Cited by 117DNA Repair MechanismsNuclear Structure and FunctionGenetic factors in colorectal cancer

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XPA: A key scaffold for human nucleotide excision repair

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Sugitani, Norie, Sivley, Robert M., Perry, Kelly E., Capra, John A., Chazin, Walter J.·2016·DNA Repair

DOI 10.1016/j.dnarep.2016.05.018PMC PMC4958585

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Abstract

Nucleotide excision repair (NER) is essential for removing many types of DNA lesions from the genome, yet the mechanisms of NER in humans remain poorly understood. This review summarizes our current understanding of the structure, biochemistry, interaction partners, mechanisms, and disease-associated mutations of one of the critical NER proteins, XPA.

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Authors: Sugitani, N., Sivley, R. M., Perry, K. E., Capra, J. A., & Chazin, W. J.
Affiliations: Vanderbilt University (US)
Corresponding author: Chazin, Walter J.
ORCID: Sugitani, Norie
Sivley, Robert M.
Perry, Kelly E.
Capra, John A.
Chazin, Walter J.
Venue: DNA Repair
Publisher: Elsevier BV
Published: 2016-08
Volume: 44
Pages: 123-135
ISSN: 1568-7856 (ISSN-L)
1568-7864
DOI: 10.1016/j.dnarep.2016.05.018
PMC: PMC4958585
OpenAlex: W2400580371
Cited by: 116
References: 131
Citations by year: 2026: 10 · 2025: 5 · 2024: 10 · 2023: 5 · 2022: 11 · 2021: 14 · 2020: 18 · 2019: 15 · 2018: 14 · 2017: 13
FWCI: 1.30
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: DNA repair (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health (ES1065561, CA092584)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nuclear Structure and Function
Health Sciences › Medicine › Pathology and Forensic Medicine › Genetic factors in colorectal cancer
Keywords: XPA, nucleotide excision repair, DNA repair proteins, DNA damage recognition, protein structure, protein-protein interaction, disease-associated mutations, DNA lesions
MeSH terms: Protein Domains, Amino Acid Sequence, Animals, DNA, DNA Damage, DNA Repair, Humans, Models, Molecular, Mutation, Protein Binding, Severity of Illness Index, Xeroderma Pigmentosum, Protein Structure, Secondary, Protein Interaction Mapping, Xeroderma Pigmentosum Group A Protein

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XPA: A key scaffold for human nucleotide excision repair

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