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Monocytes from type 2 diabetic patients have a pro-inflammatory profile
Abstract
The exact factors contributing to the pathogenesis of type 2 diabetes remain elusive. Lately, it was suggested that inflammation and activation of the innate immune system could be linked to type 2 diabetes pathogenesis and also to the development of common diabetic complications, mainly atherosclerosis. The aim of this study was to investigate the role of monocytes in this sub-clinical inflammatory state and test 1,25-dihydroxyvitamin D(3), the active form of Vitamin D, as an anti-inflammatory agent. For this purpose, monocytes from type 2 diabetic patients were compared to monocytes from healthy controls and type 1 diabetic patients. The expression profile of inflammatory markers in freshly isolated and immune-stimulated monocytes was measured by quantitative real-time RT-PCR. Type 2 diabetic patients showed significantly higher expression levels of TNF-alpha, IL-6, IL-1, IL-8, COX-2, ICAM-1 and B7-1 compared to controls and type 1 diabetic patients. 1,25-Dihydroxyvitamin D(3) was able to down-regulate the expression of TNF-alpha, IL-6, IL-1, and IL-8, confirming its immunomodulatory properties. From these data we concluded that monocytes from type 2 diabetic patients have a pro-inflammatory profile. In addition, 1,25-dihydroxyvitamin D(3) was able to modulate inflammation in these monocytes.
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“The most efficient triggers of the postprandial inflammatory response appear to be TAG, SFA, oxysterols and glucose (158 -161) .”
From Dietary factors and low-grade inflammation in relation to overweight and obesity (2011) · cites this paper as [160]
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Metadata
- Authors
- Giulietti, A., van Etten, E., Overbergh, L., Stoffels, K., Bouillon, R., & Mathieu, C.
- Affiliations
- KU Leuven (BE)
- Corresponding author
- Mathieu, Chantal
- Venue
- Diabetes Research and Clinical Practice
- Publisher
- Elsevier BV
- Published
- 2007-07
- Volume
- 77
- Issue
- 1
- Pages
- 47-57
- ISSN
- 0168-8227 (ISSN-L)
- OpenAlex
- W198103589
- Cited by
- 400
- References
- 60
- Citations by year
- 2026: 5 · 2025: 15 · 2024: 21 · 2023: 29 · 2022: 28 · 2021: 19 · 2020: 30 · 2019: 22 · 2018: 27 · 2017: 18 · 2016: 15 · 2015: 21 · 2014: 22 · 2013: 17 · 2012: 22
- FWCI
- 7.60
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Diabetes Research and Clinical Practice (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Vitamin D Research Studies
- Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
- Keywords
- type 2 diabetes, monocytes, inflammation, 1,25-dihydroxyvitamin D3, vitamin D, TNF-α, interleukin-6, interleukin-1, interleukin-8, cyclooxygenase-2, ICAM-1, CD80, type 1 diabetes, innate immunity, atherosclerosis, immunomodulation
- MeSH terms
- Adolescent, Adult, Aged, 80 and over, Anti-Inflammatory Agents, Calcitriol, Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2, Female, Humans, Inflammation, Interferon-gamma, Interleukins, Male, Middle Aged, Monocytes, Tumor Necrosis Factor-alpha, Down-Regulation, B7-1 Antigen, Intercellular Adhesion Molecule-1, Cyclooxygenase 2
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