Donor program for fecal microbiota transplantation: A 3-year experience of a large-volume Italian stool bank
Abstract
Background Due to the increasing rise of C. difficile infection, stool banks and donor programs have been launched to grant access to fecal microbiota transplantation (FMT). Our aim is to describe characteristics and outcomes of the donor program at our stool bank. Methods Donor candidates underwent a four-step selection process, including a clinical interview, blood and stool testing, a further questionnaire and a direct stool testing the day of each donation. From March 2020, specific changes to this process were introduced to avoid the potential transmission of COVID-19. We evaluated the rate of excluded candidates at each step of the screening, as well as the number of total fecal aliquots provided by qualified donors. Results Overall, 114 donor candidates were evaluated. Seventy-five candidates declined to join the program for logistic or personal issues, three were excluded after the questionnaire and seven for positive stool exams. Finally, 29 (25%) subjects qualified as stool donors, and provided 70 stool samples. Fifteen samples were excluded after direct molecular stool testing. A total of 127 aliquots was finally obtained. Conclusions Donor recruitment for FMT is a challenging process, and only a small rate of candidates are eligible as donors.
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Expanded donor screening via molecular testing can prevent the transmission of multi-drug resistant bacteria.
“expanded donor screening via molecular testing, 18 which can prevent the transmission of multi-drug resistant (MDR) bacteria”
From Key determinants of success in fecal microbiota transplantation: From microbiome to clinic (2023) · cites this paper as [18]
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- Authors
- Ianiro, G., Porcari, S., Bibbò, S., Giambò, F., Quaranta, G., Masucci, L., Sanguinetti, M., Gasbarrini, A., & Cammarota, G.
- Affiliations
- Università Cattolica del Sacro Cuore (IT)
- Corresponding author
- Cammarota, Giovanni
- ORCID
- Venue
- Digestive and Liver Disease
- Publisher
- Elsevier BV
- Published
- 2021-11
- Volume
- 53
- Issue
- 11
- Pages
- 1428-1432
- ISSN
- 1590-8658 (ISSN-L)
- OpenAlex
- W3165553292
- Cited by
- 19
- References
- 31
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 4 · 2023: 6 · 2022: 3
- FWCI
- 1.03
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Digestive and Liver Disease (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Clostridium difficile and Clostridium perfringens research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Keywords
- fecal microbiota transplantation, stool bank, donor selection, donor recruitment, Clostridium difficile infection, COVID-19 prevention, stool examination
- MeSH terms
- Fecal Microbiota Transplantation, Adult, Feces, Female, Humans, Italy, Male, Prospective Studies, Program Evaluation, Infection Control, Biological Specimen Banks, Donor Selection
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