Eukaryotic DNA damage checkpoint activation in response to double-strand breaks

Hallmarks of Cancer: The Next Generation

Hanahan, D., & Weinberg, R. A. (2011) · Cell · doi:10.1016/j.cell.2011.02.013 · Cited by 66,590 · see citing works

Crystal structure of the nucleosome core particle at 2.8 Å resolution

Luger, K., Mäder, A. W., Richmond, R. K., Sargent, D. F., & Richmond, T. J. (1997) · Nature · doi:10.1038/38444 · Cited by 9,466 · see citing works

Epigenetic Regulations of GABAergic Neurotransmission: Relevance for Neurological Disorders and Epigenetic Therapy

Shrestha, S., & Offer, S. M. (2016) · Medical Epigenetics · doi:10.1159/000444713 · Cited by 8,949 · see citing works

CDK inhibitors: positive and negative regulators of G1-phase progression

Sherr, C. J., & Roberts, J. M. (1999) · Genes & Development · doi:10.1101/gad.13.12.1501 · Cited by 6,115 · see citing works

The DNA-damage response in human biology and disease

Jackson, S. P., & Bartek, J. (2009) · Nature · doi:10.1038/nature08467 · Cited by 6,092 · see citing works

Instability and decay of the primary structure of DNA

Lindahl, T. (1993) · Nature · doi:10.1038/362709a0 · Cited by 5,679 · see citing works

DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139

Rogakou, E. P., Pilch, D. R., Orr, A. H., Ivanova, V. S., & Bonner, W. M. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.10.5858 · Cited by 5,438 · see citing works

A comprehensive analysis of protein–protein interactions in Saccharomyces cerevisiae

Uetz, P., Giot, L., Cagney, G., Mansfield, T. A., Judson, R. S., Knight, J. R., Lockshon, D., Narayan, V., Srinivasan, M., Pochart, P., et al. (2000) · Nature · doi:10.1038/35001009 · Cited by 4,706 · see citing works

Mdm2 promotes the rapid degradation of p53

Haupt, Y., Maya, R., Kazaz, A., & Oren, M. (1997) · Nature · doi:10.1038/387296a0 · Cited by 4,506 · see citing works

The DNA Damage Response: Making It Safe to Play with Knives

Ciccia, A., & Elledge, S. J. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.09.019 · Cited by 4,368 · see citing works

Global, In Vivo, and Site-Specific Phosphorylation Dynamics in Signaling Networks

Olsen, J. V., Blagoev, B., Gnad, F., Maček, B., Kumar, C., Mortensen, P., & Mann, M. (2006) · Cell · doi:10.1016/j.cell.2006.09.026 · Cited by 3,484 · see citing works

DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation

Bakkenist, C. J., & Kastan, M. B. (2003) · Nature · doi:10.1038/nature01368 · Cited by 3,466 · see citing works

Molecular Mechanisms of Mammalian DNA Repair and the DNA Damage Checkpoints

Sancar, A., Lindsey-Boltz, L. A., Ünsal-Kaçmaz, K., & Linn, S. (2004) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.73.011303.073723 · Cited by 3,317 · see citing works

The DNA damage response: putting checkpoints in perspective

Zhou, B.-B. S., & Elledge, S. J. (2000) · Nature · doi:10.1038/35044005 · Cited by 3,213 · see citing works

Checkpoints: Controls That Ensure the Order of Cell Cycle Events

Hartwell, L. H., & Weinert, T. A. (1989) · Science · doi:10.1126/science.2683079 · Cited by 3,053 · see citing works

The mechanism of double-strand DNA break repair by the nonhomologous DNA end-joining pathway

Lieber, M. R. (2010) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.052308.093131 · Cited by 2,882 · see citing works

Sensing DNA Damage Through ATRIP Recognition of RPA-ssDNA Complexes

Zou, L., & Elledge, S. J. (2003) · Science · doi:10.1126/science.1083430 · Cited by 2,693 · see citing works

Megabase Chromatin Domains Involved in DNA Double-Strand Breaks in Vivo

Rogakou, E. P., Boon, C., Redon, C., & Bonner, W. M. (1999) · The Journal of Cell Biology · doi:10.1083/jcb.146.5.905 · Cited by 2,422 · see citing works

Multiple Pathways of Recombination Induced by Double-Strand Breaks in <i>Saccharomyces cerevisiae</i>

Pâques, F., & Haber, J. E. (1999) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.63.2.349-404.1999 · Cited by 2,120 · see citing works

Activation of the ATM Kinase by Ionizing Radiation and Phosphorylation of p53

Canman, C. E., Lim, D.-S., Cimprich, K. A., Taya, Y., Tamai, K., Sakaguchi, K., Appella, E., Kastan, M. B., & Siliciano, J. D. (1998) · Science · doi:10.1126/science.281.5383.1677 · Cited by 2,042 · see citing works

ATM Phosphorylates Histone H2AX in Response to DNA Double-strand Breaks

Burma, S., Chen, B. P., Murphy, M., Kurimasa, A., & Chen, D. J. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.c100466200 · Cited by 1,954 · see citing works

ATR: an essential regulator of genome integrity

Cimprich, K. A., & Cortez, D. (2008) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2450 · Cited by 1,798 · see citing works

The DNA Damage Response: Ten Years After

Harper, J. W., & Elledge, S. J. (2007) · Molecular Cell · doi:10.1016/j.molcel.2007.11.015 · Cited by 1,705 · see citing works

A quantitative atlas of mitotic phosphorylation

Dephoure, N., Zhou, C., Villén, J., Beausoleil, S. A., Bakalarski, C. E., Elledge, S. J., & Gygi, S. P. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0805139105 · Cited by 1,608 · see citing works

Genetic Control of the Cell Division Cycle in Yeast

Hartwell, L. H., Culotti, J. G., Pringle, J. R., & Reid, B. J. (1974) · Science · doi:10.1126/science.183.4120.46 · Cited by 1,567 · see citing works

Impaired microRNA processing enhances cellular transformation and tumorigenesis

Kumar, M. S., Lü, J., Mercer, K. L., Golub, T. R., & Jacks, T. (2007) · Nature Genetics · doi:10.1038/ng2003 · Cited by 1,452 · see citing works

ATM Activation by DNA Double-Strand Breaks Through the Mre11-Rad50-Nbs1 Complex

Lee, J.-H., & Paull, T. T. (2005) · Science · doi:10.1126/science.1108297 · Cited by 1,424 · see citing works

Genomic Instability in Mice Lacking Histone H2AX

Celeste, A., Petersen, S., Romanienko, P. J., Fernandez-Capetillo, O., Chen, H. T., Sedelnikova, O. A., Reina-San-Martin, B., Coppola, V., Meffre, E., Difilippantonio, M. J., et al. (2002) · Science · doi:10.1126/science.1069398 · Cited by 1,385 · see citing works

Human CtIP promotes DNA end resection

Sartori, A. A., Lukas, C., Coates, J., Mistrik, M., Fu, S., Bartek, J., Baer, R., Lukas, J., & Jackson, S. P. (2007) · Nature · doi:10.1038/nature06337 · Cited by 1,362 · see citing works

Mitotic and G ₂ Checkpoint Control: Regulation of 14-3-3 Protein Binding by Phosphorylation of Cdc25C on Serine-216

Peng, C.-Y., Graves, P. R., Thoma, R. S., Wu, Z., Shaw, A. S., & Piwnica-Worms, H. (1997) · Science · doi:10.1126/science.277.5331.1501 · Cited by 1,341 · see citing works

Conservation of the Chk1 Checkpoint Pathway in Mammals: Linkage of DNA Damage to Cdk Regulation Through Cdc25

Sanchez, Y., Wong, C., Thoma, R. S., Richman, R., Wu, Z., Piwnica-Worms, H., & Elledge, S. J. (1997) · Science · doi:10.1126/science.277.5331.1497 · Cited by 1,320 · see citing works

Suppression of induced pluripotent stem cell generation by the p53–p21 pathway

Hong, H., Takahashi, K., Ichisaka, T., Aoi, T., Kanagawa, O., Nakagawa, M., Okita, K., & Yamanaka, S. (2009) · Nature · doi:10.1038/nature08235 · Cited by 1,301 · see citing works

DNA Damage-Induced Activation of p53 by the Checkpoint Kinase Chk2

Hirao, A., Kong, Y., Matsuoka, S., Wakeham, A. C., Ruland, J., Yoshida, H., Liu, D., Elledge, S. J., & Mak, T. W. (2000) · Science · doi:10.1126/science.287.5459.1824 · Cited by 1,288 · see citing works

The ATM–Chk2 and ATR–Chk1 Pathways in DNA Damage Signaling and Cancer

Smith, J., Tho, L. M., Xu, N., & Gillespie, D. A. (2010) · Advances in cancer research · doi:10.1016/b978-0-12-380888-2.00003-0 · Cited by 1,279 · see citing works

Conserved modes of recruitment of ATM, ATR and DNA-PKcs to sites of DNA damage

Falck, J., Coates, J., & Jackson, S. P. (2005) · Nature · doi:10.1038/nature03442 · Cited by 1,248 · see citing works

Tyrosine phosphorylation of the fission yeast cdc2+ protein kinase regulates entry into mitosis

Gould, K. L., & Nurse, P. (1989) · Nature · doi:10.1038/342039a0 · Cited by 1,235 · see citing works

The DNA-dependent protein kinase: Requirement for DNA ends and association with Ku antigen

Gottlieb, T. M., & Jackson, S. P. (1993) · Cell · doi:10.1016/0092-8674(93)90057-w · Cited by 1,233 · see citing works

Regulation of DNA repair throughout the cell cycle

Branzei, D., & Foiani, M. (2008) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2351 · Cited by 1,228 · see citing works

Structure of the Ku heterodimer bound to DNA and its implications for double-strand break repair

Walker, J. R., Corpina, R. A., & Goldberg, J. D. (2001) · Nature · doi:10.1038/35088000 · Cited by 1,216 · see citing works

The RAD9 Gene Controls the Cell Cycle Response to DNA Damage in Saccharomyces cerevisiae

Weinert, T. A., & Hartwell, L. H. (1988) · Science · doi:10.1126/science.3291120 · Cited by 1,171 · see citing works

RNF8 Ubiquitylates Histones at DNA Double-Strand Breaks and Promotes Assembly of Repair Proteins

Mailand, N., Bekker‐Jensen, S., Kildegaard, H. F., Melander, F., Bártek, J., Lukas, C., & Lukas, J. (2007) · Cell · doi:10.1016/j.cell.2007.09.040 · Cited by 1,153 · see citing works

Histone H2AX is phosphorylated in an ATR-dependent manner in response to replicational stress

Ward, I. M., & Chen, J. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.c100569200 · Cited by 1,150 · see citing works

Linking the p53 tumour suppressor pathway to somatic cell reprogramming

Kawamura, T., Suzuki, J., Wang, Y. V., Menendez, S., Morera, L. B., Raya, A., Wahl, G. M., & Belmonte, J. C. I. (2009) · Nature · doi:10.1038/nature08311 · Cited by 1,115 · see citing works

MDC1 Directly Binds Phosphorylated Histone H2AX to Regulate Cellular Responses to DNA Double-Strand Breaks

Stucki, M., Clapperton, J. A., Mohammad, D. H., Yaffe, M. B., Smerdon, S. J., & Jackson, S. P. (2005) · Cell · doi:10.1016/j.cell.2005.09.038 · Cited by 1,103 · see citing works

Dynamics of DNA damage response proteins at DNA breaks: a focus on protein modifications

Polo, S. E., & Jackson, S. P. (2011) · Genes &amp; Development · doi:10.1101/gad.2021311 · Cited by 1,092 · see citing works

The ATM-Chk2-Cdc25A checkpoint pathway guards against radioresistant DNA synthesis

Falck, J., Mailand, N., Syljuåsen, R. G., Bartek, J., & Lukas, J. (2001) · Nature · doi:10.1038/35071124 · Cited by 1,085 · see citing works

Regulation of Homologous Recombination in Eukaryotes

Heyer, W.-D., Ehmsen, K. T., & Liu, J. (2010) · Annual Review of Genetics · doi:10.1146/annurev-genet-051710-150955 · Cited by 1,066 · see citing works

ATM- and cell cycle-dependent regulation of ATR in response to DNA double-strand breaks

Jazayeri, A., Falck, J., Lukas, C., Bartek, J., Smith, G. C. M., Lukas, J., & Jackson, S. P. (2006) · Nature Cell Biology · doi:10.1038/ncb1337 · Cited by 1,064 · see citing works

Sgs1 Helicase and Two Nucleases Dna2 and Exo1 Resect DNA Double-Strand Break Ends

Zhu, Z., Chung, W.-H., Shim, E. Y., Lee, S. E., & Ira, G. (2008) · Cell · doi:10.1016/j.cell.2008.08.037 · Cited by 1,041 · see citing works

A p53-mediated DNA damage response limits reprogramming to ensure iPS cell genomic integrity

Marión, R. M., Strati, K., Li, H., Murga, M., Blanco, R., Ortega, S., Fernandez-Capetillo, O., Serrano, M., & Blasco, M. A. (2009) · Nature · doi:10.1038/nature08287 · Cited by 1,028 · see citing works

RNF8 Transduces the DNA-Damage Signal via Histone Ubiquitylation and Checkpoint Protein Assembly

Huen, M. S. Y., Grant, R. A., Manke, I. A., Minn, K. T., Yu, X., Yaffe, M. B., & Chen, J. (2007) · Cell · doi:10.1016/j.cell.2007.09.041 · Cited by 1,027 · see citing works

ATM and DNA-PK Function Redundantly to Phosphorylate H2AX after Exposure to Ionizing Radiation

Stiff, T., O’Driscoll, M., Rief, N., Iwabuchi, K., Löbrich, M., & Jeggo, P. A. (2004) · Cancer Research · doi:10.1158/0008-5472.can-03-3207 · Cited by 1,010 · see citing works

Sae2, Exo1 and Sgs1 collaborate in DNA double-strand break processing

Mimitou, E. P., & Symington, L. S. (2008) · Nature · doi:10.1038/nature07312 · Cited by 1,009 · see citing works

Histone H2AX phosphorylation is dispensable for the initial recognition of DNA breaks

Celeste, A., Fernandez-Capetillo, O., Kruhlak, M. J., Pilch, D. R., Staudt, D. W., Lee, A., Bonner, R. F., Bonner, W. M., & Nussenzweig, A. (2003) · Nature Cell Biology · doi:10.1038/ncb1004 · Cited by 989 · see citing works

ATR and ATRIP: Partners in Checkpoint Signaling

Cortez, D., Guntuku, S., Qin, J., & Elledge, S. J. (2001) · Science · doi:10.1126/science.1065521 · Cited by 985 · see citing works

Structural Basis for the Methylation State-Specific Recognition of Histone H4-K20 by 53BP1 and Crb2 in DNA Repair

Botuyan, M. V., Lee, J., Ward, I. M., Kim, J., Thompson, J. R., Chen, J., & Mer, G. (2006) · Cell · doi:10.1016/j.cell.2006.10.043 · Cited by 973 · see citing works

The human homologs of checkpoint kinases Chk1 and Cds1 (Chk2) phosphorylate p53 at multiple DNA damage-inducible sites.

Shieh, S.-Y., Ahn, J., Tamai, K., Taya, Y., & Prives, C. (2000) · Genes &amp; Development · doi:10.1101/gad.14.3.289 · Cited by 972 · see citing works

The Ink4/Arf locus is a barrier for iPS cell reprogramming

Li, H., Collado, M., Villasante, A., Strati, K., Ortega, S., Cañamero, M., Blasco, M. A., & Serrano, M. (2009) · Nature · doi:10.1038/nature08290 · Cited by 968 · see citing works

RNF168 Binds and Amplifies Ubiquitin Conjugates on Damaged Chromosomes to Allow Accumulation of Repair Proteins

Doil, C., Mailand, N., Bekker‐Jensen, S., Ménard, P., Larsen, D. H., Pepperkok, R., Ellenberg, J., Panier, S., Durocher, D., Bártek, J., et al. (2009) · Cell · doi:10.1016/j.cell.2008.12.041 · Cited by 938 · see citing works

Orchestration of the DNA-Damage Response by the RNF8 Ubiquitin Ligase

Kolas, N. K., Chapman, J. R., Nakada, S., Ylanko, J., Chahwan, R., Sweeney, F. D., Panier, S., Mendez, M., Wildenhain, J., Thomson, T. M., et al. (2007) · Science · doi:10.1126/science.1150034 · Cited by 900 · see citing works

Immortalization eliminates a roadblock during cellular reprogramming into iPS cells

Utikal, J., Polo, J., Stadtfeld, M., Maherali, N., Kulalert, W., Walsh, R. M., Khalil, A., Rheinwald, J., & Hochedlinger, K. (2009) · Nature · doi:10.1038/nature08285 · Cited by 896 · see citing works

Targets of the cyclin-dependent kinase Cdk1

Ubersax, J. A., Woodbury, E. L., Quang, P. N., Paraz, M., Blethrow, J. D., Shah, K., Shokat, K. M., & Morgan, D. O. (2003) · Nature · doi:10.1038/nature02062 · Cited by 892 · see citing works

Choreography of the DNA Damage Response

Lisby, M., Barlow, J. H., Burgess, R. C., & Rothstein, R. (2004) · Cell · doi:10.1016/j.cell.2004.08.015 · Cited by 891 · see citing works

The B-type cyclin kinase inhibitor p40SIC1 controls the G1 to S transition in S. cerevisiae

Schwob, É. (1994) · Cell · doi:10.1016/0092-8674(94)90193-7 · Cited by 886 · see citing works

Methylated lysine 79 of histone H3 targets 53BP1 to DNA double-strand breaks

Huyen, Y., Zgheib, O., DiTullio Jr, R. A., Gorgoulis, V. G., Zacharatos, P., Petty, T. J., Sheston, E. A., Mellert, H. S., Stavridi, E. S., & Halazonetis, T. D. (2004) · Nature · doi:10.1038/nature03114 · Cited by 884 · see citing works

Untitled work

(2006) · Cited by 879 · see citing works

MDC1 is a mediator of the mammalian DNA damage checkpoint

Stewart, G. S., Wang, B., Bignell, C. R., Taylor, A. M. R., & Elledge, S. J. (2003) · Nature · doi:10.1038/nature01446 · Cited by 874 · see citing works

Global Analysis of Cdk1 Substrate Phosphorylation Sites Provides Insights into Evolution

Holt, L. J., Tuch, B. B., Villén, J., Johnson, A. D., Gygi, S. P., & Morgan, D. O. (2009) · Science · doi:10.1126/science.1172867 · Cited by 859 · see citing works

Dot1p Modulates Silencing in Yeast by Methylation of the Nucleosome Core

van Leeuwen, F., Gafken, P. R., & Gottschling, D. E. (2002) · Cell · doi:10.1016/s0092-8674(02)00759-6 · Cited by 853 · see citing works

Chk2/hCds1 functions as a DNA damage checkpoint in G₁by stabilizing p53

Chehab, N. H., Malikzay, A., Appel, M., & Halazonetis, T. D. (2000) · Genes &amp; Development · doi:10.1101/gad.14.3.278 · Cited by 805 · see citing works

Rapid Destruction of Human Cdc25A in Response to DNA Damage

Mailand, N., Falck, J., Lukas, C., Syljuåsen, R. G., Welcker, M., Bartek, J., & Lukas, J. (2000) · Science · doi:10.1126/science.288.5470.1425 · Cited by 787 · see citing works

DNA damage checkpoints: from initiation to recovery or adaptation

Bartek, J., & Lukas, J. (2007) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2007.02.009 · Cited by 784 · see citing works

Saccharomyces Ku70, Mre11/Rad50, and RPA Proteins Regulate Adaptation to G2/M Arrest after DNA Damage

Lee, S. E., Moore, J. K., Holmes, A. M., Umezu, K., Kolodner, R. D., & Haber, J. E. (1998) · Cell · doi:10.1016/s0092-8674(00)81482-8 · Cited by 775 · see citing works

Toward Maintaining the Genome: DNA Damage and Replication Checkpoints

Nyberg, K. A., Michelson, R. J., Putnam, C. W., & Weinert, T. A. (2002) · Annual Review of Genetics · doi:10.1146/annurev.genet.36.060402.113540 · Cited by 770 · see citing works

BLM–DNA2–RPA–MRN and EXO1–BLM–RPA–MRN constitute two DNA end resection machineries for human DNA break repairPreprint

Nimonkar, A. V., Genschel, J., Kinoshita, E., Polaczek, P., Campbell, J. L., Wyman, C., Modrich, P. L., & Kowalczykowski, S. C. (2011) · Genes & Development · doi:10.1101/gad.2003811 · Cited by 767 · see citing works

The RIDDLE Syndrome Protein Mediates a Ubiquitin-Dependent Signaling Cascade at Sites of DNA Damage

Stewart, G. S., Panier, S., Townsend, K., Al-Hakim, A., Kolas, N. K., Miller, E. S., Nakada, S., Ylanko, J., Olivarius, S., Mendez, M., et al. (2009) · Cell · doi:10.1016/j.cell.2008.12.042 · Cited by 757 · see citing works

The DNA replication checkpoint response stabilizes stalled replication forks

Lopes, M., Cotta‐Ramusino, C., Pellicioli, A., Liberi, G., Plevani, P., Muzi-Falconi, M., Newlon, C. S., & Foiani, M. (2001) · Nature · doi:10.1038/35087613 · Cited by 749 · see citing works

TopBP1 Activates the ATR-ATRIP Complex

Kumagai, A., Lee, J., Yoo, H. Y., & Dunphy, W. G. (2006) · Cell · doi:10.1016/j.cell.2005.12.041 · Cited by 743 · see citing works

GENETIC CONTROL OF THE CELL DIVISION CYCLE IN YEAST: V. GENETIC ANALYSIS OF cdc MUTANTS

Hartwell, L. H., Mortimer, R., Culotti, J. G., & Culotti, M. (1973) · Genetics · doi:10.1093/genetics/74.2.267 · Cited by 740 · see citing works

A role for the Tip60 histone acetyltransferase in the acetylation and activation of ATM

Sun, Y., Jiang, X., Chen, S., Fernandes, N., & Price, B. D. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0504211102 · Cited by 738 · see citing works

DNA end resection, homologous recombination and DNA damage checkpoint activation require CDK1

Ira, G., Pellicioli, A., Balijja, A., Wang, X., Fiorani, S., Carotenuto, W., Liberi, G., Bressan, D., Wan, L., Hollingsworth, N. M., et al. (2004) · Nature · doi:10.1038/nature02964 · Cited by 722 · see citing works

Regulation of DNA replication fork progression through damaged DNA by the Mec1/Rad53 checkpoint

Tercero, J. A., & Diffley, J. F. X. (2001) · Nature · doi:10.1038/35087607 · Cited by 667 · see citing works

A Mec1- and Rad53-dependent checkpoint controls late-firing origins of DNA replication

Santocanale, C., & Diffley, J. F. X. (1998) · Nature · doi:10.1038/27001 · Cited by 663 · see citing works

A role for Saccharomyces cerevisiae histone H2A in DNA repair

Downs, J. A., Lowndes, N. F., & Jackson, S. P. (2000) · Nature · doi:10.1038/35050000 · Cited by 650 · see citing works

DNA damage-induced G2–M checkpoint activation by histone H2AX and 53BP1

Fernández-Capetillo, Ó., Chen, H. T., Celeste, A., Ward, I. M., Romanienko, P. J., Morales, J. C., Naka, K., Xia, Z., Camerini‐Otero, R. D., Motoyama, N., et al. (2002) · Nature Cell Biology · doi:10.1038/ncb884 · Cited by 644 · see citing works

The RING heterodimer BRCA1-BARD1 is a ubiquitin ligase inactivated by a breast cancer-derived mutation

Hashizume, R., Fukuda, M., Maeda, I., Nishikawa, H., Oyake, D., Yabuki, Y., Ogata, H., & Ohta, T. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.c000881200 · Cited by 634 · see citing works

MDC1 Maintains Genomic Stability by Participating in the Amplification of ATM-Dependent DNA Damage Signals

Lou, Z., Minter‐Dykhouse, K., Franco, S., Gostissa, M., Rivera, M. A., Celeste, A., Manis, J. P., van Deursen, J., Nussenzweig, A., Paull, T. T., et al. (2006) · Molecular Cell · doi:10.1016/j.molcel.2005.11.025 · Cited by 629 · see citing works

MicroRNA regulation by RNA-binding proteins and its implications for cancer

van Kouwenhove, M., Kedde, M., & Agami, R. (2011) · Nature Reviews Cancer · doi:10.1038/nrc3107 · Cited by 617 · see citing works

An ESP1/PDS1 Complex Regulates Loss of Sister Chromatid Cohesion at the Metaphase to Anaphase Transition in Yeast

Ciosk, R., Zachariae, W., Michaelis, C., Shevchenko, A., Mann, M., & Nasmyth, K. (1998) · Cell · doi:10.1016/s0092-8674(00)81211-8 · Cited by 595 · see citing works

A checkpoint regulates the rate of progression through S phase in S. cerevisiae in Response to DNA damage

Paulovich, A. G., & Hartwell, L. H. (1995) · Cell · doi:10.1016/0092-8674(95)90481-6 · Cited by 588 · see citing works

Regulation of G1 cyclin-dependent kinases in the mammalian cell cycle

Ekholm, S. V., & Reed, S. I. (2000) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(00)00151-4 · Cited by 587 · see citing works

Regulation of <i>RAD53</i> by the <i>ATM</i> -Like Kinases <i>MEC1</i> and <i>TEL1</i> in Yeast Cell Cycle Checkpoint Pathways

Sanchez, Y., Desany, B. A., Jones, W. J., Liu, Q., Wang, B., & Elledge, S. J. (1996) · Science · doi:10.1126/science.271.5247.357 · Cited by 585 · see citing works

DNA end-joining: from yeast to man

Critchlow, S. E., & Jackson, S. P. (1998) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(98)01284-5 · Cited by 584 · see citing works

Unequal division in Saccharomyces cerevisiae and its implications for the control of cell division.

Hartwell, L. H., & Unger, M. W. (1977) · The Journal of Cell Biology · doi:10.1083/jcb.75.2.422 · Cited by 583 · see citing works

Involvement of the cohesin protein, Smc1, in Atm-dependent and independent responses to DNA damagePreprint

Kim, S., Xu, B., & Kastan, M. B. (2002) · Genes & Development · doi:10.1101/gad.970602 · Cited by 581 · see citing works

PR-Set7 Is a Nucleosome-Specific Methyltransferase that Modifies Lysine 20 of Histone H4 and Is Associated with Silent Chromatin

Nishioka, K., Rice, J. C., Sarma, K., Erdjument‐Bromage, H., Werner, J. K., Wang, Y., Chuikov, S., Valenzuela, P., Tempst, P., Steward, R., et al. (2002) · Molecular Cell · doi:10.1016/s1097-2765(02)00548-8 · Cited by 580 · see citing works

53BP1, a Mediator of the DNA Damage Checkpoint

Wang, B., Matsuoka, S., Carpenter, P. B., & Elledge, S. J. (2002) · Science · doi:10.1126/science.1076182 · Cited by 578 · see citing works

Genetic Control of the Cell-Division Cycle in Yeast, I. Detection of Mutants

Hartwell, L. H., Culotti, J. G., & Reid, B. J. (1970) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.66.2.352 · Cited by 576 · see citing works

Nuclear localization of Cdc25 is regulated by DNA damage and a 14-3-3 protein

Lopez‐Girona, A., Furnari, B. A., Mondésert, O., & Russell, P. R. (1999) · Nature · doi:10.1038/16488 · Cited by 574 · see citing works

53BP1 promotes non-homologous end joining of telomeres by increasing chromatin mobility

Dimitrova, N., Chen, Y.-C. M., Spector, D. L., & de Lange, T. (2008) · Nature · doi:10.1038/nature07433 · Cited by 572 · see citing works

The Rad50 zinc-hook is a structure joining Mre11 complexes in DNA recombination and repair

Hopfner, K., Craig, L., Moncalián, G., Zinkel, R. A., Usui, T., Owen, B. A. L., Kärcher, A., Henderson, B., Bodmer, J.-L., McMurray, C. T., et al. (2002) · Nature · doi:10.1038/nature00922 · Cited by 571 · see citing works

DNA helicases Sgs1 and BLM promote DNA double-strand break resectionPreprint

Gravel, S., Chapman, J. R., Magill, C. P., & Jackson, S. P. (2008) · Genes & Development · doi:10.1101/gad.503108 · Cited by 562 · see citing works

Chk1 regulates the S phase checkpoint by coupling the physiological turnover and ionizing radiation-induced accelerated proteolysis of Cdc25A

Sørensen, C. S., Syljuåsen, R. G., Falck, J., Schroeder, T., Rönnstrand, L., Khanna, K. K., Zhou, B.-B., Bártek, J., & Lukas, J. (2003) · Cancer Cell · doi:10.1016/s1535-6108(03)00048-5 · Cited by 560 · see citing works

CtIP-BRCA1 modulates the choice of DNA double-strand-break repair pathway throughout the cell cycle

Yun, M. H., & Hiom, K. (2009) · Nature · doi:10.1038/nature07955 · Cited by 556 · see citing works

Phosphorylation of Sld2 and Sld3 by cyclin-dependent kinases promotes DNA replication in budding yeast

Zegerman, P., & Diffley, J. (2007) · Nature · doi:10.1038/nature05432 · Cited by 555 · see citing works

Surviving the Breakup: The DNA Damage Checkpoint

Harrison, J. C., & Haber, J. E. (2006) · Annual Review of Genetics · doi:10.1146/annurev.genet.40.051206.105231 · Cited by 550 · see citing works

H2AX Haploinsufficiency Modifies Genomic Stability and Tumor Susceptibility

Celeste, A., Difilippantonio, S., Difilippantonio, M. J., Fernández-Capetillo, Ó., Pilch, D. R., Sedelnikova, O. A., Eckhaus, M., Ried, T., Bonner, W. M., & Nussenzweig, A. (2003) · Cell · doi:10.1016/s0092-8674(03)00567-1 · Cited by 548 · see citing works

Methylation of Histone H4 Lysine 20 Controls Recruitment of Crb2 to Sites of DNA Damage

Sanders, S. L., Portoso, M., Mata, J., Bähler, J., Allshire, R. C., & Kouzarides, T. (2004) · Cell · doi:10.1016/j.cell.2004.11.009 · Cited by 545 · see citing works

Control of the DNA damage checkpoint by Chk1 and Rad53 protein kinases through distinct mechanisms

Sanchez, Y., Bachant, J., Wang, H., Hu, F., Liu, D., Tetzlaff, M., & Elledge, S. J. (1999) · Science · doi:10.1126/science.286.5442.1166 · Cited by 536 · see citing works

CDK-dependent phosphorylation of Sld2 and Sld3 initiates DNA replication in budding yeast

Tanaka, S., Umemori, T., Hirai, K., Muramatsu, S., Kamimura, Y., & Araki, H. (2007) · Nature · doi:10.1038/nature05465 · Cited by 530 · see citing works

Phosphorylation of SMC1 is a critical downstream event in the ATM–NBS1–BRCA1 pathwayPreprint

Kitagawa, R., Bakkenist, C. J., McKinnon, P. J., & Kastan, M. B. (2004) · Genes & Development · doi:10.1101/gad.1200304 · Cited by 528 · see citing works

Mrc1 transduces signals of DNA replication stress to activate Rad53

Alcasabas, A. A., Osborn, A. J., Bachant, J., Hu, F., Werler, P., Bousset, K., Furuya, K., Diffley, J. F. X., Carr, A. M., & Elledge, S. J. (2001) · Nature Cell Biology · doi:10.1038/ncb1101-958 · Cited by 516 · see citing works

Crosstalk between histone modifications during the DNA damage response

van Attikum, H., & Gasser, S. M. (2009) · Trends in Cell Biology · doi:10.1016/j.tcb.2009.03.001 · Cited by 515 · see citing works

Human CtIP Mediates Cell Cycle Control of DNA End Resection and Double Strand Break Repair

Huertas, P., & Jackson, S. P. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m808906200 · Cited by 511 · see citing works

SMC1 is a downstream effector in the ATM/NBS1 branch of the human S-phase checkpointPreprint

Yazdi, P. T., Wang, Y., Zhao, S., Patel, N., Lee, E. Y.-H. P., & Qin, J. (2002) · Genes & Development · doi:10.1101/gad.970702 · Cited by 505 · see citing works

A Multidimensional Chromatography Technology for In-depth Phosphoproteome Analysis

Albuquerque, C. P., Smolka, M. B., Payne, S. H., Bafna, V., Eng, J., & Zhou, H. (2008) · Molecular &amp; Cellular Proteomics · doi:10.1074/mcp.m700468-mcp200 · Cited by 504 · see citing works

Regulatory phosphorylation of the p34cdc2 protein kinase in vertebrates.

Norbury, C. J., Blow, J. J., & Nurse, P. (1991) · The EMBO Journal · doi:10.1002/j.1460-2075.1991.tb04896.x · Cited by 503 · see citing works

Global proteomic profiling of phosphopeptides using electron transfer dissociation tandem mass spectrometry

Molina, H., Horn, D. M., Tang, N., Mathivanan, S., & Pandey, A. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0611217104 · Cited by 502 · see citing works

The DNA Replication and Damage Checkpoint Pathways Induce Transcription by Inhibition of the Crt1 Repressor

Huang, M., Zhou, Z., & Elledge, S. J. (1998) · Cell · doi:10.1016/s0092-8674(00)81601-3 · Cited by 499 · see citing works

Distribution and Dynamics of Chromatin Modification Induced by a Defined DNA Double-Strand Break

Shroff, R., Arbel‐Eden, A., Pilch, D. R., Ira, G., Bonner, W. M., Petrini, J. H. J., Haber, J. E., & Lichten, M. (2004) · Current Biology · doi:10.1016/j.cub.2004.09.047 · Cited by 499 · see citing works

The SAD1/RAD53 protein kinase controls multiple checkpoints and DNA damage-induced transcription in yeast.Preprint

Allen, J. B., Zhou, Z. Y., Siede, W., Friedberg, E. C., & Elledge, S. J. (1994) · Genes & Development · doi:10.1101/gad.8.20.2401 · Cited by 497 · see citing works

Activation of the phosphatase activity of human cdc25A by a cdk2‐cyclin E dependent phosphorylation at the G1/S transition.

Hoffmann, I., Draetta, G. F., & Karsenti, E. (1994) · The EMBO Journal · doi:10.1002/j.1460-2075.1994.tb06750.x · Cited by 495 · see citing works

BRCA1 tumour suppression occurs via heterochromatin-mediated silencing

Zhu, Q., Pao, G. M., Huynh, A. M., Suh, H., Tonnu, N. U., Nederlof, P. M., Gage, F. H., & Verma, I. M. (2011) · Nature · doi:10.1038/nature10371 · Cited by 486 · see citing works

The Polo‐like kinase Cdc5p and the WD‐repeat protein Cdc20p/fizzy are regulators and substrates of the anaphase promoting complex in Saccharomyces cerevisiae

Shirayama, M., Zachariae, W., Ciosk, R., & Nasmyth, K. (1998) · The EMBO Journal · doi:10.1093/emboj/17.5.1336 · Cited by 483 · see citing works

Histone H2AX

Bassing, C. H., Suh, H., Ferguson, D. O., Chua, K. F., Manis, J. P., Eckersdorff, M., Gleason, M., Bronson, R. T., Lee, C., & Alt, F. W. (2003) · Cell · doi:10.1016/s0092-8674(03)00566-x · Cited by 480 · see citing works

Relocalization of telomeric Ku and SIR proteins in response to DNA strand breaks in yeast

Martin, S. G., Laroche, T., Suka, N., Grunstein, M., & Gasser, S. M. (1999) · Cell · doi:10.1016/s0092-8674(00)80773-4 · Cited by 464 · see citing works

Rapid ATM-dependent phosphorylation of MDM2 precedes p53 accumulation in response to DNA damage

Khosravi, R., Maya, R., Gottlieb, T., Oren, M., Shiloh, Y., & Shkedy, D. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.26.14973 · Cited by 461 · see citing works

CDK targets Sae2 to control DNA-end resection and homologous recombination

Huertas, P., Cortés‐Ledesma, F., Sartori, A. A., Aguilera, A., & Jackson, S. P. (2008) · Nature · doi:10.1038/nature07215 · Cited by 456 · see citing works

Serine 15 phosphorylation stimulates p53 transactivation but does not directly influence interaction with HDM2

Dumaz, N., & Meek, D. W. (1999) · The EMBO Journal · doi:10.1093/emboj/18.24.7002 · Cited by 455 · see citing works

The Rad9–Hus1–Rad1 (9–1–1) clamp activates checkpoint signaling via TopBP1Preprint

Delacroix, S., Wagner, J. M., Kobayashi, M., Yamamoto, K.-I., & Karnitz, L. M. (2007) · Genes & Development · doi:10.1101/gad.1547007 · Cited by 454 · see citing works

Phosphorylation of Sic1p by G 1 Cdk Required for Its Degradation and Entry into S Phase

Verma, R., Annan, R. S., Huddleston, M. J., Carr, S. A., Reynard, G. J., & Deshaies, R. J. (1997) · Science · doi:10.1126/science.278.5337.455 · Cited by 449 · see citing works

Differential phosphorylation of vertebrate p34cdc2 kinase at the G1/S and G2/M transitions of the cell cycle: identification of major phosphorylation sites.

Krek, W., & Nigg, E. A. (1991) · The EMBO Journal · doi:10.1002/j.1460-2075.1991.tb07951.x · Cited by 448 · see citing works

Yeast Ku as a Regulator of Chromosomal DNA End Structure

Gravel, S., Larrivée, M., Labrecque, P., & Wellinger, R. J. (1998) · Science · doi:10.1126/science.280.5364.741 · Cited by 444 · see citing works

DNA end resection by Dna2–Sgs1–RPA and its stimulation by Top3–Rmi1 and Mre11–Rad50–Xrs2

Ćejka, P., Cannavò, E., Polaczek, P., Masuda-Sasa, T., Pokharel, S., Campbell, J. L., & Kowalczykowski, S. C. (2010) · Nature · doi:10.1038/nature09355 · Cited by 442 · see citing works

Claspin, a Novel Protein Required for the Activation of Chk1 during a DNA Replication Checkpoint Response in Xenopus Egg Extracts

Kumagai, A., & Dunphy, W. G. (2000) · Molecular Cell · doi:10.1016/s1097-2765(05)00092-4 · Cited by 430 · see citing works

ATM Activation and Its Recruitment to Damaged DNA Require Binding to the C Terminus of Nbs1

You, Z., Chahwan, C., Bailis, J. M., Hunter, T. R., & Russell, P. R. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.13.5363-5379.2005 · Cited by 428 · see citing works

miR-182-Mediated Downregulation of BRCA1 Impacts DNA Repair and Sensitivity to PARP Inhibitors

Moskwa, P., Buffa, F. M., Pan, Y., Panchakshari, R. A., Gottipati, P., Muschel, R. J., Beech, J. S., Kulshrestha, R., Abdelmohsen, K., Weinstock, D. M., et al. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.12.005 · Cited by 428 · see citing works

Cell Cycle-dependent Complex Formation of BRCA1·CtIP·MRN Is Important for DNA Double-strand Break Repair

Chen, L., Nievera, C. J., Lee, A. Y., & Wu, X. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m710245200 · Cited by 425 · see citing works

Requirement for Atr in phosphorylation of Chk1 and cell cycle regulation in response to DNA replication blocks and UV-damaged DNA in <i>Xenopus</i> egg extracts

Guo, Z., Kumagai, A., Wang, S. X., & Dunphy, W. G. (2000) · Genes &amp; Development · doi:10.1101/gad.842500 · Cited by 417 · see citing works

Yeast Checkpoint Genes in DNA Damage Processing: Implications for Repair and Arrest

Lydall, D. A., & Weinert, T. A. (1995) · Science · doi:10.1126/science.270.5241.1488 · Cited by 416 · see citing works

Regulation of DNA-replication origins during cell-cycle progression

Shirahige, K., Hori, Y., Shiraishi, K., Yamashita, M., Takahashi, K., Obuse, C., Tsurimoto, T., & Yoshikawa, H. (1998) · Nature · doi:10.1038/27007 · Cited by 415 · see citing works

MMSET regulates histone H4K20 methylation and 53BP1 accumulation at DNA damage sites

Pei, H., Zhang, L. M., Luo, K., Qin, Y., Chesi, M., Fei, Y. F., Bergsagel, P. L., Wang, L., You, Z., & Lou, Z. (2011) · Nature · doi:10.1038/nature09658 · Cited by 412 · see citing works

The Mre11 Complex Is Required for Repair of Hairpin-Capped Double-Strand Breaks and Prevention of Chromosome Rearrangements

Lobachev, K. S., Gordenin, D. A., & Resnick, M. A. (2002) · Cell · doi:10.1016/s0092-8674(02)00614-1 · Cited by 412 · see citing works

p53 Binding Protein 53BP1 Is Required for DNA Damage Responses and Tumor Suppression in Mice

Ward, I. M., Minn, K. T., van Deursen, J., & Chen, J. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.7.2556-2563.2003 · Cited by 412 · see citing works

DNA Damage-Induced Cell Cycle Checkpoint Control Requires CtIP, a Phosphorylation-Dependent Binding Partner of BRCA1 C-Terminal Domains

Yu, X., & Chen, J. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.21.9478-9486.2004 · Cited by 410 · see citing works

An overview of Cdk1-controlled targets and processes

Enserink, J. M., & Kolodner, R. D. (2010) · Cell Division · doi:10.1186/1747-1028-5-11 · Cited by 409 · see citing works

Proteome-wide identification of <i>in vivo</i> targets of DNA damage checkpoint kinases

Smolka, M. B., Albuquerque, C. P., Chen, S.-H., & Zhou, H. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0701622104 · Cited by 404 · see citing works

DNA polymerase ϵ links the DNA replication machinery to the S phase checkpoint

Navas, T. A., Zhou, Z. Y., & Elledge, S. J. (1995) · Cell · doi:10.1016/0092-8674(95)90448-4 · Cited by 403 · see citing works

53BP1 functions in an ATM-dependent checkpoint pathway that is constitutively activated in human cancer

DiTullio, R. A., Mochan, T. A., Venere, M., Bártková, J., Sehested, M., Bártek, J., & Halazonetis, T. D. (2002) · Nature Cell Biology · doi:10.1038/ncb892 · Cited by 399 · see citing works

Rad53 FHA Domain Associated with Phosphorylated Rad9 in the DNA Damage Checkpoint

Sun, Z., Hsiao, J., Fay, D. S., & Stern, D. F. (1998) · Science · doi:10.1126/science.281.5374.272 · Cited by 398 · see citing works

Chk1 is a wee1 kinase in the G2 DNA damage checkpoint inhibiting cdc2 by Y15 phosphorylation

O’Connell, M. J., Raleigh, J., Verkade, H. M., & Nurse, P. (1997) · The EMBO Journal · doi:10.1093/emboj/16.3.545 · Cited by 398 · see citing works

Threonine 68 phosphorylation by ataxia telangiectasia mutated is required for efficient activation of Chk2 in response to ionizing radiation.

Ahn, J. Y., Schwarz, J. K., Piwnica-Worms, H. M., & Canman, C. E. (2000) · PubMed · Cited by 396 · see citing works

The FHA Domain Is a Modular Phosphopeptide Recognition Motif

Durocher, D., Henckel, J., Fersht, A. R., & Jackson, S. P. (1999) · Molecular Cell · doi:10.1016/s1097-2765(00)80340-8 · Cited by 396 · see citing works

A Central Role for DNA Replication Forks in Checkpoint Activation and Response

Tercero, J. A., Longhese, M. P., & Diffley, J. F. X. (2003) · Molecular Cell · doi:10.1016/s1097-2765(03)00169-2 · Cited by 394 · see citing works

The DNA damage-dependent intra–S phase checkpoint is regulated by parallel pathways

Falck, J., Petrini, J. H. J., Williams, B. R., Lukas, J., & Bartek, J. (2002) · Nature Genetics · doi:10.1038/ng845 · Cited by 392 · see citing works

The CDK regulates repair of double‐strand breaks by homologous recombination during the cell cycle

Aylon, Y., Liefshitz, B., & Kupiec, M. (2004) · The EMBO Journal · doi:10.1038/sj.emboj.7600469 · Cited by 387 · see citing works

A DNA Damage Response Pathway Controlled by Tel1 and the Mre11 Complex

Usui, T., Ogawa, H., & Petrini, J. H. J. (2001) · Molecular Cell · doi:10.1016/s1097-2765(01)00270-2 · Cited by 384 · see citing works

Two checkpoint complexes are independently recruited to sites of DNA damage in vivo

Melo, J. A., Cohen, J., & Toczyski, D. P. (2001) · Genes &amp; Development · doi:10.1101/gad.903501 · Cited by 384 · see citing works

Mechanism of the ATP-dependent DNA end-resection machinery from Saccharomyces cerevisiae

Niu, H., Chung, W.-H., Zhu, Z., Kwon, Y., Zhao, W., Chi, P., Prakash, R., Seong, C., Liu, D., Lu, L., et al. (2010) · Nature · doi:10.1038/nature09318 · Cited by 378 · see citing works

A p53 Amino-Terminal Nuclear Export Signal Inhibited by DNA Damage-Induced Phosphorylation

Zhang, Y., & Xiong, Y. (2001) · Science · doi:10.1126/science.1058637 · Cited by 378 · cited 1× · see citing works

Interaction of Ku protein and DNA-dependent protein kinase catalytic subunit with nucleic acids

Dynan, W. S., & Yoo, S. (1998) · Nucleic Acids Research · doi:10.1093/nar/26.7.1551 · Cited by 376 · see citing works

Mrc1 is a replication fork component whose phosphorylation in response to DNA replication stress activates Rad53Preprint

Osborn, A. J., & Elledge, S. J. (2003) · Genes & Development · doi:10.1101/gad.1098303 · Cited by 371 · see citing works

TEL1, an S. cerevisiae homolog of the human gene mutated in ataxia telangiectasia, is functionally related to the yeast checkpoint gene, MEC1

Morrow, D. M., Tagle, D. A., Shiloh, Y., Collins, F. S., & Hieter, P. (1995) · Cell · doi:10.1016/0092-8674(95)90480-8 · Cited by 370 · see citing works

TopBP1 activates ATR through ATRIP and a PIKK regulatory domainPreprint

Mordes, D. A., Glick, G. G., Zhao, R., & Cortez, D. (2008) · Genes & Development · doi:10.1101/gad.1666208 · Cited by 368 · see citing works

Biochemical Characterization of DNA Damage Checkpoint Complexes: Clamp Loader and Clamp Complexes with Specificity for 5′ Recessed DNA

Ellison, V., & Stillman, B. (2003) · PLoS Biology · doi:10.1371/journal.pbio.0000033 · Cited by 363 · see citing works

Pds1p, an inhibitor of anaphase in budding yeast, plays a critical role in the APC and checkpoint pathway(s).

Yamamoto, A., Guacci, V., & Koshland, D. E. (1996) · The Journal of Cell Biology · doi:10.1083/jcb.133.1.99 · Cited by 353 · see citing works

Single-Stranded DNA Orchestrates an ATM-to-ATR Switch at DNA Breaks

Shiotani, B., & Zou, L. (2009) · Molecular Cell · doi:10.1016/j.molcel.2009.01.024 · Cited by 353 · see citing works

DUN1 encodes a protein kinase that controls the DNA damage response in yeast

Zhou, Z. Y., & Elledge, S. J. (1993) · Cell · doi:10.1016/0092-8674(93)90321-g · Cited by 346 · see citing works

Purification and Functional Characterization of SET8, a Nucleosomal Histone H4-Lysine 20-Specific Methyltransferase

Fang, J., Feng, Q. F., Ketel, C. S., Wang, H., Cao, R., Xia, L., Erdjument‐Bromage, H., Tempst, P., Simon, J. A., & Zhang, Y. (2002) · Current Biology · doi:10.1016/s0960-9822(02)00924-7 · Cited by 343 · see citing works

Replication checkpoint requires phosphorylation of the phosphatase Cdc25 by Cds1 or Chk1

Zeng, Y., Forbes, K. C., Wu, Z., Moreno, S., Piwnica-Worms, H. M., & Enoch, T. (1998) · Nature · doi:10.1038/26766 · Cited by 341 · see citing works

How do Cdc7 and cyclin-dependent kinases trigger the initiation of chromosome replication in eukaryotic cells?Preprint

Labib, K. P. M. (2010) · Genes & Development · doi:10.1101/gad.1933010 · Cited by 340 · see citing works

53BP1-dependent robust localized KAP-1 phosphorylation is essential for heterochromatic DNA double-strand break repair

Noon, A. T., Shibata, A., Rief, N., Löbrich, M., Stewart, G. S., Jeggo, P. A., & Goodarzi, A. A. (2010) · Nature Cell Biology · doi:10.1038/ncb2017 · Cited by 339 · see citing works

Cell Cycle Regulation in the Yeasts Saccharomyces cerevisiae and Schizosaccharomyces pombe

Forsburg, S. L., & Nurse, P. (1991) · Annual Review of Cell Biology · doi:10.1146/annurev.cb.07.110191.001303 · Cited by 328 · see citing works

Phosphorylation Dynamics during Early Differentiation of Human Embryonic Stem Cells

Hoof, D. V., Muñoz, J., Braam, S. R., Pinkse, M. W. H., Linding, R., Heck, A. J. R., Mummery, C. L., & Krijgsveld, J. (2009) · Cell stem cell · doi:10.1016/j.stem.2009.05.021 · Cited by 323 · see citing works

Ku prevents Exo1 and Sgs1‐dependent resection of DNA ends in the absence of a functional MRX complex or Sae2

Mimitou, E. P., & Symington, L. S. (2010) · The EMBO Journal · doi:10.1038/emboj.2010.193 · Cited by 322 · see citing works

Mislocalized Activation of Oncogenic RTKs Switches Downstream Signaling Outcomes

Choudhary, C., Olsen, J. V., Brandts, C., Cox, J., Reddy, P. N. G., Böhmer, F., Gerke, V., Schmidt‐Arras, D., Berdel, W. E., Müller‐Tidow, C., et al. (2009) · Molecular Cell · doi:10.1016/j.molcel.2009.09.019 · Cited by 321 · see citing works

DNA Damage-Induced Acetylation of Lysine 3016 of ATM Activates ATM Kinase Activity

Sun, Y., Xu, Y., Roy, K., & Price, B. D. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.01382-07 · Cited by 319 · see citing works

Sae2 is an endonuclease that processes hairpin DNA cooperatively with the Mre11/Rad50/Xrs2 complex.

Lengsfeld, B., Rattray, A., Bhaskara, V., Ghirlando, R., & Paull, T. (2007) · Molecules and Cells · doi:10.1016/j.molcel.2007.11.001 · Cited by 316 · see citing works

Profiling of UV-induced ATM/ATR signaling pathways

Stokes, M. P., Rush, A. J., MacNeill, J., Ren, J. M., Sprott, K. M., Nardone, J., Yang, V., Beausoleil, S. A., Gygi, S. P., Livingstone, M., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0707579104 · Cited by 313 · see citing works

Coupling of Human Circadian and Cell Cycles by the Timeless Protein

Ünsal-Kaçmaz, K., Mullen, T. E., Kaufmann, W. K., & Sancar, A. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.8.3109-3116.2005 · Cited by 310 · see citing works

Promotion of Dnl4-Catalyzed DNA End-Joining by the Rad50/Mre11/Xrs2 and Hdf1/Hdf2 Complexes

Chen, L., Trujillo, K. M., Ramos, W., Sung, P., & Tomkinson, A. E. (2001) · Molecular Cell · doi:10.1016/s1097-2765(01)00388-4 · Cited by 304 · see citing works

53BP1 facilitates long-range DNA end-joining during V(D)J recombination

Difilippantonio, S., Gapud, E. J., Wong, N., Huang, C., Mahowald, G. K., Chen, H. T., Kruhlak, M. J., Callén, E., Livák, F., Nussenzweig, M. C., et al. (2008) · Nature · doi:10.1038/nature07476 · Cited by 302 · see citing works

A human homologue of the checkpoint kinase Cds1 directly inhibits Cdc25 phosphatase

Blasina, A., de Weyer, I. V., Laus, M. C., Luyten, W. H. M. L., Parker, A. E., & McGowan, C. H. (1999) · Current Biology · doi:10.1016/s0960-9822(99)80041-4 · Cited by 301 · see citing works

Quantitative phosphoproteome analysis using a dendrimer conjugation chemistry and tandem mass spectrometry

Tao, W. A., Wollscheid, B., O'Brien, R., Eng, J. K., Li, X., Bodenmiller, B., Watts, J. D., Hood, L., & Aebersold, R. H. (2005) · Nature Methods · doi:10.1038/nmeth776 · Cited by 300 · see citing works

Activation of the Cellular DNA Damage Response in the Absence of DNA Lesions

Soutoglou, E., & Misteli, T. (2008) · Science · doi:10.1126/science.1159051 · Cited by 299 · see citing works

Disruptor of Telomeric Silencing-1 Is a Chromatin-specific Histone H3 Methyltransferase

Lacoste, N., Utley, R. T., Hunter, J. M., Poirier, G. G., & Côté, J. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.c200366200 · Cited by 298 · see citing works

Budding yeast Rad9 is an ATP-dependent Rad53 activating machine

Gilbert, C. S., Green, C. M., & Lowndes, N. F. (2001) · Molecular Cell · doi:10.1016/s1097-2765(01)00267-2 · Cited by 296 · see citing works

Human exonuclease 1 and BLM helicase interact to resect DNA and initiate DNA repair

Nimonkar, A. V., Özsoy, A. Z., Genschel, J., Modrich, P. L., & Kowalczykowski, S. C. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0809380105 · Cited by 295 · see citing works

Regulation of p34CDC28 tyrosine phosphorylation is not required for entry into mitosis in S. cerevisiae

Amon, A., Surana, U., Muroff, I., & Nasmyth, K. (1992) · Nature · doi:10.1038/355368a0 · Cited by 290 · see citing works

The Dun1 checkpoint kinase phosphorylates and regulates the ribonucleotide reductase inhibitor Sml1

Zhao, X., & Rothstein, R. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.062502299 · Cited by 290 · see citing works

Role of Dot1-Dependent Histone H3 Methylation in G1 and S Phase DNA Damage Checkpoint Functions of Rad9

Wysocki, R., Javaheri, A., Allard, S., Sha, F., Côté, J., & Kron, S. J. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.19.8430-8443.2005 · Cited by 288 · see citing works

Histone H2AX-dependent GABAA receptor regulation of stem cell proliferation

Andäng, M., Hjerling‐Leffler, J., Moliner, A., Lundgren, K. C., Castelo‐Branco, G., Nanou, E., Pozas, E., Bryja, V., Halliez, S., Nishimaru, H., et al. (2008) · Nature · doi:10.1038/nature06488 · Cited by 288 · see citing works

The DNA Damage Checkpoint Response Requires Histone H2B Ubiquitination by Rad6-Bre1 and H3 Methylation by Dot1

Giannattasio, M., Lazzaro, F., Plevani, P., & Muzi-Falconi, M. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m414453200 · Cited by 287 · see citing works

Positive Regulation of Wee1 by Chk1 and 14-3-3 Proteins

Lee, J., Kumagai, A., & Dunphy, W. G. (2001) · Molecular Biology of the Cell · doi:10.1091/mbc.12.3.551 · Cited by 287 · see citing works

S-phase feedback control in budding yeast independent of tyrosine phosphorylation of P34cdc28

Sorger, P. K., & Murray, A. W. (1992) · Nature · doi:10.1038/355365a0 · Cited by 286 · see citing works

Chromatin dynamics and the preservation of genetic information

Downs, J. A., Nussenzweig, M. C., & Nussenzweig, A. (2007) · Nature · doi:10.1038/nature05980 · Cited by 285 · see citing works

The budding yeast Rad9 checkpoint protein is subjected to Mec1/Tel1‐dependent hyperphosphorylation and interacts with Rad53 after DNA damage

Vialard, J., Gilbert, C. S., Green, C. M., & Lowndes, N. F. (1998) · The EMBO Journal · doi:10.1093/emboj/17.19.5679 · Cited by 284 · see citing works

ATM-related Tel1 associates with double-strand breaks through an Xrs2-dependent mechanismPreprint

Nakada, D., Matsumoto, K., & Sugimoto, K. (2003) · Genes & Development · doi:10.1101/gad.1099003 · Cited by 284 · see citing works

BRCA1 ubiquitinates its phosphorylation-dependent binding partner CtIPPreprint

Yu, X., Fu, S., Lai, M., Baer, R. J., & Chen, J. (2006) · Genes & Development · doi:10.1101/gad.1431006 · Cited by 283 · see citing works

p107wee1 is a dual-specificity kinase that phosphorylates p34cdc2 on tyrosine 15.

Parker, L. L., Atherton-Fessler, S., & Piwnica-Worms, H. M. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.7.2917 · Cited by 282 · see citing works

The ATM protein kinase: regulating the cellular response to genotoxic stress, and more

Shiloh, Y., & Ziv, Y. (2013) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3546 · Cited by 1,649 · see citing works

Oxidative Stress and Programmed Cell Death in Yeast

Farrugia, G., & Balzan, R. (2012) · Frontiers in Oncology · doi:10.3389/fonc.2012.00064 · Cited by 303 · see citing works

Functional interplay between ATM/ATR-mediated DNA damage response and DNA repair pathways in oxidative stress

Yan, S., Sorrell, M., & Berman, Z. (2014) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-014-1666-4 · Cited by 247 · see citing works

FOXM1 (Forkhead box M1) in Tumorigenesis

Wierstra, I. (2013) · Advances in cancer research · doi:10.1016/b978-0-12-407190-2.00016-2 · Cited by 183 · see citing works

The Transcription Factor FOXM1 (Forkhead box M1)

Wierstra, I. (2013) · Advances in cancer research · doi:10.1016/b978-0-12-407173-5.00004-2 · Cited by 174 · see citing works

Human single-stranded DNA binding proteins are essential for maintaining genomic stability

Ashton, N. W., Bolderson, E., Cubeddu, L., O'Byrne, K. J., & Richard, D. J. (2013) · BMC Molecular Biology · doi:10.1186/1471-2199-14-9 · Cited by 113 · see citing works

Pharmacological Ascorbate Radiosensitizes Pancreatic Cancer

Du, J., Cieslak, J. A., Welsh, J. L., Sibenaller, Z. A., Allen, B. G., Wagner, B. A., Kalen, A. L., Doskey, C. M., Strother, R. K., Button, A. M., et al. (2015) · Cancer Research · doi:10.1158/0008-5472.can-14-1707 · Cited by 112 · see citing works

Stress Adaptation

Brown, A. J. P., Cowen, L. E., Pietro, A. D., & Quinn, J. (2017) · Microbiology Spectrum · doi:10.1128/microbiolspec.funk-0048-2016 · Cited by 105 · see citing works

Cohesin and the nucleolus constrain the mobility of spontaneous repair foci

Dion, V., Kalck, V., Seeber, A., Schleker, T., & Gasser, S. M. (2013) · EMBO Reports · doi:10.1038/embor.2013.142 · Cited by 103 · see citing works

Controlling DNA-end resection: a new task for CDKs

Ferretti, L. P., Lafranchi, L., & Sartori, A. A. (2013) · Frontiers in Genetics · doi:10.3389/fgene.2013.00099 · Cited by 99 · see citing works

The MRE11 complex: A versatile toolkit for the repair of broken DNA

Reginato, G., & Ćejka, P. (2020) · DNA repair · doi:10.1016/j.dnarep.2020.102869 · Cited by 95 · see citing works

Role of the Mre11 Complex in Preserving Genome Integrity

Oh, J., & Symington, L. S. (2018) · Genes · doi:10.3390/genes9120589 · Cited by 88 · see citing works

Length-dependent processing of telomeres in the absence of telomerase

Fallet, E., Jolivet, P., Soudet, J., Lisby, M., Gilson, É., & Teixeira, M. T. (2014) · Nucleic Acids Research · doi:10.1093/nar/gkt1328 · Cited by 79 · see citing works

S-phase checkpoint regulations that preserve replication and chromosome integrity upon dNTP depletion

Giannattasio, M., & Branzei, D. (2017) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-017-2474-4 · Cited by 67 · see citing works

DNA Damage Responses during the Cell Cycle: Insights from Model Organisms and Beyond

Clay, D. E., & Fox, D. T. (2021) · Genes · doi:10.3390/genes12121882 · Cited by 68 · see citing works

DNA in motion during double-strand break repair

Miné-Hattab, J., & Rothstein, R. J. (2013) · Trends in Cell Biology · doi:10.1016/j.tcb.2013.05.006 · Cited by 63 · see citing works

Mrc1 and Rad9 cooperate to regulate initiation and elongation of DNA replication in response to DNA damage

Bacal, J., Moriel‐Carretero, M., Pardo, B., Barthe, A., Sharma, S., Chabes, A., Lengronne, A., & Pasero, P. (2018) · The EMBO Journal · doi:10.15252/embj.201899319 · Cited by 63 · see citing works

O-GlcNAc: A Sweetheart of the Cell Cycle and DNA Damage Response

Liu, C., & Li, J. (2018) · Frontiers in Endocrinology · doi:10.3389/fendo.2018.00415 · Cited by 63 · see citing works

Ribosomal protein L6 (RPL6) is recruited to DNA damage sites in a poly(ADP-ribose) polymerase–dependent manner and regulates the DNA damage response

Yang, C., Zang, W., Ji, Y., Li, T., Yang, Y., & Zheng, X. (2019) · Journal of Biological Chemistry · doi:10.1074/jbc.ra118.007009 · Cited by 63 · see citing works

Parallel Profiling of the Transcriptome, Cistrome, and Epigenome in the Cellular Response to Ionizing Radiation

Rashi‐Elkeles, S., Warnatz, H.-J., Elkon, R., Kupershtein, A., Chobod, Y., Paz, A., Amstislavskiy, V. S., Sultan, M., Safer, H. M., Nietfeld, W., et al. (2014) · Science Signaling · doi:10.1126/scisignal.2005032 · Cited by 57 · see citing works

Role of protein phosphatases PP1, PP2A, PP4 and Cdc14 in the DNA damage response

Ramos, F., Villoria, M. T., Alonso‐Rodríguez, E., & Clemente‐Blanco, A. (2019) · Cell Stress · doi:10.15698/cst2019.03.178 · Cited by 60 · see citing works

Targeting WEE1 to enhance conventional therapies for acute lymphoblastic leukemia

di Rorà, A. G. L., Beeharry, N., Imbrogno, E., Ferrari, A., Robustelli, V., Righi, S., Sabattini, E., Falzacappa, M. V. V., Ronchini, C., Testoni, N., et al. (2018) · Journal of Hematology & Oncology · doi:10.1186/s13045-018-0641-1 · Cited by 52 · see citing works

Quantitative sensing and signalling of single-stranded DNA during the DNA damage response

Bantele, S. C. S., Lisby, M., & Pfander, B. (2019) · Nature Communications · doi:10.1038/s41467-019-08889-5 · Cited by 51 · see citing works

The 9-1-1 checkpoint clamp coordinates resection at DNA double strand breaks

Ngo, H.-P., & Lydall, D. A. (2015) · Nucleic Acids Research · doi:10.1093/nar/gkv409 · Cited by 53 · see citing works

Glutathione is essential to preserve nuclear function and cell survival under oxidative stress

Hatem, E., Berthonaud, V., Dardalhon, M., Lagniel, G., Baudouin‐Cornu, P., Huang, M., Labarre, J., & Chdin, S. (2014) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2014.10.746 · Cited by 49 · see citing works

Sae2 antagonizes Rad9 accumulation at DNA double-strand breaks to attenuate checkpoint signaling and facilitate end resection

Yu, T.-Y., Kimble, M. T., & Symington, L. S. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1816539115 · Cited by 47 · see citing works

Saccharomyces cerevisiae as a Model to Study Replicative Senescence Triggered by Telomere Shortening

Teixeira, M. T. (2013) · Frontiers in Oncology · doi:10.3389/fonc.2013.00101 · Cited by 47 · see citing works

Glutathione is essential to preserve nuclear function and cell survival under oxidative stress

Hatem, E., Berthonaud, V., Dardalhon, M., Lagniel, G., Baudouin‐Cornu, P., Huang, M., Labarre, J., & Chédin, S. (2013) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2013.10.807 · Cited by 48 · see citing works

Prexasertib, a Chk1/Chk2 inhibitor, increases the effectiveness of conventional therapy in B-/T- cell progenitor acute lymphoblastic leukemia

di Rorà, A. G. L., Iacobucci, I., Imbrogno, E., Papayannidis, C., Derenzini, E., Ferrari, A., Guadagnuolo, V., Robustelli, V., Parisi, S., Sartor, C., et al. (2016) · Oncotarget · doi:10.18632/oncotarget.10535 · Cited by 41 · see citing works

Multifunctional Role of ATM/Tel1 Kinase in Genome Stability: From the DNA Damage Response to Telomere Maintenance

Domenico, E. G. D., Romano, E., Porto, P. D., & Ascenzioni, F. (2014) · BioMed Research International · doi:10.1155/2014/787404 · Cited by 38 · see citing works

Oxidative Stress and Replication-Independent DNA Breakage Induced by Arsenic in Saccharomyces cerevisiae

Litwin, I., Bocer, T., Dziadkowiec, D., & Wysocki, R. (2013) · PLoS Genetics · doi:10.1371/journal.pgen.1003640 · Cited by 39 · see citing works

Rad53- and Chk1-Dependent DNA Damage Response Pathways Cooperatively Promote Fungal Pathogenesis and Modulate Antifungal Drug Susceptibility

Jung, K., Lee, Y., Huh, E. Y., Lee, S. C., Lim, S., & Bahn, Y. (2019) · mBio · doi:10.1128/mbio.01726-18 · Cited by 36 · see citing works

Chromatin mobility upon DNA damage: state of the art and remaining questions

Zimmer, C., & Fabre, E. (2018) · Current Genetics · doi:10.1007/s00294-018-0852-6 · Cited by 35 · see citing works

The Dynamic Behavior of Chromatin in Response to DNA Double-Strand Breaks

Fernández, F. G., & Fabre, E. (2022) · Genes · doi:10.3390/genes13020215 · Cited by 33 · see citing works

DNA damage checkpoint and repair: From the budding yeast Saccharomyces cerevisiae to the pathogenic fungus Candida albicans

Yao, S., Feng, Y., Zhang, Y., & Feng, J. (2021) · Computational and Structural Biotechnology Journal · doi:10.1016/j.csbj.2021.11.033 · Cited by 29 · see citing works

Cell cycle involvement in cancer therapy; WEE1 kinase, a potential target as therapeutic strategy

Vakili‐Samiani, S., Khanghah, O. J., Gholipour, E., Najafi, F., Zeinalzadeh, E., Samadi, P., Sarvarian, P., Pourvahdani, S., Kelaye, S. K., Hamblin, M. R., et al. (2022) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2022.111776 · Cited by 29 · see citing works

A multistep genomic screen identifies new genes required for repair of DNA double-strand breaks in Saccharomyces cerevisiae

McKinney, J. S., Sethi, S., Tripp, J. D., Nguyen, T. N., Sanderson, B. A., Westmoreland, J. W., Resnick, M. A., & Lewis, L. K. (2013) · BMC Genomics · doi:10.1186/1471-2164-14-251 · Cited by 29 · see citing works

Site-Specific Phosphorylation of the DNA Damage Response Mediator Rad9 by Cyclin-Dependent Kinases Regulates Activation of Checkpoint Kinase 1

Abreu, C. M. C., Kumar, R., Hamilton, D. S., Dawdy, A., Creavin, K., Eivers, S. B., Finn, K., Balsbaugh, J. L., O’Connor, R., Kiely, P. A., et al. (2013) · PLoS Genetics · doi:10.1371/journal.pgen.1003310 · Cited by 28 · see citing works

Anticancer and radiosensitizing effects of the cyclin-dependent kinase inhibitors, AT7519 and SNS‑032, on cervical cancer

Kang, M. Y., Kim, W., Jo, H.-R., Shin, Y.-J., Kim, M., & Jeong, J. (2018) · International Journal of Oncology · doi:10.3892/ijo.2018.4424 · Cited by 27 · see citing works

Protein kinase C controls activation of the DNA integrity checkpoint

Soriano-Carot, M., Quilis, I., Bañó, M. C., & Igual, J. C. (2014) · Nucleic Acids Research · doi:10.1093/nar/gku373 · Cited by 25 · see citing works

DNA double-strand breaks in telophase lead to coalescence between segregated sister chromatid loci

Ayra‐Plasencia, J., & Machín, F. (2019) · Nature Communications · doi:10.1038/s41467-019-10742-8 · Cited by 25 · see citing works

Assessment of a panel of cellular biomarkers and the kinetics of their induction in comparing genotoxic modes of action in HepG2 cells

Kopp, B., Dario, M., Zalko, D., & Audebert, M. (2018) · Environmental and Molecular Mutagenesis · doi:10.1002/em.22197 · Cited by 24 · see citing works

Cadmium Exposure Enhances Bisphenol A-Induced Genotoxicity through 8-Oxoguanine-DNA Glycosylase-1 OGG1 Inhibition in NIH3T3 Fibroblast Cells

Chen, Z., Liu, C., Lu, Y., Yang, L., Li, M., He, M., Chen, C., Zhang, L., Yu, Z., & Zhou, Z. (2016) · Cellular Physiology and Biochemistry · doi:10.1159/000447804 · Cited by 24 · see citing works

Persistent DNA damage signaling and DNA polymerase theta promote broken chromosome segregation

Clay, D. E., Bretscher, H. S., Jezuit, E. A., Bush, K. B., & Fox, D. T. (2021) · The Journal of Cell Biology · doi:10.1083/jcb.202106116 · Cited by 24 · see citing works

At the intersection of non-coding transcription, DNA repair, chromatin structure, and cellular senescence

Ohsawa, R., Seol, J.-H., & Tyler, J. K. (2013) · Frontiers in Genetics · doi:10.3389/fgene.2013.00136 · Cited by 23 · see citing works

CDK and Mec1/Tel1-catalyzed phosphorylation of Sae2 regulate different responses to DNA damage

Yu, T.-Y., Garcia, V., & Symington, L. S. (2019) · Nucleic Acids Research · doi:10.1093/nar/gkz814 · Cited by 22 · see citing works

p53-Dependent Cytoprotective Mechanisms behind Resistance to Chemo-Radiotherapeutic Agents Used in Cancer Treatment

Krishnaraj, J., Yamamoto, T., & Ohki, R. (2023) · Cancers · doi:10.3390/cancers15133399 · Cited by 22 · see citing works

Paths from DNA damage and signaling to genome rearrangements via homologous recombination

Nickoloff, J. A. (2017) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2017.07.008 · Cited by 21 · see citing works

Tumor Suppressor FBXW7 and Its Regulation of DNA Damage Response and Repair

Lan, H., & Sun, Y. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.751574 · Cited by 22 · see citing works

Structural basis of Rad53 kinase activation by dimerization and activation segment exchange

Wybenga-Groot, L. E., Ho, C. S. W., Sweeney, F. D., Ceccarelli, D. F. J., McGlade, C. J., Durocher, D., & Sicheri, F. (2014) · Cellular Signalling · doi:10.1016/j.cellsig.2014.05.004 · Cited by 20 · see citing works

A history of genome editing in Saccharomyces cerevisiae

Alexander, W. G. (2017) · Yeast · doi:10.1002/yea.3300 · Cited by 20 · see citing works

Homologous Recombination: A GRAS Yeast Genome Editing Tool

Bernardi, B., & Wendland, J. (2020) · Fermentation · doi:10.3390/fermentation6020057 · Cited by 20 · see citing works

Medical Needs and Therapeutic Options for Melanoma Patients Resistant to Anti-PD-1-Directed Immune Checkpoint Inhibition

Hassel, J. C., Zimmer, L., Sickmann, T., Eigentler, T., Meier, F. E., Mohr, P., Pukrop, T., Roesch, A., Vordermark, D., Wendl, C. M., et al. (2023) · Cancers · doi:10.3390/cancers15133448 · Cited by 19 · see citing works

Hsp90 induces increased genomic instability toward DNA-damaging agents by tuning down RAD53 transcription

Khurana, N., Laskar, S., Bhattacharyya, M. K., & Bhattacharyya, S. (2016) · Molecular Biology of the Cell · doi:10.1091/mbc.e15-12-0867 · Cited by 19 · see citing works

Processing of DNA Double-Strand Breaks in Yeast

Gnügge, R., Oh, J., & Symington, L. S. (2018) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/bs.mie.2017.11.007 · Cited by 19 · see citing works

A cell cycle-independent mode of the Rad9-Dpb11 interaction is induced by DNA damage

di Cicco, G., Bantele, S. C. S., Reußwig, K.-U., & Pfander, B. (2017) · Scientific Reports · doi:10.1038/s41598-017-11937-z · Cited by 18 · see citing works

Quantitative Profiling of DNA Damage and Apoptotic Pathways in UV Damaged Cells Using PTMScan Direct

Stokes, M. P., Silva, J. C., Jia, X., Lee, K., Polakiewicz, R. D., & Comb, M. J. (2012) · International Journal of Molecular Sciences · doi:10.3390/ijms14010286 · Cited by 18 · see citing works

Maintenance of Genome Integrity by Mi2 Homologs CHD-3 and LET-418 in Caenorhabditis elegans

Turcotte, C. A., Sloat, S. A., Rigothi, J. A., Rosenkranse, E., Northrup, A. L., Andrews, N. P., & Checchi, P. M. (2018) · Genetics · doi:10.1534/genetics.118.300686 · Cited by 17 · see citing works

Tipin Functions in the Protection against Topoisomerase I Inhibitor

Hosono, Y., Abe, T., Higuchi, M., Kajii, K., Sakuraba, S., Tada, S., Enomoto, T., & Seki, M. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.531707 · Cited by 17 · see citing works

Delineation of the role of chromatin assembly and the Rtt101Mms1 E3 ubiquitin ligase in DNA damage checkpoint recovery in budding yeast

Diao, L., Chen, C., Dennehey, B. K., Pal, S., Wang, P., Shen, Z.-J., Deem, A. K., & Tyler, J. K. (2017) · PLoS ONE · doi:10.1371/journal.pone.0180556 · Cited by 16 · see citing works

Functional interplay between the oxidative stress response and DNA damage checkpoint signaling for genome maintenance in aerobic organisms

Choi, J. E., & Chung, W. (2019) · The Journal of Microbiology · doi:10.1007/s12275-020-9520-x · Cited by 16 · see citing works

Mcm2-7 Is an Active Player in the DNA Replication Checkpoint Signaling Cascade via Proposed Modulation of Its DNA Gate

Tsai, F.-L., Vijayraghavan, S., Prinz, J. A., MacAlpine, H. K., MacAlpine, D. M., & Schwacha, A. (2015) · Molecular and Cellular Biology · doi:10.1128/mcb.01357-14 · Cited by 16 · see citing works

Adrenergic DNA damage of embryonic pluripotent cells via β2 receptor signalling

Sun, F., Ding, X., An, S.-M., Tang, Y., Yang, X., Teng, L., Zhang, C., Shen, Y. H., Chen, H., & Zhu, L. (2015) · Scientific Reports · doi:10.1038/srep15950 · Cited by 16 · see citing works

Complex Mechanisms of Antimony Genotoxicity in Budding Yeast Involves Replication and Topoisomerase I-Associated DNA Lesions, Telomere Dysfunction and Inhibition of DNA Repair

Litwin, I., Mucha, S., Pilarczyk, E., Wysocki, R., & Maciaszczyk-Dziubińska, E. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22094510 · Cited by 15 · see citing works

Adaptation in replicative senescence: a risky business

Coutelier, H., & Xu, Z. (2019) · Current Genetics · doi:10.1007/s00294-019-00933-7 · Cited by 15 · see citing works

Repeated H2O2 exposure drives cell cycle progression in an in vitro model of ulcerative colitis

Poehlmann, A., Reißig, K., Schönfeld, P., Walluscheck, D., Schinlauer, A., Hartig, R., Lessel, W., Guenther, T., Silver, A. R., & Roessner, A. (2013) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.12150 · Cited by 15 · see citing works

CTLA-4 Facilitates DNA Damage–Induced Apoptosis by Interacting With PP2A

Yan, Q., Zhang, B., Ling, X., Zhu, B., Mei, S., Yang, H., Zhang, D., Huo, J., & Zhao, Z. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.728771 · Cited by 14 · see citing works

PARP Inhibitors in Advanced Prostate Cancer in Tumors with DNA Damage Signatures

McNevin, C. S., Cadoo, K. A., Baird, A., Finn, S. P., & McDermott, R. (2022) · Cancers · doi:10.3390/cancers14194751 · Cited by 14 · see citing works

Long-range DNA end resection supports homologous recombination by checkpoint activation rather than extensive homology generation

Kimble, M. T., Johnson, M. J., Nester, M. R., & Symington, L. S. (2023) · eLife · doi:10.7554/elife.84322 · Cited by 14 · see citing works

Nuclear DNA replication and repair in parasites of the genusLeishmania: Exploiting differences to develop innovative therapeutic approaches

Uzcanga, G. L., Lara-Barba, E., Gutiérrez, F., Beaty, D., Beske, T., Terán, R., Navarro, J. C., Pasero, P., Benítez, W., & Poveda, A. (2016) · Critical Reviews in Microbiology · doi:10.1080/1040841x.2016.1188758 · Cited by 14 · see citing works

DNA resection proteins Sgs1 and Exo1 are required for G1 checkpoint activation in budding yeast

Balogun, F. O., Truman, A. W., & Kron, S. J. (2013) · DNA repair · doi:10.1016/j.dnarep.2013.06.003 · Cited by 14 · see citing works

The Slx4-Dpb11 scaffold complex: coordinating the response to replication fork stalling in S-phase and the subsequent mitosis

Princz, L. N., Gritenaite, D., & Pfander, B. (2014) · Cell Cycle · doi:10.4161/15384101.2014.989126 · Cited by 13 · see citing works

Rtt107 BRCT domains act as a targeting module in the DNA damage response

Leung, G. P., Brown, J. A. R., Glover, J. N. M., & Kobor, M. S. (2015) · DNA repair · doi:10.1016/j.dnarep.2015.10.007 · Cited by 14 · see citing works

Modified chromosome structure caused by phosphomimetic H2A modulates the DNA damage response by increasing chromatin mobility in yeast

Fernández, F. G., Lemos, B. R., Khalil, Y., Batrin, R., Haber, J. E., & Fabre, E. (2021) · Journal of Cell Science · doi:10.1242/jcs.258500 · Cited by 13 · see citing works

Dun1, a Chk2-related kinase, is the central regulator of securin-separase dynamics during DNA damage signaling

Yam, C., Chia, D. B., Shi, I. Y., Lim, H. H., & Surana, U. (2020) · Nucleic Acids Research · doi:10.1093/nar/gkaa355 · Cited by 16 · see citing works

Unrepaired DNA damage facilitates elimination of uniparental chromosomes in interspecific hybrid cells

Wang, Z., Yin, H., Lv, L., Feng, Y., Chen, S., Liang, J., Huang, Y., Jiang, X., Jiang, H., Bukhari, I., et al. (2014) · Cell Cycle · doi:10.4161/cc.28296 · Cited by 13 · see citing works

Chromothripsis: an emerging crossroad from aberrant mitosis to therapeutic opportunities

Ejaz, U., Dou, Z., Yao, P. Y., Wang, Z., Liu, X., & Yao, X. (2024) · Journal of Molecular Cell Biology · doi:10.1093/jmcb/mjae016 · Cited by 12 · see citing works

Conditional Genetic Interactions ofRTT107,SLX4, andHRQ1Reveal Dynamic Networks upon DNA Damage inS. cerevisiae

Leung, G. P., Aristizabal, M. J., Krogan, N. J., & Kobor, M. S. (2014) · G3 Genes Genomes Genetics · doi:10.1534/g3.114.011205 · Cited by 12 · see citing works

Cell cycle-dependent positive and negative functions of Fun30 chromatin remodeler in DNA damage response

Siler, J., Xia, B., Wong, C., Kath, M., & Bi, X. (2017) · DNA repair · doi:10.1016/j.dnarep.2016.12.009 · Cited by 12 · see citing works

Characterization of Pph3-mediated dephosphorylation of Rad53 during methyl methanesulfonate-induced DNA damage repair in Candida albicans

Yao, G., Wan, J., Liu, Q., Mu, C., Wang, Y., & Sang, J. (2017) · Biochemical Journal · doi:10.1042/bcj20160889 · Cited by 11 · see citing works

Stress Adaptation

Brown, A. J. P., Cowen, L. E., Pietro, A. D., & Quinn, J. (2017) · ASM Press eBooks · doi:10.1128/9781555819583.ch21 · Cited by 11 · see citing works

DNA Damage Response Checkpoint Activation Drives KP1019 Dependent Pre-Anaphase Cell Cycle Delay in S. cerevisiae

Bierle, L. A., Reich, K. L., Taylor, B. E., Blatt, E. B., Middleton, S. M., Burke, S. D., Stultz, L. K., Hanson, P. K., Partridge, J. F., & Miller, M. E. (2015) · PLoS ONE · doi:10.1371/journal.pone.0138085 · Cited by 10 · see citing works

Right time, right place—DNA damage and DNA replication checkpoints collectively safeguard S phase

Galanti, L., & Pfander, B. (2018) · The EMBO Journal · doi:10.15252/embj.2018100681 · Cited by 9 · see citing works

Rad51-Dependent Aberrant Chromosome Structures at Telomeres and Ribosomal DNA Activate the Spindle Assembly Checkpoint

Akemi, N., Masuda, K., Hiromoto, T., Takahashi, K., Matsumoto, Y., Habib, A. G. K., Darwish, A. G., Yukawa, M., Tsuchiya, E., & Ueno, M. (2014) · Molecular and Cellular Biology · doi:10.1128/mcb.01704-13 · Cited by 9 · see citing works

The miR-100-5p Targets SMARCA5 to Regulate the Apoptosis and Intracellular Survival of BCG in Infected THP-1 Cells

Su, L., Zhu, T., Liu, H., Zhu, Y., Peng, Y., Tang, T., Zhou, S., Hu, C., Chen, H., Guo, A., et al. (2023) · Cells · doi:10.3390/cells12030476 · Cited by 8 · see citing works

Replisome components—Post-translational modifications and their effects

Zech, J., & Dalgaard, J. Z. (2014) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2014.03.026 · Cited by 8 · see citing works

Pharmacological Ascorbate Enhances Chemotherapies in Pancreatic Ductal Adenocarcinoma

O’Leary, B. R., Ruppenkamp, E. K., Steers, G. J., Du, J., Carroll, R. S., Wagner, B. A., Buettner, G. R., & Cullen, J. J. (2022) · Pancreas · doi:10.1097/mpa.0000000000002086 · Cited by 8 · see citing works

Deficiency in homologous recombination is associated with changes in cell cycling and morphology in Saccharomyces cerevisiae

Holland, C. L., Weis, M., England, C. J., Berry, A. M., Hall, P. D., & Lewis, L. (2023) · Experimental Cell Research · doi:10.1016/j.yexcr.2023.113701 · Cited by 7 · see citing works

Rgf1p (Rho1p GEF) is required for double-strand break repair in fission yeast

Manjón, E., Edreira, T., Muñoz, S., & Sánchez, Y. (2017) · Nucleic Acids Research · doi:10.1093/nar/gkx176 · Cited by 7 · see citing works

Genotoxic effect of caffeine in Yarrowia lipolytica cells deficient in DNA repair mechanisms

Quiñones-González, C. A., Arredondo-Mendoza, G. I., Jiménez‐Salas, Z., Larriba-Calle, G., Ruíz-Herrera, J., & Campos‐Góngora, E. (2019) · Archives of Microbiology · doi:10.1007/s00203-019-01658-4 · Cited by 6 · see citing works

Assessment of genotoxic chemicals using chemogenomic profiling based on gene-knockout library in Saccharomyces cerevisiae

Guan, M., Zhu, Z., Jiang, Y., Tian, M., Lü, Y., Xu, X., Li, S., Chen, D., & Zhang, X. (2021) · Toxicology in Vitro · doi:10.1016/j.tiv.2021.105278 · Cited by 6 · see citing works

Nucleolar asymmetry and the importance of septin integrity upon cell cycle arrest

Rai, U., Najm, F. J., & Tartakoff, A. M. (2017) · PLoS ONE · doi:10.1371/journal.pone.0174306 · Cited by 6 · see citing works

Budding yeast Rtt107 prevents checkpoint hyperactivation after replicative stress by limiting DNA damage

Brown, J. A. R., & Kobor, M. S. (2019) · DNA repair · doi:10.1016/j.dnarep.2019.01.001 · Cited by 4 · see citing works

Distinct associations of the Saccharomyces cerevisiae Rad9 protein link Mac1-regulated transcription to DNA repair

Gkouskou, K. K., Fragiadakis, G. S., Voutsina, A., & Alexandraki, D. (2019) · Current Genetics · doi:10.1007/s00294-019-01047-w · Cited by 4 · see citing works

Preserving Yeast Genetic Heritage through DNA Damage Checkpoint Regulation and Telomere Maintenance

Baldo, V., Liang, J., Wang, G., & Zhou, H. (2012) · Biomolecules · doi:10.3390/biom2040505 · Cited by 4 · see citing works

DNA damage checkpoint dynamics drive cell cycle phase transitionsPreprint

Chao, H. X., Poovey, C. E., Privette, A. A., Grant, G. D., Chao, H. Y., Cook, J. G., & Purvis, J. E. (2017) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/137307 · Cited by 4 · see citing works

Transgenerational chromosome repair in the asexual bdelloid rotifer Adineta vagaPreprint

Houtain, A., Derzelle, A., Llirós, M., Hespeels, B., Nicolas, É., Simion, P., Virgo, J., Lenormand, T., Hallet, B., & Doninck, K. V. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.01.25.577190 · Cited by 4 · see citing works

FOXA1 Targets NEK2 to Mediate Cisplatin Resistance in Lung Adenocarcinoma Cells by Activating DNA Damage Repair

Yang, J., Yue, G., Fan, Z., Zhang, N., Nie, S., Li, J., & Ji, Y. (2025) · Drug Development Research · doi:10.1002/ddr.70087 · Cited by 3 · see citing works

The CST complex mediates a post-resection non-homologous end joining repair pathway and promotes local deletions in Saccharomyces cerevisiae

Ilioaia, O., Dudragne, L., Brocas, C., Meneu, L., Koszul, R., Dubrana, K., & Xu, Z. (2025) · Cell Genomics · doi:10.1016/j.xgen.2025.100947 · Cited by 2 · see citing works

Homolog of Saccharomyces cerevisiae SLX4 is required for cell recovery from MMS-induced DNA damage in Candida albicans

Wang, Y., Wang, N., Liu, J., Zhang, Y., Li, X., & Han, Q. (2021) · FEMS Yeast Research · doi:10.1093/femsyr/foab010 · Cited by 2 · see citing works

Chromatin modifications and chromatin remodeling during DNA repair in budding yeast

Tsabar, M., & Haber, J. E. (2013) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2012.11.015 · Cited by 30 · see citing works

Preserving Yeast Genetic Heritage through DNA Damage Checkpoint Regulation and Telomere Maintenance

Baldo, V., Liang, J., Wang, G., & Zhou, H. (2012) · Biomolecules · doi:10.3390/biom2040505 · Cited by 4 · see citing works

Checkpoint Responses to DNA Double-Strand Breaks

Waterman, D. P., Haber, J. E., & Smolka, M. B. (2020) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-011520-104722 · Cited by 178 · see citing works

Minireview

Foiani, M., Ferrari, M., Liberi, G., Lopes, M., Lucca, C., Marini, F., Pellicioli, A., Muzi-Falconi, M., & Plevani, P. (1998) · Biological Chemistry · doi:10.1515/bchm.1998.379.8-9.1019 · Cited by 17 · see citing works

DNA damage checkpoints and DNA replication controls in Saccharomyces cerevisiae

Foiani, M., Pellicioli, A., Lopes, M., Lucca, C., Ferrari, M., Liberi, G., Muzi-Falconi, M., & Plevani, P. (2000) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/s0027-5107(00)00049-x · Cited by 130 · see citing works