Cited by 148Virus-based gene therapy researchImmunotherapy and Immune ResponsesSARS-CoV-2 and COVID-19 Research

Adenovirus vector-based vaccine for infectious diseases

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Sakurai, Fuminori, Tachibana, Masashi, Mizuguchi, Hiroyuki·2022·Drug Metabolism and Pharmacokinetics

Abstract

Replication-incompetent adenovirus (Ad) vectors have been widely used as gene delivery vehicles in both gene therapy studies and basic studies for gene function analysis due to their highly advantageous properties, which include high transduction efficiencies, relatively large capacities for transgenes, and high titer production. In addition, Ad vectors induce moderate levels of innate immunity and have relatively high thermostability, making them very attractive as potential vaccine vectors. Accordingly, it is anticipated that Ad vectors will be used in vaccines for the prevention of infectious diseases, including Ebola virus disease and acquired immune deficiency syndrome (AIDS). Much attention is currently focused on the potential use of an Ad vector vaccine for coronavirus disease 2019 (COVID-19). In this review, we describe the basic properties of an Ad vector, Ad vector-induced innate immunity and immune responses to Ad vector-produced transgene products. Development of novel Ad vectors which can overcome the drawbacks of conventional Ad vector vaccines and clinical application of Ad vector vaccines to several infectious diseases are also discussed.

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Authors
Sakurai, F., Tachibana, M., & Mizuguchi, H.
Affiliations
  • The University of Osaka (JP)
  • Global Center for Medical Engineering and Informatics, The University of Osaka (JP)
  • National Institute of Biomedical Innovation, Health and Nutrition (JP)
Corresponding author
  • Sakurai, Fuminori
  • Mizuguchi, Hiroyuki
Venue
Drug Metabolism and Pharmacokinetics
Publisher
Elsevier BV
Published
2022-02
Volume
42
Pages
100432
ISSN
1347-4367 (ISSN-L)
OpenAlex
W3213418684
Cited by
148
References
109
Citations by year
2026: 16 · 2025: 42 · 2024: 37 · 2023: 32 · 2022: 21
FWCI
3.32
Type
journal article
Language
en
Open access
Locations
  • Drug Metabolism and Pharmacokinetics (acceptedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Japan Agency for Medical Research and Development (20fk0108543h0001)
  • Japan Society for the Promotion of Science (20H00664)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Virus-based gene therapy research
  • Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
  • Health Sciences › Medicine › Infectious Diseases › SARS-CoV-2 and COVID-19 Research
Keywords
adenoviral vector, vaccine vectors, infectious disease vaccines, gene delivery, innate immunity, immune response, Ebola virus disease, AIDS, COVID-19 pandemic
MeSH terms
COVID-19, SARS-CoV-2, Adenoviridae, Communicable Diseases, Genetic Vectors, Humans, Vaccines, Adenovirus Vaccines

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