Cited by 143Adipokines, Inflammation, and Metabolic DiseasesCardiovascular Disease and AdiposityLiver Disease Diagnosis and Treatment

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Impact of visceral adipose tissue on liver metabolism

Lafontan, M., Girard, J.·2008·Diabetes & Metabolism

DOI 10.1016/j.diabet.2008.04.001

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Abstract

Excess visceral adipose tissue is associated with anomalies of blood glucose homoeostasis, elevation of plasma triglycerides and low high-density lipoprotein cholesterol that contribute to the later appearance of type 2 diabetes and cardiovascular syndromes. Visceral adipose tissue releases a large amount of free fatty acids and hormones/cytokines in the portal vein that are delivered to the liver, and interact with hepatocytes and various immune cells in the liver. The functional characteristics of visceral adipose tissue will be compared with subcutaneous adipose tissue to clarify the major mechanisms affecting free fatty acid metabolism and cytokine production.

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Crossref · 10.1016/j.diabet.2008.04.001

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Background
The lipidomic and inflammatory profiles of visceral and subcutaneous adipose tissues are distinctly regulated by the SGLT2 inhibitor empagliflozin in Zucker diabetic fatty rats
Aragón‐Herrera, A., Moraña‐Fernández, S., Otero-Santiago, M., Anido‐Varela, L., Campos‐Toimil, M., García‐Seara, J., Roman, A. V., Seijas‐Amigo, J., García‐Caballero, L., Rodríguez, J., et al. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.114535 · Cited by 27
The role of obesity on chronic kidney disease development, progression, and cardiovascular complications
Than, W. H., Chan, G. C., Ng, J. K., & Szeto, C. (2020) · Advances in Biomarker Sciences and Technology · doi:10.1016/j.abst.2020.09.001 · Cited by 25
The metabolic and neuroinflammatory changes induced by consuming a cafeteria diet are age-dependent
Teixeira, D., Cecconello, A. L., Partata, W. A., de Fraga, L. S., Ribeiro, M. F. M., & Guedes, R. P. (2017) · Nutritional Neuroscience · doi:10.1080/1028415x.2017.1380892 · Cited by 25
Type 2 Innate Lymphoid Cells: Protectors in Type 2 Diabetes
Painter, J. D., & Akbari, O. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.727008 · Cited by 21
Blocking the SIRPα-CD47 axis promotes macrophage phagocytosis of exosomes derived from visceral adipose tissue and improves inflammation and metabolism in mice
Lin, Y., Pan, Y., Jiang, T., Chen, Y., Shang, T., Xu, M., Feng, H.-B., Ma, Y., Tan, Y., Wang, H., et al. (2025) · Journal of Biomedical Science · doi:10.1186/s12929-025-01124-y · Cited by 21
“Consistent with this, previous studies have showed that visceral adipocytes have enhanced lipolysis rate and susceptibility to cell apoptosis [73], while sub-cutaneous preadipocytes have enhanced lipid accumulation and proliferation rate [74].”
DNA 5-Hydroxymethylation in Human Adipose Tissue Differs Between Subcutaneous and Visceral Adipose Tissue Depots
Rohde, K., Keller, M., Stümvoll, M., Dietrich, A., Blüher, M., & Böttcher, Y. (2015) · Epigenomics · doi:10.2217/epi.15.50 · Cited by 20
Protective Effects of Korean Red Ginseng against Alcohol-Induced Fatty Liver in Rats
Lee, H. W., Ok, H. M., & Kwon, O. (2015) · Molecules · doi:10.3390/molecules200611604 · Cited by 19
“The accumulating evidence has suggested that adipose tissue dysfunction might impact hepatic lipid metabolism [5,6].”
Background
Herring Milt and Herring Milt Protein Hydrolysate Are Equally Effective in Improving Insulin Sensitivity and Pancreatic Beta-Cell Function in Diet-Induced Obese- and Insulin-Resistant Mice
Wang, Y., Nair, S. V. G., & Gagnon, J. (2020) · Marine Drugs · doi:10.3390/md18120635 · Cited by 19
Herring Milt Protein Hydrolysate Improves Insulin Resistance in High-Fat-Diet-Induced Obese Male C57BL/6J Mice
Wang, Y., Gagnon, J., Nair, S. V. G., & Sha, S. (2019) · Marine Drugs · doi:10.3390/md17080456 · Cited by 18
The cholecystokinin receptor agonist, CCK‐8, induces adiponectin production in rat white adipose tissue
Plaza, A., Merino, B., Olmo, N. D., & Ruiz‐Gayo, M. (2019) · British Journal of Pharmacology · doi:10.1111/bph.14690 · Cited by 18
“This topic has been reviewed by Lafontan and Girard (2008).”
Background
Intrahepatic lipid content is linked to insulin resistance in obese subjects
Sada, Y., Katabami, T., Asai, S., Sato, T., Furukawa, K., Ishii, S., Kato, H., KOBAYASHI, H., Kondo, A., Ohta, A., et al. (2011) · Obesity Research & Clinical Practice · doi:10.1016/j.orcp.2010.12.007 · Cited by 16
Procyanidins target mesenteric adipose tissue in Wistar lean rats and subcutaneous adipose tissue in Zucker obese rat
Ardèvol, A., Motilva, M., Serra, A., Blay, M., & Pinent, M. (2013) · Food Chemistry · doi:10.1016/j.foodchem.2013.02.104 · Cited by 17
Evaluation of Visceral Fat in Massive Obesity
Vatier, C., Poitou, C., & Clément, K. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-407869-7.00006-4 · Cited by 17
Interplay between Heart Disease and Metabolic Steatosis: A Contemporary Perspective
Ramadan, M. S., Russo, V., Nigro, G., Durante‐Mangoni, E., & Zampino, R. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10081569 · Cited by 15
“It also generates and interacts with various inflammatory hormones/cytokines secreted from places like visceral adipose tissue, macrophages, and endothelial cells, which are associated with CVD initiation and progression [109,110].”
Background
Visceral Adiposity, Insulin Resistance, and Type 2 Diabetes
Griffith, M. L., Younk, L. M., & Davis, S. N. (2010) · American Journal of Lifestyle Medicine · doi:10.1177/1559827609360959 · Cited by 14
“VAT comprises 10% to 20% of total body fat in men and 5% to 10% of total body fat in women and primarily consists of omental and mesenteric fat depots.(30) Growing evidence suggests that increased amounts of abdominal VAT may pose an increased risk of cardiometabolic disease compared with SCAT.”
Background
Chronic low-grade inflammation
Margioris, A. N., Dermitzaki, E., Venihaki, M., & Tsatsanis, C. (2013) · Elsevier eBooks · doi:10.1533/9780857095749.1.105 · Cited by 13
Increasing serum pre-adipocyte factor-1 (Pref-1) correlates with decreased body fat, increased free fatty acids, and level of recent alcohol consumption in excessive alcohol drinkers
Liangpunsakul, S., Bennett, R. D., Westerhold, C., Ross, R. A., Crabb, D. W., Lai, X., & Witzmann, F. A. (2014) · Alcohol · doi:10.1016/j.alcohol.2014.07.013 · Cited by 13
“Decreasing body fat and its storage in adipose tissue may cause excess fatty acid influx into the liver, leading to hepatic steatosis (Cusi, 2010; Lafontan & Girard, 2008; Wree, Kahraman, Gerken, & Canbay, 2011).”
Background
Associations Between Sensitivity to Thyroid Hormones and Visceral Adiposity in Euthyroid Adults
Wei, Y., Yang, M., Liu, J., Wang, Y., & Wang, G. (2024) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgae806 · Cited by 11
White Adipose Tissue
Gesta, S., & Kahn, C. R. (2011) · Springer eBooks · doi:10.1007/978-1-4614-0965-6_4 · Cited by 12
Perinephric and Epididymal Fat Affect Hepatic Metabolism in Rats
Ben‐Shlomo, S., Einstein, F. H., Zvibel, I., Atias, D., Shlomai, A., Halpern, Z., Barzilai, N., & Fishman, S. (2011) · Obesity · doi:10.1038/oby.2011.261 · Cited by 12
F4/80hiCCR2hi macrophage infiltration into the intra-abdominal fat worsens the severity of experimental IBD in obese mice with DSS colitis
Bassaganya-Riera, J., Ferrer, G., Casagran, O., Sanchez, S. P., de Horna, A., Duran, E., Orpí, M., Guri, A. J., & Hontecillas, R. (2008) · e-SPEN the European e-Journal of Clinical Nutrition and Metabolism · doi:10.1016/j.eclnm.2008.11.005 · Cited by 12
DUSP1Gene Polymorphisms Are Associated with Obesity-Related Metabolic Complications among Severely Obese Patients and Impact on Gene Methylation and Expression
Guénard, F., Bouchard, L., Tchernof, A., Deshaies, Y., Hould, F. S., Lebel, S., Marceau, P., Përusse, L., & Vohl, M. (2013) · International Journal of Genomics · doi:10.1155/2013/609748 · Cited by 11
“Excess accumulation of fat inside the abdominal cavity (visceral adipose tissue: VAT) is associated with altered insulin sensitivity, bloodpressure (BP), andplasma lipid profile [3, 4].”
Background
Decreased levels and activity of Sirt1 are modulated by increased miR-34a expression in adipose tissue mononuclear cells from subjects with overweight and obesity: A pilot study
Briones-Espinoza, M., Cortés-García, J. D., Vega‐Cárdenas, M., Uresti‐Rivera, E. E., Gómez-Otero, A., López‐López, N., Mejía-Torres, M., & Portales‐Pérez, D. P. (2020) · Diabetes & Metabolic Syndrome Clinical Research & Reviews · doi:10.1016/j.dsx.2020.07.014 · Cited by 11
Er-Miao-Fang Extracts Inhibits Adipose Lipolysis and Reduces Hepatic Gluconeogenesis via Suppression of Inflammation
Zhao, W., Feng, X., Liu, B., Xian, J.-C., & Zhang, N. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.01041 · Cited by 8
Adipose Tissue Inflammation and Metabolic Disorders
Henriques, F. D. S., Bedard, A. H., & Júnior, M. L. B. (2019) · IntechOpen eBooks · doi:10.5772/intechopen.88631 · Cited by 8
Comparison of the Lipid Composition of Three Adipose Tissue Types of Male and Female Wild Nile Crocodiles (Crocodylus niloticus)
Osthoff, G., Hugo, A., Govender, D., Huchzermeyer, F. W., & Bouwman, H. (2014) · Journal of Herpetology · doi:10.1670/13-096 · Cited by 7
“In general, the adipose fats of different body compartments of mammals differ in fatty acid composition (Lafontan and Girard, 2008).”
Background
Evaluating the effect of diallyl sulfide on regulation of inflammatory mRNA expression in 3T3L1 adipocytes and RAW 264.7 macrophages during ethanol treatment
Kema, V. H., Khan, I., Kapur, S., & Mandal, P. (2018) · Drug and Chemical Toxicology · doi:10.1080/01480545.2017.1405969 · Cited by 7
“Also, chronic ethanol feeding has been shown to increase the production and activity of the CYP2E1 enzyme in adipose tissue (Lafontan and Girard 2008, Song et al. 2008).”
Background
Impaired metabolic and hepatic functions following subcutaneous lipectomy in adult obese rats
El-Kafoury, B. M. A., Bahgat, N. M., Abdel‐Hady, E. A., Samad, A. A. A. E., Shawky, M., & Mohamed, F. A. (2019) · Experimental Physiology · doi:10.1113/ep087670 · Cited by 7
“…Chen, Reitman, & Shulman, 2000), and also that VAT, which contains a large number of inflammatory and immune cells, drains its metabolites and its secretions through the portal system to the liver where they interact with hepatocytes and affecting their functions (Lafontan & Girard, 2008).”
Background
White Adipose Tissue
Gesta, S., & Kahn, C. R. (2017) · Springer eBooks · doi:10.1007/978-3-319-52031-5_5 · Cited by 11
Effect of one session of aerobic exercise associated with abdominal laser therapy in lipolytic activity, lipid profile, and inflammatory markers
Barbosa, P. F. T., Coimbra, C., Noites, A., Vilarinho, R., Carvalho, P. J., Amorim, M., Moreira, T., & de Melo, C. A. (2020) · Journal of Cosmetic Dermatology · doi:10.1111/jocd.13781 · Cited by 6
Comparative three-dimensional genome architectures of adipose tissues provide insight into human-specific regulation of metabolic homeostasis
Liu, P., Li, D., Zhang, J., He, M., Gao, D., Wang, Y., Lin, Y., Pan, D., Li, P., Wang, T., et al. (2023) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2023.104757 · Cited by 5
“The human VAT drains into the portal vein, therefore the free fatty acids and adipokines released from them can be delivered to the liver and influence liver metabolism (8).”
Background
Short-Term Effects of Early Menopause on Adiposity, Fatty Acids Profile and Insulin Sensitivity of a Swine Model of Female Obesity
Heras-Molina, A., Pacheco, J. L. P., Vázquez-Gómez, M., García-Contreras, C., Astiz, S., Isabel, B., & Gonzalez‐Bulnes, A. (2020) · Biology · doi:10.3390/biology9090284 · Cited by 5
Circulating Plasma Free Fatty Acids, Insulin Resistance and Metabolic Markers in Obese Women
Zaki, M. E., Hussein, J., Ibrahim, A. M. M., & Youness, E. R. (2020) · Biomedical & Pharmacology Journal · doi:10.13005/bpj/2034 · Cited by 5
Liver Fat Storage Is a Better Predictor of Coronary Artery Disease than Visceral Fat
Basheer, M., Saad, E., Jeries, H., & Assy, N. (2023) · Metabolites · doi:10.3390/metabo13080896 · Cited by 5
“In fasting states, lipolysis performed in adipose tissue results in the release of nonesterified fatty acids [41].”
Background
The Heterogeneity of White Adipose Tissue
Luong, Q. V., & Lee, K. Y. (2018) · InTech eBooks · doi:10.5772/intechopen.76898 · Cited by 5
“Indeed leptin is capable of inducing IL-1Ra; and as a negative feedback loop, IL-1Ra antagonizes leptin activity [97, 160].”
Background
FDA regulation of adipose cell use in clinical trials and clinical translation
Chirba, M. A., Jones, V. M., Simon, P., & Katz, A. J. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-819376-1.00003-2 · Cited by 4
Visceral obesity and cardiometabolic risks: lessons from the VACTION.J study
Kishida, K., Funahashi, T., Matsuzawa, Y., & Shimomura, I. (2012) · Clinical Lipidology · doi:10.2217/clp.12.54 · Cited by 4
Adipose tissue distribution in metabolic disease: depot-specific biology, clinical assessment, and therapeutic remodeling
Liuli, A., Zhang, T., & Feng, Z. (2026) · Frontiers in Endocrinology · doi:10.3389/fendo.2026.1822659 · Cited by 3
Les actions physiologiques de l’insuline
Girard, J. R. (2008) · Médecine des Maladies Métaboliques · doi:10.1016/s1957-2557(08)70611-4 · Cited by 3
Self-citation
Role of -675 4G/5G in the Plasminogen Activator Inhibitor-1 Gene and -308G/A Tumor Necrosis Factor-α Gene Polymorphisms in Obese Argentinean Patients
Wingeyer, S. D. P., Graffigna, M. N., Belli, S., Benetucci, J. A., & Larrañaga, G. F. D. (2011) · Genetic Testing and Molecular Biomarkers · doi:10.1089/gtmb.2011.0253 · Cited by 3
“Adipose tissue actively participates in hormonal and inflammatory systems (Lafontan and Girard, 2008; Gustafson 2010).”

Authors: Lafontan, M., & Girard, J.
Affiliations: Université Toulouse III - Paul Sabatier (FR)
Centre National de la Recherche Scientifique (FR)
Corresponding author: Lafontan, M.
Venue: Diabetes & Metabolism
Publisher: Elsevier BV
Published: 2008-09
Volume: 34
Issue: 4
Pages: 317-327
ISSN: 1262-3636 (ISSN-L)
DOI: 10.1016/j.diabet.2008.04.001
OpenAlex: W1980825557
Cited by: 143
References: 100
Citations by year: 2026: 6 · 2025: 3 · 2024: 2 · 2023: 5 · 2022: 5 · 2021: 4 · 2020: 7 · 2019: 8 · 2018: 8 · 2017: 7 · 2016: 6 · 2015: 11 · 2014: 9 · 2013: 13 · 2012: 12
FWCI: 1.28
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Diabetes & Metabolism (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
Health Sciences › Medicine › Hepatology › Liver Disease Diagnosis and Treatment
Keywords: visceral adipose tissue, hepatic metabolism, free fatty acid metabolism, cytokines, adipokines, portal vein, subcutaneous adipose tissue, glucose homeostasis, hypertriglyceridemia, low HDL cholesterol, type 2 diabetes, cardiovascular risk, hepatocytes
MeSH terms: Diabetes Mellitus, Type 2, Fatty Acids, Nonesterified, Female, Humans, Insulin Resistance, Liver, Male, Obesity, Adipocytes, Glucose Intolerance, Intra-Abdominal Fat, Abdominal Fat, Subcutaneous Fat, Abdominal, Adipokines

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Impact of visceral adipose tissue on liver metabolism

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