Cited by 110Stress Responses and CortisolAdrenal Hormones and DisordersEstrogen and related hormone effects

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Age-Dependent and Gender-Dependent Regulation of Hypothalamic-Adrenocorticotropic-Adrenal Axis

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Veldhuis, Johannes D., Sharma, Animesh, Roelfsema, Ferdinand·2013·Endocrinology and Metabolism Clinics of North America

DOI 10.1016/j.ecl.2013.02.002PMC PMC3675779

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Abstract

Tightly regulated output of glucocorticoids is critical to maintaining immune competence, the structure of neurons, muscle, and bone, blood pressure, glucose homeostasis, work capacity, and vitality in the human and experimental animal. Age, sex steroids, gender, stress, body composition, and disease govern glucocorticoid availability through incompletely understood mechanisms. According to an ensemble concept of neuroendocrine regulation, successful stress adaptations require repeated incremental signaling adjustments among hypothalamic corticotropin-releasing hormone and arginine vasopressin, pituitary adrenocorticotropic hormone, and adrenal corticosteroids. Signals are transduced via (positive) feedforward and (negative) feedback effects. Age and gonadal steroids strongly modulate stress-adaptive glucocorticoid secretion by such interlinked pathways.

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Authors: Veldhuis, J. D., Sharma, A., & Roelfsema, F.
Affiliations: Mayo Clinic (US)
Leiden University Medical Center (NL)
Corresponding author: Veldhuis, Johannes D.
ORCID: Veldhuis, Johannes D.
Roelfsema, Ferdinand
Venue: Endocrinology and Metabolism Clinics of North America
Publisher: Elsevier BV
Published: 2013-06
Volume: 42
Issue: 2
Pages: 201-225
ISSN: 0889-8529 (ISSN-L)
DOI: 10.1016/j.ecl.2013.02.002
PMC: PMC3675779
OpenAlex: W2070843702
Cited by: 110
References: 261
Citations by year: 2026: 8 · 2025: 4 · 2024: 5 · 2023: 12 · 2022: 10 · 2021: 7 · 2020: 9 · 2019: 8 · 2018: 8 · 2017: 11 · 2016: 8 · 2015: 12 · 2014: 8
FWCI: 0.76
Type: journal article
Language: en
Open access: green
europepmc.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Endocrinology and Metabolism Clinics of North America (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Data Archiving and Networked Services (DANS) (submittedVersion)
Leiden Repository (Leiden University) (submittedVersion)
Funders: National Institute of Diabetes and Digestive and Kidney Diseases (P30DK050456, R01DK073148, DK050456)
National Center for Research Resources (UL1RR024150)
Topics: Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Estrogen and related hormone effects
Keywords: hypothalamic-pituitary-adrenal axis, glucocorticoid regulation, aging, sex differences, sex steroids, corticotropin-releasing factor, vasopressin, ACTH, stress adaptation, neuroendocrine regulation, glucocorticoid negative feedback, positive feedback
MeSH terms: Adrenocorticotropic Hormone, Aging, Animals, Corticotropin-Releasing Hormone, Female, Humans, Hydrocortisone, Hypothalamo-Hypophyseal System, Male, Pituitary-Adrenal System, Sex Characteristics, Feedback, Physiological

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Age-Dependent and Gender-Dependent Regulation of Hypothalamic-Adrenocorticotropic-Adrenal Axis

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