Factors associated with poor sleep quality in patients with multiple sclerosis differ by disease duration
Abstract
Background Sleep disturbance is a common symptom of multiple sclerosis (MS) and knowledge about factors that contribute to poor sleep quality is scarce.Objective The aim was to explore the differences in the prevalence and determinants of poor sleep quality in a sample of patients with MS with disease duration ≤ 5 years and >5 years.Methods We collected data from 152 consecutive patients with MS; 66 patients (78% women, averaged 37.35 ± 10.1 years) were in the group with disease duration ≤ 5 years and 86 patients (73.3% women, averaged 42.10 ± 9.4 years) in the group with disease duration >5 years. Patients filled out the Pittsburgh Sleep Quality Index, the Hospital Anxiety and Depression Scale, the Multidimensional Fatigue Inventory, one item of the Incapacity Status Scale regarding bladder problems and one item of the Short Form-36 regarding pain. Multiple linear regression was used to analyze the relationship between the study variables.Results The prevalence of poor sleep is significantly higher in patients with longer disease duration (34.8 vs. 51.2%). Anxiety, reduced motivation and mental fatigue (all p < 0.05) were associated with poor sleep quality in patients with disease duration ≤5 years, whereas pain (p < 0.01), depression and mental fatigue (both p < 0.05) were in patients with disease duration >5 years.Conclusion Sleep problems are present in patients with MS with both short and long disease duration, but these problems are associated with different factors. These should be recognized and managed in addition to the treatment of sleep disorders.
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Anxiety negatively impacts quality of life, physical disability, and sleep quality in persons with multiple sclerosis.
“As with depression, anxiety negatively impacts quality of life (Dubayova et al., 2013”
From Systematic review and meta-analysis of interventions for depression and anxiety in persons with multiple sclerosis (2016) · cites this paper as Vitkova et al., 2014
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Fiest, K. M., Walker, J. R., Bernstein, C. N., Graff, L. A., Zarychanski, R., Abou-Setta, A. M., Patten, S. B., Sareen, J., Bolton, J. M., Marriott, J. J., et al. (2016) · Multiple Sclerosis and Related Disorders · doi:10.1016/j.msard.2015.10.004 · Cited by 198 · see citing works
- Authors
- Vitkova, M., Gdovinova, Z., Rosenberger, J., Szilasiova, J., Nagyová, I., Mikula, P., Krokavcova, M., Groothoff, J. W., & van Dijk, J. P.
- Affiliations
- University of Pavol Jozef Šafárik (SK)
- University Medical Center Groningen (NL)
- Venue
- Disability and health journal
- Publisher
- Elsevier BV
- Published
- 2014-10
- Volume
- 7
- Issue
- 4
- Pages
- 466-471
- ISSN
- 1876-7583 (ISSN-L)
- 1936-6574
- OpenAlex
- W2148031308
- Cited by
- 63
- References
- 36
- Citations by year
- 2026: 3 · 2025: 7 · 2024: 4 · 2023: 9 · 2022: 6 · 2021: 4 · 2020: 7 · 2019: 4 · 2018: 7 · 2017: 3 · 2016: 7 · 2015: 2
- FWCI
- 5.55
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Disability and health journal (publishedVersion)
- PubMed (publishedVersion)
- University of Groningen research database (University of Groningen / Centre for Information Technology) (submittedVersion)
- Topics
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
- Health Sciences › Medicine › Pathology and Forensic Medicine › Multiple Sclerosis Research Studies
- Health Sciences › Medicine › Physiology › Obstructive Sleep Apnea Research
- Keywords
- multiple sclerosis, sleep quality, sleep disorders, disease duration, anxiety, depression, mental fatigue, pain, fatigue, bladder dysfunction
- MeSH terms
- Adolescent, Adult, Anxiety, Urinary Bladder, Depression, Fatigue, Female, Persons with Disabilities, Humans, Male, Middle Aged, Motivation, Multiple Sclerosis, Pain, Quality of Life, Surveys and Questionnaires, Risk Factors, Sleep, Sleep Wake Disorders, Prevalence, Linear Models, Young Adult
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