Role of histone acetyltransferases MOF and Tip60 in genome stability
Abstract
The accurate repair of DNA damage specifically the chromosomal double-strand breaks (DSBs) arising from exposure to physical or chemical agents, such as ionizing radiation (IR) and radiomimetic drugs is critical in maintaining genomic integrity. The DNA DSB response and repair is facilitated by hierarchical signaling networks that orchestrate chromatin structural changes specifically histone modifications which impact cell-cycle checkpoints through enzymatic activities to repair the broken DNA ends. Various histone posttranslational modifications such as phosphorylation, acetylation, methylation and ubiquitylation have been shown to play a role in DNA damage repair. Recent studies have provided important insights into the role of histone-specific modifications in sensing DNA damage and facilitating the DNA repair. Histone modifications have been shown to determine the pathway choice for repair of DNA DSBs. This review will summarize the role of important histone acetyltransferases MOF and Tip60 mediated acetylation in repair of DNA DSBs in eukaryotic cells.
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Tip60 engagement is important to recruit other DDR factors.
“Tip60 engagement is important to recruit other factors of the DDR (Mir et al., 2021).”
From HDACs and the epigenetic plasticity of cancer cells: target the complexity (2022) · cites this paper as Mir et al., 2021
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HDACs and the epigenetic plasticity of cancer cells: target the complexity
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- Authors
- Mir, U. S., Bhat, A., Mushtaq, A., Pandita, S., Altaf, M., & Pandita, T. K.
- Affiliations
- University of Kashmir (IN)
- Central University of Jammu (IN)
- Saint Louis University (US)
- Baylor College of Medicine (US)
- Corresponding author
- Altaf, Mohammad
- Pandita, Tej K.
- Venue
- DNA repair
- Publisher
- Elsevier BV
- Published
- 2021-11
- Volume
- 107
- Pages
- 103205
- ISSN
- 1568-7856 (ISSN-L)
- 1568-7864
- OpenAlex
- W3191780297
- Cited by
- 32
- References
- 116
- Citations by year
- 2026: 6 · 2025: 8 · 2024: 7 · 2023: 6 · 2022: 5
- FWCI
- 0.47
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- DNA repair (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (CA129537, GM109768)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Chromatin Remodeling and Cancer
- Keywords
- histone acetyltransferase, MOF, Tip60, histone acetylation, genome stability, DNA double-strand break repair, DNA damage response, histone modifications, cell cycle checkpoints, ionizing radiation, radiomimetic drugs, chromatin structure
- MeSH terms
- Lysine Acetyltransferase 5, Acetylation, Animals, DNA Repair, Histones, Humans, Protein Processing, Post-Translational, Genomic Instability, Histone Acetyltransferases, DNA Breaks, Double-Stranded
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