Cited by 110Stress Responses and CortisolAdrenal Hormones and DisordersEstrogen and related hormone effects

The DOI matches its Crossref record; 259 of the 261 references it cites were found in a registry or an index.

Age-Dependent and Gender-Dependent Regulation of Hypothalamic-Adrenocorticotropic-Adrenal Axis

Open access

Veldhuis, Johannes D., Sharma, Animesh, Roelfsema, Ferdinand·2013·Endocrinology and Metabolism Clinics of North America

DOI 10.1016/j.ecl.2013.02.002PMC PMC3675779

Open this paper in CoChat — free account

Abstract

Tightly regulated output of glucocorticoids is critical to maintaining immune competence, the structure of neurons, muscle, and bone, blood pressure, glucose homeostasis, work capacity, and vitality in the human and experimental animal. Age, sex steroids, gender, stress, body composition, and disease govern glucocorticoid availability through incompletely understood mechanisms. According to an ensemble concept of neuroendocrine regulation, successful stress adaptations require repeated incremental signaling adjustments among hypothalamic corticotropin-releasing hormone and arginine vasopressin, pituitary adrenocorticotropic hormone, and adrenal corticosteroids. Signals are transduced via (positive) feedforward and (negative) feedback effects. Age and gonadal steroids strongly modulate stress-adaptive glucocorticoid secretion by such interlinked pathways.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1016/j.ecl.2013.02.002

Cites

259 of 259 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Lifetime and 12-Month Prevalence of DSM-III-R Psychiatric Disorders in the United States: Results From the National Comorbidity Survey
Kessler, R. C. (1994) · Archives of General Psychiatry · doi:10.1001/archpsyc.1994.03950010008002 · Cited by 12,370
Stress and the brain: from adaptation to disease
de Kloet, E. R., Joëls, M., & Holsboer, F. (2005) · Nature Reviews Neuroscience · doi:10.1038/nrn1683 · Cited by 4,621
Impact of Gender, Menstrual Cycle Phase, and Oral Contraceptives on the Activity of the Hypothalamus-Pituitary-Adrenal Axis
Kirschbaum, C., Kudielka, B. M., Gaab, J., Schommer, N. C., & Hellhammer, D. H. (1999) · Psychosomatic Medicine · doi:10.1097/00006842-199903000-00006 · Cited by 1,890
Pathophysiology of the Neuroregulation of Growth Hormone Secretion in Experimental Animals and the Human*
Giustina, A., & Veldhuis, J. D. (1998) · Endocrine Reviews · doi:10.1210/edrv.19.6.0353 · Cited by 1,253
Self-citation
A new view on hypocortisolism
Fries, E., Hesse, J., Hellhammer, J., & Hellhammer, D. H. (2005) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2005.04.006 · Cited by 1,204
Depression and cortisol responses to psychological stress: A meta-analysis
Burke, H. M., Davis, M. C., Otte, C., & Mohr, D. C. (2005) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2005.02.010 · Cited by 1,194
Stress-Related Cortisol Secretion in Men: Relationships with Abdominal Obesity and Endocrine, Metabolic and Hemodynamic Abnormalities
Rosmond, R., Dallman, M. F., & Björntorp, P. A. (1998) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.83.6.4843 · Cited by 959
Effects of gender and age on the levels and circadian rhythmicity of plasma cortisol
Van Cauter, E. (1996) · Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.81.7.2468 · Cited by 951
Stressor specificity of central neuroendocrine responses: implications for stress-related disorders
Pacák, K., & Palkovits, M. (2001) · Endocrine Reviews · doi:10.1210/edrv.22.4.0436 · Cited by 926
Sex differences in depression
Wilhelm, K. A. (1991) · Choice Reviews Online · doi:10.5860/choice.28-3566 · Cited by 852

Flagged first, then by citations

Show all 261 references

2 of the 261 references couldn’t be matched to a known paper.

Sorted by citations

Understanding the relationships between physiological and psychosocial stress, cortisol and cognition
James, K. A., Stromin, J., Steenkamp, N., & Combrinck, M. I. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1085950 · Cited by 479
The physiology of endocrine systems with ageing
van den Beld, A. W., Kaufman, J.-M., Zillikens, M. C., Lamberts, S. W. J., Egan, J. M., & van der Lely, A. J. (2018) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(18)30026-3 · Cited by 349
The use of hair cortisol for the assessment of stress in animals
Heimbürge, S., Kanitz, E., & Otten, W. (2018) · General and Comparative Endocrinology · doi:10.1016/j.ygcen.2018.09.016 · Cited by 329
Revisiting Metchnikoff: Age-related alterations in microbiota-gut-brain axis in the mouse
Scott, K. A., Ida, M., Peterson, V. L., Prenderville, J. A., Moloney, G. M., Izumo, T., Murphy, K., Murphy, A., Ross, R. P., Stanton, C., et al. (2017) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2017.02.004 · Cited by 202
Hypothalamic‐Pituitary‐Adrenal (HPA) Axis and Aging
Gupta, D., & Morley, J. E. (2014) · Comprehensive physiology · doi:10.1002/cphy.c130049 · Cited by 210
Emergence of sex differences in the development of substance use and abuse during adolescence
Kuhn, C. M. (2015) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2015.06.003 · Cited by 192
Sleep and circadian regulation of cortisol: A short review
O'Byrne, N. A., Yuen, F., Butt, W. Z., & Liu, P. Y. (2021) · Current Opinion in Endocrine and Metabolic Research · doi:10.1016/j.coemr.2021.03.011 · Cited by 145
The role of the hypothalamic-pituitary-adrenal axis in depression across the female reproductive lifecycle: current knowledge and future directions
Hantsoo, L. V., Jagodnik, K. M., Novick, A. M., Baweja, R., di Scalea, T. L., Özerdem, A., McGlade, E., Simeonova, D. I., Dekel, S., Kornfield, S. L., et al. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1295261 · Cited by 175
Sexual dimorphism in COVID-19: potential clinical and public health implications
Bechmann, N., Barthel, A., Schedl, A., Herzig, S., Varga, Z., Gebhard, C., Mayr, M., Hantel, C., Beuschlein, F., Wolfrum, C., et al. (2022) · Publikationen an der Universität Bielefeld (Universität Bielefeld) · Cited by 110
Sexual dimorphism in COVID-19: potential clinical and public health implications
Bechmann, N., Barthel, A., Schedl, A., Herzig, S., Varga, Z., Gebhard, C., Mayr, M., Hantel, C., Beuschlein, F., Wolfrum, C., et al. (2022) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(21)00346-6 · Cited by 123
Impact of age, sex and body mass index on cortisol secretion in 143 healthy adults
Roelfsema, F., van Heemst, D., Iranmanesh, A., Takahashi, P., Yang, R., & Veldhuis, J. D. (2017) · Endocrine Connections · doi:10.1530/ec-17-0160 · Cited by 100
“Although the HPA axis has been studied for several decades, published reports on the influence of age, sex and body mass on HPA dynamics are conflicting (3, 4, 5, 6, 10, 11, 12, 13, 14, 15, 16, 17, 18).”
Self-citation
Hormones and Aging: An Endocrine Society Scientific Statement
Cappola, A. R., Auchus, R. J., Fuleihan, G. E., Handelsman, D. J., Kalyani, R. R., McClung, M. R., Stuenkel, C. A., Thorner, M. O., & Verbalis, J. G. (2023) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgad225 · Cited by 108
Copeptin, Insulin Resistance, and Risk of Incident Diabetes in Older Men
Wannamethee, S. G., Welsh, P. I., Papacosta, O., LENNON, L. T., Whincup, P. H., & Sattar, N. A. (2015) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2015-2362 · Cited by 92
Sleep, testosterone and cortisol balance, and ageing men
Liu, P. Y., & Reddy, R. T. (2022) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-022-09755-4 · Cited by 80
Examination of peripheral basal and reactive cortisol levels in major depressive disorder and the burnout syndrome: A systematic review
Rothe, N., Steffen, J., Penz, M. S., Kirschbaum, C., & Walther, A. (2020) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2020.02.024 · Cited by 90
Targeting Cell Senescence and Senolytics: Novel Interventions for Age-Related Endocrine Dysfunction
Suda, M., Paul, K. H., Tripathi, U., Minamino, T., Tchkonia, T., & Kirkland, J. L. (2024) · Endocrine Reviews · doi:10.1210/endrev/bnae010 · Cited by 83
The Endocrinology of Ageing: A Mini-Review
Jones, C. M., & Boelaert, K. (2014) · Gerontology · doi:10.1159/000367692 · Cited by 83
The Impact of Traumatic Brain Injury on Later Life: Effects on Normal Aging and Neurodegenerative Diseases
Griesbach, G. S., Masel, B. E., Helvie, R. E., & Ashley, M. J. (2017) · Journal of Neurotrauma · doi:10.1089/neu.2017.5103 · Cited by 80
Sex, the brain and hypertension: brain oestrogen receptors and high blood pressure risk factors
Hay, M. (2015) · Clinical Science · doi:10.1042/cs20150654 · Cited by 75
Steroid secretion in healthy aging
Fiacco, S., Walther, A., & Ehlert, U. (2018) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2018.09.035 · Cited by 71
Hormones as “difference makers” in cognitive and socioemotional aging processes
Ebner, N. C., Kamin, H. S., Diaz, V. G., Cohen, R. A., & MacDonald, K. S. (2015) · Frontiers in Psychology · doi:10.3389/fpsyg.2014.01595 · Cited by 59
Impact of Cortisol on Reduction in Muscle Strength and Mass: A Mendelian Randomization Study
Katsuhara, S., Yokomoto-Umakoshi, M., Umakoshi, H., Matsuda, Y., Iwahashi, N., Kaneko, H., Ogata, M., Fukumoto, T., Terada, E., Sakamoto, R., et al. (2022) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgab862 · Cited by 55
A Clinical Perspective of Sleep and Andrological Health: Assessment, Treatment Considerations, and Future Research
Liu, P. Y. (2019) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2019-00683 · Cited by 55
Possible Molecular Mediators Involved and Mechanistic Insight into Fibromyalgia and Associated Co-morbidities
Singh, L., Kaur, A., Bhatti, M. S., & Bhatti, R. (2019) · Neurochemical Research · doi:10.1007/s11064-019-02805-5 · Cited by 55
Sex differences in chronic stress responses and Alzheimer's disease
Yan, Y., Dominguez, S., Fisher, D. W., & Dong, H. (2018) · Neurobiology of Stress · doi:10.1016/j.ynstr.2018.03.002 · Cited by 56
Impact of shift work on the diurnal cortisol rhythm: a one-year longitudinal study in junior physicians
Li, J., Bidlingmaier, M., Petru, R., Gil, F. P., Loerbroks, A., & Angerer, P. (2018) · Journal of Occupational Medicine and Toxicology · doi:10.1186/s12995-018-0204-y · Cited by 53
The stress of growing old: sex- and season-specific effects of age on allostatic load in wild grey mouse lemurs
Hämäläinen, A., Heistermann, M., & Kraus, C. (2015) · Oecologia · doi:10.1007/s00442-015-3297-3 · Cited by 54
PTSD and obesity in younger and older veterans: Results from the mind your heart study
Smith, B. N., Tyzik, A. L., Neylan, T. C., & Cohen, B. E. (2015) · Psychiatry Research · doi:10.1016/j.psychres.2015.07.044 · Cited by 48
The hunt for a selective 17,20 lyase inhibitor; learning lessons from nature
Bird, I. M., & Abbott, D. H. (2016) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2016.04.021 · Cited by 43
Estradiol, but not testosterone, heightens cortisol-mediated negative feedback on pulsatile ACTH secretion and ACTH approximate entropy in unstressed older men and women
Sharma, A. N., Aoun, P., Wigham, J. R., Weist, S. M., & Veldhuis, J. D. (2014) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00551.2013 · Cited by 39
Self-citation
Associations between the FKBP5 haplotype, exposure to violence and anxiety in females
Isaksson, J., Comasco, E., Åslund, C., Rehn, M., Tuvblad, C., Andershed, H., & Nilsson, K. W. (2016) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2016.07.206 · Cited by 30
Factors impacting on the action of glucocorticoids in patients receiving glucocorticoid therapy
Dineen, R., Stewart, P. M., & Sherlock, M. (2019) · Clinical Endocrinology · doi:10.1111/cen.13837 · Cited by 30
The Age-Dependent Changes of the Human Adrenal Cortical Zones Are Not Congruent
Tezuka, Y., Atsumi, N., Blinder, A., Rege, J., Giordano, T. J., Rainey, W. E., & Turcu, A. F. (2021) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgab007 · Cited by 27
Potential Factors That Contribute to Post-COVID-19 Fatigue in Women
Rudroff, T., Workman, C. D., & Bryant, A. (2022) · Brain Sciences · doi:10.3390/brainsci12050556 · Cited by 25
Nociceptin Receptors Upregulated in Cocaine Use Disorder: A Positron Emission Tomography Imaging Study Using [ 11 C]NOP-1A
Narendran, R., Tollefson, S., Himes, M. L., Paris, J., Lopresti, B. J., Ciccocioppo, R., & Mason, N. S. (2019) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2019.18081007 · Cited by 23
Diurnal Salivary Cortisol in Sarcopenic Postmenopausal Women: The OsteoLaus Cohort
Rodríguez, E. G., Marques-Vidal, P. M., Aubry‐Rozier, B., Papadakis, G. E., Preisig, M., Kuehner, C., Vollenweider, P., Waeber, G., Hans, D. B., & Lamy, O. (2021) · Calcified Tissue International · doi:10.1007/s00223-021-00863-y · Cited by 22
Prevalence of subclinical hypercortisolism in type 2 diabetic patients from the Rio de Janeiro Type 2 Diabetes Cohort Study
Costa, D., Conceição, F. L., Leite, N. C., Ferreira, M. T., Salles, G. F., & Cardoso, C. R. L. (2016) · Journal of Diabetes and its Complications · doi:10.1016/j.jdiacomp.2016.05.006 · Cited by 22
High Evening Cortisol Level Is Associated With Low TBS and Increased Prevalent Vertebral Fractures: OsteoLaus Study
Rodríguez, E. G., Lamy, O., Stoll, D., Metzger, M., Preisig, M., Kuehner, C., Vollenweider, P., Marques-Vidal, P. M., Waeber, G., Aubry‐Rozier, B., et al. (2017) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2016-3804 · Cited by 21
Can a single session of noninvasive brain stimulation applied over the prefrontal cortex prevent stress-induced cortisol release?
Vignaud, P., Adam, O., Palm, U., Baeken, C., Prieto, N., Poulet, E., & Brunelin, J. (2022) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2022.110667 · Cited by 21
Lithium therapy subdues neuroinflammation to maintain pyramidal cells arborization and rescues neurobehavioural impairments in ovariectomized rats
Rana, A. K., Sharma, S., Patial, V., & Singh, D. (2022) · Molecular Neurobiology · doi:10.1007/s12035-021-02719-w · Cited by 24
Water intake keeps type 2 diabetes away? Focus on copeptin
Muscogiuri, G., Barrea, L., Annunziata, G., Vecchiarini, M., Orio, F., Somma, C. D., Colao, A., & Savastano, S. (2018) · Endocrine · doi:10.1007/s12020-018-1680-7 · Cited by 19
A Gut Feeling: The Importance of the Intestinal Microbiota in Psychiatric Disorders
Ochoa‐Repáraz, J., Ramelow, C. C., & Kasper, L. H. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.510113 · Cited by 21
Stress-induced changes in the aged-rat adrenal cortex. Histological and histomorphometric study
Zaki, S. M., Gawad, F. A.-R. A., El-Shaarawy, E. A. A., Radwan, R. A. K., & Aboulhoda, B. E. (2015) · Folia Morphologica · doi:10.5603/fm.a2018.0035 · Cited by 19
Relationship between handgrip strength and endogenous hormones in postmenopausal women
García-Alfaro, P., García, S., Rodríguez, I., Bergamaschi, L., & Pérez-López, F. R. (2022) · Menopause The Journal of The North American Menopause Society · doi:10.1097/gme.0000000000002093 · Cited by 19
Serum cortisol and insulin-like growth factor 1 levels in major depressive disorder and schizophrenia
Arinami, H., Watanabe, Y., Suzuki, Y., Tajiri, M., Tsuneyama, N., & Someya, T. (2023) · Scientific Reports · doi:10.1038/s41598-023-28449-8 · Cited by 19
Aging-Related Mechanisms Contribute to Corticosteroid Insensitivity in Elderly Asthma
Ford, M. L., Ruwanpathirana, A., Lewis, B. W., & Britt, R. D. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24076347 · Cited by 18
Changes in cortisol and cortisone in hair of pigs reared under heat stress conditions
Escribano, D., Contreras-Jodar, A., López-Arjona, M., Cerón, J. M. C., Fàbrega, E., Aymerich, P., & Dalmau, A. (2023) · Frontiers in Veterinary Science · doi:10.3389/fvets.2023.1156480 · Cited by 16
Mediterranean Diet and Physical Activity for Successful Aging: An Update for Nutritionists and Endocrinologists
Frías-Toral, E., Chapela, S. P., Carignano, M. D. L. A., Moretti, D., Martinuzzi, A. L. N., Veintimilla, D. R., Guerrero, M., Pugliese, G., Muscogiuri, G., & Barrea, L. (2021) · Endocrines · doi:10.3390/endocrines2040034 · Cited by 16
Self-Organization and Coherency in Biology and Medicine
Goushcha, A. O., Hushcha, T. O., Christophorov, L. N., & Goldsby, M. E. (2014) · Open Journal of Biophysics · doi:10.4236/ojbiphy.2014.44014 · Cited by 14
Sex Differences in Adolescent Neurobiological Risk for Substance Use and Substance Use Disorders
Dir, A. L., & Hulvershorn, L. A. (2019) · Current Addiction Reports · doi:10.1007/s40429-019-00276-w · Cited by 14
Perinatal programming of depressive-like behavior by inflammation in adult offspring mice whose mothers were fed polluted eels: Gender selective effects
Soualeh, N., Dridi, I., Eppe, G., Némos, C., Soulimani, R., & Bouayed, J. (2016) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2016.09.029 · Cited by 13
Endocrine and Cognitive Adaptations to Cope with Stress in Immature Common Marmosets (Callithrix jacchus): Sex and Age Matter
de Sousa, M. B. C., Galvão, A. C. D. M., Sales, C. J. R., de Castro, D. C., & Coelho, N. L. G. (2015) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2015.00160 · Cited by 13
Subjective insomnia symptoms and sleep duration are not related to hypothalamic–pituitary–adrenal axis activity in older adults
van Neijenhof, R. J. G. P., van Duijn, E., van den Berg, J. F., de Waal, M. W. M., van der Mast, R. C., & Comijs, H. C. (2017) · Journal of Sleep Research · doi:10.1111/jsr.12570 · Cited by 12
Neuroendocrine and Inflammatory Effects of Childhood Trauma Following Psychosocial and Inflammatory Stress in Women with Remitted Major Depressive Disorder
Cassiers, L., Niemegeers, P., Fransén, E., Morrens, M., Boer, P. D., Nueten, L. V., Claes, S. J., Sabbe, B., & Eede, F. V. D. (2019) · Brain Sciences · doi:10.3390/brainsci9120375 · Cited by 12
Endocrine Events Involved in Puberty: A Revisit to Existing Knowledge
Aslam, S. (2020) · Life and Science · doi:10.37185/lns.1.1.43 · Cited by 13
Socio-Ecological Challenges as Modulators of Women's Reproductive Trajectories
Nepomnaschy, P. A., Rowlands, A., Costa, A. P. P., & Salvante, K. G. (2020) · Annual Review of Anthropology · doi:10.1146/annurev-anthro-102317-045930 · Cited by 13
Corticosteroid Use and Long-Term Changes in Weight and Waist Circumference: The Lifelines Cohort Study
Mohseni, M., van der Valk, E. S., den Hurk, M. J. B. V., Savas, M., Boon, M. R., & van Rossum, E. F. C. (2025) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgaf166 · Cited by 11
Characterization of the Hypothalamic-Pituitary-Adrenal-Axis in Familial Longevity under Resting Conditions
Jansen, S. W. M., Roelfsema, F., Akintola, A. A., Oei, N. Y. L., Cobbaert, C. M., Ballieux, B. E. P. B., van der Grond, J., Westendorp, R. G. J., Pijl, H., & van Heemst, D. (2015) · PLoS ONE · doi:10.1371/journal.pone.0133119 · Cited by 11
Self-citation
Treatment of Hypertension in Older Persons: What Is the Evidence?
Morley, J. E. (2014) · Drugs & Aging · doi:10.1007/s40266-014-0171-7 · Cited by 10
A proprietary black cumin oil extract (Nigella sativa) (BlaQmax®) modulates stress-sleep-immunity axis safely: Randomized double-blind placebo-controlled study
Mohan, M. E., Thomas, J. V., Mohan, M. C., Syam Das, S., Prabhakaran, P., & Sasidharan, B. C. P. (2023) · Frontiers in Nutrition · doi:10.3389/fnut.2023.1152680 · Cited by 10
Correlation Between Differentiation of Adrenocortical Zones and Telomere Lengths Measured by Q-FISH
Nonaka, K., Aida, J., Takubo, K., Yamazaki, Y., Takakuma, S., Kakizaki, M., Matsuda, Y., Ishikawa, N., Ishiwata, T., Chong, J., et al. (2019) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2019-00592 · Cited by 10
Endocrinology and Aging
Lamberts, S. W. J., & van den Beld, A. W. (2016) · Elsevier eBooks · doi:10.1016/b978-0-323-29738-7.00027-7 · Cited by 10
The effects of sex and neonatal stress on pituitary adenylate cyclase‐activating peptide expression
Mosca, E. V., Rousseau, J. P., Gulemetova, R., Kinkead, R., & Wilson, R. J. A. (2014) · Experimental Physiology · doi:10.1113/expphysiol.2014.082180 · Cited by 10
The Participation of Hormones in the Processes of Cognitive and Socio-Emotional Aging
Bulgakova, S. V., & Romanchuk, N. (2020) · Bulletin of Science and Practice · doi:10.33619/2414-2948/57/09 · Cited by 9
Growth hormone and cortisol secretion in the elderly evaluated using the glucagon stimulation test
Tavares, A. B. W., Seixas-da-Silva, I. A., Silvestre, D. H., Pinheiro, M. F. C., Vaisman, M., & Conceição, F. L. (2017) · Endocrine · doi:10.1007/s12020-017-1275-8 · Cited by 9
Interrelationships Between Pituitary Hormones as Assessed From 24-hour Serum Concentrations in Healthy Older Subjects
van der Spoel, E., Roelfsema, F., Akintola, A. A., Jansen, S. W. M., Slagboom, P. E., Westendorp, R. G. J., Blauw, G. J., Pijl, H., & van Heemst, D. (2019) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgz253 · Cited by 9
Self-citation
Role of Stress and Hormones of the Hypothalamic-Pituitary-Adrenal (HPA) Axis in Aging
Gupta, A. (2019) · Springer eBooks · doi:10.1007/978-981-13-3585-3_12 · Cited by 8
Day/night changes of thymus-deriving natural regulatory T cell development and function
Kiernozek, E., Kowalik, A., Markowska, M., Kozłowska, E., & Drela, N. (2014) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2014.07.002 · Cited by 8
Associations between social burden, perceived stress, and diurnal cortisol profiles in older adults: implications for cognitive aging
Pretscher, A., Kauzner, S., Rohleder, N., & Becker, L. (2021) · European Journal of Ageing · doi:10.1007/s10433-021-00616-8 · Cited by 10
Global 11 Beta-Hydroxysteroid Dehydrogenase Activity Assessed by the Circulating Cortisol to Cortisone Ratio is Associated with Features of Metabolic Syndrome
Chailurkit, L., Aekplakorn, W., Paiyabhroma, N., & Ongphiphadhanakul, B. (2020) · Metabolic Syndrome and Related Disorders · doi:10.1089/met.2020.0013 · Cited by 5
Cortisol Concentration in Horsehair and its Relationship to Body Location, Coat Colour, and Gender
Lelláková, M., Lešková, L., Florián, M., Mesarčová, L., Skurková, L., Peťková, B., Takáčová, D., & Kottferová, J. (2022) · Journal of Equine Veterinary Science · doi:10.1016/j.jevs.2022.104010 · Cited by 7
Physiological Resilience and the Impact on Health
Klinedinst, N. J., & Hackney, A. J. (2018) · Springer eBooks · doi:10.1007/978-3-030-04555-5_6 · Cited by 7
Stress-related changes in leukocyte profiles and telomere shortening in the shortest-lived tetrapod, Furcifer labordi
Eckhardt, F. S., Pauliny, A., Rollings, N., Mutschmann, F., Olsson, M. M., Kraus, C., & Kappeler, P. M. (2020) · BMC Evolutionary Biology · doi:10.1186/s12862-020-01724-2 · Cited by 8
Incidence of hypocortisolism with long‐term budesonide irrigation for chronic rhinosinusitis
Silva, B. R. C., Tyler, M. A., Ma, Y., Wang, J., Nayak, J. V., Patel, Z. M., & Hwang, P. H. (2023) · International Forum of Allergy & Rhinology · doi:10.1002/alr.23227 · Cited by 6
Restoring rhythm to prevent age-related fractures
Smit, A. E., Schilperoort, M., & Winter, E. M. (2022) · Aging · doi:10.18632/aging.204192 · Cited by 6
From shared mechanisms to treatment gaps: a review of the comorbidity between eating disorders and PTSD
Ouyang, H., Wang, Y., & Chen, J. (2025) · Journal of Eating Disorders · doi:10.1186/s40337-025-01454-0 · Cited by 6
Addressing Mental Health Symptoms Among COVID‐19 Healthcare Workers: A Heart Rate Variability Biofeedback Pilot Study
Lee, D., Erande, A. S., Christodoulou, G., & Malik, S. (2024) · Stress and Health · doi:10.1002/smi.3502 · Cited by 7
Coping with the COVID‐19 pandemic by strengthening immunity as a nonpharmaceutical intervention: A major public health challenge
Uddin, N., Acter, T., Rashid, M. H., Chowdhury, A. I., & Jahan, E. A. (2023) · Health Science Reports · doi:10.1002/hsr2.1562 · Cited by 4
Dynamics of neutrophil gelatinase‐associated lipocalin plasma and cerebrospinal fluid concentrations in older males
Naudé, P. J. W., Dekens, D. W., Eisel, U. L. M., den Daas, I., & Deyn, P. P. D. (2017) · European Journal of Clinical Investigation · doi:10.1111/eci.12853 · Cited by 5
Glucocorticoid Hormones in Aging
Kharwanlang, B., & Sharma, R. (2017) · Healthy ageing and longevity · doi:10.1007/978-3-319-63001-4_3 · Cited by 5
Examining the impact of physiological stress on time perception: a systematic review and meta-analysis.
Vignaud, P., Brunelin, J., Galia, P., Grondin, S., Morin, A., Prieto, N., Poulet, E., & Vallet, W. (2025) · Neuroscience and Biobehavioral Reviews · doi:10.1016/j.neubiorev.2025.106382 · Cited by 3
Validating a Non-Invasive Method for Assessing Cortisol Concentrations in Scraped Epidermal Skin from Common Bottlenose Dolphins and Belugas
Agustí, C., Manteca, X., García‐Párraga, D., & Talló-Parra, O. (2024) · Animals · doi:10.3390/ani14091377 · Cited by 4
Circadian rhythms, endogenous glucocorticoids and skeletal health
Macfarlane, E., Zhou, H., & Seibel, M. J. (2026) · European Journal of Endocrinology · doi:10.1093/ejendo/lvag012 · Cited by 3
Associations of cortisol with Alzheimer’s disease fluid and neuroimaging biomarkers: A systematic review
Holleman, J., Toopchiani, S. T., Robinson, O., Kåreholt, I., Kivipelto, M., Middleton, L. T., Solomon, A., Udeh‐Momoh, C. T., & Sindi, S. (2026) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2026.101246 · Cited by 3
Endokrin változások, endokrin betegségek időskorban
Kőhalmi, E., & Bakó, G. (2024) · Orvosi Hetilap · doi:10.1556/650.2024.32950 · Cited by 3
Relationship Between Overnight Dexamethasone Suppression Test and Aging
Çiftel, S., & Mercantepe, F. (2023) · Cureus · doi:10.7759/cureus.48383 · Cited by 3
Analytical and biological validation of a noninvasive measurement of glucocorticoid metabolites in feces of Geoffroy's spider monkeys (Ateles geoffroyi)
Damm, J., Aureli, F., Negrín, A. R., Barradas‐Moctezuma, M., & Dias, P. A. D. (2024) · American Journal of Primatology · doi:10.1002/ajp.23598 · Cited by 3
Gene deletion of the PACAP / VIP receptor, VPAC2R , alters glycemic responses during metabolic and psychogenic stress in adult female mice
Kozlova, E. V., Bishay, A. E., Denys, M. E., Chinthirla, B. D., Valdez, M. C., Spurgin, K. A., Krum, J. M., Basappa, K. R., & Currás‐Collazo, M. (2023) · Journal of Neuroendocrinology · doi:10.1111/jne.13354 · Cited by 3
Distinct Symptom Profiles in Younger and Older Patients With Cancer Receiving Chemotherapy
Lh, M., Weiss, S. M., Ritchie, C. S., Wong, M. L., Cooper, B. A., Hammer, M. J., Conley, Y. P., Paul, S. M., Levine, J., & Miaskowski, C. A. (2026) · Cancer Medicine · doi:10.1002/cam4.71652 · Cited by 2
A Circadian Trough in Glucocorticoid Signaling Is Essential for Bone Health in Mice
Smit, A. E., Yue, K., Kooijman, S., Afkir, S., Schilperoort, M., Koedam, M., van der Eerden, B. C. J., Kroon, J., Meijer, O. C., & Winter, E. M. (2026) · Aging Cell · doi:10.1111/acel.70479 · Cited by 2
Stress and Brain Aging: Role of Glucocorticoid and Mineralocorticoid Hormones
de Kloet, E. R. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-809324-5.22064-6 · Cited by 2
Endocrine Noise: Sex-Specific Disruption of Hypothalamic–Pituitary–Adrenal (HPA) Axis by Endocrine-Disrupting Chemicals
Xega, V., Yang, M. H., & Liu, J.-L. (2026) · Sexes · doi:10.3390/sexes7020022 · Cited by 1
Environmental and Physiological Cues on the Hypothalamus During Aging
Nehlin, J. O. (2017) · Healthy ageing and longevity · doi:10.1007/978-3-319-63001-4_9 · Cited by 1
Interleukin-2 Transiently Inhibits Pulsatile Growth Hormone Secretion in Young but not Older Healthy Men
Roelfsema, F., Yang, R. J., & Veldhuis, J. D. (2021) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgab484 · Cited by 1
Self-citation
A literature review on hypothalamic–pituitary–adrenal (HPA) axis dysregulation in older adults with cancer: A missing link in predicting treatment toxicity?
Nys, L. D. (2026) · Journal of Geriatric Oncology · doi:10.1016/j.jgo.2026.102854 · Cited by 2
A short story: senescence in an annual reptile, Labord’s chameleon (Furcifer labordi)
Eckhardt, F. S. (2020) · doi:10.53846/goediss-8355 · Cited by 1
Sex-specific aging: Sex differences in survival and health in a wild primate population
Hämäläinen, A. (2015) · doi:10.53846/goediss-4865
Pituitary Physiology and Endocrinology
Padilla, M., & Carmichael, J. D. (2015) · Springer eBooks · doi:10.1007/978-3-319-22855-6_3
Differential Associations of Stress and Cortisol with Brain Structure and Cognition in Cognitively Normal Older Adults
Kim, A. (2016) · Open Scholarship Institutional Repository (Washington University in St. Louis) · doi:10.7936/k7p26whw
Estudio de envejecimiento de Mataró: Factores hormonales y genéticos que influyen en el envejecimiento
Mora, M. (2015) · Dipòsit Digital de la Universitat de Barcelona (Universitat de Barcelona)

Authors: Veldhuis, J. D., Sharma, A., & Roelfsema, F.
Affiliations: Mayo Clinic (US)
Leiden University Medical Center (NL)
Corresponding author: Veldhuis, Johannes D.
ORCID: Veldhuis, Johannes D.
Roelfsema, Ferdinand
Venue: Endocrinology and Metabolism Clinics of North America
Publisher: Elsevier BV
Published: 2013-06
Volume: 42
Issue: 2
Pages: 201-225
ISSN: 0889-8529 (ISSN-L)
DOI: 10.1016/j.ecl.2013.02.002
PMC: PMC3675779
OpenAlex: W2070843702
Cited by: 110
References: 261
Citations by year: 2026: 8 · 2025: 4 · 2024: 5 · 2023: 12 · 2022: 10 · 2021: 7 · 2020: 9 · 2019: 8 · 2018: 8 · 2017: 11 · 2016: 8 · 2015: 12 · 2014: 8
FWCI: 0.76
Type: journal article
Language: en
Open access: green
europepmc.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Endocrinology and Metabolism Clinics of North America (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Data Archiving and Networked Services (DANS) (submittedVersion)
Leiden Repository (Leiden University) (submittedVersion)
Funders: National Institute of Diabetes and Digestive and Kidney Diseases (P30DK050456, R01DK073148, DK050456)
National Center for Research Resources (UL1RR024150)
Topics: Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Estrogen and related hormone effects
Keywords: hypothalamic-pituitary-adrenal axis, glucocorticoid regulation, aging, sex differences, sex steroids, corticotropin-releasing factor, vasopressin, ACTH, stress adaptation, neuroendocrine regulation, glucocorticoid negative feedback, positive feedback
MeSH terms: Adrenocorticotropic Hormone, Aging, Animals, Corticotropin-Releasing Hormone, Female, Humans, Hydrocortisone, Hypothalamo-Hypophyseal System, Male, Pituitary-Adrenal System, Sex Characteristics, Feedback, Physiological

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Age-Dependent and Gender-Dependent Regulation of Hypothalamic-Adrenocorticotropic-Adrenal Axis

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks