Tip60: Connecting chromatin to DNA damage signaling

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High-Resolution Profiling of Histone Methylations in the Human Genome

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ATM and ATR Substrate Analysis Reveals Extensive Protein Networks Responsive to DNA Damage

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The Mammalian Epigenome

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A Chromatin Landmark and Transcription Initiation at Most Promoters in Human Cells

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Loss of acetylation at Lys16 and trimethylation at Lys20 of histone H4 is a common hallmark of human cancer

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Loss of the Suv39h Histone Methyltransferases Impairs Mammalian Heterochromatin and Genome Stability

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γH2AX and cancer

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ATM Activation by DNA Double-Strand Breaks Through the Mre11-Rad50-Nbs1 Complex

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How chromatin-binding modules interpret histone modifications: lessons from professional pocket pickers

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Conserved modes of recruitment of ATM, ATR and DNA-PKcs to sites of DNA damage

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MDC1 Directly Binds Phosphorylated Histone H2AX to Regulate Cellular Responses to DNA Double-Strand Breaks

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Requirement of the MRN complex for ATM activation by DNA damage

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Reversal of Histone Lysine Trimethylation by the JMJD2 Family of Histone Demethylases

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Involvement of the TIP60 Histone Acetylase Complex in DNA Repair and Apoptosis

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RNF8 Transduces the DNA-Damage Signal via Histone Ubiquitylation and Checkpoint Protein Assembly

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Ataxia-telangiectasia: from a rare disorder to a paradigm for cell signalling and cancer

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Orchestration of the DNA-Damage Response by the RNF8 Ubiquitin Ligase

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ATM Signaling Facilitates Repair of DNA Double-Strand Breaks Associated with Heterochromatin

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Structure of HP1 Chromodomain Bound to a Lysine 9-Methylated Histone H3 Tail

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Direct Activation of the ATM Protein Kinase by the Mre11/Rad50/Nbs1 Complex

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Acetylation of the p53 DNA-binding domain regulates apoptosis induction.

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A role for the Tip60 histone acetyltransferase in the acetylation and activation of ATM

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Chromatin relaxation in response to DNA double-strand breaks is modulated by a novel ATM- and KAP-1 dependent pathway

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Tip60-Dependent Acetylation of p53 Modulates the Decision between Cell-Cycle Arrest and Apoptosis

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Dynamic Regulation of Histone Lysine Methylation by Demethylases

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Covalent modifications of histones during development and disease pathogenesis

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RAP80 Targets BRCA1 to Specific Ubiquitin Structures at DNA Damage Sites

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Acetylation by Tip60 Is Required for Selective Histone Variant Exchange at DNA Lesions

Kusch, T., Florens, L. A., McDonald, W. H., Swanson, S. K., Glaser, R. L., Yates, J. R., Abmayr, S. M., Washburn, M. P., & Workman, J. L. (2004) · Science · doi:10.1126/science.1103455 · Cited by 669 · see citing works

Structure of the HP1 chromodomain bound to histone H3 methylated at lysine 9

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Maintenance of Stable Heterochromatin Domains by Dynamic HP1 Binding

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Histone acetylation by Trrap–Tip60 modulates loading of repair proteins and repair of DNA double-strand breaks

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Structural and Functional Conservation of the NuA4 Histone Acetyltransferase Complex from Yeast to Humans

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Binding of Chromatin-Modifying Activities to Phosphorylated Histone H2A at DNA Damage Sites

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The diverse functions of histone acetyltransferase complexes

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Acetylation of histone H4 by Esa1 is required for DNA double-strand break repair

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Activation and regulation of ATM kinase activity in response to DNA double-strand breaks

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Crosstalk between histone modifications during the DNA damage response

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Systematic mapping of genetic interactions in Caenorhabditis elegans identifies common modifiers of diverse signaling pathways

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Tudor, MBT and chromo domains gauge the degree of lysine methylation

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Histone H3 methylation links DNA damage detection to activation of the tumour suppressor Tip60

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An RNAi Screen of Chromatin Proteins Identifies Tip60-p400 as a Regulator of Embryonic Stem Cell Identity

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ATM Activation and Its Recruitment to Damaged DNA Require Binding to the C Terminus of Nbs1

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The PHD finger, a nuclear protein-interaction domain

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Multiple recurrent genetic events converge on control of histone lysine methylation in medulloblastoma

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γH2AX and MDC1: Anchoring the DNA-damage-response machinery to broken chromosomes

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Profile of Histone Lysine Methylation across Transcribed Mammalian Chromatin

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HP1-β mobilization promotes chromatin changes that initiate the DNA damage response

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DNA Damage-Dependent Acetylation and Ubiquitination of H2AX Enhances Chromatin Dynamics

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TopBP1 activates ATR through ATRIP and a PIKK regulatory domainPreprint

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Screen for DNA‐damage‐responsive histone modifications identifies H3K9Ac and H3K56Ac in human cells

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Tip60 is a haplo-insufficient tumour suppressor required for an oncogene-induced DNA damage response

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DNA Damage-Induced Acetylation of Lysine 3016 of ATM Activates ATM Kinase Activity

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Tip60 and Histone Deacetylase 1 Regulate Androgen Receptor Activity through Changes to the Acetylation Status of the Receptor

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Protein Acetylation Microarray Reveals that NuA4 Controls Key Metabolic Target Regulating Gluconeogenesis

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Tip60 in DNA damage response and growth control: many tricks in one HAT

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Emerging common themes in regulation of PIKKs and PI3Ks

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Role of Dot1-Dependent Histone H3 Methylation in G1 and S Phase DNA Damage Checkpoint Functions of Rad9

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The DNA Damage Checkpoint Response Requires Histone H2B Ubiquitination by Rad6-Bre1 and H3 Methylation by Dot1

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Involvement of novel autophosphorylation sites in ATM activation

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Autophosphorylation of ataxia‐telangiectasia mutated is regulated by protein phosphatase 2A

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Heterochromatin protein 1 is recruited to various types of DNA damage

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Inhibition of histone acetyltransferase activity by anacardic acid sensitizes tumor cells to ionizing radiation

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Two-step activation of ATM by DNA and the Mre11–Rad50–Nbs1 complex

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Role of Nbs1 in the activation of the Atm kinase revealed in humanized mouse models

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Tip60 acetylates six lysines of a specific class in core histones in vitro

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Expression of Tip60, an androgen receptor coactivator, and its role in prostate cancer development

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Epigenetic regulation of heterochromatic DNA stability

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Autophosphorylation at serine 1987 is dispensable for murine Atm activation in vivo

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ATM signaling and genomic stability in response to DNA damage

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The Global Histone Modification Pattern Correlates with Cancer Recurrence and Overall Survival in Gastric Adenocarcinoma

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Ataxia‐telangiectasia, cancer and the pathobiology of the ATM gene

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PR-Set7–dependent lysine methylation ensures genome replication and stability through S phase

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Human Rvb1/Tip49 Is Required for the Histone Acetyltransferase Activity of Tip60/NuA4 and for the Downregulation of Phosphorylation on H2AX after DNA Damage

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Structure of histone acetyltransferases 1 1Edited by P. W. Wright

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Active and Repressive Chromatin Are Interspersed without Spreading in an Imprinted Gene Cluster in the Mammalian Genome

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The FATC Domains of PIKK Proteins Are Functionally Equivalent and Participate in the Tip60-dependent Activation of DNA-PKcs and ATM

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Activation of ATM depends on chromatin interactions occurring before induction of DNA damage

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Homozygous disruption of the tip60 gene causes early embryonic lethality

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Multiple autophosphorylation sites are dispensable for murine ATM activation in vivo

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Histone modifications in response to DNA damage

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p14 ARF Activates a Tip60-Dependent and p53-Independent ATM/ATR/CHK Pathway in Response to Genotoxic Stress

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The p400/Tip60 ratio is critical for colorectal cancer cell proliferation through DNA damage response pathways

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