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Cited by 313

The DOI matches its Crossref record; 62 of the 62 references it cites were found in a registry or an index.

Klebsiella species: Taxonomy, hypervirulence and multidrug resistance

Open access
Dong, Ning, Yang, Xuemei, Chan, Edward Wai-Chi, Zhang, Rong, Chen, Sheng·2022·eBioMedicine
DOI 10.1016/j.ebiom.2022.103998
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Abstract

Members of the genus Klebsiella have rapidly evolved within the past decade, generating organisms that simultaneously exhibit both multidrug resistance and hypervirulence (MDR-hv) phenotypes; such organisms are associated with severe hospital- and community-acquired infections. Carbapenem-resistant infections with unknown optimal treatment regime were of particular concern among the MDR-hv Klebsiella strains. Recent studies have revealed the molecular features and the mobile resistance elements they harbour, allowing identification of genetic loci responsible for transmission, stable inheritance, and expression of mobile resistance or virulence-encoding elements that confer the new phenotypic characteristics of MDR-hv Klebsiella spp. Here, we provide a comprehensive review on the taxonomic position, species composition and different phylotypes of Klebsiella spp., describing the diversity and worldwide distribution of the MDR-hv clones, the genetic mutation and horizontal gene transfer events that drive the evolution of such clones, and the potential impact of MDR-hv infections on human health.

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Metadata

Authors
Dong, N., Yang, X., Chan, E. W.-C., Zhang, R., & Chen, S.
Venue
eBioMedicine
Publisher
Elsevier BV
Published
2022-05
Volume
79
Pages
103998
ISSN
2352-3964 (ISSN-L)
DOI
10.1016/j.ebiom.2022.103998
OpenAlex
W4223610939
Cited by
313
References
62
FWCI
17.34
Type
journal article
Language
en
Open access
gold

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CoChat. (2026). Citation check: Klebsiella species: Taxonomy, hypervirulence and multidrug resistance. https://app.cochat.ai/papers/10.1016/j.ebiom.2022.103998
The paper
Dong, N., Yang, X., Chan, E. W.-C., Zhang, R., & Chen, S. (2022). Klebsiella species: Taxonomy, hypervirulence and multidrug resistance. eBioMedicine. https://doi.org/10.1016/j.ebiom.2022.103998

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.