The DOI matches its Crossref record; 97 of the 100 references it cites were found in a registry or an index.
Impact of visceral adipose tissue on liver metabolism
Abstract
Excess visceral adipose tissue is associated with anomalies of blood glucose homoeostasis, elevation of plasma triglycerides and low high-density lipoprotein cholesterol that contribute to the later appearance of type 2 diabetes and cardiovascular syndromes. Visceral adipose tissue releases a large amount of free fatty acids and hormones/cytokines in the portal vein that are delivered to the liver, and interact with hepatocytes and various immune cells in the liver. The functional characteristics of visceral adipose tissue will be compared with subcutaneous adipose tissue to clarify the major mechanisms affecting free fatty acid metabolism and cytokine production.
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“This led to increased lifespan in model organisms and in animal models (280,281) .”
From Dietary factors and low-grade inflammation in relation to overweight and obesity (2011) · cites this paper as [281]
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1 retracted
Visfatin: A Protein Secreted by Visceral Fat That Mimics the Effects of Insulin
Fukuhara, A., Matsuda, M., Nishizawa, M., Segawa, K., Tanaka, M., Kishimoto, K., Matsuki, Y., Murakami, M., Ichisaka, T., Murakami, H., et al. (2005) · Science · doi:10.1126/science.1097243 · Cited by 1,906
RetractedRole of Insulin Resistance in Human Disease
Reaven, G. M. (1988) · Diabetes · doi:10.2337/diab.37.12.1595 · Cited by 12,154
Obesity is associated with macrophage accumulation in adipose tissue
Weisberg, S. P., McCann, D., Desai, M., Rosenbaum, M., Leibel, R. L., & Ferrante, A. W. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200319246 · Cited by 10,041
Inflammation and metabolic disorders
Hotamisligil, G. S. (2006) · Nature · doi:10.1038/nature05485 · Cited by 9,199
Xu, H., Barnes, G. T., Yang, Q., Tan, G., Yang, D., Chou, C. J., Sole, J., Nichols, A., Ross, J. S., Tartaglia, L. A., et al. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200319451 · Cited by 6,760
Adipose Tissue as an Endocrine Organ
Kershaw, E. E., & Flier, J. S. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-0395 · Cited by 5,522
Banting lecture 1988. Role of insulin resistance in human disease.
Reaven, G. (1988) · Diabetes · doi:10.2337/diabetes.37.12.1595 · Cited by 3,801
Adiponectin and Adiponectin Receptors
Kadowaki, T., & Yamauchi, T. (2005) · Endocrine Reviews · doi:10.1210/er.2005-0005 · Cited by 2,634
Secretion of angiogenic and antiapoptotic factors by human adipose stromal cells
Rehman, J., Traktuev, D., Li, J., Merfeld-Clauss, S., Temm-Grove, C. J., Bovenkerk, J. E., Pell, C. L., Johnstone, B. H., Considine, R. V., & March, K. L. (2004) · Circulation · doi:10.1161/01.cir.0000121425.42966.f1 · Cited by 2,269
Adipokines: inflammation and the pleiotropic role of white adipose tissue
Trayhurn, P., & Wood, I. S. (2004) · British Journal of Nutrition · doi:10.1079/bjn20041213 · Cited by 2,210
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Metabolism disrupting chemicals and metabolic disorders
Heindel, J. J., Blumberg, B., Cave, M., Machtinger, R., Mantovani, A., Mendez, M. A., Nadal, A., Palanza, P., Panzica, G., Sargis, R., et al. (2017) · Reproductive Toxicology · doi:10.1016/j.reprotox.2016.10.001 · Cited by 1,101
“Intra-abdominal (visceral) depots are associated with T2D and cardiovascular disease while subcutaneous depots seem protective against these diseases [99].”
Dietary factors and low-grade inflammation in relation to overweight and obesity
Calder, P. C., Ahluwalia, N., Brouns, F., Buetler, T., Clement, K., Cunningham, K., Esposito, K., Jönsson, L. S., Kolb, H., Lansink, M., et al. (2011) · British Journal of Nutrition · doi:10.1017/s0007114511005460 · Cited by 1,098
“expression of multiple genes, and response to insulin, catecholamines, sex hormones and cortisol((51)).”
Cho, A.-S., Jeon, S.-M., Kim, M., Yeo, J., Seo, K., Choi, M., & Lee, M. (2010) · Food and Chemical Toxicology · doi:10.1016/j.fct.2010.01.003 · Cited by 787
Altered adipose tissue and adipocyte function in the pathogenesis of metabolic syndrome
Kahn, C. R., Wang, G., & Lee, K. Y. (2019) · Journal of Clinical Investigation · doi:10.1172/jci129187 · Cited by 686
“Consistent with this, subcutaneous preadipocytes have increased rates of proliferation and lipid accumulation (20, 21), whereas visceral adipocytes have increased rates of lipolysis and increased susceptibility to apoptosis (22, 23).”
BackgroundDistinct Hypothalamic Neurons Mediate Estrogenic Effects on Energy Homeostasis and Reproduction
Xu, Y., Nedungadi, T. P., Zhu, L., Sobhani, N., Irani, B. G., Davis, K. E., Zhang, X., Zou, F., Gent, L. M., Hahner, L. D., et al. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.08.009 · Cited by 597
“Given that increased visceral fat is commonly associated with impaired glucose homeostasis (Lafontan and Girard, 2008), we performed glucose tolerance tests and found that ERa/ SF1-Cre females were glucose intolerant (Figure 2L).”
Background
Metadata
- Authors
- Lafontan, M., & Girard, J.
- Affiliations
- Université Toulouse III - Paul Sabatier (FR)
- Centre National de la Recherche Scientifique (FR)
- Corresponding author
- Lafontan, M.
- Venue
- Diabetes & Metabolism
- Publisher
- Elsevier BV
- Published
- 2008-09
- Volume
- 34
- Issue
- 4
- Pages
- 317-327
- ISSN
- 1262-3636 (ISSN-L)
- OpenAlex
- W1980825557
- Cited by
- 143
- References
- 100
- Citations by year
- 2026: 6 · 2025: 3 · 2024: 2 · 2023: 5 · 2022: 5 · 2021: 4 · 2020: 7 · 2019: 8 · 2018: 8 · 2017: 7 · 2016: 6 · 2015: 11 · 2014: 9 · 2013: 13 · 2012: 12
- FWCI
- 1.28
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Diabetes & Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
- Health Sciences › Medicine › Hepatology › Liver Disease Diagnosis and Treatment
- Keywords
- visceral adipose tissue, hepatic metabolism, free fatty acid metabolism, cytokines, adipokines, portal vein, subcutaneous adipose tissue, glucose homeostasis, hypertriglyceridemia, low HDL cholesterol, type 2 diabetes, cardiovascular risk, hepatocytes
- MeSH terms
- Diabetes Mellitus, Type 2, Fatty Acids, Nonesterified, Female, Humans, Insulin Resistance, Liver, Male, Obesity, Adipocytes, Glucose Intolerance, Intra-Abdominal Fat, Abdominal Fat, Subcutaneous Fat, Abdominal, Adipokines
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