Regulation of Histone Gene Expression in Budding Yeast
Open accessAbstract
We discuss the regulation of the histone genes of the budding yeast Saccharomyces cerevisiae. These include genes encoding the major core histones (H3, H4, H2A, and H2B), histone H1 (HHO1), H2AZ (HTZ1), and centromeric H3 (CSE4). Histone production is regulated during the cell cycle because the cell must replicate both its DNA during S phase and its chromatin. Consequently, the histone genes are activated in late G1 to provide sufficient core histones to assemble the replicated genome into chromatin. The major core histone genes are subject to both positive and negative regulation. The primary control system is positive, mediated by the histone gene-specific transcription activator, Spt10, through the histone upstream activating sequences (UAS) elements, with help from the major G1/S-phase activators, SBF (Swi4 cell cycle box binding factor) and perhaps MBF (MluI cell cycle box binding factor). Spt10 binds specifically to the histone UAS elements and contains a putative histone acetyltransferase domain. The negative system involves negative regulatory elements in the histone promoters, the RSC chromatin-remodeling complex, various histone chaperones [the histone regulatory (HIR) complex, Asf1, and Rtt106], and putative sequence-specific factors. The SWI/SNF chromatin-remodeling complex links the positive and negative systems. We propose that the negative system is a damping system that modulates the amount of transcription activated by Spt10 and SBF. We hypothesize that the negative system mediates negative feedback on the histone genes by histone proteins through the level of saturation of histone chaperones with histone. Thus, the negative system could communicate the degree of nucleosome assembly during DNA replication and the need to shut down the activating system under replication-stress conditions. We also discuss post-transcriptional regulation and dosage compensation of the histone genes.
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Rtt106 regulates the activity of the histone gene promoters during the cell cycle in S. cerevisiae.
“Apart from its role in histone deposition during replication and transcription elongation, Rtt106 regulates the activity of the histone gene promoters during the cell cycle in S. cerevisiae30.”
From SWI/SNF and the histone chaperone Rtt106 drive expression of the Pleiotropic Drug Resistance network genes (2022) · cites this paper as [30]
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Jackson, C. A., Castro, D. M., Saldi, G.-A., Bonneau, R., & Gresham, D. (2020) · eLife · doi:10.7554/elife.51254 · Cited by 174 · see citing works
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Nikolov, V. N., Malavia, D., & Kubota, T. (2022) · Nature Communications · doi:10.1038/s41467-022-29591-z · Cited by 16 · see citing works
- Authors
- Eriksson, P. R., Ganguli, D., Nagarajavel, V, & Clark, D. J.
- Affiliations
- National Institutes of Health (US)
- Corresponding author
- Clark, David J
- ORCID
- Clark, David J
- Venue
- Genetics
- Publisher
- Oxford University Press (OUP)
- Published
- 2012-05-01
- Volume
- 191
- Issue
- 1
- Pages
- 7-20
- ISSN
- 0016-6731 (ISSN-L)
- 1943-2631
- PMC
- PMC3338271
- OpenAlex
- W2158298861
- Cited by
- 114
- References
- 117
- Citations by year
- 2026: 4 · 2025: 4 · 2024: 6 · 2023: 5 · 2022: 7 · 2021: 6 · 2020: 26 · 2019: 5 · 2018: 9 · 2017: 10 · 2016: 9 · 2015: 7 · 2014: 6 · 2013: 6 · 2012: 4
- FWCI
- 0.67
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model (vor)
- Locations
- Genetics (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- National Institute of Child Health and Human Development
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Chromatin Remodeling and Cancer
- Keywords
- histone gene expression, Saccharomyces cerevisiae, core histones, histone H1, histone H2A variant, CENH3, upstream activating sequence, simulated body fluid, MBF, RSC complex, SWI/SNF complex, histone chaperone, Asf1, histone acetyltransferase, chromatin remodeling, nucleosome assembly, replication stress, post-transcriptional regulation, dosage compensation, cell cycle regulation
- MeSH terms
- Base Sequence, Cell Cycle, Histones, Saccharomyces cerevisiae, Transcription, Genetic, Transcriptional Activation, Gene Expression Regulation, Fungal
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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