Drug repurposing: a promising tool to accelerate the drug discovery process

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Items 101–200 of 598

1. WaterMap and Molecular Dynamic Simulation-Guided Discovery of Potential PAK1 Inhibitors Using Repurposing Approaches
   Jayashree Biswal, Prajisha Jayaprakash, Suresh Kumar Rayala, Ganesh Venkatraman, Raghu Rangaswamy, Jeyaraman Jeyakanthan · 2021 · ACS Omega
2. Giving Drugs a Second Chance: Antibacterial and Antibiofilm Effects of Ciclopirox and Ribavirin against Cystic Fibrosis Pseudomonas aeruginosa Strains
   Giovanni Di Bonaventura, Veronica Lupetti, Simone De Fabritiis, Alessandra Piccirilli, Annamaria Porreca, Marta Di Nicola, Arianna Pompilio · 2022 · International Journal of Molecular Sciences
3. Paradigms and Success Stories of Natural Products in Drug Discovery Against Neurodegenerative Disorders (NDDs)
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4. Bestatin analogs-4-quinolinone hybrids as antileishmanial hits: Design, repurposing rational, synthesis, in vitro and in silico studies
   Ahmed H.E. Hassan, Kazem Mahmoud, Trong-Nhat Phan, Moataz Ahmed Shaldam, Chae Hyeon Lee, Yeon Ju Kim, Soo Bin Cho, Waleed A. Bayoumi, Selwan M. El‐Sayed, Yeonwoo Choi et al. · 2023 · European Journal of Medicinal Chemistry
5. Cinchonine, a Potential Oral Small-Molecule Glucagon-Like Peptide-1 Receptor Agonist, Lowers Blood Glucose and Ameliorates Non-Alcoholic Steatohepatitis
   Huan Xue, Hao-Jie Xing, Bin Wang, Chao Fu, Yushan Zhang, Xi Qiao, Chao Guo, Xiaoli Zhang, Bin Hu, Xin Zhao et al. · 2023 · Drug Design Development and Therapy
6. Vismodegib Identified as a Novel COX-2 Inhibitor via Deep-Learning-Based Drug Repositioning and Molecular Docking Analysis
   Muhammad Yasir, Jinyoung Park, Eun‐Taek Han, Won Sun Park, Jin‐Hee Han, Yong-Soo Kwon, Hee Jae Lee, Wanjoo Chun · 2023 · ACS Omega
7. Drug Repositioning via Graph Neural Networks: Identifying Novel JAK2 Inhibitors from FDA-Approved Drugs through Molecular Docking and Biological Validation
   Muhammad Yasir, Jinyoung Park, Eun‐Taek Han, Won Sun Park, Jin‐Hee Han, Wanjoo Chun · 2024 · Molecules
8. Nuplazid suppresses esophageal squamous cell carcinoma growth in vitro and in vivo by targeting PAK4
   Yaxing Wei, Wenjie Wu, Yanan Jiang, Hao Zhou, Yu Yin, Lili Zhao, Xiangyu Wu, Xuebo Lu, Qiang Yuan, Zitong Wang et al. · 2021 · British Journal of Cancer
9. Local Anesthetic Ropivacaine Exhibits Therapeutic Effects in Cancers
   Peng Xu, Shao-bo Zhang, Lili Tan, Lei Wang, Zhongwei Yang, Jinbao Li · 2022 · Frontiers in Oncology
10. Repositioning of tubocurarine as analgesic and anti-inflammatory agent: Exploring beyond myorelaxant activity
    Saraswati Patel, Jyoti Shukla, Smita Jain, Vartika Paliwal, Neetika Tripathi, Sarvesh Paliwal, Swapnil K. Sharma · 2022 · Biochemical Pharmacology
11. Drug Repurposing for Spinal Cord Injury: Progress Towards Therapeutic Intervention for Primary Factors and Secondary Complications
    Lahanya Guha, Hemant Kumar · 2023 · Pharmaceutical Medicine
12. Disulfiram in glioma: Literature review of drug repurposing
    Shiyu Zhong, Shengyu Liu, Xin Shi, Xudong Zhang, Kunhang Li, Guojun Liu, Lishuai Li, Shanwei Tao, Bowen Zheng, Weichen Sheng et al. · 2022 · Frontiers in Pharmacology
13. Drug reprofiling history and potential therapies against Parkinson’s disease
    Komal Latif, Aman Ullah, Anastasiia D. Shkodina, Dmytro I. Boiko, Zakia Rafique, Badrah Saeed Ali Alghamdi, Mohamed A. Alfaleh, Ghulam Md Ashraf · 2022 · Frontiers in Pharmacology
14. A Multi-Objective Approach for Anti-Osteosarcoma Cancer Agents Discovery through Drug Repurposing
    Alejandro Cabrera‐Andrade, Andrés López‐Cortés, Gabriela Jaramillo-Koupermann, Humberto González‐Díaz, Alejandro Pazos, Cristian Robert Munteanu, Yunierkis Pérez‐Castillo, Eduardo Tejera · 2020 · Pharmaceuticals
15. CRISPR-dCas9-Based Artificial Transcription Factors to Improve Efficacy of Cancer Treatment With Drug Repurposing: Proposal for Future Research
    Alejandro Martinez‐Escobar, Benjamín Luna-Callejas, Eva Ramón‐Gallegos · 2021 · Frontiers in Oncology
16. Identification and Development of Therapeutics for COVID-19
    Halie M. Rando, Nils Wellhausen, Soumita Ghosh, Alexandra J. Lee, Anna Ada Dattoli, Fengling Hu, James Brian Byrd, Diane N. Rafizadeh, Ronan Lordan, Yanjun Qi et al. · 2021 · mSystems
17. Pyrrolidine-based 3-deoxysphingosylphosphorylcholine analogs as possible candidates against neglected tropical diseases (NTDs): identification of hit compounds towards development of potential treatment of Leishmania donovani
    Ahmed H.E. Hassan, Trong-Nhat Phan, Seolmin Yoon, Cheol Jung Lee, Hye Rim Jeon, Seunghwan Kim, Joo Hwan No, Yong Sup Lee · 2021 · Journal of Enzyme Inhibition and Medicinal Chemistry
18. Locally Applied Repositioned Hormones for Oral Bone and Periodontal Tissue Engineering: A Narrative Review
    Gamal Abdel Nasser Atia, Hany K. Shalaby, Mehrukh Zehravi, Mohamed Mohamady Ghobashy, Zubair Ahmad, Farhat S. Khan, Abhijit Dey, Md. Habibur Rahman, Sang Woo Joo, Hasi Rani Barai et al. · 2022 · Polymers
19. Screening of GPCR drugs for repurposing in breast cancer
    Noor Mazin Abdulkareem, Raksha R. Bhat, Reid Trenton Powell, Soumya G. Chikermane, S. Yande, Lisa Trinh, Hala Y. Abdelnasser, Mantasha Tabassum, Alexis Ruiz, Mary M. Sobieski et al. · 2022 · Frontiers in Pharmacology
20. Seleno-Analogs of Scaffolds Resembling Natural Products a Novel Warhead toward Dual Compounds
    Nora Astrain-Redín, Irene Talavera, Esther Moreno, María Javier Ramírez, Nuria Martínez‐Sáez, Ignacio Encı́o, Arun Kumar Sharma, Carmen Sanmartín, Daniel Plano · 2023 · Antioxidants
21. Pharmacometabolomics for the Study of Lipid-Lowering Therapies: Opportunities and Challenges
    Erica Gianazza, Maura Brioschi, Ada Iezzi, Giuseppe Paglia, Cristina Banfi · 2023 · International Journal of Molecular Sciences
22. Virtual screening of antimicrobial plant extracts by machine-learning classification of chemical compounds in semantic space
    Hiroaki Yabuuchi, Kazuhito Hayashi, A. Shigemoto, Makiko Fujiwara, Yuhei Nomura, Mayumi Nakashima, Takeshi Ogusu, Megumi Mori, Shin-ichi Tokumoto, Kazuyuki Miyai · 2023 · PLoS ONE
23. Harnessing machine learning potential for personalised drug design and overcoming drug resistance
    Mohammed Ageeli Hakami · 2024 · Journal of drug targeting
24. Phyotochemical candidates repurposing for cancer therapy and their molecular mechanisms
    Ji Hoon Jung, Jisung Hwang, Ju‐Ha Kim, Deok Yong Sim, Eunji Im, Ji Eon Park, Woon Yi Park, Bum‐Sang Shim, Bonglee Kim, Sung‐Hoon Kim · 2019 · Seminars in Cancer Biology
25. Leveraging Artificial Intelligence to Achieve Sustainable Public Healthcare Services in Saudi Arabia: A Systematic Literature Review of Critical Success Factors
    Rakesh Kumar, Ajay Kumar Singh, Ahmed Subahi Ahmed Kassar, Mohammed Ismail Humaida, Sudhanshu Joshi, Manu Sharma · 2025 · Computer Modeling in Engineering & Sciences
26. Drug-Target Prediction Based on Dynamic Heterogeneous Graph Convolutional Network
    Peng Xu, Zhitao Wei, Chuchu Li, Jiaqi Yuan, Zaiyi Liu, Wenbin Liu · 2024 · IEEE Journal of Biomedical and Health Informatics
27. Simvastatin Treatment Does Not Ameliorate Muscle Pathophysiology in a Mouse Model for Duchenne Muscular Dystrophy
    Ingrid E.C. Verhaart, Ornella Cappellari, Christa L. Tanganyika-de Winter, Jaap J. Plomp, Sofia Nnorom, Kim E. Wells, John C. W. Hildyard, David Bull, Annemieke M Aartsma-Rus, Dominic J. Wells · 2020 · Journal of Neuromuscular Diseases
28. Nano-synergistic combination of Erlotinib and Quinacrine for non-small cell lung cancer (NSCLC) therapeutics – Evaluation in biologically relevant in-vitro models
    Nishant S. Kulkarni, Bhuvaneshwar Vaidya, Vivek Gupta · 2021 · Materials Science and Engineering C
29. Nitazoxanide, an Antiprotozoal Drug, Reduces Bone Loss in Ovariectomized Mice by Inhibition of RANKL-Induced Osteoclastogenesis
    Changhong Li, Zirui Lü, Zhenda Zhao, Xinyu Wang, Huijie Leng, Yan Niu, Mopei Wang · 2021 · Frontiers in Pharmacology
30. Antihistamines H1 as Potential Anthelmintic Agents against the Zoonotic Parasite Angiostrongylus cantonensis
    Daniel Brenneisen Roquini, Bruna Lima Lemes, Amanda Luiza Baumgartner Kreutz, Sophia Carolline Spoladore, Monique C. Amaro, Flávia Barrio Lopes, João Paulo S. Fernandes, Josué de Moraes · 2024 · ACS Omega
31. Impact of drug repurposing between 1985 and 2024 on pharmaceutical innovation
    Sanae Akodad, Xixian Niu, Berta Secades, Hilde Stevens · 2026 · Communications Medicine
32. Mefloquine synergism with anti-tuberculosis drugs and correlation to membrane effects: Biologic, spectroscopic and molecular dynamics simulations studies
    Marinalva Cardoso dos Santos, João L. Scaini, Márcio Vinicius Costa Lopes, Beatriz Gonçalves Rodrigues, Nichole Osti Silva, Carla Roberta Lopes de Azambuja Borges, Sandra Cruz dos Santos, Karina Machado, Adriano Velasque Werhli, Pedro Eduardo Almeida da Silva et al. · 2021 · Bioorganic Chemistry
33. Computational Drug Repurposing Approach to Identify Novel Inhibitors of ILK Protein for Treatment of Esophageal Squamous Cell Carcinoma
    Juan Liu, Xiaoli Ma, Leiyu Cao, Yu Wei, Yan Gao, Chengcheng Qu, Nuersimanguli Maimaitiming, Li Zhang · 2022 · Journal of Oncology
34. Structure–Activity Relationships and Therapeutic Applications of Retinoids in View of Potential Benefits from Drug Repurposing Process
    Piotr Kawczak, Igor Jarosław Feszak, Piotr Brzeziński, Tomasz Bączek · 2024 · Biomedicines
35. Repurposing Quinacrine for Treatment of Malignant Mesothelioma: In-Vitro Therapeutic and Mechanistic Evaluation
    Nishant S. Kulkarni, Bhuvaneshwar Vaidya, Vineela Parvathaneni, Debarati Bhanja, Vivek Gupta · 2020 · International Journal of Molecular Sciences
36. Smart Safety Surveillance (3S): Multi-Country Experience of Implementing the 3S Concepts and Principles
    Noha Iessa, Viola Macolić Šarinić, Lilit Ghazaryan, Naira Romanova, Asnakech Alemu, Watcharee Rungapiromnan, Porntip Jiamsuchon, Pattreya Pokhagul, José L. Castro, Diego Macías Saint-Gerons et al. · 2021 · Drug Safety
37. 2-(2-Methyl-2-nitrovinyl)furan but Not Furvina Interfere with Staphylococcus aureus Agr Quorum-Sensing System and Potentiate the Action of Fusidic Acid against Biofilms
    Diana Magalhaes de Oliveira, Anabela de Sousa Borges, Reinaldo Molina, Zenaida Rodríguez Negrín, Simona Distinto, Fernanda Borges, Manuel V. Simões · 2021 · International Journal of Molecular Sciences
38. Exploring Amodiaquine’s Repurposing Potential in Breast Cancer Treatment—Assessment of In-Vitro Efficacy & Mechanism of Action
    Vineela Parvathaneni, Rameswari Chilamakuri, Nishant S. Kulkarni, Nabeela Baig, Saurabh Agarwal, Vivek Gupta · 2022 · International Journal of Molecular Sciences
39. Exploring drug repositioning for leishmaniasis treatment: Ivermectin plus polymeric micelles induce immunological response and protection against tegumentary leishmaniasis
    Camila Simões de Freitas, Daniela Pagliara Lage, Amanda S. Machado, Danniele Luciana Vale, Vívian Tamietti Martins, Jamille Mirelle de Oliveira Cardoso, João A. Oliveira‐da‐Silva, Thiago A.R. Reis, Grasiele S.V. Tavares, Fernanda Fonseca Ramos et al. · 2023 · Cytokine
40. Computational approaches for drug repurposing in oncology: untapped opportunity for high value innovation
    Shraddha Mahesh Dalwadi, Andrew Hunt, Mark Bonnen, Yohannes T. Ghebre · 2023 · Frontiers in Oncology
41. Drug repurposing based on the similarity gene expression signatures to explore for potential indications of quercetin: a case study of multiple sclerosis
    Yulong Chen, Mingliang Zhang, Weixia Li, Xiaoyan Wang, Xiaofei Chen, Yali Wu, Hui Zhang, Liuqing Yang, Bing Han, Jinfa Tang · 2023 · Frontiers in Chemistry
42. Analysis of Structures of SARS-CoV-2 Papain-like Protease Bound with Ligands Unveils Structural Features for Inhibiting the Enzyme
    Ann Varghese, Jie Liu, Bailang Liu, Wenjing Guo, Fan Dong, Tucker A. Patterson, Huixiao Hong · 2025 · Molecules
43. Potential Exploration of Recent FDA-Approved Anticancer Drugs Against Models of SARS-CoV-2’s Main Protease and Spike Glycoprotein: A Computational Study
    2020 · Biointerface Research in Applied Chemistry
44. Tegaserod Maleate Suppresses the Growth of Gastric Cancer In Vivo and In Vitro by Targeting MEK1/2
    Zitong Wang, Yingying Chen, Xiaoyu Li, Yuhan Zhang, Xiaokun Zhao, Hao Zhou, Xuebo Lu, Lili Zhao, Qiang Yuan, Yunshu Shi et al. · 2022 · Cancers
45. Novel Organic Salts Based on Mefloquine: Synthesis, Solubility, Permeability, and In Vitro Activity against Mycobacterium tuberculosis
    Dário Silva, Márcio Vinicius Costa Lopes, Željko Petrovski, Miguel M. Santos, Jussevania Pereira Santos, Sueli Fumie Yamada‐Ogatta, Marcelle de Lima Ferreira Bispo, M.V.N. De Souza, Ana Rita C. Duarte, Maria Cristina S. Lourenço et al. · 2022 · Molecules
46. Therapeutic efficacy of tylvalosin combined with Poria cocos polysaccharides against porcine reproductive and respiratory syndrome
    Hong Shi, Wentao Luo, Shuaiyang Wang, Jun Dai, Cuilan Chen, Shuo Li, Jie Liu, Weiyuan Zhang, Qi Huang, Rui Zhou · 2023 · Frontiers in Veterinary Science
47. Identification of the exosomal PD-L1 inhibitor to promote the PD-1 targeting therapy of gastric cancer
    Jiangang Sun, Ya Gao, Yongshun Gao, Xing‐Jie Dai, Peng Chen · 2024 · European Journal of Medicinal Chemistry
48. Ponatinib, Lestaurtinib, and mTOR/PI3K Inhibitors Are Promising Repurposing Candidates against Entamoeba histolytica
    Mônica Mendes Kangussu-Marcolino, Upinder Singh · 2021 · Antimicrobial Agents and Chemotherapy
49. Rifampicin may be repurposed for COVID-19 treatment: Insights from an in-silico study
    Yamini Pathak, Amaresh Mishra, Vishwas Tripathi · 2020
50. From Lab to Clinic: Success Stories of Repurposed Drugs in Treating Major Diseases
    Md Sadique Hussain, Prince Ahad Mir, Nishant Kumar, Roohi Mohi-ud-din, Adil Farooq Wali, Reyaz Hassan Mir, Sirajunisa Talath, Sathvik Belagodu Sridhar, Javedh Shareef, Manjunatha Goud et al. · 2025 · Advances in Pharmacological and Pharmaceutical Sciences
51. Vitamin D analog calcitriol for breast cancer therapy; an integrated drug discovery approach
    B. S. Nagaraj, P. K. Krishnan Namboori, Akey Krishna Swaroop, Sathianarayanan Sankaran, Rajesh Raman, Jawahar Natarajan, Jubie Selvaraj · 2023 · Journal of Biomolecular Structure and Dynamics
52. Elaboration of the Effective Multi-Target Therapeutic Platform for the Treatment of Alzheimer’s Disease Based on Novel Monoterpene-Derived Hydroxamic Acids
    Yulia R. Aleksandrova, Aldar A. Munkuev, Evgenii S. Mozhaitsev, Е. В. Суслов, Dmitry O. Tsypyshev, Kirill Chaprov, Роман Сергеевич Бегунов, Konstantin Petrovich Volcho, Nariman Faridovich Salakhutdinov, Маргарита Е. Неганова · 2023 · International Journal of Molecular Sciences
53. Dual Representation Learning for Predicting Drug-Side Effect Frequency Using Protein Target Information
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54. Use of Drug Sensitisers to Improve Therapeutic Index in Cancer
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55. Structure-based screening, optimization and biological evaluation of novel chrysin-based derivatives as selective PPARγ modulators for the treatment of T2DM and hepatic steatosis
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56. Repositioning fluphenazine as a cuproptosis-dependent anti-breast cancer drug candidate based on TCGA database
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57. Ten challenges and opportunities in computational immuno-oncology
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58. Recent advances in medicinal chemistry strategies for the development of METTL3 inhibitors
    Gengwu Li, Wei Chen, Dan Liu, Shibing Tang · 2025 · European Journal of Medicinal Chemistry
59. Clinical microbiology and artificial intelligence: Different applications, challenges, and future prospects
    Wafaa S. Khalaf, Radwa N. Morgan, Walid Faisal Elkhatib · 2025 · Journal of Microbiological Methods
60. Integrating Molecular Dynamics, Molecular Docking, and Machine Learning for Predicting SARS-CoV-2 Papain-like Protease Binders
    Ann Varghese, Jie Liu, Tucker A. Patterson, Huixiao Hong · 2025 · Molecules
61. Drug Repurposing Prediction and Validation From Clinical Big Data for the Effective Treatment of Interstitial Lung Disease
    Soni Siswanto, Hiroki Yamamoto, Haruka Furuta, Mone Kobayashi, Takuya Nagashima, Gen Kayanuma, Kazuki Nagayasu, Yumiko Imai, Shuji Kaneko · 2021 · Frontiers in Pharmacology
62. Artificial Intelligence in ADME Property Prediction
    Vishal B. Siramshetty, Xin Xu, Pranav Shah · 2023 · Methods in molecular biology
63. Nanoformulations of chemotherapeutic activators of the cGAS–STING pathway in tumor chemoimmunotherapy
    Lingzhi Wang, Zhuo Yu, Jihong Zhang, Jianfeng Guo · 2024 · Drug Discovery Today
64. A new era of psoriasis treatment: Drug repurposing through the lens of nanotechnology and machine learning
    M Taha Tarek, Riham I. El-Gogary, Amany O. Kamel · 2025 · International Journal of Pharmaceutics
65. Functional diversification and exaptation: the emergence of new drug uses in the pharma industry
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66. Bias-force guided simulations combined with experimental validations towards GPR17 modulators identification
    Sana Kari, Akshaya Murugesan, Thiyagarajan Ramesh, Srivatsan Kidambi, Jamoliddin Razzokov, Chandrabose Selvaraj, Meenakshisundaram Kandhavelu, Parthiban Marimuthu · 2023 · Biomedicine & Pharmacotherapy
67. Identification of Potential Tryptase Inhibitors from FDA-Approved Drugs Using Machine Learning, Molecular Docking, and Experimental Validation
    Muhammad Yasir, Jinyoung Park, Eun‐Taek Han, Won Sun Park, Jin‐Hee Han, Wanjoo Chun · 2024 · ACS Omega
68. Development of novel ALOX15 inhibitors combining dual machine learning filtering and fragment substitution optimisation approaches, molecular docking and dynamic simulation methods
    Yinglin Liao, Peng Cao, Lianxiang Luo · 2024 · Journal of Enzyme Inhibition and Medicinal Chemistry
69. Natural compound library screening to identify berberine as a treatment for rheumatoid arthritis
    Li Zhang, Min Tan, Jing Mao, Juan Zhang, Xiao-Yuan Wang, Yan Zhang, Ruixue Duo, Jia-Yao Hao, Hai-Li Shen · 2024 · Clinical Rheumatology
70. How health technology assessment can help to address challenges in drug repurposing: a conceptual framework
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71. SGLT2 Inhibitors Empagliflozin and Canagliflozin Ameliorate Allergic Asthma Responses in Mice
    Y.-A. Lee, Dong‐Soon Im · 2024 · International Journal of Molecular Sciences
72. Repurposing FDA-approved drugs for COVID-19: targeting the main protease through multi-phase in silico approach
    Ahmed M. Metwaly, Eslam B. Elkaeed, Aisha A. Alsfouk, Ibrahim M. Ibrahim, Hazem Elkady, Ibrahim H. Eissa · 2024 · Antiviral Therapy
73. Structure-based drug repurposing targeting pathogenic virus superfamily 1 helicase: An integrated multi-computational screening and bioactivity identification strategy
    Zhenxing Li, Yue Ding, Xinxin Tuo, Jinhong Hu, Taihong Zhang, Xiang Zhou, Liwei Liu, Song Yang · 2024 · Chinese Chemical Letters
74. Does drug repurposing bridge the gaps in management of Parkinson’s disease? Unravelling the facts and fallacies
    Bushra Bashir, Sukriti Vishwas, Gaurav Gupta, Keshav Raj Paudel, Harish Dureja, Puneet Kumar, Hyunah Cho, Vrashabh V. Sugandhi, Popat Kumbhar, John Disouza et al. · 2025 · Ageing Research Reviews
75. Drug Repurposing to Inhibit Histamine N-Methyl Transferase
    Elvia Mera Jiménez, Teresa Żołek, Paola Gabriela Hernández Perez, René Miranda, María Inés Nicolás‐Vázquez, Maricarmen Hernández Rodríguez · 2023 · Molecules
76. Design, synthesis, and repurposing of O-aminoalkyl-sulfuretin analogs towards discovery of potential lead compounds as antileishmanial agents
    Ahmed H.E. Hassan, Trong-Nhat Phan, Suyeon Moon, Chae Hyeon Lee, Yeon Ju Kim, Soo Bin Cho, Selwan M. El‐Sayed, Yeonwoo Choi, Joo Hwan No, Yong Sup Lee · 2023 · European Journal of Medicinal Chemistry
77. Computational Screening of Approved Drugs for Inhibition of the Antibiotic Resistance Gene mecA in Methicillin-Resistant Staphylococcus aureus (MRSA) Strains
    Benson Otarigho, Mofolusho O. Falade · 2023 · BioTech
78. Bedaquiline-Loaded Solid Lipid Nanoparticles Drug Delivery in the Management of Non-Small-Cell Lung Cancer (NSCLC)
    Shehla Nasar Mir Najib Ullah, Obaid Afzal, Abdulmalik Saleh Alfawaz Altamimi, Manal Abdullah Alossaimi, Waleed Hassan Almalki, Abdulaziz Alzahrani, Md. Abul Barkat, Tahani Musleh Almeleebia, Hanan M. Alshareef, Eman Shorog et al. · 2023 · Pharmaceuticals
79. Introduction to Drug Repurposing: Exploring New Applications for Existing Drugs
    Zubair Ahmad, Abdur Rauf, Saima Naz, Hassan A. Hemeg · 2024 · Pharmaceutical science.
80. Targeting notch signaling pathway in breast cancer stem cells through drug repurposing approach
    Yamini Pathak, Ihosvany Camps, Amaresh Mishra, Vishwas Tripathi · 2022 · Molecular Diversity
81. Membrane-Targeting Antivirals
    Maxim S. Krasilnikov, Vladislav S. Denisov, Коршун Владимир Аркадьевич, Alexey V. Ustinov, Vera A. Alferova · 2025 · International Journal of Molecular Sciences
82. Selective inhibition of overactive warmth-sensitive Ca2+-permeable TRPV3 channels by antispasmodic agent flopropione for alleviation of skin inflammation
    Yimei Xu, Yaxuan Qu, Congxiao Zhang, Canyang Niu, Xiaowen Tang, Xiaoying Sun, KeWei Wang · 2023 · Journal of Biological Chemistry
83. DiPPI: A Curated Data Set for Drug-like Molecules in Protein–Protein Interfaces
    Fatma Cankara, Simge Senyuz, Ahenk Zeynep Sayin, Attila Gürsoy, Özlem Keskin · 2024 · Journal of Chemical Information and Modeling
84. Recent Applications of In Silico Approaches for Studying Receptor Mutations Associated with Human Pathologies
    Matteo Pappalardo, Federica Maria Sipala, Milena Cristina Nicolosi, Salvatore Guccione, Simone Ronsisvalle · 2024 · Molecules
85. The anti-inflammatory properties of the methanolic extract of Cucumis melo Linn. against prostate enlargement in Wistar rats
    R.S. Rajasree, Sibi P. Ittiyavirah, Punnoth Poonkuzhi Naseef, Mohamed Saheer Kuruniyan, Muhammed Elayadeth‐Meethal, S Sankar · 2022 · Saudi Journal of Biological Sciences
86. Identification of a new and diverse set of Mycobacterium tuberculosis uracil-DNA glycosylase (MtUng) inhibitors using structure-based virtual screening: Experimental validation and molecular dynamics studies
    Prateek Raj, Karthik Selvam, Koyel Roy, Shailesh Mani Tripathi, Sharyu Kesharwani, B. Gopal, Umesh Varshney, Sandeep Sundriyal · 2022 · Bioorganic & Medicinal Chemistry Letters
87. Drug Repurposing for Targeting Myeloid-Derived Suppressor-Cell-Generated Immunosuppression in Ovarian Cancer: A Literature Review of Potential Candidates
    Yani Berckmans, Yannick Hoffert, Ann Vankerckhoven, Erwin Dreesen, An Coosemans · 2023 · Pharmaceutics
88. A new integrated framework for the identification of potential virus–drug associations
    Jia Qu, Zihao Song, Xiaolong Cheng, Zhibin Jiang, Jie Zhou · 2023 · Frontiers in Microbiology
89. Open MoA: revealing the mechanism of action (MoA) based on network topology and hierarchy
    Xinmeng Liao, Mehmet Özcan, Mengnan Shi, Woonghee Kim, Han Jin, Xiangyü Li, Hasan Türkez, Adnane Achour, Mathias Uhlén, Adil Mardinoğlu et al. · 2023 · Bioinformatics
90. The Discovery of inhibitors of the SARS-CoV-2 S protein through computational drug repurposing
    Ana Isabel Avilés‐Alía, João Zulaica, Juan Jesús Pérez, J. Rubio, Ron Geller, José M. Granadino‐Roldán · 2024 · Computers in Biology and Medicine
91. Repositioning VU ‐0365114 as a novel microtubule‐destabilizing agent for treating cancer and overcoming drug resistance
    Yao‐Yu Hsieh, Jialing Du, Pei‐Ming Yang · 2023 · Molecular Oncology
92. Repurposing FDA-Approved Drugs as Potential Inhibitors of SARS-CoV-2 PLpro: A Comprehensive Computational Study
    Ahmed M. Metwaly, Eslam B. Elkaeed, Aisha A. Alsfouk, Ibrahim M. Ibrahim, Omar Soliman, Hazem Elkady, Ibrahim H. Eissa · 2024 · Journal of Computational Biophysics and Chemistry
93. Single-cell technology for drug discovery and development
    Anzhuo Zhang, Jiawei Zou, Yue Xi, Lianchong Gao, Fulan Deng, Yujun Liu, Pengfei Gao, Henry H. Y. Tong, Lianjiang Tan, Xin Zou et al. · 2024 · Frontiers in Drug Discovery
94. Discovery of potential FDA-approved SARS-CoV-2 Papain-like protease inhibitors: A multi-phase in silico approach
    Ahmed M. Metwaly, Eslam B. Elkaeed, Mohamed M. Khalifa, Aisha A. Alsfouk, Fatma G. Amin, Ibrahim M. Ibrahim, Ibrahim H. Eissa · 2024 · Journal of Chemical Research
95. Advances in the Repurposing and Blood–Brain Barrier Penetrance of Drugs in Pediatric Brain Tumors
    Julian S. Rechberger, Stephanie A. Toll, Subhasree Biswas, Hyo Bin You, William D. Chow, Nicholas A. S. Kendall, Pournima D. Navalkele, Soumen Khatua · 2025 · Cancers
96. The Role of the Hfq Protein in Bacterial Resistance to Antibiotics: A Narrative Review
    Sylwia Bloch, Grzegorz Węgrzyn, Véronique Arluison · 2025 · Microorganisms
97. AI-Driven Drug Discovery, Design, and Development in Immunological Disorders
    Odangowei Inetiminebi Ogidi, Deghinmotei Alfred-Ugbenbo, Blessing Elohor Poripo · 2025 · Advances in computational intelligence and robotics book series
98. Antiviral drug repurposing: different approaches and the case of antifungal drugs
    Sara Tuci, Beatrice Mercorelli, Arianna Loregian · 2025 · Pharmacology & Therapeutics
99. Unlocking Novel Therapeutic Potential of Angiotensin II Receptor Blockers
    Filippos Panteleimon Chatzipieris, Kyriaki Mavromoustakou, John Matsoukas, Thomas Mavromoustakos · 2025 · International Journal of Molecular Sciences
100. Drug Repurposing for Identification of S1P1 agonists with Potential Application in Multiple Sclerosis Using in Silico Drug Design Approaches
     Ali Akbar Alizadeh, Behzad Jafari, Siavoush Dastmalchi · 2022 · Advanced Pharmaceutical Bulletin