2020) · OncoTargets and Therapy · doi:10.2147/ott.s265324 · Cited by 8 · see citing works
Hashemolhosseini, S., & Gessler, L. (2024) · Neural Regeneration Research · doi:10.4103/nrr.nrr-d-24-00417 · Cited by 7 · see citing works
β-Arrestin 1 mediates non-canonical Wnt pathway to regulate convergent extension movements
Kim, G., Park, E. C., Lee, H.-Y., Na, H.-J., Choi, S., & Han, J. (2013) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2013.04.088 · Cited by 6 · see citing works
Wang, Q., Wen, B., Micah, A. D., Gao, J., & Chen, Z. (2022) · Hydrobiologia · doi:10.1007/s10750-022-04921-w · Cited by 6 · see citing works
- Authors
- Hausmann, G., Bänziger, C., & Basler, K.
- Affiliations
- University of Zurich (CH)
- Corresponding author
- Basler, Konrad
- Venue
- Nature Reviews Molecular Cell Biology
- Published
- 2007-03-07
- Volume
- 8
- Issue
- 4
- Pages
- 331-336
- ISSN
- 1471-0072 (ISSN-L)
- 1471-0080
- OpenAlex
- W2065824248
- Cited by
- 147
- References
- 59
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 6 · 2023: 5 · 2022: 3 · 2021: 9 · 2020: 3 · 2019: 4 · 2018: 5 · 2016: 11 · 2015: 12 · 2014: 7 · 2013: 11 · 2012: 10
- FWCI
- 1.18
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Reviews Molecular Cell Biology (publishedVersion)
- PubMed (publishedVersion)
- Zurich Open Repository and Archive (University of Zurich) (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Wnt/β-catenin signaling in development and cancer
- Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Keywords
- Wnt secretion, Wnt signaling, EVI, SRT, retromer complex, lipoprotein particles, protein secretion mechanism
- MeSH terms
- Animals, Golgi Apparatus, Humans, Lipoproteins, Membrane Proteins, Models, Biological, Endosomes, Signal Transduction, Protein Transport, Wnt Proteins
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