Cited by 143Adipokines, Inflammation, and Metabolic DiseasesCardiovascular Disease and AdiposityLiver Disease Diagnosis and Treatment

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Impact of visceral adipose tissue on liver metabolism

Lafontan, M., Girard, J.·2008·Diabetes & Metabolism

DOI 10.1016/j.diabet.2008.04.001

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Abstract

Excess visceral adipose tissue is associated with anomalies of blood glucose homoeostasis, elevation of plasma triglycerides and low high-density lipoprotein cholesterol that contribute to the later appearance of type 2 diabetes and cardiovascular syndromes. Visceral adipose tissue releases a large amount of free fatty acids and hormones/cytokines in the portal vein that are delivered to the liver, and interact with hepatocytes and various immune cells in the liver. The functional characteristics of visceral adipose tissue will be compared with subcutaneous adipose tissue to clarify the major mechanisms affecting free fatty acid metabolism and cytokine production.

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Authors: Lafontan, M., & Girard, J.
Affiliations: Université Toulouse III - Paul Sabatier (FR)
Centre National de la Recherche Scientifique (FR)
Corresponding author: Lafontan, M.
Venue: Diabetes & Metabolism
Publisher: Elsevier BV
Published: 2008-09
Volume: 34
Issue: 4
Pages: 317-327
ISSN: 1262-3636 (ISSN-L)
DOI: 10.1016/j.diabet.2008.04.001
OpenAlex: W1980825557
Cited by: 143
References: 100
Citations by year: 2026: 6 · 2025: 3 · 2024: 2 · 2023: 5 · 2022: 5 · 2021: 4 · 2020: 7 · 2019: 8 · 2018: 8 · 2017: 7 · 2016: 6 · 2015: 11 · 2014: 9 · 2013: 13 · 2012: 12
FWCI: 1.28
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Diabetes & Metabolism (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
Health Sciences › Medicine › Hepatology › Liver Disease Diagnosis and Treatment
Keywords: visceral adipose tissue, hepatic metabolism, free fatty acid metabolism, cytokines, adipokines, portal vein, subcutaneous adipose tissue, glucose homeostasis, hypertriglyceridemia, low HDL cholesterol, type 2 diabetes, cardiovascular risk, hepatocytes
MeSH terms: Diabetes Mellitus, Type 2, Fatty Acids, Nonesterified, Female, Humans, Insulin Resistance, Liver, Male, Obesity, Adipocytes, Glucose Intolerance, Intra-Abdominal Fat, Abdominal Fat, Subcutaneous Fat, Abdominal, Adipokines

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Impact of visceral adipose tissue on liver metabolism

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