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Cited by 93Circadian rhythm and melatoninHypothalamic control of reproductive hormonesSleep and Wakefulness Research

The biological clock of very premature primate infants is responsive to light

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Hao, Haiping, Rivkees, Scott A.·1999·Proceedings of the National Academy of Sciences
DOI 10.1073/pnas.96.5.2426PMC PMC26800
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Abstract

Each year more than 250,000 infants in the United States are exposed to artificial lighting in hospital nurseries with little consideration given to environmental lighting cycles. Essential in determining whether environmental lighting cycles need to be considered in hospital nurseries is identifying when the infant’s endogenous circadian clock becomes responsive to light. Using a non-human primate model of the developing human, we examined when the circadian clock, located in the hypothalamic suprachiasmatic nuclei (SCN), becomes responsive to light. Preterm infant baboons of different ages were exposed to light (5,000 lux) at night, and then changes in SCN metabolic activity and gene expression were assessed. After exposure to bright light at night, robust increases in SCN metabolic activity and gene expression were seen at ages that were equivalent to human infants at 24 weeks after conception. These data provide direct evidence that the biological clock of very premature primate infants is responsive to light.

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  • Premature infants kept in regular light-dark conditions also fed orally sooner and spent fewer days on ventilator assistance, but had similar motor coordination compared with infants under continuous near darkness in the NICU (28-32 weeks of gestation).

    “Premature infants kept in regular light–dark conditions also fed orally sooner and spent fewer days on ventilator assistance, but had similar motor coordination compared with infants under continuous near darkness in the NICU (28–32 weeks of gestation)79–85.”

    From Rhythms of life: circadian disruption and brain disorders across the lifespan (2019) · cites this paper as [82]

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Authors
Hao, H., & Rivkees, S. A.
Affiliations
Yale University (US)
ORCID
Venue
Proceedings of the National Academy of Sciences
Publisher
National Academy of Sciences
Published
1999-03-02
Volume
96
Issue
5
Pages
2426-2429
ISSN
  • 0027-8424 (ISSN-L)
  • 1091-6490
DOI
10.1073/pnas.96.5.2426
PMC
PMC26800
OpenAlex
W2003439549
Cited by
93
References
34
Citations by year
2026: 2 · 2025: 1 · 2024: 1 · 2023: 3 · 2022: 4 · 2021: 3 · 2020: 1 · 2019: 1 · 2018: 2 · 2017: 2 · 2016: 5 · 2015: 1 · 2014: 3 · 2013: 3 · 2012: 3
FWCI
2.16
Type
journal article
Language
en
Open access
Locations
  • Proceedings of the National Academy of Sciences (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health
  • University of Illinois at Urbana-Champaign
  • National Institute of Neurological Disorders and Stroke (R01NS032624, R01NS32624)
Topics
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
  • Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
Keywords
circadian clock, suprachiasmatic nucleus, preterm infants, very preterm infants, light exposure at night, baboons, hypothalamic gene expression, neonatal development
MeSH terms
Animals, Autoradiography, Biological Clocks, Carbon Radioisotopes, Circadian Rhythm, Deoxyglucose, Gene Expression Regulation, Humans, Infant, Newborn, Infant, Premature, Light, Lighting, Papio, RNA, Messenger, Suprachiasmatic Nucleus, Transcription, Genetic

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