The DOI matches its Crossref record; 259 of the 261 references it cites were found in a registry or an index.
Age-Dependent and Gender-Dependent Regulation of Hypothalamic-Adrenocorticotropic-Adrenal Axis
Open accessAbstract
Tightly regulated output of glucocorticoids is critical to maintaining immune competence, the structure of neurons, muscle, and bone, blood pressure, glucose homeostasis, work capacity, and vitality in the human and experimental animal. Age, sex steroids, gender, stress, body composition, and disease govern glucocorticoid availability through incompletely understood mechanisms. According to an ensemble concept of neuroendocrine regulation, successful stress adaptations require repeated incremental signaling adjustments among hypothalamic corticotropin-releasing hormone and arginine vasopressin, pituitary adrenocorticotropic hormone, and adrenal corticosteroids. Signals are transduced via (positive) feedforward and (negative) feedback effects. Age and gonadal steroids strongly modulate stress-adaptive glucocorticoid secretion by such interlinked pathways.
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“Older men have a phase-advanced acrophase of almost 3 h”
From Sleep, testosterone and cortisol balance, and ageing men (2022) · cites this paper as [67]
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“so the 1500 to 1800 time period represents a later circadian time compared to young men [67].”
From Sleep, testosterone and cortisol balance, and ageing men (2022) · cites this paper as [67]
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“These [65, 66] and other [67] studies are consistent in showing that age is associated with higher late-afternoon and early-evening cortisol, and an advance in the timing (i.e. phase) of the cortisol rhythm, but not with cortisol-binding protein [68].”
From Sleep, testosterone and cortisol balance, and ageing men (2022) · cites this paper as [67]
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Cites
Kessler, R. C. (1994) · Archives of General Psychiatry · doi:10.1001/archpsyc.1994.03950010008002 · Cited by 12,370
Stress and the brain: from adaptation to disease
de Kloet, E. R., Joëls, M., & Holsboer, F. (2005) · Nature Reviews Neuroscience · doi:10.1038/nrn1683 · Cited by 4,621
Kirschbaum, C., Kudielka, B. M., Gaab, J., Schommer, N. C., & Hellhammer, D. H. (1999) · Psychosomatic Medicine · doi:10.1097/00006842-199903000-00006 · Cited by 1,890
Giustina, A., & Veldhuis, J. D. (1998) · Endocrine Reviews · doi:10.1210/edrv.19.6.0353 · Cited by 1,253
Self-citationFries, E., Hesse, J., Hellhammer, J., & Hellhammer, D. H. (2005) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2005.04.006 · Cited by 1,204
Depression and cortisol responses to psychological stress: A meta-analysis
Burke, H. M., Davis, M. C., Otte, C., & Mohr, D. C. (2005) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2005.02.010 · Cited by 1,194
Rosmond, R., Dallman, M. F., & Björntorp, P. A. (1998) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.83.6.4843 · Cited by 959
Effects of gender and age on the levels and circadian rhythmicity of plasma cortisol
Van Cauter, E. (1996) · Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.81.7.2468 · Cited by 951
Stressor specificity of central neuroendocrine responses: implications for stress-related disorders
Pacák, K., & Palkovits, M. (2001) · Endocrine Reviews · doi:10.1210/edrv.22.4.0436 · Cited by 926
Wilhelm, K. A. (1991) · Choice Reviews Online · doi:10.5860/choice.28-3566 · Cited by 852
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James, K. A., Stromin, J., Steenkamp, N., & Combrinck, M. I. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1085950 · Cited by 506
The physiology of endocrine systems with ageing
van den Beld, A. W., Kaufman, J.-M., Zillikens, M. C., Lamberts, S. W. J., Egan, J. M., & van der Lely, A. J. (2018) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(18)30026-3 · Cited by 349
The use of hair cortisol for the assessment of stress in animals
Heimbürge, S., Kanitz, E., & Otten, W. (2018) · General and Comparative Endocrinology · doi:10.1016/j.ygcen.2018.09.016 · Cited by 329
Revisiting Metchnikoff: Age-related alterations in microbiota-gut-brain axis in the mouse
Scott, K. A., Ida, M., Peterson, V. L., Prenderville, J. A., Moloney, G. M., Izumo, T., Murphy, K., Murphy, A., Ross, R. P., Stanton, C., et al. (2017) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2017.02.004 · Cited by 202
Hypothalamic‐Pituitary‐Adrenal (HPA) Axis and Aging
Gupta, D., & Morley, J. E. (2014) · Comprehensive physiology · doi:10.1002/cphy.c130049 · Cited by 206
Metadata
- Authors
- Veldhuis, J. D., Sharma, A., & Roelfsema, F.
- Affiliations
- Mayo Clinic (US)
- Leiden University Medical Center (NL)
- Corresponding author
- Veldhuis, Johannes D.
- Venue
- Endocrinology and Metabolism Clinics of North America
- Publisher
- Elsevier BV
- Published
- 2013-06
- Volume
- 42
- Issue
- 2
- Pages
- 201-225
- ISSN
- 0889-8529 (ISSN-L)
- PMC
- PMC3675779
- OpenAlex
- W2070843702
- Cited by
- 110
- References
- 261
- Citations by year
- 2026: 8 · 2025: 4 · 2024: 5 · 2023: 12 · 2022: 10 · 2021: 7 · 2020: 9 · 2019: 8 · 2018: 8 · 2017: 11 · 2016: 8 · 2015: 12 · 2014: 8
- FWCI
- 0.76
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Endocrinology and Metabolism Clinics of North America (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Leiden Repository (Leiden University) (submittedVersion)
- Funders
- National Institute of Diabetes and Digestive and Kidney Diseases (P30DK050456, R01DK073148, DK050456)
- National Center for Research Resources (UL1RR024150)
- Topics
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Estrogen and related hormone effects
- Keywords
- hypothalamic-pituitary-adrenal axis, glucocorticoid regulation, aging, sex differences, sex steroids, corticotropin-releasing factor, vasopressin, ACTH, stress adaptation, neuroendocrine regulation, glucocorticoid negative feedback, positive feedback
- MeSH terms
- Adrenocorticotropic Hormone, Aging, Animals, Corticotropin-Releasing Hormone, Female, Humans, Hydrocortisone, Hypothalamo-Hypophyseal System, Male, Pituitary-Adrenal System, Sex Characteristics, Feedback, Physiological
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