The DOI matches its Crossref record; 130 of the 131 references it cites were found in a registry or an index.
XPA: A key scaffold for human nucleotide excision repair
Open accessAbstract
Nucleotide excision repair (NER) is essential for removing many types of DNA lesions from the genome, yet the mechanisms of NER in humans remain poorly understood. This review summarizes our current understanding of the structure, biochemistry, interaction partners, mechanisms, and disease-associated mutations of one of the critical NER proteins, XPA.
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“The targeting of XPA to the nucleus occurs via its nuclear localization sequence (NLS) which contains basic residues located at positons 30–34 of the 273 amino acid protein 62, 63, 82, 68.”
From Xeroderma Pigmentosa Group A (XPA), Nucleotide Excision Repair and Regulation by ATR in Response to Ultraviolet Irradiation (2017) · cites this paper as [82]
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Nucleotide Excision Repair in EukaryotesPreprint
Schärer, O. D. (2013) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a012609 · Cited by 863
Molecular Mechanisms of Mammalian Global Genome Nucleotide Excision Repair
Gillet, L. C. J., & Schärer, O. D. (2006) · Chemical Reviews · doi:10.1021/cr040483f · Cited by 642 · cited 1×
“Deletion of any of the remaining exons (2-5), which code for the DNA binding domain, resulted in complete loss of NER activity.”
A dynamic model for replication protein A (RPA) function in DNA processing pathways
Fanning, E. (2006) · Nucleic Acids Research · doi:10.1093/nar/gkl550 · Cited by 589
Flagged first, then by citations
1 of the 131 references couldn’t be matched to a known paper.
Research works printed but not linked: 3
- Cleaver, 1997, The DNA damage-recognition problem in human and other eukaryotic cells: the XPA damage binding protein, Biochem. J, 12, 1, 10.1042/bj3280001 · DOI
- States, 1998, Distribution of mutations in the human xeroderma pigmentosum group A gene and their relationships to the functional regions of the DNA damage recognition protein, Hum. Mutat., 12, 103, 10.1002/(SICI)1098-1004(1998)12:2<103::AID-HUMU5>3.0.CO;2-6 · DOI
- Wakasugi, 2009, Physical and functional interaction between DDB and XPA in nucleotide excision repair, Nucleic Acids Res., 37, 516, 10.1093/nar/gkn964 · DOI
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Luong, T. L. A., Hoang, T. L., Tran, D. P., Le, T. M., Tran, H., Ho, P. T., Hoang, H. N., Giang, H., Vu, D. L., Dinh, N. H., et al. (2024) · Personalized Medicine · doi:10.1080/17410541.2024.2393073
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A Splicing Variant in XPA Results in Delayed Onset of Clinical Features of Xeroderma Pigmentosum
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Host DNA repair factors empower a mechanism of antiviral nucleoside analog resistance
Longmire, P., Chen, H., McKinzey, D. R., Savanagouder, M., Kosarek, N. N., Pesola, J. M., Bobak, C. A., Bosco, G., Felicia, G., & Coen, D. M. (2026) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2618057123
DNA Proofreading, Damage, and Repair: Implications in Health and Disease
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XPA confers ability of endonucleases to act processively and to incise damaged nucleosomal DNA
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XPA lactylation is required for UV-induced DNA damage repair
Yang, J., Ding, X., Zeng, Z., Yin, H., He, Y., Jin, M., Huang, B., Wang, Z., Yang, X., Li, R., et al. (2026) · Nucleic Acids Research · doi:10.1093/nar/gkag947
Metadata
- Authors
- Sugitani, N., Sivley, R. M., Perry, K. E., Capra, J. A., & Chazin, W. J.
- Affiliations
- Vanderbilt University (US)
- Corresponding author
- Chazin, Walter J.
- Venue
- DNA Repair
- Publisher
- Elsevier BV
- Published
- 2016-08
- Volume
- 44
- Pages
- 123-135
- ISSN
- 1568-7856 (ISSN-L)
- 1568-7864
- PMC
- PMC4958585
- OpenAlex
- W2400580371
- Cited by
- 116
- References
- 131
- Citations by year
- 2026: 10 · 2025: 5 · 2024: 10 · 2023: 5 · 2022: 11 · 2021: 14 · 2020: 18 · 2019: 15 · 2018: 14 · 2017: 13
- FWCI
- 1.30
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- DNA repair (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (ES1065561, CA092584)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nuclear Structure and Function
- Health Sciences › Medicine › Pathology and Forensic Medicine › Genetic factors in colorectal cancer
- Keywords
- XPA, nucleotide excision repair, DNA repair proteins, DNA damage recognition, protein structure, protein-protein interaction, disease-associated mutations, DNA lesions
- MeSH terms
- Protein Domains, Amino Acid Sequence, Animals, DNA, DNA Damage, DNA Repair, Humans, Models, Molecular, Mutation, Protein Binding, Severity of Illness Index, Xeroderma Pigmentosum, Protein Structure, Secondary, Protein Interaction Mapping, Xeroderma Pigmentosum Group A Protein
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