Alternative Splicing in the Mammalian Nervous System: Recent Insights into Mechanisms and Functional Roles
Open accessAbstract
High-throughput transcriptomic profiling approaches have revealed that alternative splicing (AS) of precursor mRNAs, a fundamental process by which cells expand their transcriptomic diversity, is particularly widespread in the nervous system. AS events detected in the brain are more highly conserved than those detected in other tissues, suggesting that they more often provide conserved functions. Our understanding of the mechanisms and functions of neural AS events has significantly advanced with the coupling of various computational and experimental approaches. These studies indicate that dynamic regulation of AS in the nervous system is critical for modulating protein-protein interactions, transcription networks, and multiple aspects of neuronal development. Furthermore, several underappreciated classes of AS with the aforementioned roles in neuronal cells have emerged from unbiased, global approaches. Collectively, these findings emphasize the importance of characterizing neural AS in order to gain new insight into pathways that may be altered in neurological diseases and disorders.
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The mammalian nervous system makes extensive use of splicing regulation to generate specialized protein isoforms that affect all aspects of neuronal development and function.
“the mammalian nervous system makes extensive use of splicing regulation to generate specialized protein isoforms that affect all aspects of neuronal development and function1–4.”
From The neurogenetics of alternative splicing (2016) · cites this paper as [3]
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- Authors
- Raj, B., & Blencowe, B. J.
- Affiliations
- University of Toronto (CA)
- Corresponding author
- Raj, Bushra
- Blencowe, Benjamin J.
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2015-07
- Volume
- 87
- Issue
- 1
- Pages
- 14-27
- ISSN
- 0896-6273 (ISSN-L)
- OpenAlex
- W1488980960
- Semantic Scholar
- 60755665e90f3a9c77a22020f599b3e56dfde862
- Cited by
- 475
- References
- 126
- Citations by year
- 2026: 37 · 2025: 38 · 2024: 55 · 2023: 42 · 2022: 38 · 2021: 59 · 2020: 48 · 2019: 33 · 2018: 47 · 2017: 43 · 2016: 30 · 2015: 3 · 2013: 1
- FWCI
- 3.97
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Neuron (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Research and Splicing
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA regulation and disease
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer-related molecular mechanisms research
- Keywords
- alternative splicing, nervous system, brain, neural development, protein-protein interaction, neurological disorders, transcriptomic diversity, splicing regulation
- MeSH terms
- Animals, Brain, Gene Expression Regulation, Humans, Nervous System, Neurons, RNA, Messenger, Alternative Splicing, Mice, Gene Regulatory Networks, Neurogenesis
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
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