CoChat
Sign Up
Cited by 293

The DOI matches its Crossref record; 17 of the 17 references it cites were found in a registry or an index.

Targeting amino acid metabolism for cancer therapy

Lukey, Michael J., Katt, William P., Cerione, Richard A.·2017·Drug Discovery Today
DOI 10.1016/j.drudis.2016.12.003PMC PMC5429979
Open this paper in CoChat — free account

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1016/j.drudis.2016.12.003

Cites

17 of 17 references verified0 citation errors · 0 not checkable

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Flagged first, then by citations

Show all 17 references

Research works printed but not linked: 47

  1. Warburg, 1927, The metabolism of tumors in the body, J. Gen. Physiol., 8, 519, 10.1085/jgp.8.6.519 · DOI · Paper page
  2. Eagle, 1955, Nutrition needs of mammalian cells in tissue culture, Science, 122, 501, 10.1126/science.122.3168.501 · DOI · Paper page
  3. Jain, 2012, Metabolite profiling identifies a key role for glycine in rapid cancer cell proliferation, Science, 336, 1040, 10.1126/science.1218595 · DOI · Paper page
  4. Hosios, 2016, Amino acids rather than glucose account for the majority of cell mass in proliferating mammalian cells, Dev. Cell, 36, 540, 10.1016/j.devcel.2016.02.012 · DOI · Paper page
  5. Yang, 2016, Serine and one-carbon metabolism in cancer, Nat. Rev. Cancer, 16, 650, 10.1038/nrc.2016.81 · DOI · Paper page
  6. Altman, 2016, From Krebs to clinic: glutamine metabolism to cancer therapy, Nat. Rev. Cancer, 16, 619, 10.1038/nrc.2016.71 · DOI · Paper page
  7. Challapalli, 2016, Positron emission tomography imaging of tumor cell metabolism and application to therapy response monitoring, Front. Oncol., 6, 44, 10.3389/fonc.2016.00044 · DOI
  8. Covini, 2012, Expanding targets for a metabolic therapy of cancer: l-asparaginase, Recent Pat. Anticancer. Drug Discov., 7, 4, 10.2174/157489212798358001 · DOI
  9. Qiu, 2015, Targeting arginine metabolism pathway to treat arginine-dependent cancers, Cancer Lett., 364, 1, 10.1016/j.canlet.2015.04.020 · DOI
  10. Lukey, 2016, The oncogenic transcription factor c-Jun regulates glutaminase expression and sensitizes cells to glutaminase-targeted therapy, Nat. Commun., 7, 11321, 10.1038/ncomms11321 · DOI
  11. Bhutia, 2015, Amino acid transporters in cancer and their relevance to glutamine addiction: novel targets for the design of a new class of anticancer drugs, Cancer Res., 75, 1782, 10.1158/0008-5472.CAN-14-3745 · DOI
  12. Elgadi, 1999, Cloning and analysis of unique human glutaminase isoforms generated by tissue-specific alternative splicing, Physiol. Genomics, 1, 51, 10.1152/physiolgenomics.1999.1.2.51 · DOI
  13. Zhang, 2013, Epigenetic silencing of glutaminase 2 in human liver and colon cancers, BMC Cancer, 13, 601, 10.1186/1471-2407-13-601 · DOI
  14. Giacobbe, 2013, p63 regulates glutaminase 2 expression, Cell Cycle, 12, 1395, 10.4161/cc.24478 · DOI
  15. Lukey, 2013, Therapeutic strategies impacting cancer cell glutamine metabolism, Future Med. Chem., 5, 1685, 10.4155/fmc.13.130 · DOI
  16. Katt, 2014, Glutaminase regulation in cancer cells: a druggable chain of events, Drug Discov. Today, 19, 450, 10.1016/j.drudis.2013.10.008 · DOI
  17. Le, 2012, Glucose-independent glutamine metabolism via TCA cycling for proliferation and survival in B cells, Cell Metab., 15, 110, 10.1016/j.cmet.2011.12.009 · DOI · Paper page
  18. Wang, 2010, Targeting mitochondrial glutaminase activity inhibits oncogenic transformation, Cancer Cell, 18, 207, 10.1016/j.ccr.2010.08.009 · DOI · Paper page
  19. Gross, 2014, Antitumor activity of the glutaminase inhibitor CB-839 in triple-negative breast cancer, Mol. Cancer Ther., 13, 890, 10.1158/1535-7163.MCT-13-0870 · DOI · Paper page
  20. Bromley-Dulfano, 2013, Antitumor activity of the glutaminase inhibitor CB-839 in hematological malignances, Blood, 122, 4226, 10.1182/blood.V122.21.4226.4226 · DOI
  21. Garber, 2016, Cancer anabolic metabolism inhibitors move into clinic, Nat. Biotechnol., 34, 794, 10.1038/nbt0816-794 · DOI
  22. Mullard, 2016, Cancer metabolism pipeline breaks new ground, Nat. Rev. Drug Discov., 15, 735, 10.1038/nrd.2016.223 · DOI
  23. Davidson, 2016, Environment impacts the metabolic dependencies of ras-driven non-small cell lung cancer, Cell Metab., 23, 517, 10.1016/j.cmet.2016.01.007 · DOI · Paper page
  24. Zhang, 2014, Asparagine plays a critical role in regulating cellular adaptation to glutamine depletion, Mol. Cell, 56, 205, 10.1016/j.molcel.2014.08.018 · DOI · Paper page
  25. Hettmer, 2015, Functional genomic screening reveals asparagine dependence as a metabolic vulnerability in sarcoma, Elife, 4, e09436, 10.7554/eLife.09436 · DOI
  26. Dixon, 2014, Pharmacological inhibition of cystine-glutamate exchange induces endoplasmic reticulum stress and ferroptosis, Elife, 3, e02523, 10.7554/eLife.02523 · DOI · Paper page
  27. Coloff, 2016, Differential glutamate metabolism in proliferating and quiescent mammary epithelial cells, Cell Metab., 23, 867, 10.1016/j.cmet.2016.03.016 · DOI · Paper page
  28. Hao, 2016, Oncogenic PIK3CA mutations reprogram glutamine metabolism in colorectal cancer, Nat. Commun., 7, 11971, 10.1038/ncomms11971 · DOI · Paper page
  29. Smith, 2016, Addiction to coupling of the Warburg effect with glutamine catabolism in cancer cells, Cell Rep., 17, 821, 10.1016/j.celrep.2016.09.045 · DOI
  30. Jin, 2015, Glutamate dehydrogenase 1 signals through antioxidant glutathione peroxidase 1 to regulate redox homeostasis and tumor growth, Cancer Cell, 27, 257, 10.1016/j.ccell.2014.12.006 · DOI
  31. Mayers, 2016, Tissue of origin dictates branched-chain amino acid metabolism in mutant Kras-driven cancers, Science, 353, 1161, 10.1126/science.aaf5171 · DOI · Paper page
  32. Mattaini, 2016, The importance of serine metabolism in cancer, J. Cell Biol., 214, 249, 10.1083/jcb.201604085 · DOI
  33. Locasale, 2011, Phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis, Nat. Genet., 43, 869, 10.1038/ng.890 · DOI · Paper page
  34. Maddocks, 2013, Serine starvation induces stress and p53-dependent metabolic remodelling in cancer cells, Nature, 493, 542, 10.1038/nature11743 · DOI · Paper page
  35. Nilsson, 2014, Metabolic enzyme expression highlights a key role for MTHFD2 and the mitochondrial folate pathway in cancer, Nat. Commun., 5, 3128, 10.1038/ncomms4128 · DOI · Paper page
  36. Pacold, 2016, A PHGDH inhibitor reveals coordination of serine synthesis and one-carbon unit fate, Nat. Chem. Biol., 12, 452, 10.1038/nchembio.2070 · DOI · Paper page
  37. Mullarky, 2016, Identification of a small molecule inhibitor of 3-phosphoglycerate dehydrogenase to target serine biosynthesis in cancers, Proc. Natl. Acad. Sci. U. S. A., 113, 1778, 10.1073/pnas.1521548113 · DOI · Paper page
  38. Liu, 2012, Reprogramming of proline and glutamine metabolism contributes to the proliferative and metabolic responses regulated by oncogenic transcription factor c-MYC, Proc. Natl. Acad. Sci. U. S. A., 109, 8983, 10.1073/pnas.1203244109 · DOI · Paper page
  39. Loayza-Puch, 2016, Tumour-specific proline vulnerability uncovered by differential ribosome codon reading, Nature, 530, 490, 10.1038/nature16982 · DOI
  40. Prendergast, 2008, Immune escape as a fundamental trait of cancer: focus on IDO, Oncogene, 27, 3889, 10.1038/onc.2008.35 · DOI
  41. Vacchelli, 2014, Trial watch: IDO inhibitors in cancer therapy, Oncoimmunology, 3, e957994, 10.4161/21624011.2014.957994 · DOI
  42. Pilotte, 2012, Reversal of tumoral immune resistance by inhibition of tryptophan 2,3-dioxygenase, Proc. Natl. Acad. Sci. U. S. A., 109, 2497, 10.1073/pnas.1113873109 · DOI
  43. Marin-Valencia, 2012, Analysis of tumor metabolism reveals mitochondrial glucose oxidation in genetically diverse human glioblastomas in the mouse brain in vivo, Cell Metab., 15, 827, 10.1016/j.cmet.2012.05.001 · DOI · Paper page
  44. Zhao, 2016, Tumor microenvironment derived exosomes pleiotropically modulate cancer cell metabolism, Elife, 5, e10250, 10.7554/eLife.10250 · DOI · Paper page
  45. Yang, 2016, Targeting stromal glutamine synthetase in tumors disrupts tumor microenvironment-regulated cancer cell growth, Cell Metab., 24, 685, 10.1016/j.cmet.2016.10.011 · DOI
  46. Souba, 1993, Glutamine and cancer, Ann. Surg., 218, 715, 10.1097/00000658-199312000-00004 · DOI
  47. Basun, 1990, Amino acid concentrations in cerebrospinal fluid and plasma in Alzheimer's disease and healthy control subjects, J. Neural Transm. Park Dis. Dement. Sect., 2, 295, 10.1007/BF02252924 · DOI

Cited by

Sorted by citations

See all 293

Metadata

Authors
Lukey, M. J., Katt, W. P., & Cerione, R. A.
Venue
Drug Discovery Today
Publisher
Elsevier BV
Published
2017-05
Volume
22
Issue
5
Pages
796-804
ISSN
1359-6446
DOI
10.1016/j.drudis.2016.12.003
PMC
PMC5429979
Cited by
293
References
17
Language
en
Licence

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review