Hypopituitarism after traumatic brain injury
Open accessAbstract
The prevalence of hypopituitarism after traumatic brain (TBI) injury is widely variable in the literature; a meta-analysis determined a pooled prevalence of anterior hypopituitarism of 27.5%. Growth hormone deficiency is the most prevalent hormone insufficiency after TBI; however, the prevalence of each type of pituitary deficiency is influenced by the assays used for diagnosis, severity of head trauma, and time of evaluation. Recent studies have demonstrated improvement in cognitive function and cognitive quality of life with substitution therapy in GH-deficient patients after TBI.
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Traumatic brain injury has been suggested a frequent cause of hypopituitarism at all ages with a prevalence of central hypothyroidism between 5% and 29%.
“Traumatic brain injury has been suggested a frequent cause of hypopituitarism at all ages with a prevalence of central hypothyroidism between 5% and 29% (Fernandez-Rodriguez et al., 2015;Krewer et al., 2016).”
From The hypothalamus-pituitary-thyroid (HPT)-axis and its role in physiology and pathophysiology of other hypothalamus-pituitary functions (2021) · cites this paper as Fernandez-Rodriguez et al., 2015
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“tary abnormalities is lower and comparable to the prevalence expected for the general population.(33)”
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Central hypothyroidism — a neglected thyroid disorder
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- Authors
- Fernandez-Rodriguez, E., Bernabeu, I., Castro, A. I., & Casanueva, F. F.
- Affiliations
- Universidade de Santiago de Compostela (ES)
- Corresponding author
- Casanueva, Felipe F.
- ORCID
- Casanueva, Felipe F.
- Venue
- Endocrinology and Metabolism Clinics of North America
- Publisher
- Elsevier BV
- Published
- 2015-03
- Volume
- 44
- Issue
- 1
- Pages
- 151-159
- ISSN
- 0889-8529 (ISSN-L)
- OpenAlex
- W2120536600
- Cited by
- 40
- References
- 68
- Citations by year
- 2026: 2 · 2025: 2 · 2023: 2 · 2022: 2 · 2021: 5 · 2020: 5 · 2019: 5 · 2018: 2 · 2017: 5 · 2016: 4 · 2015: 6
- FWCI
- 0.80
- Type
- journal article
- Language
- en
- Open access
- green
- hdl.handle.net
- Licence
- Locations
- Endocrinology and Metabolism Clinics of North America (publishedVersion)
- PubMed (publishedVersion)
- RUNA. Repositorio Institucional del Sergas (Servicio Gallego de Salud (SERGAS)) (submittedVersion, other-oa)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pituitary Gland Disorders and Treatments
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
- Health Sciences › Medicine › Neurology › Traumatic Brain Injury and Neurovascular Disturbances
- Keywords
- hypopituitarism, traumatic brain injury, growth hormone deficiency, anterior pituitary insufficiency, prevalence, hormone replacement therapy, cognitive function, quality of life
- MeSH terms
- Brain Injuries, Humans, Hypopituitarism, Human Growth Hormone
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