Cited by 148Wnt/β-catenin signaling in development and cancerDrug Transport and Resistance MechanismsDevelopmental Biology and Gene Regulation

Helping Wingless take flight: how WNT proteins are secreted

Hausmann, George, Bänziger, Carla, Basler, Konrad·2007·Nature Reviews Molecular Cell Biology

Abstract

How functional WNT proteins are made and how their secretion is regulated is becoming a focal point for the WNT-signalling field. Recently, lipoprotein particles, WNT lipid modifications, the conserved transmembrane protein Wntless (WLS; also known as EVI and SRT) and the retromer complex have been implicated in WNT secretion. Our aim is to synthesize ideas from these new findings for the mechanisms that underlie WNT secretion.

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Crossref · 10.1038/nrm2141

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  • The porcupine protein plays an important role in the palmitolation of the Wnt proteins, and their secretion is regulated by the wntless or evenness interrupted proteins and the retromer complex.

    “The porcupine protein has been shown to play an important role in the palmitolation of the Wnt proteins, and their secretion is regulated by the wntless or evenness interrupted proteins and the retromer complex.11–14”

    From Wnt signal transduction pathways (2008) · cites this paper as [13]

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Authors
Hausmann, G., Bänziger, C., & Basler, K.
Affiliations
University of Zurich (CH)
Corresponding author
Basler, Konrad
Venue
Nature Reviews Molecular Cell Biology
Published
2007-03-07
Volume
8
Issue
4
Pages
331-336
ISSN
  • 1471-0072 (ISSN-L)
  • 1471-0080
OpenAlex
W2065824248
Cited by
147
References
59
Citations by year
2026: 2 · 2025: 3 · 2024: 6 · 2023: 5 · 2022: 3 · 2021: 9 · 2020: 3 · 2019: 4 · 2018: 5 · 2016: 11 · 2015: 12 · 2014: 7 · 2013: 11 · 2012: 10
FWCI
1.18
Type
journal article
Language
en
Open access
closed
Locations
  • Nature Reviews Molecular Cell Biology (publishedVersion)
  • PubMed (publishedVersion)
  • Zurich Open Repository and Archive (University of Zurich) (submittedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Wnt/β-catenin signaling in development and cancer
  • Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
Keywords
Wnt secretion, Wnt signaling, EVI, SRT, retromer complex, lipoprotein particles, protein secretion mechanism
MeSH terms
Animals, Golgi Apparatus, Humans, Lipoproteins, Membrane Proteins, Models, Biological, Endosomes, Signal Transduction, Protein Transport, Wnt Proteins

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