Cited by 32DNA Repair MechanismsGenomics and Chromatin DynamicsChromatin Remodeling and Cancer

Role of histone acetyltransferases MOF and Tip60 in genome stability

Mir, Ulfat Syed, Bhat, Audesh, Mushtaq, Arjamand, Pandita, Shruti, Altaf, Mohammad, Pandita, Tej K.·2021·DNA repair

Abstract

The accurate repair of DNA damage specifically the chromosomal double-strand breaks (DSBs) arising from exposure to physical or chemical agents, such as ionizing radiation (IR) and radiomimetic drugs is critical in maintaining genomic integrity. The DNA DSB response and repair is facilitated by hierarchical signaling networks that orchestrate chromatin structural changes specifically histone modifications which impact cell-cycle checkpoints through enzymatic activities to repair the broken DNA ends. Various histone posttranslational modifications such as phosphorylation, acetylation, methylation and ubiquitylation have been shown to play a role in DNA damage repair. Recent studies have provided important insights into the role of histone-specific modifications in sensing DNA damage and facilitating the DNA repair. Histone modifications have been shown to determine the pathway choice for repair of DNA DSBs. This review will summarize the role of important histone acetyltransferases MOF and Tip60 mediated acetylation in repair of DNA DSBs in eukaryotic cells.

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Crossref · 10.1016/j.dnarep.2021.103205

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Authors
Mir, U. S., Bhat, A., Mushtaq, A., Pandita, S., Altaf, M., & Pandita, T. K.
Affiliations
  • University of Kashmir (IN)
  • Central University of Jammu (IN)
  • Saint Louis University (US)
  • Baylor College of Medicine (US)
Corresponding author
  • Altaf, Mohammad
  • Pandita, Tej K.
Venue
DNA repair
Publisher
Elsevier BV
Published
2021-11
Volume
107
Pages
103205
ISSN
  • 1568-7856 (ISSN-L)
  • 1568-7864
OpenAlex
W3191780297
Cited by
32
References
116
Citations by year
2026: 6 · 2025: 8 · 2024: 7 · 2023: 6 · 2022: 5
FWCI
0.47
Type
journal article
Language
en
Open access
closed
Locations
  • DNA repair (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Institutes of Health (CA129537, GM109768)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Chromatin Remodeling and Cancer
Keywords
histone acetyltransferase, MOF, Tip60, histone acetylation, genome stability, DNA double-strand break repair, DNA damage response, histone modifications, cell cycle checkpoints, ionizing radiation, radiomimetic drugs, chromatin structure
MeSH terms
Lysine Acetyltransferase 5, Acetylation, Animals, DNA Repair, Histones, Humans, Protein Processing, Post-Translational, Genomic Instability, Histone Acetyltransferases, DNA Breaks, Double-Stranded

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