Integrated personalized diabetes management improves glycemic control in patients with insulin-treated type 2 diabetes: Results of the PDM-ProValue study program
Open accessAbstract
AIMS: Globally, many patients with insulin-treated type-2 diabetes are suboptimally controlled. The PDM-ProValue study program evaluated whether integrated personalized diabetes management (iPDM) has the potential to improve clinical outcomes. METHODS: 101 practices with 907 patients participated in the 12-month, prospective, controlled, cluster-randomized study program. HbA1c levels, therapy changes, frequency of hypoglycemic episodes, patient reported outcomes, and physician satisfaction were assessed. RESULTS: iPDM led to a greater reduction in HbA1c after 12 months vs. usual care (-0.5%, p < 0.0001 vs. -0.3%, p < 0.0001), (Diff. 0.2%, p = 0.0324). Most of the HbA1c reduction occurred after 3 months and remained stable thereafter. The percentage of patients with therapy adjustments was higher in the iPDM group at all visits (p < 0.01 at week 3, month 3, month 6). Patient adherence at month 12 was higher in the iPDM group compared to baseline (Odds ratio = 2.39; p = 0.0003); also, patient treatment satisfaction (DTSQc: 12.2 vs. 10.4, δ = 1.78, p = 0.004; DTSQs: 31.0 vs. 30.0, δ = 0.924, p = 0.02), and physician satisfaction was higher in the intervention group. CONCLUSIONS: iPDM improved the use of diagnostic data leading to better glycemic control, more timely treatment adjustments (indicating reduced clinical inertia), and increased patient adherence and treatment satisfaction among patients and physicians.
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“…sessions with a health coach for 6 weeks, and subsequent post-intervention assessments and then follow-up assessments at 6 and 12 weeks after end of intervention. participants to initiate intervention in the chosen domain (e.g., fi xed sleep schedules due to work may constrain a person ’ s…”
- Authors
- Kulzer, B., Daenschel, W., Daenschel, I., Schramm, W., Messinger, D., Weissmann, J., Vesper, I., Parkin, C. G., & Heinemann, L.
- Affiliations
- Forschungsinstitut der Diabetes Akademie Mergentheim (DE)
- Heilbronn University (DE)
- Roche Diabetes Care GmbH (Germany) (DE)
- Corresponding author
- Kulzer, Bernhard
- Schramm, Wendelin
- Messinger, Diethelm
- Weissmann, Joerg
- Vesper, Iris
- Parkin, Christopher G.
- Heinemann, Lutz
- Venue
- Diabetes Research and Clinical Practice
- Publisher
- Elsevier BV
- Published
- 2018-10
- Volume
- 144
- Pages
- 200-212
- ISSN
- 0168-8227 (ISSN-L)
- OpenAlex
- W2891618874
- Cited by
- 77
- References
- 41
- Citations by year
- 2026: 5 · 2025: 9 · 2024: 11 · 2023: 10 · 2022: 16 · 2021: 7 · 2020: 8 · 2019: 9 · 2018: 2
- FWCI
- 5.17
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Diabetes Research and Clinical Practice (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Funders
- Roche Diabetes Care Deutschland GmbH
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Education
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
- Keywords
- personalized diabetes management, type 2 diabetes, insulin therapy, glycemic control, HbA1c, clinical inertia, medication adherence, treatment satisfaction, physician satisfaction, patient-reported outcomes, hypoglycemia, primary care
- MeSH terms
- Aged, Diabetes Mellitus, Type 2, Female, Glycated Hemoglobin, Humans, Hypoglycemic Agents, Insulin, Male, Middle Aged, Prognosis, Prospective Studies, Research Design, Blood Glucose Self-Monitoring, Glycemic Index
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