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Cited by 61Infant Development and Preterm CareCircadian rhythm and melatoninSleep and Wakefulness Research

Very preterm infants show earlier emergence of 24-hour sleep–wake rhythms compared to term infants

Guyer, Caroline, Huber, Reto, Fontijn, Jehudith, Bucher, Hans Ulrich, Nicolai, Heide, Werner, Helene, Molinari, Luciano, Latal, Beatrice +1 more·2015·Early Human Development
DOI 10.1016/j.earlhumdev.2014.11.002
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Abstract

Background Previous studies show contradictory results about the emergence of 24-h rhythms and the influence of external time cues on sleep-wake behavior in preterm compared to term infants.Aims To examine whether very preterm infants (<32 weeks of gestational age) differ in their emergence of the 24-h sleep-wake rhythm at 5, 11 and 25 weeks corrected age compared to term infants and whether cycled light conditions during neonatal intermediate care affects postnatal 24-h sleep-wake rhythms in preterm infants.Study design Prospective cohort study with nested interventional trial.Subjects 34 preterm and 14 control term infants were studied. During neonatal hospitalization, preterm infants were randomly assigned to cycled light [7 am-7 pm lights on, 7 pm-7 am lights off, n=17] or dim light condition [lights off whenever the child is asleep, n=17].Outcome measures Sleep and activity behavior recorded by parental diary and actigraphy at 5, 11 and 25 weeks corrected age.Results Sleep at nighttime and the longest consolidated sleep period between 12 pm-6 am was longer (mixed model analysis, factor group: p=0.02, resp. p=0.01) and activity at nighttime was lower (p=0.005) at all ages in preterm compared to term infants. Cycled light exposed preterm infants showed the longest nighttime sleep duration. Dim light exposed preterm infants were the least active.Conclusions Preterm infants show an earlier emergence of the 24-h sleep-wake rhythm compared to term infants. Thus, the length of exposure to external time cues such as light may be important for the maturation of infant sleep-wake rhythms. Trial registry number: This trial has been registered at www.clinicaltrials.gov (identifier NCT01513226).

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Authors
Guyer, C., Huber, R., Fontijn, J., Bucher, H. U., Nicolai, H., Werner, H., Molinari, L., Latal, B., & Jenni, O. G.
Affiliations
  • University Children's Hospital Zurich (CH)
  • University Hospital Zurich (CH)
Corresponding author
Jenni, Oskar G.
ORCID
Venue
Early Human Development
Publisher
Elsevier BV
Published
2015-01
Volume
91
Issue
1
Pages
37-42
ISSN
0378-3782 (ISSN-L)
DOI
10.1016/j.earlhumdev.2014.11.002
OpenAlex
W2063762464
Cited by
61
References
36
Citations by year
2026: 2 · 2025: 6 · 2024: 5 · 2023: 9 · 2022: 8 · 2021: 5 · 2020: 2 · 2019: 4 · 2018: 4 · 2017: 8 · 2016: 8
FWCI
5.02
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Early Human Development (publishedVersion)
  • PubMed (publishedVersion)
  • Zurich Open Repository and Archive (University of Zurich) (acceptedVersion)
  • Zurich Open Repository and Archive (University of Zurich) (submittedVersion)
Funders
  • Velux Stiftung
  • Universitätsspital Zürich
Topics
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Infant Development and Preterm Care
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
Keywords
very preterm infants, term infants, dim light, neonatal intermediate care, nighttime sleep duration, actigraphy
MeSH terms
Activity Cycles, Female, Humans, Infant, Newborn, Male, Sleep, Infant, Extremely Premature

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