Revisiting Metchnikoff: Age-related alterations in microbiota-gut-brain axis in the mouse
Open accessAbstract
Over the last decade, there has been increased interest in the role of the gut microbiome in health including brain health. This is by no means a new theory; Elie Metchnikoff proposed over a century ago that targeting the gut by consuming lactic acid bacteria such as those in yogurt, could improve or delay the onset of cognitive decline associated with ageing. However, there is limited information characterising the relationship between the behavioural and physiological sequelae of ageing and alterations in the gut microbiome. To this end, we assessed the behavioural, physiological and caecal microbiota profile of aged male mice. Older mice (20-21months old) exhibited deficits in spatial memory and increases in anxiety-like behaviours compared to younger mice (2-3months old). They also exhibited increased gut permeability, which was directly correlated with elevations in peripheral pro-inflammatory cytokines. Furthermore, stress exacerbated the gut permeability of aged mice. Examination of the caecal microbiota revealed significant increases in phylum TM7, family Porphyromonadaceae and genus Odoribacter of aged mice. This represents a shift of aged microbiota towards a profile previously associated with inflammatory disease, particularly gastrointestinal and liver disorders. Furthermore, Porphyromonadaceae, which has also been associated with cognitive decline and affective disorders, was directly correlated with anxiety-like behaviour in aged mice. These changes suggest that changes in the gut microbiota and associated increases in gut permeability and peripheral inflammation may be important mediators of the impairments in behavioural, affective and cognitive functions seen in ageing.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Aged mice have a higher relative abundance of Porphyromonadaceae and the levels of this family correlate with increased anxiety-like behavior.
“aged mice have a higher relative abundance of Porphyromonadaceae and that the levels of this family correlate with increased anxiety-like behavior”
From The Microbiota-Gut-Brain Axis (2019) · cites this paper as Scott et al., 2017
The intestinal microbiota is implicated as a key regulator of systemic homeostasis, including neuroinflammation and behavioral disorders.
“Sequencing studies showing associations between particular gut microbiota profiles and various diseases in humans, along with studies modifying the gut bacterial composition in animal models, by probiotic administration or microbiota transfer, implicate the gut microbiota as a key regulator of systemic homeostasis, including neuroinflammation and behavioral disorders [16, 106].”
From Fecal microbiota transfer between young and aged mice reverses hallmarks of the aging gut, eye, and brain (2022) · cites this paper as [106]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Validation of open:closed arm entries in an elevated plus-maze as a measure of anxiety in the rat
Pellow, S., Chopin, P., File, S. E., & Briley, M. (1985) · Journal of Neuroscience Methods · doi:10.1016/0165-0270(85)90031-7 · Cited by 5,822 · see citing works
Mind-altering microorganisms: the impact of the gut microbiota on brain and behaviour
Cryan, J. F., & Dinan, T. G. (2012) · Nature Reviews Neuroscience · doi:10.1038/nrn3346 · Cited by 4,572 · see citing works
Self-citationMicroglia-mediated neurotoxicity: uncovering the molecular mechanisms
Block, M. L., Zecca, L., & Hong, J.-S. (2007) · Nature Reviews Neuroscience · doi:10.1038/nrn2038 · Cited by 4,110 · see citing works
Host microbiota constantly control maturation and function of microglia in the CNS
Erny, D., Hrabě de Angelis, A. L., Jaitin, D., Wieghofer, P., Staszewski, O., David, E., Keren-Shaul, H., Mahlakoiv, T., Jakobshagen, K., Buch, T., et al. (2015) · Nature Neuroscience · doi:10.1038/nn.4030 · Cited by 3,569 · see citing works
Gut microbiota composition correlates with diet and health in the elderly
Claesson, M. J., Jeffery, I. B., Conde, S., Power, S. E., O’Connor, E. M., Cusack, S., Harris, H. M. B., Coakley, M., Lakshminarayanan, B., O’Sullivan, O., et al. (2012) · Nature · doi:10.1038/nature11319 · Cited by 3,314 · see citing works
Self-citationBehavioural despair in rats: A new model sensitive to antidepressant treatments
Porsolt, R. D., Anton, G., Blavet, N., & Jalfre, M. (1978) · European Journal of Pharmacology · doi:10.1016/0014-2999(78)90118-8 · Cited by 3,138 · see citing works
The gut microbiota influences blood-brain barrier permeability in mice
Braniste, V., Al-Asmakh, M., Kowal, C., Anuar, F., Abbaspour, A., Tóth, M., Korecka, A., Bakocevic, N., Ng, L. G., Kundu, P., et al. (2014) · Science Translational Medicine · doi:10.1126/scitranslmed.3009759 · Cited by 2,530 · see citing works
The novel object recognition memory: neurobiology, test procedure, and its modifications
Antunes, M., & Biala, G. (2012) · Cognitive Processing · doi:10.1007/s10339-011-0430-z · Cited by 2,390 · see citing works
Altered fecal microbiota composition in patients with major depressive disorder
Jiang, H., Ling, Z., Zhang, Y., Mao, H., Ma, Z., Yin, Y., Wang, W., Tang, W., Tan, Z., Shi, J., et al. (2015) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2015.03.016 · Cited by 2,275 · see citing works
Serotonin, tryptophan metabolism and the brain-gut-microbiome axis
O’Mahony, S. M., Clarke, G., Borre, Y. E., Dinan, T. G., & Cryan, J. F. (2015) · Behavioural Brain Research · doi:10.1016/j.bbr.2014.07.027 · Cited by 2,012 · see citing works
Self-citationKelly, J. R., Borre, Y., O' Brien, C., Patterson, E., El Aidy, S., Deane, J., Kennedy, P. J., Beers, S., Scott, K., Moloney, G., et al. (2016) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2016.07.019 · Cited by 1,683 · see citing works
Self-citationThe interplay between the intestinal microbiota and the brain
Collins, S. M., Surette, M., & Bercik, P. (2012) · Nature Reviews Microbiology · doi:10.1038/nrmicro2876 · Cited by 1,611 · cited 3× · see citing works
“In a study of encephalopathic patients with cirrhosis, increases in Porphyromonadaceae positively correlated with increased cognitive dysfunction (Bajaj et al. 2012, Collins et al. 2012).”
BackgroundResultCattaneo, A., Cattane, N., Galluzzi, S., Provasi, S., Lopizzo, N., Festari, C., Ferrari, C., Guerra, U. P., Paghera, B., Muscio, C., et al. (2017) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2016.08.019 · Cited by 1,382 · see citing works
Molecular inflammation: Underpinnings of aging and age-related diseases
Chung, H. Y., Cesari, M., Anton, S., Marzetti, E., Giovannini, S., Seo, A. Y., Carter, C., Yu, B. P., & Leeuwenburgh, C. (2009) · Ageing Research Reviews · doi:10.1016/j.arr.2008.07.002 · Cited by 1,203 · see citing works
Microbiota and neurodevelopmental windows: implications for brain disorders
Borre, Y. E., O’Keeffe, G. W., Clarke, G., Stanton, C., Dinan, T. G., & Cryan, J. F. (2014) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2014.05.002 · Cited by 1,089 · see citing works
Self-citationGene-expression profile of the ageing brain in mice
Lee, C.-K., Weindruch, R., & Prolla, T. A. (2000) · Nature Genetics · doi:10.1038/77046 · Cited by 1,055 · see citing works
From gut dysbiosis to altered brain function and mental illness: mechanisms and pathways
Rogers, G. B., Keating, D. J., Young, R. L., Wong, M.-L., Licinio, J., & Wesselingh, S. (2016) · Molecular Psychiatry · doi:10.1038/mp.2016.50 · Cited by 969 · see citing works
Inflammatory mediators in the elderly
Krabbe, K. S., Pedersen, M., & Bruunsgaard, H. (2004) · Experimental Gerontology · doi:10.1016/j.exger.2004.01.009 · Cited by 928 · see citing works
Using the rat forced swim test to assess antidepressant-like activity in rodents
Slattery, D. A., & Cryan, J. F. (2012) · Nature Protocols · doi:10.1038/nprot.2012.044 · Cited by 903 · see citing works
Self-citationMicrobiota is essential for social development in the mouse
Desbonnet, L., Clarke, G., Shanahan, F., Dinan, T. G., & Cryan, J. F. (2014) · Molecular Psychiatry · doi:10.1038/mp.2013.65 · Cited by 866 · see citing works
Self-citationGut instincts: microbiota as a key regulator of brain development, ageing and neurodegeneration
Dinan, T. G., & Cryan, J. F. (2017) · The Journal of Physiology · doi:10.1113/jp273106 · Cited by 813 · see citing works
Self-citationGut microbiota depletion from early adolescence in mice: implications for brain and behaviour
Desbonnet, L., Clarke, G., Traplin, A., O’Sullivan, O., Crispie, F., Moloney, R. D., Cotter, P. D., Dinan, T. G., & Cryan, J. F. (2015) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2015.04.004 · Cited by 760 · see citing works
Self-citationFröhlich, E. E., Farzi, A., Mayerhofer, R., Reichmann, F., Jačan, A., Wagner, B., Zinser, E., Bordag, N., Magnes, C., Fröhlich, E., et al. (2016) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2016.02.020 · Cited by 720 · see citing works
McKinney, W. T. (1969) · Archives of General Psychiatry · doi:10.1001/archpsyc.1969.01740200112015 · Cited by 710 · see citing works
The Gut Microbiome and the Brain
Galland, L. (2014) · Journal of Medicinal Food · doi:10.1089/jmf.2014.7000 · Cited by 648 · see citing works
Hughes, R. N. (2004) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2004.06.006 · Cited by 641 · cited 1× · see citing works
“The Y-maze was performed as a test of spontaneous alternation, used to assess exploration, cognition and hippocampal-dependent memory (Hughes 2004, Senechal et al. 2007).”
Cryan, J. F., & Mombereau, C. (2004) · Molecular Psychiatry · doi:10.1038/sj.mp.4001457 · Cited by 616 · see citing works
Self-citationLinkage of gut microbiome with cognition in hepatic encephalopathy
Bajaj, J. S., Ridlon, J. M., Hylemon, P. B., Thacker, L. R., Heuman, D. M., Smith, S., Sikaroodi, M., & Gillevet, P. M. (2012) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00190.2011 · Cited by 547 · see citing works
Adult hippocampal neurogenesis is regulated by the microbiome
Ogbonnaya, E. S., Clarke, G., Shanahan, F., Dinan, T. G., Cryan, J. F., & O’Leary, O. F. (2015) · Biological Psychiatry · doi:10.1016/j.biopsych.2014.12.023 · Cited by 491 · see citing works
Self-citationStress and the gastrointestinal tract
Bhatia, V., & Tandon, R. (2005) · Journal of Gastroenterology and Hepatology · doi:10.1111/j.1440-1746.2004.03508.x · Cited by 486 · see citing works
Möhle, L., Mattei, D., Heimesaat, M. M., Bereswill, S., Fischer, A., Alutis, M., French, T., Hambardzumyan, D., Matzinger, P., Dunay, I. R., et al. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.04.074 · Cited by 470 · see citing works
Intestinal bacteria and ageing
Woodmansey, E. J. (2007) · Journal of Applied Microbiology · doi:10.1111/j.1365-2672.2007.03400.x · Cited by 446 · see citing works
Microbial shifts in the aging mouse gut
Langille, M. G., Meehan, C. J., Koenig, J. E., Dhanani, A. S., Rose, R. A., Howlett, S. E., & Beiko, R. G. (2014) · Microbiome · doi:10.1186/s40168-014-0050-9 · Cited by 437 · see citing works
Signatures of early frailty in the gut microbiota
Jackson, M. A., Jeffery, I. B., Beaumont, M., Bell, J. T., Clark, A. G., Ley, R. E., O’Toole, P. W., Spector, T. D., & Steves, C. J. (2016) · Genome Medicine · doi:10.1186/s13073-016-0262-7 · Cited by 436 · see citing works
Mild cognitive impairment and its management in older people
Eshkoor, S. A., Mun, C. Y., Ng, C. K., & Hamid, T. A. (2015) · Clinical Interventions in Aging · doi:10.2147/cia.s73922 · Cited by 428 · see citing works
A Review of the Relationship between Proinflammatory Cytokines and Major Depressive Disorder
Young, J. J., Bruno, D., & Pomara, N. (2014) · Journal of Affective Disorders · doi:10.1016/j.jad.2014.07.032 · Cited by 422 · see citing works
Ageing of the human metaorganism: the microbial counterpart
Biagi, E., Candela, M., Fairweather‐Tait, S. J., Franceschi, C., & Brigidi, P. (2011) · AGE · doi:10.1007/s11357-011-9217-5 · Cited by 365 · see citing works
Age-Associated Remodeling of the Intestinal Epithelial Barrier
Tran, L., & Greenwood-Van Meerveld, B. (2013) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/glt106 · Cited by 320 · see citing works
Immune homeostasis, dysbiosis and therapeutic modulation of the gut microbiota
Peterson, C. T., Sharma, V., Elmén, L., & Peterson, S. N. (2014) · Clinical & Experimental Immunology · doi:10.1111/cei.12474 · Cited by 318 · see citing works
Bangsgaard Bendtsen, K. M., Krych, L., Sørensen, D. B., Pang, W., Nielsen, D. S., Josefsen, K., Hansen, L. H., Sørensen, S. J., & Hansen, A. K. (2012) · PLoS ONE · doi:10.1371/journal.pone.0046231 · Cited by 299 · see citing works
Recycling Metchnikoff: Probiotics, the Intestinal Microbiome and the Quest for Long Life
Mackowiak, P. A. (2013) · Frontiers in Public Health · doi:10.3389/fpubh.2013.00052 · Cited by 294 · see citing works
Yarandi, S., Peterson, D. A., Treisman, G. J., Moran, T. H., & Pasricha, P. J. (2016) · Journal of Neurogastroenterology and Motility · doi:10.5056/jnm15146 · Cited by 294 · see citing works
Contribution of systemic inflammation to chronic neurodegeneration
Perry, V. H. (2010) · Acta Neuropathologica · doi:10.1007/s00401-010-0722-x · Cited by 277 · see citing works
Ageing and gut microbes: Perspectives for health maintenance and longevity
Biagi, E., Candela, M., Turroni, S., Garagnani, P., Franceschi, C., & Brigidi, P. (2013) · Pharmacological Research · doi:10.1016/j.phrs.2012.10.005 · Cited by 276 · cited 1× · see citing works
“Furthermore, the composition of the gut microbiota in both humans and laboratory animals varies across the lifespan (Rehman 2012, Biagi et al. 2013, Jeffery and O'Toole 2013, Langille et al. 2014, Lynch et al. 2015).”
Meddings, J. B., & Swain, M. G. (2000) · Gastroenterology · doi:10.1053/gast.2000.18152 · Cited by 269 · see citing works
Immune aging, dysmetabolism, and inflammation in neurological diseases
Deleidi, M., Jäggle, M., & Rubino, G. (2015) · Frontiers in Neuroscience · doi:10.3389/fnins.2015.00172 · Cited by 260 · see citing works
Microbiota and the gut-liver axis: Bacterial translocation, inflammation and infection in cirrhosis
Giannelli, V. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i45.16795 · Cited by 237 · see citing works
What do we know about aging and spatial cognition? Reviews and perspectives
Klencklen, G., Després, O., & Dufour, A. (2011) · Ageing Research Reviews · doi:10.1016/j.arr.2011.10.001 · Cited by 233 · see citing works
O’Tuathaigh, C. M. P., Babovic, D., O’Sullivan, G. J., Clifford, J. J., Tighe, O., Croke, D. T., Harvey, R. P., & Waddington, J. L. (2007) · Neuroscience · doi:10.1016/j.neuroscience.2007.03.051 · Cited by 230 · see citing works
A study of the rat's behavior in a field : a contribution to method in comparative psychology
Hall, C. S., & Ballachey, E. L. (1932) · University of California Press eBooks · Cited by 213 · see citing works
Diet-microbiota interactions and their implications for healthy living
Jeffery, I., & O'Toole, P. (2013) · Nutrients · doi:10.3390/nu5010234 · Cited by 199 · see citing works
Heijtz, R. D. (2016) · Seminars in Fetal and Neonatal Medicine · doi:10.1016/j.siny.2016.04.012 · Cited by 193 · see citing works
Towards understanding brain-gut-microbiome connections in Alzheimer’s disease
Xu, R., & Wang, Q. (2016) · BMC Systems Biology · doi:10.1186/s12918-016-0307-y · Cited by 175 · see citing works
D'Mello, C., Ronaghan, N., Zaheer, R., Dicay, M., Le, T., MacNaughton, W. K., Surrette, M. G., & Swain, M. G. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.0575-15.2015 · Cited by 169 · see citing works
Aging of the mammalian gastrointestinal tract: a complex organ system
Saffrey, M. J. (2013) · AGE · doi:10.1007/s11357-013-9603-2 · Cited by 139 · see citing works
Adding fuel to the fire: the impact of stress on the ageing brain
Prenderville, J. A., Kennedy, P. J., Dinan, T. G., & Cryan, J. F. (2015) · Trends in Neurosciences · doi:10.1016/j.tins.2014.11.001 · Cited by 136 · see citing works
Self-citationAging impairs hippocampus-dependent long-term memory for object location in mice
Wimmer, M. E., Hernandez, P. J., Blackwell, J. M., & Abel, T. G. (2011) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2011.07.007 · Cited by 128 · see citing works
Microbiota and neuroimmune signalling—Metchnikoff to microglia
Cryan, J. F., & Dinan, T. G. (2015) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2015.127 · Cited by 122 · see citing works
Self-citationThe impact of ageing on the intestinal epithelial barrier and immune system
Man, A., Gicheva, N., & Nicoletti, C. (2014) · Cellular Immunology · doi:10.1016/j.cellimm.2014.04.001 · Cited by 114 · see citing works
Age-Dependent and Gender-Dependent Regulation of Hypothalamic-Adrenocorticotropic-Adrenal Axis
Veldhuis, J. D., Sharma, A., & Roelfsema, F. (2013) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/j.ecl.2013.02.002 · Cited by 110 · see citing works
Mood and anxiety related phenotypes in mice characterization using behavioral tests
Gould, T. D. (2009) · Cited by 109 · see citing works
Ren, W., Wu, K., Li, X., Luo, M., Liu, H., Zhang, S., & Hu, Y. (2013) · Aging Clinical and Experimental Research · doi:10.1007/s40520-013-0148-0 · Cited by 94 · see citing works
Bailey, M. T. (2014) · Advances in experimental medicine and biology · doi:10.1007/978-1-4939-0897-4_12 · Cited by 88 · see citing works
CREIGHTON, A. S., Davison, T. E., & Kissane, D. W. (2015) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.4378 · Cited by 87 · see citing works
New Research on Anxiety Disorders in the Elderly and an Update on Evidence-Based Treatments
Andreescu, C., & Varon, D. (2015) · Current Psychiatry Reports · doi:10.1007/s11920-015-0595-8 · Cited by 85 · cited 2× · see citing works
“Anxiety is often reported in the elderly, as are anxiety-like behaviours in aged laboratory animals (Kastenschmidt and Kennedy 2011, Brouwer-Brolsma et al. 2014, Andreescu and Varon 2015, Ellison et al. 2015, Creighton et al. 2016).”
BackgroundThe Ups and Downs of Modelling Mood Disorders in Rodents
Slattery, D. A., & Cryan, J. F. (2014) · ILAR Journal · doi:10.1093/ilar/ilu026 · Cited by 85 · see citing works
Self-citationMaintenance of a healthy trajectory of the intestinal microbiome during aging: A dietary approach
Candela, M., Biagi, E., Brigidi, P., O’Toole, P. W., & de Vos, W. M. (2013) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2013.12.004 · Cited by 85 · see citing works
CREIGHTON, A. S., Davison, T. E., & Kissane, D. W. (2016) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.4604 · Cited by 77 · see citing works
Role of the Gut Microbiota in Age-Related Chronic Inflammation
Rehman, T. (2012) · Endocrine, Metabolic & Immune Disorders-Drug Targets · doi:10.2174/187153012803832620 · Cited by 67 · see citing works
Microbiota and healthy ageing: observational and nutritional intervention studies
Brüssow, H. (2013) · Microbial Biotechnology · doi:10.1111/1751-7915.12048 · Cited by 61 · see citing works
Elderly patients have an altered gut-brain axis regardless of the presence of cirrhosis
Bajaj, J. S., Ahluwalia, V., Steinberg, J. L., Hobgood, S. E., Boling, P. A., Godschalk, M., Habib, S., White, M. B., Fagan, A., Gavis, E. A., et al. (2016) · Scientific Reports · doi:10.1038/srep38481 · Cited by 59 · see citing works
Role of the Brain-Gut Axis in the Pathophysiology of Crohn’s Disease
Stasi, C., & Orlandelli, E. (2008) · Digestive Diseases · doi:10.1159/000116774 · Cited by 54 · see citing works
Amyloid precursor protein knockdown by siRNA impairs spontaneous alternation in adult mice
Sénéchal, Y., Kelly, P. H., Cryan, J. F., Natt, F., & Dev, K. K. (2007) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2007.04672.x · Cited by 52 · see citing works
Self-citationAged rats are hypo-responsive to acute restraint: implications for psychosocial stress in aging
Buechel, H. M., Popović, J., Staggs, K. E., Anderson, K. L., Thibault, O., & Blalock, E. M. (2014) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2014.00013 · Cited by 45 · see citing works
Mabbott, N. A. (2015) · Clinical Science · doi:10.1042/cs20150364 · Cited by 39 · see citing works
Age Is Not Necessarily Aging: Another Step towards Understanding the ‘Clocks’ That Time Aging
Li, S., & Schmiedek, F. (2002) · Gerontology · doi:10.1159/000048917 · Cited by 35 · see citing works
Watanabe, Y., Arase, S., Nagaoka, N., Kawai, M., & Matsumoto, S. (2016) · PLoS ONE · doi:10.1371/journal.pone.0150559 · Cited by 35 · see citing works
Thinking outside the brain for cognitive improvement: Is peripheral immunomodulation on the way?
Zheng, X., Zhang, X., An, K., Ran, C., Wang, G., & Hao, H. (2014) · Neuropharmacology · doi:10.1016/j.neuropharm.2014.06.020 · Cited by 29 · see citing works
Depression and Anxiety in Late Life: Diagnostic Insights and Therapeutic Options
Kastenschmidt, E. K., & Kennedy, G. J. (2011) · Mount Sinai Journal of Medicine A Journal of Translational and Personalized Medicine · doi:10.1002/msj.20266 · Cited by 26 · see citing works
Brouwer-Brolsma, E. M., Schuurman, T., de Groot, C. P. G. M., Feskens, E. J. M., Lute, C., Naninck, E. F. G., Arndt, S. S., van der Staay, F. J., Bravenboer, N., Kőrösi, A., et al. (2014) · Behavioural Brain Research · doi:10.1016/j.bbr.2014.03.038 · Cited by 25 · see citing works
Ellison, D. L., White, D., & Farrar, F. C. (2015) · Nursing Clinics of North America · doi:10.1016/j.cnur.2014.10.014 · Cited by 24 · see citing works
Role of the Intestinal Microbiota in Host Responses to Stressor Exposure
Mackos, A. R., Varaljay, V. A., Maltz, R. M., Gur, T., & Bailey, M. T. (2016) · International review of neurobiology · doi:10.1016/bs.irn.2016.08.002 · Cited by 23 · see citing works
The role of the microbiota in ageing: current state and perspectives
Lynch, D. B., Jeffery, I. B., & O’Toole, P. W. (2015) · WIREs Systems Biology and Medicine · doi:10.1002/wsbm.1293 · Cited by 18 · see citing works
Critical Care Issues of the Geriatric Patient
Joyce, M. F., & Reich, J. A. (2015) · Anesthesiology Clinics · doi:10.1016/j.anclin.2015.05.009 · Cited by 8 · see citing works
Age-related changes in detection of spatial novelty
Maasberg, D. W., Shelley, L. E., & Gilbert, P. E. (2011) · Behavioural Brain Research · doi:10.1016/j.bbr.2011.12.024 · Cited by 8 · see citing works
Filaretova, L. P. (2007) · Neuroscience and Behavioral Physiology · doi:10.1007/s11055-007-0021-8 · Cited by 5 · see citing works
Flagged first, then by citations
1 of the 87 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Cryan, J. F., O'Riordan, K. J., Cowan, C. S. M., Sandhu, K. V., Bastiaanssen, T. F. S., Boehme, M., Codagnone, M. G., Cussotto, S., Fulling, C., Golubeva, A. V., et al. (2019) · Physiological Reviews · doi:10.1152/physrev.00018.2018 · Cited by 5,286 · see citing works
Self-citationThe gut microbiome in neurological disorders
Cryan, J. F., O'Riordan, K. J., Sandhu, K., Peterson, V., & Dinan, T. G. (2020) · The Lancet Neurology · doi:10.1016/s1474-4422(19)30356-4 · Cited by 1,336 · see citing works
Self-citationThevaranjan, N., Puchta, A., Schulz, C., Naidoo, A., Szamosi, J. C., Verschoor, C. P., Loukov, D., Schenck, L. P., Jury, J., Foley, K. P., et al. (2017) · Cell Host & Microbe · doi:10.1016/j.chom.2017.03.002 · Cited by 1,322 · see citing works
van de Wouw, M., Boehme, M., Lyte, J. M., Wiley, N., Strain, C., O'Sullivan, O., Clarke, G., Stanton, C., Dinan, T. G., & Cryan, J. F. (2018) · The Journal of Physiology · doi:10.1113/jp276431 · Cited by 789 · see citing works
Self-citationKim, M.-S., Kim, Y., Choi, H., Kim, W., Park, S., Lee, D., Kim, D. K., Kim, H. J., Choi, H., Hyun, D.-W., et al. (2020) · Gut · doi:10.1136/gutjnl-2018-317431 · Cited by 614 · see citing works
Inflammation: the link between comorbidities, genetics, and Alzheimer’s disease
Newcombe, E. A., Camats-Perna, J., Silva, M. L., Valmas, N., Huat, T. J., & Medeiros, R. (2018) · Journal of Neuroinflammation · doi:10.1186/s12974-018-1313-3 · Cited by 532 · see citing works
Parker, A., Romano, S., Ansorge, R., Aboelnour, A., Le Gall, G., Savva, G. M., Pontifex, M. G., Telatin, A., Baker, D., Jones, E., et al. (2022) · Microbiome · doi:10.1186/s40168-022-01243-w · Cited by 368 · see citing works
The neuroendocrinology of the microbiota-gut-brain axis: a behavioural perspective
Cussotto, S., Sandhu, K. V., Dinan, T. G., & Cryan, J. F. (2018) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2018.04.002 · Cited by 326 · see citing works
“behaviour characteristic in late life (Scott et al., 2017).”
Self-citationMicrobiota from young mice counteracts selective age-associated behavioral deficits
Boehme, M., Guzzetta, K. E., Bastiaanssen, T. F. S., van de Wouw, M., Moloney, G. M., Gual-Grau, A., Spichak, S., Olavarría-Ramírez, L., Fitzgerald, P., Morillas, E., et al. (2021) · Nature Aging · doi:10.1038/s43587-021-00093-9 · Cited by 313 · see citing works
Self-citationRecent developments in understanding the role of the gut microbiota in brain health and disease
Sherwin, E., Dinan, T. G., & Cryan, J. F. (2018) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.13416 · Cited by 338 · see citing works
Self-citationDifferential effects of psychotropic drugs on microbiome composition and gastrointestinal function
Cussotto, S., Strain, C. R., Fouhy, F., Strain, R. G., Peterson, V. L., Clarke, G., Stanton, C., Dinan, T. G., & Cryan, J. F. (2019) · Psychopharmacology · doi:10.1007/s00213-018-5006-5 · Cited by 266 · see citing works
Self-citationAhmadi, S., Wang, S., Nagpal, R., Wang, B., Jain, S., Razazan, A. P., Mishra, S. P., Zhu, X., Wang, Z., Kavanagh, K., et al. (2020) · JCI Insight · doi:10.1172/jci.insight.132055 · Cited by 261 · see citing works
Livshits, G., & Kalinkovich, A. (2019) · Ageing Research Reviews · doi:10.1016/j.arr.2019.100980 · Cited by 239 · see citing works
Chen, D., Yang, X., Yang, J., Lai, G., Yong, T., Tang, X., Shuai, O., Zhou, G., Xie, Y., & Wu, Q. (2017) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2017.00403 · Cited by 227 · see citing works
Gut microbiota, cognitive frailty and dementia in older individuals: A systematic review
Ticinesi, A., Tana, C., Nouvenne, A., Prati, B., Lauretani, F., & Meschi, T. (2018) · Clinical Interventions in Aging · doi:10.2147/cia.s139163 · Cited by 215 · see citing works
Making Sense of … the Microbiome in Psychiatry
Bastiaanssen, T. F. S., Cowan, C. S. M., Claesson, M. J., Dinan, T. G., & Cryan, J. F. (2018) · The International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyy067 · Cited by 223 · see citing works
Self-citationNeuroimmune circuits in inter-organ communication
Huh, J. R., & Veiga‐Fernandes, H. (2019) · Nature reviews. Immunology · doi:10.1038/s41577-019-0247-z · Cited by 216 · see citing works
You’ve got male: Sex and the microbiota-gut-brain axis across the lifespan
Jaggar, M., Rea, K., Spichak, S., Dinan, T. G., & Cryan, J. F. (2020) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2019.100815 · Cited by 200 · see citing works
Self-citationShoji, H., & Miyakawa, T. (2019) · Neuropsychopharmacology Reports · doi:10.1002/npr2.12052 · Cited by 203 · see citing works
Age-Associated Changes in the Immune System and Blood–Brain Barrier Functions
Erickson, M. A., & Banks, W. A. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20071632 · Cited by 192 · see citing works
Brunt, V. E., Gioscia‐Ryan, R. A., Richey, J. J., Zigler, M. C., Cuevas, L. M., Gonzalez, A., Vázquez‐Baeza, Y., Battson, M. L., Smithson, A. T., Gilley, A. D., et al. (2019) · The Journal of Physiology · doi:10.1113/jp277336 · Cited by 182 · see citing works
Comprehensive approaches for assessing the safety of probiotic bacteria
Pradhan, D., Mallappa, R. H., & Grover, S. (2020) · Food Control · doi:10.1016/j.foodcont.2019.106872 · Cited by 179 · see citing works
Poor cognitive ageing: Vulnerabilities, mechanisms and the impact of nutritional interventions
Miquel, S., Champ, C., Day, J. E. L., Aarts, E., Bahr, B. A., Bakker, M. J., Bánáti, D., Calabrese, V., Cederholm, T., Cryan, J. F., et al. (2017) · Ageing Research Reviews · doi:10.1016/j.arr.2017.12.004 · Cited by 163 · see citing works
Self-citationTime to test antibacterial therapy in Alzheimer’s disease
Panza, F., Lozupone, M., Solfrizzi, V., Watling, M., & Imbimbo, B. P. (2019) · Brain · doi:10.1093/brain/awz244 · Cited by 161 · see citing works
Lu, S., Zhao, Q., Yu, G., Sun, Z., Li, W., Guo, S., & Zhang, A. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.117207 · Cited by 182 · see citing works
Gutted! Unraveling the Role of the Microbiome in Major Depressive Disorder
Bastiaanssen, T. F. S., Cussotto, S., Claesson, M. J., Clarke, G., Dinan, T. G., & Cryan, J. F. (2020) · Harvard Review of Psychiatry · doi:10.1097/hrp.0000000000000243 · Cited by 159 · see citing works
Self-citationLee, J., Venna, V. R., Durgan, D. J., Shi, H., Hudobenko, J., Putluri, N., Petrosino, J. F., McCullough, L. D., & Bryan, R. M. (2020) · Gut Microbes · doi:10.1080/19490976.2020.1814107 · Cited by 151 · see citing works
Park, J. Y., Choi, J., Lee, Y., Lee, J.-E., Lee, E. H., Kwon, H.-J., Yang, J., Jeong, B.-R., Kim, Y., & Han, P. (2017) · Experimental Neurobiology · doi:10.5607/en.2017.26.6.369 · Cited by 148 · see citing works
Ahmadi, S., Razazan, A. P., Nagpal, R., Jain, S., Wang, B., Mishra, S. P., Wang, S., Justice, J. N., Ding, J., McClain, D. A., et al. (2020) · The Journals of Gerontology Series A · doi:10.1093/gerona/glaa056 · Cited by 146 · see citing works
Boehme, M., van de Wouw, M., Bastiaanssen, T. F. S., Olavarría-Ramírez, L., Lyons, K., Fouhy, F., Golubeva, A. V., Moloney, G. M., Minuto, C., Sandhu, K. V., et al. (2020) · Molecular Psychiatry · doi:10.1038/s41380-019-0425-1 · Cited by 128 · see citing works
Self-citationLynch, C. M. K., Cowan, C. S. M., Bastiaanssen, T. F. S., Moloney, G. M., Theune, N., van de Wouw, M., Florensa-Zanuy, E., Ventura‐Silva, A. P., Codagnone, M. G., Villalobos-Manríquez, F., et al. (2022) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2022.12.008 · Cited by 133 · see citing works
Self-citationHeat-killed lactobacilli alter both microbiota composition and behaviour
Warda, A. K., Rea, K., Fitzgerald, P., Hueston, C. M., González-Tortuero, E., Dinan, T. G., & Hill, C. (2018) · Behavioural Brain Research · doi:10.1016/j.bbr.2018.12.047 · Cited by 123 · see citing works
Self-citationNutrients in the Prevention of Alzheimer’s Disease
Cremonini, A. L., Caffa, I., Cea, M., Nencioni, A., Odetti, P. R., & Monacelli, F. (2019) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2019/9874159 · Cited by 114 · see citing works
Gutsy Moves: The Amygdala as a Critical Node in Microbiota to Brain Signaling
Cowan, C. S. M., Hoban, A. E., Ventura‐Silva, A. P., Dinan, T. G., Clarke, G. A., & Cryan, J. F. (2017) · BioEssays · doi:10.1002/bies.201700172 · Cited by 107 · see citing works
Self-citationGut Microbiota Interaction with the Central Nervous System throughout Life
Ojeda, J., Ávila, A., & Vidal, P. M. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10061299 · Cited by 107 · see citing works
Zhu, X., Shen, J., Feng, S., Huang, C., Wang, H., Huo, F., & Liu, H. (2023) · Microbiome · doi:10.1186/s40168-023-01567-1 · Cited by 104 · see citing works
Sariola, S., & Gilbert, S. F. (2020) · Microorganisms · doi:10.3390/microorganisms8050746 · Cited by 97 · see citing works
O’Hagan, C., Li, J. V., Marchesi, J. R., Plummer, S. F., Garaiová, I., & Good, M. A. (2017) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2017.05.015 · Cited by 97 · see citing works
Of microbes and minds: A narrative review on the second brain aging
Calvani, R., Picca, A., Lo Monaco, M. R., Landi, F., Bernabei, R., & Marzetti, E. (2018) · Frontiers in Medicine · doi:10.3389/fmed.2018.00053 · Cited by 92 · see citing works
Probiotic, Prebiotic, and Brain Development
Cerdó, T., Ruiz-Rodriguez, A., Suárez, A., & Campoy, C. (2017) · Nutrients · doi:10.3390/nu9111247 · Cited by 94 · see citing works
Dietary phospholipids: Role in cognitive processes across the lifespan
Schverer, M., O’Mahony, S. M., O’Riordan, K. J., Donoso, F., Roy, B. L., Stanton, C., Dinan, T. G., Schellekens, H., & Cryan, J. F. (2020) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2020.01.012 · Cited by 91 · see citing works
Self-citationTang, W., Meng, Z., Li, N., Liu, Y., Li, L., Chen, D., & Yang, Y. (2021) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2020.611014 · Cited by 89 · see citing works
The microbiota-gut-brain axis: Focus on the fundamental communication pathways
Bistoletti, M., Bosi, A., Banfi, D., Giaroni, C., & Baj, A. (2020) · Progress in molecular biology and translational science · doi:10.1016/bs.pmbts.2020.08.012 · Cited by 88 · see citing works
Alcohol, microbiome, and their effect on psychiatric disorders
Hillemacher, T., Bachmann, O. P., Kahl, K. G., & Frieling, H. (2018) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2018.04.015 · Cited by 87 · see citing works
Lv, Y., Qin, X., Jia, H., Chen, S., Sun, W., & Wang, X. (2019) · British Journal Of Nutrition · doi:10.1017/s0007114519001909 · Cited by 85 · see citing works
Sencio, V., Gallerand, A., Machado, M. G., Deruyter, L., Heumel, S., Soulard, D., Barthelemy, J., Cuinat, C., Vieira, A. T., Barthélémy, A., et al. (2021) · Infection and Immunity · doi:10.1128/iai.00734-20 · Cited by 82 · see citing works
Gu, X., Zhou, J., Zhou, Y., Wang, H., Si, N., Ren, W., Zhao, W., Fan, X., Gao, W., Wei, X., et al. (2021) · Alzheimer's Research & Therapy · doi:10.1186/s13195-021-00779-7 · Cited by 81 · see citing works
Janiak, M. C., Montague, M. J., Villamil, C. I., Stock, M. K., Trujillo, A. E., DePasquale, A. N., Orkin, J. D., Bauman, S. E., González, O., Platt, M. L., et al. (2021) · Microbiome · doi:10.1186/s40168-021-01009-w · Cited by 79 · see citing works
The intestinal microbiome and its relevance for functionality in older persons
Ticinesi, A., Tana, C., & Nouvenne, A. (2019) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0000000000000521 · Cited by 80 · see citing works
Gut-brain axis: A matter of concern in neuropsychiatric disorders…!
Naveed, M., Zhou, Q.-G., Chu, X., Taleb, A., Meng, F. J., Ahmed, B., Zhang, Y., Fukunaga, K., & Han, F. (2020) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2020.110051 · Cited by 81 · see citing works
Age-dependent remodeling of gut microbiome and host serum metabolome in mice
Wu, C., Muthyala, S. D. V., Klemashevich, C. L., Ufondu, A., Menon, R., Chen, Z., Devaraj, S., Jayaraman, A., & Sun, Y. (2021) · Aging · doi:10.18632/aging.202525 · Cited by 80 · see citing works
Ribera, C., Sánchez‐Ortí, J. V., Clarke, G. A., Marx, W., Mörkl, S., & Balanzá‐Martínez, V. (2024) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2024.105561 · Cited by 85 · see citing works
El Dib, R., Periyasamy, A. G., de Barros, J. L., França, C. G., Senefonte, F. L., Vesentini, G., Alves, M. G. O., Rodrigues, J. V. D. S., Gomaa, H., Gomes Júnior, J. R., et al. (2021) · Clinical Nutrition ESPEN · doi:10.1016/j.clnesp.2021.07.027 · Cited by 75 · see citing works
Age-Related Hearing Loss: The Link between Inflammaging, Immunosenescence, and Gut Dysbiosis
Kociszewska, D., & Vlajkovic, S. M. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23137348 · Cited by 77 · see citing works
Microbiota-immune-brain interactions: A lifespan perspective
Ratsika, A., Cruz-Pereira, J. S., Lynch, C. M. K., Clarke, G. A., & Cryan, J. F. (2022) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2022.102652 · Cited by 78 · see citing works
Self-citationNeuroimmune contributions to Alzheimer’s disease: a focus on human data
Haage, V., & De Jager, P. L. (2022) · Molecular Psychiatry · doi:10.1038/s41380-022-01637-0 · Cited by 74 · see citing works
Sadovnikova, I. S., Gureev, A. P., Ignatyeva, D. A., Vladimirovna, G. M., Chernyshova, E. V., Krutskikh, E. P., Novikova, A. G., & Popov, V. N. (2021) · Pharmaceuticals · doi:10.3390/ph14070607 · Cited by 73 · see citing works
van der Lugt, B., Rusli, F., Lute, C., Lamprakis, A., Salazar, E., Boekschoten, M. V., Hooiveld, G. J., Müller, M., Vervoort, J., Kersten, S., et al. (2018) · Aging · doi:10.18632/aging.101439 · Cited by 72 · see citing works
Wnt signaling in bone, kidney, intestine, and adipose tissue and interorgan interaction in aging
Chen, D., Xie, R., Shu, B., LANDAY, A. L., Wei, C., Reiser, J., Spagnoli, A., Torquati, A., Forsyth, C. B., Keshavarzian, A., et al. (2018) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.13945 · Cited by 69 · see citing works
Neuromicrobiology: How Microbes Influence the Brain
de la Fuente‐Núñez, C., Meneguetti, B. T., Franco, O. L., & Lu, T. K. (2017) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.7b00373 · Cited by 68 · see citing works
Groh, K. J., Geueke, B., & Muncke, J. (2017) · Food and Chemical Toxicology · doi:10.1016/j.fct.2017.08.023 · Cited by 66 · see citing works
Gondalia, S. V., Parkinson, L., Stough, C. K. K., & Scholey, A. B. (2019) · Psychopharmacology · doi:10.1007/s00213-019-05248-6 · Cited by 66 · see citing works
O’Toole, P. W., & Shiels, P. G. (2020) · Journal of Internal Medicine · doi:10.1111/joim.13021 · Cited by 61 · see citing works
Sex-dependent associations between addiction-related behaviors and the microbiome in outbred rats
Peterson, V. L., Richards, J. B., Meyer, P., Cabrera‐Rubio, R., Tripi, J. A., King, C. P., Polesskaya, O., Baud, A., Chitre, A. S., Bastiaanssen, T. F. S., et al. (2020) · EBioMedicine · doi:10.1016/j.ebiom.2020.102769 · Cited by 59 · see citing works
Self-citationExploring the microbiota-gut-brain axis: impact on brain structure and function
Yassin, L. K., Nakhal, M. M., Alderei, A., Almehairbi, A., Mydeen, A. B., Akour, A. A., & Hamad, M. I. K. (2025) · Frontiers in Neuroanatomy · doi:10.3389/fnana.2025.1504065 · Cited by 60 · see citing works
Target Dysbiosis of Gut Microbes as a Future Therapeutic Manipulation in Alzheimer’s Disease
Zhu, F., Li, C., Chu, F., Tian, X., & Zhu, J. (2020) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2020.544235 · Cited by 58 · see citing works
The contribution of age-related changes in the gut-brain axis to neurological disorders
Khan, R., Gesù, C. M. D., Lee, J., & McCullough, L. D. (2024) · Gut Microbes · doi:10.1080/19490976.2024.2302801 · Cited by 60 · see citing works
Zhao, Z., Wang, B., Mu, L., Wang, H., Luo, J., Yang, Y., Yang, H., Li, M., Zhou, L., & Tao, C. (2020) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2020.00258 · Cited by 57 · see citing works
Prebiotics and probiotics as potential therapy for cognitive impairment
Romo‐Araiza, A., & Ibarra, A. (2019) · Medical Hypotheses · doi:10.1016/j.mehy.2019.109410 · Cited by 60 · see citing works
Lin, S.-W., Tsai, Y., Chen, Y., Wang, M.-F., Chen, C., Lin, W., & Fang, T. J. (2021) · Nutrients · doi:10.3390/nu13082860 · Cited by 56 · see citing works
Relationship between diet, the gut microbiota, and brain function
Tengeler, A. C., Kozicz, T., & Kiliaan, A. J. (2018) · Nutrition Reviews · doi:10.1093/nutrit/nuy016 · Cited by 57 · see citing works
Kuti, D., Winkler, Z., Horváth, K., Juhász, B., Paholcsek, M., Stágel, A., Gulyás, G., Czeglédi, L., Ferenczi, S., & Kovács, K. (2019) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2019.12.004 · Cited by 56 · see citing works
Gut Microbiota Influences Experimental Outcomes in Mouse Models of Colorectal Cancer
Leystra, A. A., & Clapper, M. L. (2019) · Genes · doi:10.3390/genes10110900 · Cited by 56 · see citing works
Mazarati, A. M., Medel‐Matus, J., Shin, D. H., Jacobs, J. P., & Sankar, R. (2021) · Epilepsia · doi:10.1111/epi.16909 · Cited by 54 · see citing works
The gut microbiota is an emerging target for improving brain health during ageing
Boehme, M., Guzzetta, K. E., Wasén, C., & Cox, L. M. (2022) · Gut Microbiome · doi:10.1017/gmb.2022.11 · Cited by 56 · see citing works
The Roles of the Gut Microbiota and Chronic Low-Grade Inflammation in Older Adults With Frailty
Xu, Y., Liu, X., Liu, X., Chen, D., Wang, M., Jiang, X., & Xiong, Z. (2021) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2021.675414 · Cited by 57 · see citing works
Age-related cognitive decline in spatial learning and memory of C57BL/6J mice
Hendrickx, J. O., Moudt, S. D., Calus, E., Deyn, P. P. D., Dam, D. V., & Meyer, G. R. Y. D. (2021) · Behavioural Brain Research · doi:10.1016/j.bbr.2021.113649 · Cited by 52 · see citing works
Crowley, E. K., Long-Smith, C. M., Murphy, A., Patterson, E., Murphy, K., O’Gorman, D. M., Stanton, C., & Nolan, Y. M. (2018) · Marine Drugs · doi:10.3390/md16060216 · Cited by 53 · see citing works
Self-citationO’Connor, R., Moloney, G. M., Fülling, C., O’Riordan, K. J., Fitzgerald, P., Bastiaanssen, T. F. S., Schellekens, H., Dinan, T. G., & Cryan, J. F. (2021) · Behavioural Brain Research · doi:10.1016/j.bbr.2021.113156 · Cited by 50 · see citing works
Self-citationThe microbiota drives diurnal rhythms in tryptophan metabolism in the stressed gut
Gheorghe, C. E., Leigh, S., Tofani, G. S. S., Bastiaanssen, T. F. S., Lyte, J. M., Gardellin, E., Govindan, A., Strain, C., Martínez-Herrero, S., Goodson, M. S., et al. (2024) · Cell Reports · doi:10.1016/j.celrep.2024.114079 · Cited by 51 · see citing works
Self-citationThe microbiome and cognitive aging: a review of mechanisms
Komanduri, M., Gondalia, S. V., Scholey, A. B., & Stough, C. K. K. (2019) · Psychopharmacology · doi:10.1007/s00213-019-05231-1 · Cited by 48 · see citing works
Bailey, M. T., & Cryan, J. F. (2017) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2017.08.017 · Cited by 47 · see citing works
Self-citationSharma, G., Biswas, S. S., Mishra, J., Navik, U., Kandimalla, R. J. L., Reddy, P. H., Bhatti, G. K., & Bhatti, J. S. (2023) · Life Sciences · doi:10.1016/j.lfs.2023.121882 · Cited by 46 · see citing works
Impact of Gut Microbiota in Brain Ageing: Polyphenols as Beneficial Modulators
Sarubbo, F., Moranta, D., Tejada, S., Jiménez-García, M., & Esteban, S. (2023) · Antioxidants · doi:10.3390/antiox12040812 · Cited by 44 · see citing works
Age-related changes in microbial composition and function in cynomolgus macaques
Duan, J., Yin, B., Li, W., Chai, T., Liang, W., Huang, Y., Tan, X., Zheng, P., Wu, J., Li, Y., et al. (2019) · Aging · doi:10.18632/aging.102541 · Cited by 42 · see citing works
Monocyte mobilisation, microbiota & mental illness
van de Wouw, M., Boehme, M., Dinan, T. G., & Cryan, J. F. (2019) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2019.07.019 · Cited by 40 · see citing works
Self-citationWang, F., Xu, T. C., Zhang, Y., Zheng, T., He, Y., He, F., & Jiang, Y. (2020) · FEMS Microbiology Letters · doi:10.1093/femsle/fnaa048 · Cited by 41 · see citing works
Microbial Reconstitution Improves Aging-Driven Lacrimal Gland Circadian Dysfunction
Jiao, X., Pei, X., Lu, D., Qi, D., Huang, S., He, S., & Li, Z. (2021) · American Journal Of Pathology · doi:10.1016/j.ajpath.2021.08.006 · Cited by 40 · see citing works
Ross, F. C., Mayer, D. E., Horn, J. V., Cryan, J. F., Rio, D. D., Randolph, E., Gill, C. I. R., Gupta, A., Ross, R. P., Stanton, C., et al. (2024) · Nutritional Neuroscience · doi:10.1080/1028415x.2023.2298098 · Cited by 37 · see citing works
Self-citationWang, D., Dong, X., Wang, B., Liu, Y., & Li, S. (2019) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.9b03977 · Cited by 34 · see citing works
Immunosenescence: A Critical Factor Associated With Organ Injury After Sepsis
Lü, X., Yang, Y.-M., & Lu, Y. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.917293 · Cited by 35 · see citing works
Age-related alterations in gut homeostasis are microbiota dependent
Jing, Y., Wang, Q., Bai, F., Li, Z., Li, Y., Liu, W., Yan, Y., Zhang, S., Chen, G., & Yu, Y. (2025) · npj Biofilms and Microbiomes · doi:10.1038/s41522-025-00677-y · Cited by 34 · see citing works
Age-specific urinary metabolite signatures and functions in patients with major depressive disorder
Chen, J., Xie, J., Li, W., Bai, S., Wang, W., Zheng, P., & Xie, P. (2019) · Aging · doi:10.18632/aging.102133 · Cited by 34 · see citing works
Therapeutic Potential of the Microbiome in the Treatment of Neuropsychiatric Disorders
Evrensel, A., Ünsalver, B. Ö., & Ceylan, M. E. (2019) · Medical Sciences · doi:10.3390/medsci7020021 · Cited by 33 · see citing works
The role of the microbiota in acute stress-induced myeloid immune cell trafficking
van de Wouw, M., Lyte, J. M., Boehme, M., Sichetti, M., Moloney, G. M., Goodson, M. S., Kelley‐Loughnane, N., Dinan, T. G., Clarke, G. A., & Cryan, J. F. (2019) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2019.12.003 · Cited by 33 · see citing works
Self-citationQu, Y., Wu, Y.-Q., Zhao, Y., Lin, L., Du, Y., Li, P., Li, H., & Ji, X. (2020) · PeerJ · doi:10.7717/peerj.10271 · Cited by 32 · see citing works
Becker, L. S., Bishop, E. S., Sinha, S. R., Haileselassie, Y., & Habtezion, A. (2018) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2018.09.001 · Cited by 32 · see citing works
Oberman, K., Hovens, I. B., de Haan, J. J., Salles, J. F., van Leeuwen, B. L., & Schoemaker, R. G. (2021) · Journal of Neuroinflammation · doi:10.1186/s12974-021-02206-y · Cited by 32 · see citing works
The role of the gut microbiome in mediating neurotoxic outcomes to PCB exposure
Rude, K. M., Keogh, C. E., & Gareau, M. G. (2019) · NeuroToxicology · doi:10.1016/j.neuro.2019.08.010 · Cited by 31 · see citing works
de la Barquera, B. S. Y. S., Carrillo, B. E. M., Garrido, J. F. A., Martínez-Méndez, R., Arciniega, A. D. B., Valdés‐Ramos, R., & Piña, A. E. S. (2022) · The journal of nutrition health & aging · doi:10.1007/s12603-022-1842-4 · Cited by 28 · see citing works
- Authors
- Scott, K. A., Ida, M., Peterson, V. L., Prenderville, J. A., Moloney, G. M., Izumo, T., Murphy, K., Murphy, A., Ross, R. P., Stanton, C., Dinan, T. G., & Cryan, J. F.
- Affiliations
- University College Cork (IE)
- Suntory (Japan) (JP)
- Teagasc - The Irish Agriculture and Food Development Authority (IE)
- Corresponding author
- Cryan, John F.
- ORCID
- Venue
- Brain, Behavior, and Immunity
- Publisher
- Elsevier BV
- Published
- 2017-10
- Volume
- 65
- Pages
- 20-32
- ISSN
- 0889-1591 (ISSN-L)
- OpenAlex
- W2585159410
- Cited by
- 202
- References
- 87
- Citations by year
- 2026: 5 · 2025: 13 · 2024: 21 · 2023: 15 · 2022: 32 · 2021: 27 · 2020: 24 · 2019: 34 · 2018: 20 · 2017: 11
- FWCI
- 9.95
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (am, 300 d)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
- Locations
- Brain Behavior and Immunity (acceptedVersion)
- PubMed (publishedVersion)
- Arrow@dit (Dublin Institute of Technology) (acceptedVersion)
- Cork Open Research Archive (University College Cork, Ireland) (submittedVersion, cc-by-nc-nd)
- Funders
- Science Foundation Ireland
- SFI
- Health Research Board (12)
- Department of Agriculture, Food & the Marine
- Enterprise Ireland
- APC Microbiome Institute
- University College Cork
- AstraZeneca
- Mead Johnson
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Keywords
- gut microbiota, microbiota-gut-brain axis, aging, cognitive decline, spatial memory, anxiety-like behavior, intestinal permeability, peripheral inflammation, inflammatory cytokines, Porphyromonadaceae, Odoribacter, cecal microbiota, stress, lactic acid bacteria, mouse model
- MeSH terms
- Gastrointestinal Microbiome, Age Factors, Animals, Anxiety, Behavior, Animal, Brain, Cognition, Inflammation, Male, Mice, Inbred C57BL, Cytokines, Porphyromonas, Gastrointestinal Tract, Mice, Microbiota
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
