Adenovirus vector-based vaccine for infectious diseases
Open accessAbstract
Replication-incompetent adenovirus (Ad) vectors have been widely used as gene delivery vehicles in both gene therapy studies and basic studies for gene function analysis due to their highly advantageous properties, which include high transduction efficiencies, relatively large capacities for transgenes, and high titer production. In addition, Ad vectors induce moderate levels of innate immunity and have relatively high thermostability, making them very attractive as potential vaccine vectors. Accordingly, it is anticipated that Ad vectors will be used in vaccines for the prevention of infectious diseases, including Ebola virus disease and acquired immune deficiency syndrome (AIDS). Much attention is currently focused on the potential use of an Ad vector vaccine for coronavirus disease 2019 (COVID-19). In this review, we describe the basic properties of an Ad vector, Ad vector-induced innate immunity and immune responses to Ad vector-produced transgene products. Development of novel Ad vectors which can overcome the drawbacks of conventional Ad vector vaccines and clinical application of Ad vector vaccines to several infectious diseases are also discussed.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Isolation of a Common Receptor for Coxsackie B Viruses and Adenoviruses 2 and 5
Bergelson, J. M., Cunningham, J. A., Droguett, G., Kurt‐Jones, E. A., Krithivas, A., Hong, J. S., Horwitz, M. S., Crowell, R. L., & Finberg, R. W. (1997) · Science · doi:10.1126/science.275.5304.1320 · Cited by 3,102 · see citing works
Chan, J. F., Kok, K., Zhu, Z., Chu, H., To, K. K., Yuan, S., & Yuen, K. (2020) · Emerging Microbes & Infections · doi:10.1080/22221751.2020.1719902 · Cited by 3,063 · see citing works
Safety and Efficacy of Single-Dose Ad26.COV2.S Vaccine against Covid-19
Sadoff, J., Gray, G., Vandebosch, A., Cárdenas, V., Shukarev, G., Grinsztejn, B., Goepfert, P. A., Truyers, C., Fennema, H., Spiessens, B., et al. (2021) · New England Journal of Medicine · doi:10.1056/nejmoa2101544 · Cited by 2,397 · see citing works
Thrombotic thrombocytopenia after ChAdOx1 nCov-19 vaccination
Greinacher, A., Thiele, T., Warkentin, T. E., Weisser, K., Kyrle, P. A., & Eichinger, S. (2021) · New England Journal of Medicine · doi:10.1056/nejmoa2104840 · Cited by 2,259 · see citing works
Integrins αvβ3 and αvβ5 promote adenovirus internalization but not virus attachment
Wickham, T. J., Mathias, P., Cheresh, D. A., & Nemerow, G. R. (1993) · Cell · doi:10.1016/0092-8674(93)90231-e · Cited by 2,199 · see citing works
Logunov, D. Y., Dolzhikova, I. V., Shcheblyakov, D. V., Tukhvatulin, A. I., Zubkova, O. V., Dzharullaeva, A. S., Kovyrshina, A. V., Lubenets, N. L., Grousova, D. M., Erokhova, A. S., et al. (2021) · The Lancet · doi:10.1016/s0140-6736(21)00234-8 · Cited by 1,747 · see citing works
Buchbinder, S. P., Mehrotra, D. V., Duerr, A., Fitzgerald, D. W., Mogg, R., Li, D., Gilbert, P. B., Lama, J. R., Marmor, M., del Rio, C., et al. (2008) · The Lancet · doi:10.1016/s0140-6736(08)61591-3 · Cited by 1,713 · see citing works
CGAS produces a 2′-5′-linked cyclic dinucleotide second messenger that activates STING.
Ablasser, A., Goldeck, M., Cavlar, T., Deimling, T., Witte, G., Röhl, I., Hopfner, K.-P., Ludwig, J., & Hornung, V. (2013) · Nature · doi:10.1038/nature12306 · Cited by 1,695 · see citing works
Zhu, F.-C., Li, Y.-H., Guan, X.-H., Hou, L.-H., Wang, W.-J., Li, J.-X., Wu, S.-P., Wang, B.-S., Wang, Z., Wang, L., et al. (2020) · The Lancet · doi:10.1016/s0140-6736(20)31208-3 · Cited by 1,382 · see citing works
Zhu, F.-C., Guan, X.-H., Li, Y.-H., Huang, J.-Y., Jiang, T., Hou, L.-H., Li, J.-X., Yang, B.-F., Wang, L., Wang, W.-J., et al. (2020) · The Lancet · doi:10.1016/s0140-6736(20)31605-6 · Cited by 1,225 · see citing works
Logunov, D. Y., Dolzhikova, I. V., Zubkova, O. V., Tukhvatulin, A. I., Shcheblyakov, D. V., Dzharullaeva, A. S., Grousova, D. M., Erokhova, A. S., Kovyrshina, A. V., Botikov, A. G., et al. (2020) · The Lancet · doi:10.1016/s0140-6736(20)31866-3 · Cited by 1,055 · see citing works
The inflammasome recognizes cytosolic microbial and host DNA and triggers an innate immune response
Muruve, D. A., Pétrilli, V., Zaiss, A. K., White, L. R., Clark, S. A., Ross, P. J., Parks, R. J., & Tschopp, J. (2008) · Nature · doi:10.1038/nature06664 · Cited by 936 · see citing works
CD46 is a cellular receptor for group B adenoviruses
Gaggar, A., Shayakhmetov, D. M., & Lieber, A. (2003) · Nature Medicine · doi:10.1038/nm952 · Cited by 793 · see citing works
Single-Shot Ad26 Vaccine Protects Against SARS-CoV-2 in Rhesus Macaques
Mercado, N. B., Zahn, R., Wegmann, F., Loos, C., Chandrashekar, A., Yu, J., Liu, J., Peter, L., McMahan, K., Tostanoski, L. H., et al. (2020) · Nature · doi:10.1038/s41586-020-2607-z · Cited by 789 · see citing works
HIV-1 vaccine-induced immunity in the test-of-concept Step Study: a case–cohort analysis
McElrath, M. J., Rosa, S. C. D., Moodie, Z., Dubey, S. A., Kierstead, L. S., Janes, H., Defawe, O., Carter, D. K., Hural, J., Akondy, R. S., et al. (2008) · The Lancet · doi:10.1016/s0140-6736(08)61592-5 · Cited by 712 · see citing works
The coxsackievirus and adenovirus receptor is a transmembrane component of the tight junction
Cohen, C. J., Shieh, J. T. C., Pickles, R. J., Okegawa, T., Hsieh, J., & Bergelson, J. M. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.261452898 · Cited by 702 · see citing works
Adenovirus Serotype 5 Hexon Mediates Liver Gene Transfer
Waddington, S. N., McVey, J. H., Bhella, D., Parker, A. L., Barker, K., Atoda, H., Pink, R., Buckley, S. M. K., Greig, J. A., Denby, L., et al. (2008) · Cell · doi:10.1016/j.cell.2008.01.016 · Cited by 644 · see citing works
Emary, K. R. W., Golubchik, T., Aley, P. K., Ariani, C. V., Angus, B., Bibi, S., Blane, B., Bonsall, D., Cicconi, P., Charlton, S., et al. (2021) · The Lancet · doi:10.1016/s0140-6736(21)00628-0 · Cited by 603 · see citing works
Antibodies mediate intracellular immunity through tripartite motif-containing 21 (TRIM21)
Mallery, D. L., McEwan, W. A., Bidgood, S. R., Towers, G. J., Johnson, C. M., & James, L. C. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1014074107 · Cited by 517 · see citing works
Abbink, P., Lemckert, A. A. C., Ewald, B. A., Lynch, D. M., Denholtz, M., Smits, S., Holterman, L., Damen, I., Vogels, R., Thorner, A. R., et al. (2007) · Journal of Virology · doi:10.1128/jvi.02696-06 · Cited by 503 · see citing works
Hexon-chimaeric adenovirus serotype 5 vectors circumvent pre-existing anti-vector immunity
Roberts, D. M., Nanda, A., Havenga, M. J. E., Abbink, P., Lynch, D. M., Ewald, B. A., Liu, J., Thorner, A. R., Swanson, P. E., Gorgone, D. A., et al. (2006) · Nature · doi:10.1038/nature04721 · Cited by 490 · see citing works
Anticipating the international spread of Zika virus from Brazil
Bogoch, I. I., Brady, O. J., Kraemer, M. U. G., German, M. L., Creatore, M., Kulkarni, M. A., Brownstein, J. S., Mekaru, S. R., Hay, S. I., Groot, E., et al. (2016) · The Lancet · doi:10.1016/s0140-6736(16)00080-5 · Cited by 464 · see citing works
Desmoglein 2 is a receptor for adenovirus serotypes 3, 7, 11 and 14
Wang, H., Li, Z.-Y., Liu, Y., Persson, J., Beyer, I., Möller, T., Koyuncu, D., Drescher, M. R., Strauss, R., Zhang, X., et al. (2010) · Nature Medicine · doi:10.1038/nm.2270 · Cited by 436 · see citing works
Regulation of RIG-I-like receptor-mediated signaling: interaction between host and viral factors
Onomoto, K., Onoguchi, K., & Yoneyama, M. (2021) · Cellular and Molecular Immunology · doi:10.1038/s41423-020-00602-7 · Cited by 427 · see citing works
O’Riordan, C. R., Lachapelle, A., Delgado, C., Parkes, V., Wadsworth, S. C., Smith, A. E., & Francis, G. E. (1999) · Human Gene Therapy · doi:10.1089/10430349950018021 · Cited by 409 · see citing works
Generation of recombinant adenovirus vectors with modified fibers for altering viral tropism
Krasnykh, V. N., Mikheeva, G., Douglas, J. T., & Curiel, D. T. (1996) · Journal of Virology · doi:10.1128/jvi.70.10.6839-6846.1996 · Cited by 387 · see citing works
Dicks, M. D. J., Spencer, A. J., Edwards, N. J., Wadell, G., Bojang, K., Gilbert, S. C., Hill, A. V. S., & Cottingham, M. G. (2012) · PLoS ONE · doi:10.1371/journal.pone.0040385 · Cited by 384 · see citing works
Walters, R. W., Grunst, T., Bergelson, J. M., Finberg, R. W., Welsh, M. J., & Zabner, J. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.15.10219 · Cited by 372 · see citing works
ISOLATION AND PARTIAL CHARACTERISATION OF A NEW VIRUS CAUSING ACUTE HÆMORRHAGIC FEVER IN ZAIRE
Johnson, K. M., Lange, J., Webb, P. A., & Murphy, F. A. (1977) · The Lancet · doi:10.1016/s0140-6736(77)92000-1 · Cited by 371 · see citing works
Sumida, S. M., Truitt, D. M., Lemckert, A. A. C., Vogels, R., Custers, J. H. H. V., Addo, M. M., Lockman, S., PETER, T. F., Peyerl, F. W., Kishko, M., et al. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.174.11.7179 · Cited by 369 · see citing works
Efficient Gene Transfer into Human CD34 + Cells by a Retargeted Adenovirus Vector
Shayakhmetov, D. M., Papayannopoulou, T., Stamatoyannopoulos, G., & Lieber, A. (2000) · Journal of Virology · doi:10.1128/jvi.74.6.2567-2583.2000 · Cited by 367 · see citing works
Adenovirus Type 11 Uses CD46 as a Cellular Receptor
Segerman, A., Atkinson, J. P., Marttila, M., Dennerquist, V., Wadell, G., & Arnberg, N. (2003) · Journal of Virology · doi:10.1128/jvi.77.17.9183-9191.2003 · Cited by 358 · see citing works
Stanley, D. A., Honko, A. N., Asiedu, C. K., Trefry, J. C., Lau-Kilby, A. W., Johnson, J. C., Hensley, L. E., Ammendola, V., Abbate, A., Grazioli, F., et al. (2014) · Nature Medicine · doi:10.1038/nm.3702 · Cited by 350 · see citing works
Adenovirus Type 37 Uses Sialic Acid as a Cellular Receptor
Arnberg, N., Edlund, K., Kidd, A. H., & Wadell, G. (2000) · Journal of Virology · doi:10.1128/jvi.74.1.42-48.2000 · Cited by 316 · see citing works
The role of the nuclear pore complex in adenovirus DNA entry
Greber, U. F., Suomalainen, M., Stidwill, R. P., Boucke, K., Ebersold, M. W., & Helenius, A. (1997) · The EMBO Journal · doi:10.1093/emboj/16.19.5998 · Cited by 299 · see citing works
Replication-Defective Vector Based on a Chimpanzee Adenovirus
Farina, S. F., Gao, G., Xiang, Z. Q., Rux, J. J., Burnett, R. M., Alvira, M. R., Marsh, J. A., Ertl, H. C. J., & Wilson, J. M. (2001) · Journal of Virology · doi:10.1128/jvi.75.23.11603-11613.2001 · Cited by 271 · see citing works
Nwanegbo, E. C., Vardas, E., Gao, W., Whittle, H. C., Sun, H., Rowe, D., Robbins, P. D., & Gambotto, A. A. (2004) · Clinical and Vaccine Immunology · doi:10.1128/cdli.11.2.351-357.2004 · Cited by 266 · see citing works
ChAdOx1 nCoV-19 vaccination prevents SARS-CoV-2 pneumonia in rhesus macaques
van Doremalen, N., Lambe, T., Spencer, A., Belij-Rammerstorfer, S., Purushotham, J. N., Port, J. R., Avanzato, V., Bushmaker, T., Flaxman, A., Ulaszewska, M., et al. (2020) · doi:10.1101/2020.05.13.093195 · Cited by 246 · see citing works
Safety and immunogenicity of adenovirus-vectored nasal and epicutaneous influenza vaccines in humans
Kampen, K. R. V., Shi, Z., Gao, P., Zhang, J., Foster, K. W., Chen, D., Marks, D. H., Elmets, C. A., & Tang, D.-C. C. (2004) · Vaccine · doi:10.1016/j.vaccine.2004.07.043 · Cited by 220 · see citing works
Appledorn, D. M., Patial, S., McBride, A. J., Godbehere, S., van Rooijen, N., Parameswaran, N., & Amalfitano, A. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.181.3.2134 · Cited by 198 · see citing works
Zhu, F., Hou, L., Li, J., Wu, S., Liu, P., Zhang, G., Hu, Y., Meng, F., Xu, J., Tang, R., et al. (2015) · The Lancet · doi:10.1016/s0140-6736(15)60553-0 · Cited by 184 · see citing works
Gray, G., Buchbinder, S., & Duerr, A. C. (2010) · Current Opinion in HIV and AIDS · doi:10.1097/coh.0b013e32833d2d2b · Cited by 172 · see citing works
Mapping and role of T cell response in SARS-CoV-2–infected mice
Zhuang, Z., Lai, X., Sun, J., Chen, Z., Zhang, Z., Dai, J., Liu, D., Li, Y., Li, F., Wang, Y., et al. (2021) · The Journal of Experimental Medicine · doi:10.1084/jem.20202187 · Cited by 171 · see citing works
Nalbantoglu, J. N., Pari, G., Karpati, G., & Holland, P. C. (1999) · Human Gene Therapy · doi:10.1089/10430349950018409 · Cited by 169 · see citing works
Bricker, T. L., Darling, T. L., Hassan, A. O., Harastani, H., Soung, A., Jiang, X., Dai, Y.-N., Zhao, H., Adams, L. J., Holtzman, M. J., et al. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.109400 · Cited by 168 · see citing works
Holterman, L., Vogels, R., van der Vlugt, R., Sieuwerts, M., Grimbergen, J. M., Kaspers, J., Geelen, E., van der Helm, E., Lemckert, A. A. C., Gillissen, G. F., et al. (2004) · Journal of Virology · doi:10.1128/jvi.78.23.13207-13215.2004 · Cited by 148 · see citing works
Adenovirus-Based Vaccines: Comparison of Vectors from Three Species of Adenoviridae
Chen, H., Xiang, Z., Li, Y., Kurupati, R. K., Jia, B., Bian, A., Zhou, D., Hutnick, N. A., Yuan, S., Gray, C., et al. (2010) · Journal of Virology · doi:10.1128/jvi.00450-10 · Cited by 145 · see citing works
Toll-like Receptor 9 Triggers an Innate Immune Response to Helper-dependent Adenoviral Vectors
Cerullo, V., Seiler, M. P., Mane, V. P., Brunetti‐Pierri, N., Clarke, C., Bertin, T., Rodgers, J. R., & Lee, B. (2007) · Molecular Therapy · doi:10.1038/sj.mt.6300031 · Cited by 143 · see citing works
Adenovirus Vaccines in the U.S. Military
Gaydos, C. A., & Gaydos, J. C. (1995) · Military Medicine · doi:10.1093/milmed/160.6.300 · Cited by 139 · see citing works
Coughlan, L., Sridhar, S., Payne, R., Edmans, M. D., Milicic, A., Venkatraman, N., Lugonja, B., Clifton, L., Qi, C., Folegatti, P. M., et al. (2018) · EBioMedicine · doi:10.1016/j.ebiom.2018.02.011 · Cited by 138 · see citing works
MAIT cell activation augments adenovirus vector vaccine immunogenicity
Provine, N. M., Amini, A., Garner, L. C., Spencer, A. J., Dold, C., Hutchings, C. L., Silva-Reyes, L., FitzPatrick, M. E. B., Chinnakannan, S. K., Oguti, B., et al. (2021) · Science · doi:10.1126/science.aax8819 · Cited by 130 · see citing works
Bilamellar Cationic Liposomes Protect Adenovectors from Preexisting Humoral Immune Responses
Yotnda, P., Chen, D.-H., Chiu, W., Piedra, P. A., Davis, A. R., Templeton, N. S., & Brenner, M. K. (2002) · Molecular Therapy · doi:10.1006/mthe.2002.0545 · Cited by 113 · see citing works
Circumvention of Immunity to the Adenovirus Major Coat Protein Hexon
Roy, S., Shirley, P. S., McClelland, A., & Kaleko, M. (1998) · Journal of Virology · doi:10.1128/jvi.72.8.6875-6879.1998 · Cited by 111 · see citing works
Antigen expression determines adenoviral vaccine potency independent of IFN and STING signaling
Quinn, K. M., Zak, D. E., Costa, A. D. S., Yamamoto, A., Kastenmüller, K., Hill, B. J., Lynn, G. M., Darrah, P. A., Lindsay, R. W. B., Wang, L., et al. (2015) · Journal of Clinical Investigation · doi:10.1172/jci78280 · Cited by 110 · see citing works
Identification and quantification of complement regulator CD46 on normal human tissues.
Johnstone, R. W., Loveland, B. E., & McKenzie, I. F. C. (1993) · PubMed · Cited by 108 · see citing works
Basner‐Tschakarjan, E., Gaffal, E., O’Keeffe, M. A., Tormo, D., Limmer, A., Wagner, H., Hochrein, H., & Tüting, T. (2006) · The Journal of Gene Medicine · doi:10.1002/jgm.964 · Cited by 102 · see citing works
Development and Assessment of Human Adenovirus Type 11 as a Gene Transfer Vector
Stone, D., Ni, S., Li, Z.-Y., Gaggar, A., Paolo, N. C. D., Feng, Q., Sandig, V., & Lieber, A. (2005) · Journal of Virology · doi:10.1128/jvi.79.8.5090-5104.2005 · Cited by 102 · see citing works
Characterization of in vitro and in vivo gene transfer properties of adenovirus serotype 35 vector
Sakurai, F., Mizuguchi, H., Yamaguchi, T., & Hayakawa, T. (2003) · Molecular Therapy · doi:10.1016/s1525-0016(03)00243-0 · Cited by 100 · see citing works
Li, R., Xiaohua, T., Li, Y., Zhang, H., Ma, R., Ji, T., Dong, W., Tong, T., Liu, Y., Chen, D., et al. (2016) · Biomaterials · doi:10.1016/j.biomaterials.2016.02.025 · Cited by 100 · see citing works
Human adenovirus type 26 uses sialic acid–bearing glycans as a primary cell entry receptor
Baker, A. T., Mundy, R. M., Davies, J. A., Rizkallah, P. J., & Parker, A. L. (2019) · Science Advances · doi:10.1126/sciadv.aax3567 · Cited by 92 · see citing works
Efficient gene transfer into human CD34+ cells by an adenovirus type 35 vector
Sakurai, F., Mizuguchi, H., & Hayakawa, T. (2003) · Gene Therapy · doi:10.1038/sj.gt.3301959 · Cited by 88 · see citing works
Baden, L. R., Stieh, D. J., Sarnecki, M., Walsh, S. R., Tomaras, G. D., Kublin, J. G., McElrath, M. J., Alter, G., Ferrari, G., Montefiori, D. C., et al. (2020) · The Lancet HIV · doi:10.1016/s2352-3018(20)30229-0 · Cited by 88 · see citing works
Role of MyD88 and TLR9 in the Innate Immune Response Elicited by Serotype 5 Adenoviral Vectors
Yamaguchi, T., Kawabata, K., Koizumi, N., Sakurai, F., Kaneda‐Nakashima, K., Sakurai, H., Sasaki, T., Okada, N., Yamanishi, K., & Mizuguchi, H. (2007) · Human Gene Therapy · doi:10.1089/hum.2007.016 · Cited by 87 · see citing works
Minamitani, T., Iwakiri, D., & Takada, K. (2011) · Journal of Virology · doi:10.1128/jvi.02160-10 · Cited by 87 · see citing works
Innate immunity to adenovirus: lessons from mice
Atasheva, S., Yao, J., & Shayakhmetov, D. M. (2019) · FEBS Letters · doi:10.1002/1873-3468.13696 · Cited by 87 · see citing works
Lemckert, A. A. C., Grimbergen, J. M., Smits, S., Hartkoorn, E., Holterman, L., Berkhout, B., Barouch, D. H., Vogels, R., Quax, P. H. A., Goudsmit, J., et al. (2006) · Journal of General Virology · doi:10.1099/vir.0.82079-0 · Cited by 85 · see citing works
Matsuda, K., Migueles, S. A., Huang, J., Bolkhovitinov, L., Stuccio, S., Griesman, T., Pullano, A. A., Kang, B. H., Ishida, E., Zimmerman, M. G., et al. (2021) · Journal of Clinical Investigation · doi:10.1172/jci140794 · Cited by 83 · see citing works
Salisch, N. C., Stephenson, K. E., Williams, K. L., Cox, F., van der Fits, L., Heerwegh, D., Truyers, C., Habets, M. N., Kanjilal, D. G., Larocca, R. A., et al. (2021) · Annals of Internal Medicine · doi:10.7326/m20-5306 · Cited by 81 · see citing works
Klonjkowski, B., Gilardi‐Hebenstreit, P., Hadchouel, J., Randrianarison-Huetz, V., Boutin, S., Yeh, P., Perricaudet, M., & Kremer, E. J. (1997) · Human Gene Therapy · doi:10.1089/hum.1997.8.17-2103 · Cited by 80 · see citing works
Hage, E., Liebert, U. G., Bergs, S., Ganzenmueller, T., & Heim, A. (2015) · Journal of General Virology · doi:10.1099/vir.0.000196 · Cited by 80 · see citing works
Rhee, E. G., Blattman, J. N., Kasturi, S. P., Kelley, R., Kaufman, D. R., Lynch, D. M., Porte, A. L., Simmons, N. L., Clark, S., Pulendran, B., et al. (2010) · Journal of Virology · doi:10.1128/jvi.01597-10 · Cited by 79 · see citing works
Xu, K., Song, Y., Dai, L., Zhang, Y., Lu, X., Xie, Y., Zhang, H., Tao, C., Wang, Q., Huang, Q., et al. (2018) · Journal of Virology · doi:10.1128/jvi.01722-17 · Cited by 76 · see citing works
Cheng, C., Gall, J. G. D., Nason, M., King, C. R., Koup, R. A., Roederer, M., McElrath, M. J., Morgan, C. A., Churchyard, G., Baden, L. R., et al. (2009) · Journal of Virology · doi:10.1128/jvi.00866-09 · Cited by 75 · see citing works
Hayton, E., Rose, A., Ibrahimsa, U., Sorbo, M. D., Capone, S., Crook, A., Black, A. P., Dorrell, L., & Hanke, T. (2014) · PLoS ONE · doi:10.1371/journal.pone.0101591 · Cited by 74 · see citing works
Ophorst, O. J. A. E., Radošević, K., Havenga, M. J. E., Pau, M. G., Holterman, L., Berkhout, B., Goudsmit, J., & Tsuji, M. (2005) · Infection and Immunity · doi:10.1128/iai.74.1.313-320.2006 · Cited by 73 · see citing works
Kaufman, D., Liu, J.-Y., Carville, A., Mansfield, K., Havenga, M., Goudsmit, J., & Barouch, D. (2008) · Journal of Immunology · doi:10.4049/jimmunol.181.6.4188 · Cited by 72 · see citing works
Induction of type I interferon by adenovirus-encoded small RNAs
Yamaguchi, T., Kawabata, K., Kouyama, E., Ishii, K. J., Katayama, K., Suzuki, T., Kurachi, S., Sakurai, F., Akira, S., & Mizuguchi, H. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1009823107 · Cited by 66 · see citing works
Kaufman, D. R., Bivas‐Benita, M., Simmons, N. L., Miller, D. D., & Barouch, D. H. (2010) · Journal of Virology · doi:10.1128/jvi.02563-09 · Cited by 66 · see citing works
Baden, L. R., Liu, J., Li, H., Johnson, J. A., Walsh, S. R., Kleinjan, J. A., Engelson, B. A., Peter, L. E., Abbink, P., Milner, D. A., et al. (2014) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiu485 · Cited by 66 · see citing works
Anghelina, D., Lam, E., & Falck-Pedersen, E. (2016) · Journal of Virology · doi:10.1128/jvi.00500-16 · Cited by 59 · see citing works
Volkmann, A., Williamson, A., Weidenthaler, H., Meyer, T. P. H., Robertson, J. S., Excler, J., CONDIT, R. C., Evans, E., Smith, E. R., Kim, D., et al. (2020) · Vaccine · doi:10.1016/j.vaccine.2020.08.050 · Cited by 58 · see citing works
Ebola from emergence to epidemic: the virus and the disease, global preparedness and perspectives
Dhama, K., Malik, Y. S., Malik, S. V. S., & Singh, R. K. (2015) · The Journal of Infection in Developing Countries · doi:10.3855/jidc.6197 · Cited by 57 · see citing works
Guo, Q., Chan, J. F., Poon, V. K., Wu, S., Chan, C. C., Hou, L., Yip, C. C., Ren, C., Cai, J., Zhao, M., et al. (2018) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiy187 · Cited by 56 · see citing works
Membrane Cofactor Protein (CD46) Is a Basolateral Protein That Is Not Endocytosed
Maisner, A., Zimmer, G., Liszewski, M. K., Lublin, D. M., Atkinson, J. P., & Herrler, G. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.33.20793 · Cited by 46 · see citing works
Patterson, L. J., Kuate, S., Daltabuit-Test, M., Li, Q., Xiao, P., McKinnon, K. M., DiPasquale, J., Cristillo, A. D., Venzon, D. J., Haase, A. T., et al. (2012) · Clinical and Vaccine Immunology · doi:10.1128/cvi.00010-12 · Cited by 46 · see citing works
Comparison of vaccine-induced thrombotic events between ChAdOx1 nCoV-19 and Ad26.COV.2.S vaccines
Hwang, J., Lee, S. B., Lee, S. W., Lee, M. H., Koyanagi, A., Jacob, L., Tizaoui, K., Yon, D. K., Shin, J. I., & Smith, L. (2021) · Journal of Autoimmunity · doi:10.1016/j.jaut.2021.102681 · Cited by 45 · see citing works
Zhong, Z., Shi, S., Han, J., Zhang, Z., & Sun, X. (2009) · Molecular Pharmaceutics · doi:10.1021/mp900151k · Cited by 44 · see citing works
Liu, F., Niu, Q., Fan, X., Liu, C., Zhang, J., Wei, Z., Hou, W., Kanneganti, T., Robb, M. L., Kim, J. H., et al. (2017) · The Journal of Immunology · doi:10.4049/jimmunol.1700698 · Cited by 44 · see citing works
Creation of a panel of vectors based on ape adenovirus isolates
Roy, S., Medina‐Jaszek, A., Wilson, M. J., Sandhu, A. K., Calcedo, R., Lin, J., & Wilson, J. M. (2010) · The Journal of Gene Medicine · doi:10.1002/jgm.1530 · Cited by 43 · see citing works
Kakiuchi, Y., Kuroda, S., Kanaya, N., Kumon, K., Tsumura, T., Hashimoto, M., Yagi, C., Sugimoto, R., Hamada, Y., Kikuchi, S., et al. (2021) · Molecular Therapy · doi:10.1016/j.ymthe.2021.05.015 · Cited by 42 · see citing works
Sørensen, A. L. T., Rolland, M., Hartmann, J. P., Harboe, Z. B., Roed, C., Jensen, T. Ø., Kolte, L., Fassi, D. E., Hillingsø, J., Radziwon‐Balicka, A., et al. (2021) · Blood Advances · doi:10.1182/bloodadvances.2021004904 · Cited by 41 · see citing works
Zhang, Y., Wu, J., Zhang, H., Wei, J., & Wu, J. (2020) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2020.574007 · Cited by 40 · see citing works
Park, K. S., Lee, J., Ahn, S. S., Byun, Y.-H., Seong, B. L., Baek, Y. H., Song, M., Choi, Y. K., Na, Y. J., Hwang, I., et al. (2009) · Virology · doi:10.1016/j.virol.2009.09.018 · Cited by 39 · see citing works
Barouch, D. H., Liu, J., Lynch, D. M., O’Brien, K. L., Porte, A. L., Simmons, N. L., Riggs, A. M., Clark, S., Abbink, P., Montefiori, D. C., et al. (2009) · Journal of Virology · doi:10.1128/jvi.00821-09 · Cited by 36 · see citing works
Appledorn, D., Patial, S., Godbehere, S., Parameswaran, N., & Amalfitano, A. (2009) · Journal of Innate Immunity · doi:10.1159/000207194 · Cited by 34 · see citing works
Human CD46-transgenic mice in studies involving replication-incompetent adenoviral type 35 vectors
Verhaagh, S., de Jong, E., Goudsmit, J., Lecollinet, S., Gillissen, G. F., de Vries, M. R., van Leuven, K., Que, I., Ouwehand, K., Mintardjo, R., et al. (2006) · Journal of General Virology · doi:10.1099/vir.0.81293-0 · Cited by 30 · see citing works
Chéneau, C., Eichholz, K., Tran, T. H., Tran, T. T. P., Paris, O., Henriquet, C., Bajramovic, J. J., Pugnière, M., & Kremer, E. J. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.685218 · Cited by 30 · see citing works
Luo, S., Zhang, P., Ma, X., Wang, Q., Lu, J., Liu, B., Zhao, W., Allain, J., Li, C.-Y., & Li, T. (2019) · Virus Research · doi:10.1016/j.virusres.2019.05.008 · Cited by 23 · see citing works
Fukuhara, H., Hayashi, Y., Yamamoto, N., Fukui, T., Nishikawa, M., Mitsudo, K., Tohnai, I., Ueda, M., Mizuno, M., & Yoshida, J. (2003) · Oral Oncology · doi:10.1016/s1368-8375(03)00047-2 · Cited by 21 · see citing works
Hexon-specific PEGylated adenovirus vectors utilizing avidin-biotin interaction
Suzuki‐Kouyama, E., Katayama, K., Sakurai, F., Yamaguchi, T., Kurachi, S., Kawabata, K., Nakagawa, S., & Mizuguchi, H. (2010) · Biomaterials · doi:10.1016/j.biomaterials.2010.10.060 · Cited by 18 · see citing works
Anchim, A., Raddi, N., Zig, L., Perrieau, P., Goffic, R. L., Ryffel, B., & Benihoud, K. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00124 · Cited by 14 · see citing works
Hemmi, M., Tachibana, M., Fujimoto, N., Shoji, M., Sakurai, F., Kobiyama, K., Ishii, K. J., Akira, S., & Mizuguchi, H. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01456 · Cited by 11 · see citing works
A hexon-specific PEGylated adenovirus vector utilizing blood coagulation factor X
Matsui, H., Sakurai, F., Katayama, K., Yamaguchi, T., Okamoto, S., Takahira, K., Tachibana, M., Nakagawa, S., & Mizuguchi, H. (2012) · Biomaterials · doi:10.1016/j.biomaterials.2012.02.011 · Cited by 10 · see citing works
Shoji, M., Tachibana, M., Katayama, K., Tomita, K., Tsuzuki, S., Sakurai, F., Kawabata, K., Ishii, K. J., Akira, S., & Mizuguchi, H. (2012) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2012.07.056 · Cited by 8 · see citing works
Larochelle, N., Deol, J. R., Srivastava, V. K., Allen, C. A., Mizuguchi, H., Karpati, G., Holland, P. C., & Nalbantoglu, J. N. (2007) · Human Gene Therapy · doi:10.1089/hum.2007.040 · Cited by 7 · see citing works
Influenza vaccine for 2020-2021.
(2020) · PubMed · Cited by 3 · see citing works
Flagged first, then by citations
3 of the 109 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
COVID-19 mRNA vaccines: Platforms and current developments
Szabó, G. T., Mahiny, A. J., & Vlatkovic, I. (2022) · Molecular Therapy · doi:10.1016/j.ymthe.2022.02.016 · Cited by 308 · see citing works
Wang, S., Liang, B., Wang, W., Li, L., Feng, N., Zhao, Y., Wang, T., Yan, F., Yang, S., & Xia, X. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01408-5 · Cited by 222 · see citing works
Souto, E. B., Blanco-Llamero, C., Krambeck, K., Kiran, N. S., Yashaswini, C., Postwala, H. I., Severino, P. B., Priefer, R., Prajapati, B. G., & Maheshwari, R. (2024) · Acta Biomaterialia · doi:10.1016/j.actbio.2024.04.010 · Cited by 182 · see citing works
Two centuries of vaccination: historical and conceptual approach and future perspectives
Montero, D. A., Vidal, R. M., Velasco, J., Carreño, L. J., Torres, J. P., O., M. A. B., Tovar-Rosero, Y.-Y., Oñate, A. A., & O’Ryan, M. (2024) · Frontiers in Public Health · doi:10.3389/fpubh.2023.1326154 · Cited by 160 · see citing works
Chitosan-Based Nanomaterial as Immune Adjuvant and Delivery Carrier for Vaccines
Gong, X., Gao, Y., Shu, J., Zhang, C., & Zhao, K. (2022) · Vaccines · doi:10.3390/vaccines10111906 · Cited by 138 · see citing works
Adenoviruses in medicine: innocuous pathogen, predator, or partner
MacNeil, K. M., Dodge, M. J., Evans, A. M., Tessier, T. M., Weinberg, J. B., & Mymryk, J. S. (2022) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2022.10.001 · Cited by 91 · see citing works
Vaccine Strategies to Elicit Mucosal Immunity
Song, Y., Mehl, F., & Zeichner, S. L. (2024) · Vaccines · doi:10.3390/vaccines12020191 · Cited by 80 · see citing works
Oral Vaccines: A Better Future of Immunization
Kwong, K. W.-Y., Xin, Y., Lai, N. C.-Y., Sung, J. C.-C., Wu, K.-C., Hamied, Y. K., Sze, E. T.-P., & Lam, D. M. (2023) · Vaccines · doi:10.3390/vaccines11071232 · Cited by 74 · see citing works
Kiszel, P., Sík, P., Miklós, J., Kajdácsi, E., Sinkovits, G., Cervenak, L., & Prohászka, Z. (2023) · Scientific Reports · doi:10.1038/s41598-023-40103-x · Cited by 69 · see citing works
Nasal vaccines for respiratory infections
Kiyono, H., & Ernst, P. B. (2025) · Nature · doi:10.1038/s41586-025-08910-6 · Cited by 58 · see citing works
Nasal vaccines: solutions for respiratory infectious diseases
Nakahashi-Ouchida, R., Fujihashi, K., Kurashima, Y., Yuki, Y., & Kiyono, H. (2022) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2022.10.009 · Cited by 54 · see citing works
Development of Nasal Vaccines and the Associated Challenges
Nian, X., Zhang, J., Huang, S., Duan, K., Li, X., & Yang, X. (2022) · Pharmaceutics · doi:10.3390/pharmaceutics14101983 · Cited by 48 · see citing works
Evolving Horizons: Adenovirus Vectors’ Timeless Influence on Cancer, Gene Therapy and Vaccines
Trivedi, P. D., Byrne, B. J., & Corti, M. (2023) · Viruses · doi:10.3390/v15122378 · Cited by 46 · see citing works
CCHFV vaccine development, current challenges, limitations, and future directions
Ahata, B., & Akçapınar, G. B. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1238882 · Cited by 40 · see citing works
Clinical Application of Adenovirus (AdV): A Comprehensive Review
Salauddin, M., Saha, S., Hossain, M. G., Okuda, K., & Shimada, M. (2024) · Viruses · doi:10.3390/v16071094 · Cited by 36 · see citing works
Glycan masking in vaccine design: Targets, immunogens and applications
Martina, C. E., Crowe, J. E., & Meiler, J. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1126034 · Cited by 34 · see citing works
Swine influenza A virus: challenges and novel vaccine strategies
Petro-Turnquist, E. M., Pekarek, M. J., & Weaver, E. A. (2024) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2024.1336013 · Cited by 34 · see citing works
Advances of Recombinant Adenoviral Vectors in Preclinical and Clinical Applications
Scarsella, L., Ehrke‐Schulz, E., Paulussen, M., Thal, S. C., Ehrhardt, A., & Aydin, M. (2024) · Viruses · doi:10.3390/v16030377 · Cited by 23 · see citing works
Cancer mRNA vaccines: clinical application progress and challenges
Li, H., Min, L., Du, H., Wei, X., & Tong, A. (2025) · Cancer Letters · doi:10.1016/j.canlet.2025.217752 · Cited by 24 · see citing works
Current Advances in Viral Nanoparticles for Biomedicine
Sun, X., Tian, T., Lian, Y., & Cui, Z. (2024) · ACS Nano · doi:10.1021/acsnano.4c13146 · Cited by 21 · see citing works
Identification of Inhibitors and Drug Targets for Human Adenovirus Infections
Liu, M., Jiang, L., Cao, W., Wu, J., & Chen, X. (2022) · Viruses · doi:10.3390/v14050959 · Cited by 19 · see citing works
Wang, S., Liu, W.-Q., Li, Y., Li, J., & Zhu, F. (2023) · Expert Review of Vaccines · doi:10.1080/14760584.2023.2242528 · Cited by 18 · see citing works
Novel technologies are turning a dream into reality: conditionally replicating viruses as vaccines
Tang, Y., Yu, C., & Cai, X. (2023) · Trends in Microbiology · doi:10.1016/j.tim.2023.09.002 · Cited by 19 · see citing works
Progress in African Swine Fever Vector Vaccine Development
Yang, Y., Yuan, H., Zhang, Y., Luan, J., & Wang, H. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26030921 · Cited by 18 · see citing works
Cohen, G., Jungsomsri, P., Sangwongwanich, J., Tawinprai, K., Siripongboonsitti, T., Porntharukchareon, T., Wittayasak, K., Thonwirak, N., Soonklang, K., Sornsamdang, G., et al. (2022) · Human Vaccines & Immunotherapeutics · doi:10.1080/21645515.2022.2052525 · Cited by 17 · see citing works
Bukharova, T. B., Nedorubova, I. A., Mokrousova, V., Meglei, A. Y., Basina, V. P., Nedorubov, A. A., Vasilyev, A. V., Grigoriev, T. E., Zagoskin, Y. D., Чвалун, С. Н., et al. (2023) · Cells · doi:10.3390/cells12131762 · Cited by 17 · see citing works
Tkaczyk, C., Newton, M. R., Patnaik, M. M., Thom, G., Strain, M., Gamson, A., Daramola, O., Murthy, A., Douthwaite, J. A., Stepanov, O., et al. (2024) · Molecular Therapy · doi:10.1016/j.ymthe.2024.05.036 · Cited by 16 · see citing works
Vaccine formulation design: challenges and opportunities
Zafar, S., Akhtar, A., Sayed, E., Onaiwu, E., Arshad, M. S., & Ahmad, Z. (2025) · RSC Pharmaceutics · doi:10.1039/d5pm00017c · Cited by 16 · see citing works
Guillain-Barré syndrome and COVID-19 vaccines: focus on adenoviral vectors
Rzymski, P. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1183258 · Cited by 16 · see citing works
Feng, Y., Fan, J., Wu, D., Liu, Q., Li, H., Zhang, X., Li, S., Tang, F. R., Liu, Z., Zhang, L., et al. (2022) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2022.12.158 · Cited by 15 · see citing works
Revolutionizing antiviral therapy with nanobodies: Generation and prospects
Mustafa, M. I., & Mohammed, A. (2023) · Biotechnology Reports · doi:10.1016/j.btre.2023.e00803 · Cited by 14 · see citing works
Gao, A., Chen, Y., Liang, H., Cui, X., Zhang, A., & Cui, D. (2023) · Theranostics · doi:10.7150/thno.83390 · Cited by 14 · see citing works
Kumar, A., Tripathi, P., Kumar, P., Shekhar, R., & Pathak, R. (2024) · Vaccines · doi:10.3390/vaccines12050459 · Cited by 15 · see citing works
Tawinprai, K., Siripongboonsitti, T., Porntharukchareon, T., Wittayasak, K., Thonwirak, N., Soonklang, K., Sornsamdang, G., Auewarakul, C. U., & Mahanonda, N. (2022) · Vaccine · doi:10.1016/j.vaccine.2022.02.019 · Cited by 14 · see citing works
Mucosal Vaccination: A Promising Alternative Against Flaviviruses
Lurı́a-Pérez, R., Sánchez-Vargas, L. A., Muñoz-López, P., & Mellado‐Sánchez, G. (2022) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2022.887729 · Cited by 13 · see citing works
Oral mucosa immunity: ultimate strategy to stop spreading of pandemic viruses
Jang, H., Matsuoka, M., & Freire, M. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1220610 · Cited by 13 · see citing works
Vaccine Development for Human Leishmaniasis
Clímaco, M. D. C., Kraemer, L. R., & Fujiwara, R. T. (2023) · Springer eBooks · doi:10.1007/978-3-031-24355-4_14 · Cited by 13 · see citing works
mRNA vaccines: a transformative technology with applications beyond COVID ‐19
Overmars, I., Au‐Yeung, G., Nolan, T. M., & Steer, A. C. (2022) · The Medical Journal of Australia · doi:10.5694/mja2.51620 · Cited by 12 · see citing works
Khan, S., Salisch, N. C., Gil, A. I., Boedhoe, S., Boer, K. F.-D., Serroyen, J., Schuitemaker, H., & Zahn, R. C. (2022) · npj Vaccines · doi:10.1038/s41541-022-00567-w · Cited by 12 · see citing works
Pharmaceutical strategies for optimized mRNA expression
Shi, Y., Mao, J., Wang, S., Ma, S., Luo, L., & You, J. (2024) · Biomaterials · doi:10.1016/j.biomaterials.2024.122853 · Cited by 11 · see citing works
Adenoviral Vectors for Gene Therapy of Hereditary Diseases
Muravyeva, A., & Smirnikhina, S. (2024) · Biology · doi:10.3390/biology13121052 · Cited by 11 · see citing works
Adenoviral Vectors: Potential as Anti-HBV Vaccines and Therapeutics
Farhad, T., Neves, K., Arbuthnot, P. B., & Maepa, M. B. (2022) · Genes · doi:10.3390/genes13111941 · Cited by 11 · see citing works
Săndulescu, O., Streinu-Cercel, A., Miron, V. D., Covăcescu, M., Streinu‐Cercel, A., & Craiu, M. (2023) · Microorganisms · doi:10.3390/microorganisms11020302 · Cited by 9 · see citing works
Kindi, H. A., Meredith, L. W., Al‐Jardani, A., Sajina, F., Al-Shukri, I., al Haj, R., Alyaquobi, F., Wahaibi, A. S. A., & Al-Maani, A. S. (2023) · Influenza and Other Respiratory Viruses · doi:10.1111/irv.13233 · Cited by 9 · see citing works
SARS-CoV-2 Vaccination and the Multi-Hit Hypothesis of Oncogenesis
Angues, R. V., & Bustos, Y. P. (2023) · Cureus · doi:10.7759/cureus.50703 · Cited by 9 · see citing works
Fayad, D., & Frenck, R. W. (2023) · Journal of Clinical Medicine · doi:10.3390/jcm13010087 · Cited by 9 · see citing works
Development of a perfusion process for serum-free adenovirus vector herpes zoster vaccine production
Sun, Y., Huang, L., Nie, J., Feng, K., Liu, Y., & Bai, Z. (2022) · AMB Express · doi:10.1186/s13568-022-01398-7 · Cited by 8 · see citing works
Integrating Affinity Chromatography in the Platform Process for Adenovirus Purification
Wu, Y., Barbieri, E., Smith, W. K., Minzoni, A., Kilgore, R., Chu, W., Daniele, M. A.-A., & Menegatti, S. (2025) · Biotechnology and Bioengineering · doi:10.1002/bit.29006 · Cited by 7 · see citing works
Wang, N., & Wang, T. (2024) · Biotechnology Journal · doi:10.1002/biot.202300658 · Cited by 10 · see citing works
Sowndharya, C. K., Mehnath, S., Ponbharathi, A., & Jeyaraj, M. (2024) · ACS Infectious Diseases · doi:10.1021/acsinfecdis.4c00619 · Cited by 7 · see citing works
Monkeypox outbreak: after COVID-19, another challenge for the hemostatic system?
Marietta, M., Coluccio, V., & Luppi, M. (2022) · Internal and Emergency Medicine · doi:10.1007/s11739-022-03112-8 · Cited by 7 · see citing works
One HA stalk topping multiple heads as a novel influenza vaccine
Zhou, P., Qiu, T., Wang, X., Yang, X., Shi, H., Zhu, C., Dai, W., Xing, M., Zhang, X., Xu, J., et al. (2023) · Emerging Microbes & Infections · doi:10.1080/22221751.2023.2290838 · Cited by 7 · see citing works
Schröer, K., Arakrak, F., Bremke, A., Ehrhardt, A., & Zhang, W.-L. (2022) · Genes · doi:10.3390/genes13112129 · Cited by 4 · see citing works
Chakraborty, C., Lo, Y.-H., Bhattacharya, M., Das, A., & Wen, Z. (2025) · Molecular Therapy — Nucleic Acids · doi:10.1016/j.omtn.2025.102527 · Cited by 7 · see citing works
Sallard, E., Schulte, L., van den Boom, A., Klimovitskii, A. E., Knierer, J., Hagedorn, C., Knocks, M., Zhang, W., Kreppel, F., Ehrhardt, A., et al. (2023) · The Journal of Gene Medicine · doi:10.1002/jgm.3576 · Cited by 6 · see citing works
Recent Advances in Vaccine Adjuvants: From Lab to Clinic
Vardikar, A., Prajapati, M. K., Gholap, A. D., Rojekar, S. V., Keshari, R., Jain, H., & Rajput, A. (2025) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2025.126180 · Cited by 5 · see citing works
Gene therapies for osteoarthritis: progress and prospects
Defois, A., Bon, N., Mével, M., Deniaud, D., Maugars, Y., Guicheux, J., Adjali, O., & Vinatier, C. S. (2024) · Journal of Cartilage & Joint Preservation · doi:10.1016/j.jcjp.2024.100186 · Cited by 5 · see citing works
ADEVO: Proof-of-concept of adenovirus-directed EVOlution by random peptide display on the fiber knob
Sallard, E., Fischer, J., Schröer, K., Dawson, L.-M., Beaude, N., Affes, A., Ehrke‐Schulz, E., Zhang, W., Westhaus, A., Cabanes‐Creus, M., et al. (2024) · Molecular Therapy Oncology · doi:10.1016/j.omton.2024.200867 · Cited by 5 · see citing works
Sallard, E., Pembaur, D., Schröer, K., Schellhorn, S., Koukou, G., Schmidt, N., Zhang, W., Kreppel, F., & Ehrhardt, A. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.11.07.515483 · Cited by 5 · see citing works
Engineering immune cells for next-generation therapies
Han, M., Lou, J., Pan, M., Xu, S., Jiang, X., & Jing, W. (2026) · Journal of Controlled Release · doi:10.1016/j.jconrel.2026.115012 · Cited by 4 · see citing works
Onishi, R., Ikemoto, S., Shiota, A., Tsukamoto, T., Asayama, A., Tachibana, M., Sakurai, F., & Mizuguchi, H. (2024) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2024.124480 · Cited by 4 · see citing works
Liu, W., Li, Y., Li, X., Wang, F., Qi, R., Zhu, T., & Li, J. (2025) · Vaccines · doi:10.3390/vaccines13030333 · Cited by 4 · see citing works
Wang, Y., Yang, L., Tang, K., Zhang, Y., Zhang, C., Zhang, Y., Jin, B., Zhang, Y., Zhuang, R., & Ma, Y. (2023) · Viruses · doi:10.3390/v16010052 · Cited by 4 · see citing works
Wang, M., Wu, C., Liu, N., Jiang, X., Dong, H., Zhao, S., Li, C., Xu, S., & Gu, L. (2024) · Engineering Microbiology · doi:10.1016/j.engmic.2024.100162 · Cited by 4 · see citing works
Galván‐Salazar, H. R., Delgado‐Machuca, M., Hernández‐Fuentes, G. A., Aurelien-Cabezas, N. S., Rodríguez‐Hernández, A., Veloz, I. G., Mendoza-Hernandez, M. A., Martínez‐Fierro, M. L., Zaizar-Fregoso, S. A., Rodriguez-Sanchez, I. P., et al. (2024) · Microbiology Research · doi:10.3390/microbiolres15030105 · Cited by 4 · see citing works
Hoang, T. N. A., Byrne, A., Quach, H., Bannister-Tyrrell, M., & VOGT, F. M. (2024) · Transactions of the Royal Society of Tropical Medicine and Hygiene · doi:10.1093/trstmh/trae082 · Cited by 4 · see citing works
Voronina, D. V., Викторовна, В. И., Zubkova, O. V., Ozharovskaia, T. A., Popova, O. D., Chugunova, A. S., Павловна, Г. П., Игоревич, З. Д., Savina, D. M., Favorskaya, I. A., et al. (2025) · Viruses · doi:10.3390/v17081085 · Cited by 3 · see citing works
Tanaka, Y., Hamano, S., Ishii‐Watabe, A., Saito, Y., & Kikura‐Hanajiri, R. (2025) · Molecular Therapy — Methods & Clinical Development · doi:10.1016/j.omtm.2025.101549 · Cited by 3 · see citing works
Nogales‐Altozano, P., Gómez‐Marcos, L., Carlón, A. B., Louloudes-Lázaro, A., Rivera-Rodríguez, A., Larraga, J., Alcolea, P. J., Alonso, A., Larraga, V., Martı́n, V., et al. (2025) · Vaccines · doi:10.3390/vaccines13090991 · Cited by 3 · see citing works
Comprehensive review on COVID-19: etiology, pathogenicity, and treatment
Zawily, A. E., Eckert, S., Adajar, R. C., Wagih, N., Elmaidomy, A. H., Helmy, A. M., Mustafa, M., Elshorbagi, M., Ghali, E., Fadl, R. G., et al. (2025) · Frontiers in Medicine · doi:10.3389/fmed.2025.1569013 · Cited by 3 · see citing works
Microneedles Based Thermally Stable Ad‐5 Viral Vector for Vaccine Delivery
Singh, P., Sharma, N., Huang, F., Bhaskar, N., Akbaba, H., Park, J., Radhakrishnan, A., Sakhrie, A., Nguyen, L., Ge, G., et al. (2026) · Advanced Healthcare Materials · doi:10.1002/adhm.202504342 · Cited by 3 · see citing works
Mucosal immunity and vaccine development
Hong, W., Alu, A., Zhang, Z., Zhang, Y. L., He, X., Xu, L., Li, M., He, W., & Wang, J. (2026) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-026-02687-4 · Cited by 3 · see citing works
A universal recombinant adenovirus type 5 vector-based COVID-19 vaccine
Li, X., Peng, Q., Liu, X., Xu, H., Liu, J., Wu, X., Ye, Q., Li, M., & Li, Y. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1374486 · Cited by 3 · see citing works
Mao, T., Zhang, P., Jiang, S., Li, D.-D., Li, J., Zhang, Q., Wang, H., Kong, X., & Duan, Z. (2025) · Journal of Medical Virology · doi:10.1002/jmv.70236 · Cited by 3 · see citing works
A Critical Assessment of COVID-19 Genomic Vaccines
Sabbah, D. A., Hajjo, R., & Sunoqrot, S. (2023) · Current Topics in Medicinal Chemistry · doi:10.2174/1568026623666230825094341 · Cited by 3 · see citing works
Shoushtari, M. M., Salehi-Vaziri, ., Kadkhodazadeh, M., Teimoori, A., Arashkia, A., Roohvand, F., Teimoori‐Toolabi, L., Pouriayevali, M. H., & Azadmanesh, K. (2025) · International Immunopharmacology · doi:10.1016/j.intimp.2025.114032 · Cited by 3 · see citing works
Safety and immunogenicity of Ad26.COV2.S in adolescents: Phase 2 randomized clinical trial
Tica, J., Rezelj, V. V., Baron, B., van Paassen, V., Zaidman, J., Fairlie, L., Scheper, G. C., Gars, M. L., Struyf, F., Douoguih, M., et al. (2025) · Human Vaccines & Immunotherapeutics · doi:10.1080/21645515.2025.2450120 · Cited by 3 · see citing works
LAVR-289, an Orally Bioavailable Inhibitor of Adenovirus Replication In Vitro and In Vivo
Quentin-Froignant, C., Tollefson, A. E., Cline-Smith, A., Kappler‐Gratias, S., Landrein, N., Roy, V., Agrofoglio, L. A., Tóth, K., Wodrich, H., & Gallardo, F. (2025) · ACS Infectious Diseases · doi:10.1021/acsinfecdis.5c00170 · Cited by 3 · see citing works
Genetically Mediated Cell Membrane Engineering Strategies and Their Scope in Biomedical Applications
Tollabi, M., Kheirandish, M. H., Mehrabi, A., Poursalehi, Z., Heidari, M., & Milan, P. B. (2025) · Springer eBooks · doi:10.1007/978-3-031-93425-4_6 · Cited by 2 · see citing works
Development and immunogenicity of adenoviral Fc-fused FMDV virus-like particle vaccine in swine
Park, J., Lee, H., Kang, K.-J., Jung, M. K., Mun, J. Y., Kim, M., Pyun, J., Hwang, S. Y., Park, J.-H., & Shin, H.-J. (2025) · Veterinary Quarterly · doi:10.1080/01652176.2025.2564443 · Cited by 2 · see citing works
Lamers, O. A. C., Franke-Fayard, B. M. D., Roestenberg, M., & Krol, J. M. M. (2025) · npj Vaccines · doi:10.1038/s41541-025-01265-z · Cited by 2 · see citing works
Application of biomimetic approaches in the treatment of neurological disorders
Sun, J., Li, H., Wang, J., & Yang, W. (2025) · Materials Today Bio · doi:10.1016/j.mtbio.2025.102334 · Cited by 2 · see citing works
Enhancing the breadth of protection in mice with a multivalent influenza vaccine
Wang, X., Niu, Y., Hu, Y., Zhu, C., Yang, X., Shi, H., Yan, Y., Zhou, P., Ding, L., Zhang, M., et al. (2026) · Communications Biology · doi:10.1038/s42003-025-09451-4 · Cited by 2 · see citing works
Sonugür, F. G., Babahan, C., Abgarmi, S. A., & Akbulut, H. (2022) · Molecular Biotechnology · doi:10.1007/s12033-022-00616-8 · Cited by 2 · see citing works
A Novel Vaccine Strategy to Prevent Cytauxzoonosis in Domestic Cats
Weerarathne, P., Maker, R., Huang, C., Taylor, B., Cowan, S. R., Hyatt, J., Selvan, M. T., Shatnawi, S., Thomas, J. E., Meinkoth, J. H., et al. (2023) · Vaccines · doi:10.3390/vaccines11030573 · Cited by 2 · see citing works
Recent Advancement of Microneedle Technique in Diagnosis and Therapy of Diseases
Kanugo, A. (2023) · International Journal of Pharmaceutical Sciences and Nanotechnology · doi:10.37285/ijpsn.2023.16.4.8 · Cited by 2 · see citing works
Choi, S. J., Lee, W., Kim, S. C., Jo, H.-Y., Park, H., Kim, H. B., Park, W., Park, S. H., Ko, J., & Lee, J. S. (2024) · Vaccine · doi:10.1016/j.vaccine.2024.07.019 · Cited by 2 · see citing works
Lu, S., Lee, Y.-Y., Andres, F. G. M., Moyer, D. A., & Barry, M. A. (2024) · Molecular Therapy — Methods & Clinical Development · doi:10.1016/j.omtm.2024.101356 · Cited by 2 · see citing works
Achievement of maximal SARS-CoV-2 collective immunity among the Tajik population by March 2022
Popova, A. Y., Смирнов, В. С., Egorova, S. A., Abdullozoda, J. A., Мехмондустович, Р. М., Milichkina, A. M., Ivanov, V. A., Д., В. С., Ramsay, E. S., Mullodzhanova, M. M., et al. (2023) · Medical Immunology (Russia) · doi:10.15789/1563-0625-aom-2630 · Cited by 2 · see citing works
Cheng, L., Chan, W. K., Lijie, Z., Chao, M. H., & Wang, Y. (2024) · Vaccines · doi:10.3390/vaccines12050552 · Cited by 2 · see citing works
Weiss, F., Kolibius, J., Freitag, P. C., Gantenbein, F., Kipar, A., & Plückthun, A. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.04.27.591433 · Cited by 2 · see citing works
Manufacturing and Control of Viral‐Vector Vaccines
Chavda, V. P., Vaghela, D. A., Barman, D., Newar, A., & Ahmed, N. (2025) · doi:10.1002/9781394271566.ch8 · Cited by 2 · see citing works
Tennakoon, M. S. B. W. T. M. N. S., Park, J., Lee, H., Ryu, J.-H., & Shin, H. (2025) · Microbial Pathogenesis · doi:10.1016/j.micpath.2025.107509 · Cited by 1 · see citing works
Adenovirus-Based Single-Dose Vaccines for SARS-CoV-2: A Review
Chavda, V. P., Mehta, A. A., Zafar, H., Raza, F., Paiva‐Santos, A. C., Balar, P. C., Apostolopoulos, V., & Vora, L. K. (2025) · Frontiers in Bioscience-Landmark · doi:10.31083/fbl25094 · Cited by 2 · see citing works
Xu, H., Wang, T., Zhang, Y., Wang, H., Yu, S., Hou, X., Zhang, B., Sun, P., Wu, J., & Liu, B. (2025) · Glycoscience & Therapy · doi:10.1016/j.glycos.2025.100019 · Cited by 1 · see citing works
The role of TgEfhc3 in Toxoplasma gondii biology and its prospects as a subunit vaccine
Tian, X., Ma, H., Wang, Q., Zhu, B., Li, Y., Zhang, J., Wang, J., Hu, Y., Li, Y., Zhang, Z., et al. (2026) · Parasites & Vectors · doi:10.1186/s13071-026-07274-8 · Cited by 1 · see citing works
Oba, M., Borjigin, S., Kikuchi, F., Oi, T., Takemae, H., Ishida, H., Murakami, H., Aihara, N., Shiga, T., Kamiie, J., et al. (2022) · Viruses · doi:10.3390/v14112400 · Cited by 1 · see citing works
Mucosal immune probiotic vector vaccines: Development and prospects for application in COVID-19
Zha, R., Yi, B., Liao, C., Li, X., & Lu, J. (2023) · One Health Bulletin · doi:10.4103/2773-0344.387693 · Cited by 1 · see citing works
Xie, W., Yuan, Y., Liu, B., & Liang, M. (2023) · Acta Virologica · doi:10.3389/av.2023.11642 · Cited by 1 · see citing works
Effect of silencing SSB1 gene on the expression of NBS1 in irradiated rat submandibular gland cells
Gao, L., Lv, Q., Huang, Y., Fan, Y., Zhao, L., Zhao, Y., Wang, X., Mo, D., Lu, H., & Wang, D. (2024) · Cellular and Molecular Biology · doi:10.14715/cmb/2024.70.1.15 · Cited by 1 · see citing works
- Authors
- Sakurai, F., Tachibana, M., & Mizuguchi, H.
- Affiliations
- The University of Osaka (JP)
- Global Center for Medical Engineering and Informatics, The University of Osaka (JP)
- National Institute of Biomedical Innovation, Health and Nutrition (JP)
- Corresponding author
- Sakurai, Fuminori
- Mizuguchi, Hiroyuki
- Venue
- Drug Metabolism and Pharmacokinetics
- Publisher
- Elsevier BV
- Published
- 2022-02
- Volume
- 42
- Pages
- 100432
- ISSN
- 1347-4367 (ISSN-L)
- PMC
- PMC8585960
- OpenAlex
- W3213418684
- Cited by
- 148
- References
- 109
- Citations by year
- 2026: 16 · 2025: 42 · 2024: 37 · 2023: 32 · 2022: 21
- FWCI
- 3.32
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Drug Metabolism and Pharmacokinetics (acceptedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Japan Agency for Medical Research and Development (20fk0108543h0001)
- Japan Society for the Promotion of Science (20H00664)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Virus-based gene therapy research
- Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
- Health Sciences › Medicine › Infectious Diseases › SARS-CoV-2 and COVID-19 Research
- Keywords
- adenoviral vector, vaccine vectors, infectious disease vaccines, gene delivery, innate immunity, immune response, Ebola virus disease, AIDS, COVID-19 pandemic
- MeSH terms
- COVID-19, SARS-CoV-2, Adenoviridae, Communicable Diseases, Genetic Vectors, Humans, Vaccines, Adenovirus Vaccines
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review